LOCUS       NM_017654               6806 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens sterile alpha motif domain containing 9 (SAMD9),
            transcript variant 1, mRNA.
ACCESSION   NM_017654
VERSION     NM_017654.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6806)
  AUTHORS   McSweeney,K., Hoover,P., Ramirez-Solano,M., Liu,Q. and
            Schwartz,J.R.
  TITLE     Overexpression of human SAMD9 inhibits protein translation and
            alters MYC signaling resulting in cell cycle arrest
  JOURNAL   Exp Hematol 137, 104249 (2024)
   PUBMED   38848876
  REMARK    GeneRIF: Overexpression of human SAMD9 inhibits protein translation
            and alters MYC signaling resulting in cell cycle arrest.
REFERENCE   2  (bases 1 to 6806)
  AUTHORS   Zhang,L., Chen,W., Shi,Z. and Shang,Z.
  TITLE     PARP14 correlates with GBM proliferation and poor prognosis by
            elevating expression of SAMD/SAMD9L
  JOURNAL   Ir J Med Sci 193 (2), 585-593 (2024)
   PUBMED   37612499
  REMARK    GeneRIF: PARP14 correlates with GBM proliferation and poor
            prognosis by elevating expression of SAMD/SAMD9L.
REFERENCE   3  (bases 1 to 6806)
  AUTHORS   Gahr,S., Perinetti Casoni,G., Falk-Paulsen,M., Maschkowitz,G.,
            Bryceson,Y.T. and Voss,M.
  TITLE     Viral host range factors antagonize pathogenic SAMD9 and SAMD9L
            variants
  JOURNAL   Exp Cell Res 425 (2), 113541 (2023)
   PUBMED   36894052
  REMARK    GeneRIF: Viral host range factors antagonize pathogenic SAMD9 and
            SAMD9L variants.
REFERENCE   4  (bases 1 to 6806)
  AUTHORS   Shang,Q.W., Xue,L., Zhang,L.P. and Lu,A.D.
  TITLE     [Pancytopenia in children caused by SAMD9/9L mutation: 5 cases
            report and literature review]
  JOURNAL   Zhonghua Xue Ye Xue Za Zhi 44 (4), 340-343 (2023)
   PUBMED   37357006
  REMARK    GeneRIF: [Pancytopenia in children caused by SAMD9/9L mutation: 5
            cases report and literature review].
            Review article
REFERENCE   5  (bases 1 to 6806)
  AUTHORS   Li,Q., Luo,H., Dai,F.Q., Wang,R.T., Fan,X.Q., Luo,Y.Y., Deng,M.S.,
            Wang,Y., Long,T., Guo,W., Xu,B., Xu,C.X. and Jin,H.
  TITLE     SAMD9 Promotes Postoperative Recurrence of Esophageal Squamous Cell
            Carcinoma by Stimulating MYH9-Mediated GSK3beta/beta-Catenin
            Signaling
  JOURNAL   Adv Sci (Weinh) 10 (11), e2203573 (2023)
   PUBMED   36757050
  REMARK    GeneRIF: SAMD9 Promotes Postoperative Recurrence of Esophageal
            Squamous Cell Carcinoma by Stimulating MYH9-Mediated
            GSK3beta/beta-Catenin Signaling.
REFERENCE   6  (bases 1 to 6806)
  AUTHORS   Hershkovitz,D., Gross,Y., Nahum,S., Yehezkel,S., Sarig,O., Uitto,J.
            and Sprecher,E.
  TITLE     Functional characterization of SAMD9, a protein deficient in
            normophosphatemic familial tumoral calcinosis
  JOURNAL   J Invest Dermatol 131 (3), 662-669 (2011)
   PUBMED   21160498
  REMARK    GeneRIF: SAMD9, an IFN-gamma-responsive protein, interacts with
            RGL2 to diminish the expression of EGR1, a protein of direct
            relevance to the pathogenesis of ectopic calcification and
            inflammation.
REFERENCE   7  (bases 1 to 6806)
  AUTHORS   Tanaka,M., Shimbo,T., Kikuchi,Y., Matsuda,M. and Kaneda,Y.
  TITLE     Sterile alpha motif containing domain 9 is involved in death
            signaling of malignant glioma treated with inactivated Sendai virus
            particle (HVJ-E) or type I interferon
  JOURNAL   Int J Cancer 126 (8), 1982-1991 (2010)
   PUBMED   19830690
  REMARK    GeneRIF: SAMD9 could be a key molecule to control cancer cell death
            by inactivated Sendai virus particle or IFN-beta treatment.
REFERENCE   8  (bases 1 to 6806)
  AUTHORS   Chefetz,I., Ben Amitai,D., Browning,S., Skorecki,K., Adir,N.,
            Thomas,M.G., Kogleck,L., Topaz,O., Indelman,M., Uitto,J.,
            Richard,G., Bradman,N. and Sprecher,E.
  TITLE     Normophosphatemic familial tumoral calcinosis is caused by
            deleterious mutations in SAMD9, encoding a TNF-alpha responsive
            protein
  JOURNAL   J Invest Dermatol 128 (6), 1423-1429 (2008)
   PUBMED   18094730
  REMARK    GeneRIF: SAMD9 may have a role in the TNF-alpha signaling pathway
            and in the regulation of extra-osseous calcification
REFERENCE   9  (bases 1 to 6806)
  AUTHORS   Li,C.F., MacDonald,J.R., Wei,R.Y., Ray,J., Lau,K., Kandel,C.,
            Koffman,R., Bell,S., Scherer,S.W. and Alman,B.A.
  TITLE     Human sterile alpha motif domain 9, a novel gene identified as
            down-regulated in aggressive fibromatosis, is absent in the mouse
  JOURNAL   BMC Genomics 8, 92 (2007)
   PUBMED   17407603
  REMARK    GeneRIF: SAMD9 and SAMD9L are a novel family of genes, which play a
            role regulating cell proliferation and suppressing the neoplastic
            phenotype; the human gene exists in rat, but is lost in mouse, due
            to a mouse specific rearrangement
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 6806)
  AUTHORS   Topaz,O., Indelman,M., Chefetz,I., Geiger,D., Metzker,A.,
            Altschuler,Y., Choder,M., Bercovich,D., Uitto,J., Bergman,R.,
            Richard,G. and Sprecher,E.
  TITLE     A deleterious mutation in SAMD9 causes normophosphatemic familial
            tumoral calcinosis
  JOURNAL   Am J Hum Genet 79 (4), 759-764 (2006)
   PUBMED   16960814
  REMARK    GeneRIF: Mutation analysis revealed a homozygous mutation in the
            SAMD9 gene (K1495E), which was found to segregate with the disease
            in all families and to interfere with the protein expression.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF445355.1 and AA628487.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_017654.3.
            
            Summary: This gene encodes a sterile alpha motif domain-containing
            protein. The encoded protein localizes to the cytoplasm and may
            play a role in regulating cell proliferation and apoptosis.
            Mutations in this gene are the cause of normophosphatemic familial
            tumoral calcinosis. Alternate splicing results in multiple
            transcript variants that encode the same protein.[provided by
            RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647072.1, AF445355.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467147 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379958.3/ ENSP00000369292.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6805              AF445355.1         45-6849
            6806-6806           AA628487.1         6-6                 c
FEATURES             Location/Qualifiers
     source          1..6806
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.2"
     gene            1..6806
                     /gene="SAMD9"
                     /gene_synonym="C7orf5; DRIF1; M7MLS2; MIRAGE; NFTC; OEF1;
                     OEF2"
                     /note="sterile alpha motif domain containing 9"
                     /db_xref="GeneID:54809"
                     /db_xref="HGNC:HGNC:1348"
                     /db_xref="MIM:610456"
     exon            1..117
                     /gene="SAMD9"
                     /gene_synonym="C7orf5; DRIF1; M7MLS2; MIRAGE; NFTC; OEF1;
                     OEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            118..218
                     /gene="SAMD9"
                     /gene_synonym="C7orf5; DRIF1; M7MLS2; MIRAGE; NFTC; OEF1;
                     OEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            219..6806
                     /gene="SAMD9"
                     /gene_synonym="C7orf5; DRIF1; M7MLS2; MIRAGE; NFTC; OEF1;
                     OEF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..4996
                     /gene="SAMD9"
                     /gene_synonym="C7orf5; DRIF1; M7MLS2; MIRAGE; NFTC; OEF1;
                     OEF2"
                     /note="expressed in aggressive fibromatosis; SAM
                     domain-containing protein 9"
                     /codon_start=1
                     /product="sterile alpha motif domain-containing protein 9"
                     /protein_id="NP_060124.2"
                     /db_xref="CCDS:CCDS34680.1"
                     /db_xref="GeneID:54809"
                     /db_xref="HGNC:HGNC:1348"
                     /db_xref="MIM:610456"
                     /translation="MAKQLNLPENTDDWTKEDVNQWLESHKIDQKHREILTEQDVNGA
                     VLKWLKKEHLVDMGITHGPAIQIEELFKELRKTAIEDSIQTSKMGKPSKNAPKDQTVS
                     QKERRETSKQKQKGKENPDMANPSAMSTTAKGSKSLKVELIEDKIDYTKERQPSIDLT
                     CVSYPFDEFSNPYRYKLDFSLQPETGPGNLIDPIHEFKAFTNTATATEEDVKMKFSNE
                     VFRFASACMNSRTNGTIHFGVKDKPHGKIVGIKVTNDTKEALINHFNLMINKYFEDHQ
                     VQQAKKCIREPRFVEVLLPNSTLSDRFVIEVDIIPQFSECQYDYFQIKMQNYNNKIWE
                     QSKKFSLFVRDGTSSKDITKNKVDFRAFKADFKTLAESRKAAEEKFRAKTNKKEREGP
                     KLVKLLTGNQDLLDNSYYEQYILVTNKCHPDQTKHLDFLKEIKWFAVLEFDPESNING
                     VVKAYKESRVANLHFPSVYVEQKTTPNETISTLNLYHQPSWIFCNGRLDLDSEKYKPF
                     DPSSWQRERASDVRKLISFLTHEDIMPRGKFLVVFLLLSSVDDPRDPLIETFCAFYQD
                     LKGMENILCICVHPHIFQGWKDLLEARLIKHQDEISSQCISALSLEEINGTILKLKSV
                     TQSSKRLLPSIGLSTVLLKKEEDIMTALEIICENECEGTLLEKDKNKFLEFKASKEED
                     FYRGGKVSWWNFYFSSESYSSPFVKRDKYERLEAMIQNCADSSKPTSTKIIHLYHHPG
                     CGGTTLAMHILWELRKKFRCAVLKNKTVDFSEIGEQVTSLITYGAMNRQEYVPVLLLV
                     DDFEEQDNVYLLQYSIQTAIAKKYIRYEKPLVIILNCMRSQNPEKSARIPDSIAVIQQ
                     LSPKEQRAFELKLKEIKEQHKNFEDFYSFMIMKTNFNKEYIENVVRNILKGQNIFTKE
                     AKLFSFLALLNSYVPDTTISLSQCEKFLGIGNKKAFWGTEKFEDKMGTYSTILIKTEV
                     IECGNYCGVRIIHSLIAEFSLEELKKSYHLNKSQIMLDMLTENLFFDTGMGKSKFLQD
                     MHTLLLTRHRDEHEGETGNWFSPFIEALHKDEGNEAVEAVLLESIHRFNPNAFICQAL
                     ARHFYIKKKDFGNALNWAKQAKIIEPDNSYISDTLGQVYKSKIRWWIEENGGNGNISV
                     DDLIALLDLAEHASSAFKESQQQSEDREYEVKERLYPKSKRRYDTYNIAGYQGEIEVG
                     LYTIQILQLIPFFDNKNELSKRYMVNFVSGSSDIPGDPNNEYKLALKNYIPYLTKLKF
                     SLKKSFDFFDEYFVLLKPRNNIKQNEEAKTRRKVAGYFKKYVDIFCLLEESQNNTGLG
                     SKFSEPLQVERCRRNLVALKADKFSGLLEYLIKSQEDAISTMKCIVNEYTFLLEQCTV
                     KIQSKEKLNFILANIILSCIQPTSRLVKPVEKLKDQLREVLQPIGLTYQFSEPYFLAS
                     LLFWPENQQLDQHSEQMKEYAQALKNSFKGQYKHMHRTKQPIAYFFLGKGKRLERLVH
                     KGKIDQCFKKTPDINSLWQSGDVWKEEKVQELLLRLQGRAENNCLYIEYGINEKITIP
                     ITPAFLGQLRSGRSIEKVSFYLGFSIGGPLAYDIEIV"
     regulatory      6789..6794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAMD9"
                     /gene_synonym="C7orf5; DRIF1; M7MLS2; MIRAGE; NFTC; OEF1;
                     OEF2"
                     /note="hexamer: AATAAA"
     polyA_site      6806
                     /gene="SAMD9"
                     /gene_synonym="C7orf5; DRIF1; M7MLS2; MIRAGE; NFTC; OEF1;
                     OEF2"
                     /note="major polyA site"
ORIGIN      
        1 ggaaaatact tttctctagc atcgtaggag gaagaaaaca aacacatcag atattttcag
       61 cactaaaaga gatggttttc cccacatata tgtaaaagaa atttgcaaga ctactggatt
      121 ttgatctcat ggttgcagtg ggtgaatagg tggccttttg tgatctccta catcaccctg
      181 gaagtgagac ttcttcggtt tcttctagag tcagtttggt atcagaatgg caaagcaact
      241 taaccttcca gaaaatacag atgattggac aaaagaggat gtaaatcagt ggttagaaag
      301 tcataagatt gaccaaaaac acagggaaat tttgactgaa caagacgtga atggagcagt
      361 cttgaagtgg ttaaaaaaag aacatcttgt tgatatgggc atcacacatg gaccagctat
      421 tcaaatagaa gaactattca aagaattgcg gaaaacagcc attgaagatt cgattcagac
      481 atctaagatg ggaaagccca gtaaaaatgc tcctaaagac caaactgtgt ctcaaaagga
      541 acgtagagaa acttcaaagc aaaaacaaaa gggtaaagag aacccagata tggctaatcc
      601 gtctgcaatg agtacaactg ctaaaggttc taagtcacta aaagttgagc tcatagaaga
      661 taaaatagat tatacaaagg aaaggcaacc atccatagac ctgacatgtg tatcatatcc
      721 atttgatgaa ttcagtaatc catatcgtta caagttggat tttagtctac agcctgaaac
      781 aggaccaggc aatctcattg atccgataca tgaattcaaa gccttcacaa atacagcaac
      841 agccacagaa gaggatgtca agatgaaatt tagcaatgag gttttccgat ttgcttcagc
      901 ttgtatgaat tcacgtacca atggcactat tcattttgga gtcaaagaca aaccccatgg
      961 gaaaattgtt ggcatcaaag tcaccaatga taccaaggaa gccctcatta accatttcaa
     1021 tctgatgata aacaagtatt ttgaagacca tcaagtccaa caagcaaaga agtgcattcg
     1081 agagccaaga tttgtggaag ttttactgcc aaatagtact ctatctgaca gatttgttat
     1141 tgaagtggac attattccac agttctctga atgccaatat gattatttcc agattaaaat
     1201 gcaaaattac aacaacaaaa tatgggaaca aagtaaaaaa ttctcactat ttgtgcgaga
     1261 tgggaccagc tctaaggaca ttacgaaaaa taaagttgat ttcagagcat ttaaagcaga
     1321 ttttaaaaca ctggcagagt ccagaaaagc agcagaagaa aaattcagag caaaaacaaa
     1381 taaaaaagaa agagagggac caaagttggt taaattattg acaggaaatc aagatttgtt
     1441 agataattca tactatgaac agtacattct tgtaacaaat aaatgccacc cagatcaaac
     1501 aaaacactta gatttcctga aggaaattaa atggtttgct gtattggagt ttgatcctga
     1561 gtctaacatc aatggagtgg tcaaagctta caaagaaagc cgagtagcaa accttcactt
     1621 tccaagtgta tatgtagaac agaaaaccac accaaatgag acgatttcta ctctaaatct
     1681 ttaccatcaa cccagctgga ttttctgcaa tggcaggtta gaccttgaca gtgaaaaata
     1741 taaacccttt gatccaagtt cctggcaaag agaaagagct tctgatgtca ggaaactgat
     1801 ttcatttctt acacatgaag acataatgcc aagagggaag tttttggtgg tatttctatt
     1861 actgtcctct gtggatgacc caagagatcc cctcattgag actttctgtg ctttctacca
     1921 ggatctcaaa ggaatggaaa atatactgtg tatttgtgtg cacccacaca tatttcaggg
     1981 atggaaagat ctacttgaag caagattaat aaaacaccaa gatgaaattt caagccaatg
     2041 tatttctgct ttaagccttg aagagatcaa tggcactatt cttaaactaa aatctgtgac
     2101 tcaatcttca aaaaggcttt tgccatctat tggtttatcg actgtccttc tgaaaaagga
     2161 agaagatatc atgactgctc tggaaattat ctgtgaaaat gaatgtgagg gtacactgtt
     2221 agagaaggac aaaaataaat tccttgaatt caaggcatca aaagaggaag acttctatcg
     2281 aggtggcaaa gtgtcatggt ggaacttcta cttctcttct gaaagttatt cttcaccttt
     2341 tgtcaaaagg gataaatatg aaagacttga agcaatgatt caaaactgtg cagattcttc
     2401 taaaccaaca agtaccaaaa ttattcatct gtatcatcat ccaggctgtg ggggaactac
     2461 cttggctatg cacattctct gggaactaag gaagaaattc agatgtgctg tgctgaaaaa
     2521 caagacagtg gatttttctg aaattggaga acaggtaacc agtttaatca cctatggggc
     2581 aatgaaccgt caggaatacg tacctgtact actccttgtt gatgattttg aagaacaaga
     2641 taatgtctat cttctgcagt actctattca aacagctata gctaaaaagt acattcgata
     2701 tgaaaaacct ctggtgatta tcctaaattg tatgagatca caaaatcctg aaaaaagtgc
     2761 aaggatccca gacagtattg ccgtaataca gcaactctct cccaaagaac agagagcttt
     2821 tgagcttaaa ttgaaagaaa tcaaagaaca gcataaaaac tttgaggatt tttattcctt
     2881 tatgatcatg aaaaccaatt ttaataaaga atacatagaa aatgtggtcc ggaatatcct
     2941 gaaagggcag aatattttca ccaaggaagc aaagctcttt tcttttctgg ctcttcttaa
     3001 ttcatatgtg cctgatacca ccatttcact atcacagtgt gaaaaattct taggaattgg
     3061 aaacaagaag gctttctggg ggacagaaaa atttgaagac aagatgggca cctactctac
     3121 aattctgata aaaacagagg tcatcgaatg tgggaactac tgtggagtac gcatcattca
     3181 ctctttgatt gcagagttct cactggaaga attgaagaaa agctatcacc tgaataaaag
     3241 tcaaattatg ttggatatgc taactgagaa tttgttcttc gatactggta tgggaaaaag
     3301 taaatttttg caagatatgc acacactcct actcacaaga caccgcgatg aacatgaagg
     3361 tgaaacagga aattggtttt ccccatttat tgaagcatta cataaagatg aaggaaatga
     3421 agcagttgaa gctgtattgc ttgaaagtat ccatcggttc aacccaaatg cattcatttg
     3481 ccaagcgttg gcaagacatt tctacattaa aaagaaggac tttggcaatg ctctaaactg
     3541 ggcaaaacaa gcaaaaatca tagaacctga caattcttat atctcagata cactgggtca
     3601 agtctacaaa agtaaaataa gatggtggat agaggaaaac ggaggaaacg ggaacatttc
     3661 agttgatgat ctaattgctc ttttggattt agcagaacat gcctcaagtg cattcaaaga
     3721 atctcaacag caaagtgaag atagagagta tgaagtgaag gaaagattgt atccgaagtc
     3781 aaaaaggcgg tatgatactt acaatatagc tggttatcaa ggagagatag aagttgggct
     3841 ttacacaatc caaattctcc agctcattcc tttttttgat aataaaaatg agctatctaa
     3901 aagatatatg gtcaattttg tatcaggaag tagtgatatt ccaggggatc caaacaatga
     3961 atataaatta gccctcaaaa actatattcc ttatttaact aaattgaaat tttctttgaa
     4021 aaagtccttt gatttttttg atgaatactt tgtcctgcta aaacccagga acaatattaa
     4081 gcaaaatgaa gaggccaaaa ctcggagaaa ggtggctgga tattttaaga aatatgtaga
     4141 tatattttgt ctcttagaag aatcacaaaa caacacaggt cttggatcaa agttcagtga
     4201 gccacttcaa gtagagagat gcaggagaaa cctagtagct ttaaaagcag acaagttttc
     4261 tgggctcttg gaatatctta tcaaaagtca agaggatgct ataagcacta tgaaatgtat
     4321 agtgaacgaa tatacttttc tcttagaaca atgcactgtc aaaatccagt caaaagaaaa
     4381 gctaaatttc atcttggcca acattattct ctcctgtatc caacctacct ccagattagt
     4441 aaagccagtt gaaaaactaa aagatcagct tcgagaagtc ttgcaaccaa taggactgac
     4501 ttatcagttt tcagaaccgt attttctagc ttccctctta ttctggccag aaaatcaaca
     4561 actagatcaa cattctgaac aaatgaaaga gtatgctcaa gcactaaaaa attctttcaa
     4621 ggggcaatat aaacatatgc atcgtacaaa gcaaccaatt gcatatttct ttcttggaaa
     4681 aggtaaaaga ctggaaagac ttgttcacaa aggaaaaatt gaccagtgct ttaagaagac
     4741 accagatatt aattccttgt ggcagagtgg agatgtgtgg aaggaggaaa aagtccaaga
     4801 acttttgctt cgtttacaag gtcgagctga aaacaattgt ttatatatag aatatggaat
     4861 caatgaaaaa atcacaatac ccatcactcc cgctttttta ggtcaactta gaagtggcag
     4921 aagcatagag aaggtgtctt tttacctggg attttccatt ggaggcccac ttgcttatga
     4981 cattgaaatt gtttaagagc ctgatattct tcctccaaga atttgatctc agtacccatt
     5041 taattttttt ggactcaaga tctatgcttt aaaccggcaa ggttatagat acagcctcta
     5101 gctcttcaga tctgtacatg cagtatttaa tttcctctta aacatgttat gagttctaca
     5161 aagacaatag tgaaaaagga aggagtgaga tatatgaaaa gtagcaaata tgttccttgg
     5221 tttggttaac atcattgatg acaaaataat aaggagctat gactggagtc aggagaagtt
     5281 agtgtaataa gctggctaca cagaacccca ctacttacca ggcatggatt gaagaagatt
     5341 gtctactcaa atggcattta gacattagaa tgtctgggaa aatatttctc aaagacagca
     5401 aaaacctctc aaactgagga gcaacattta ttcttactaa gcagatcatc aatgtatcat
     5461 gtgcttggca ctcaaggatc ttccaaaaca gaggaccaac cagtcttctg aaggtcatgc
     5521 ccacagaagt catcagacct taccaaagta ggttggagaa ttagattgcc ttttcatgca
     5581 gtgagattca gttaagcaaa aatgaaattt gtctctatag ctaattagct tatcaactcc
     5641 cctccaaaca aacaattaaa aaaaaaacat acagacactc aaattccaca agctaatgaa
     5701 caaaagggac tcttgtgaga agactaatga gtccctcatc cagaagatgc caatgtactg
     5761 gcagattaac atacaaccta tgttttgaac aaaaacaacc agcgatacgt aatcaaaatg
     5821 taattttccc ctaataaaat tatggatatg ggcagtcatc aatggctgcc aaaaccatta
     5881 agtggaaagc tgattaaaaa acaaaaattt ctaatggatt tatcaaactg tcccaaatcc
     5941 tgataaatat taacatcaca gaggaagacc agacattatg ggcctggaag tactatagga
     6001 gtgcacacat cacccgtgac atggtcttgc caaataatta aacctgaatt tgatcaggtc
     6061 tctggatctt atttgcaatt caaaagaaat tttaaaaaaa tcctactaac accaccacaa
     6121 atatgcaatc agcaatatcc agaaagggga aattcacagg acaaaaacct ggttttcttt
     6181 tttggtttct tcaaccaaaa aagaaagaaa ttgcaaagga ccaaaaaaat gttggggaat
     6241 ctatacatta taagggactt aacaactaaa gggcaacata tagactttag atcctaattt
     6301 gagcaaaatc taaaatcaat tattaggcaa tcagaaaaat ttgaacacag actagatatt
     6361 tgaggatatt aaggtactat attattgaag attccatggt tatgtttttt aaagagttca
     6421 tgccttttag agatacatac taaagtattt gtaaataaat gacatgatct agaatcagta
     6481 attttgtgtt tggggtgtgg gggtggtgaa agggaagtag aaccgaaaca agattagtcc
     6541 tgagttaaca atggctgcaa gctggataca tggaattcag cacacttttc tccctcttac
     6601 tgattatgct tttgaaattt tctcttgtaa aacatttaga aaacaaaaac aaaaaaaatg
     6661 tgatttgttt ctgtcttcaa aatctcatta gaattttttc actggaggaa gattttccct
     6721 tgcttctgca taaaatttta actccataac ttataagctc actctttatt gttactttct
     6781 aattgacaaa taaaaattgt atatta
//
