LOCUS       NM_001030060            6326 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens sterile alpha motif domain containing 5 (SAMD5), mRNA.
ACCESSION   NM_001030060 XM_371851
VERSION     NM_001030060.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6326)
  AUTHORS   Yagai,T., Matsui,S., Harada,K., Inagaki,F.F., Saijou,E., Miura,Y.,
            Nakanuma,Y., Miyajima,A. and Tanaka,M.
  TITLE     Expression and localization of sterile alpha motif domain
            containing 5 is associated with cell type and malignancy of biliary
            tree
  JOURNAL   PLoS One 12 (4), e0175355 (2017)
   PUBMED   28388653
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6326)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 6326)
  AUTHORS   Fellay,J., Ge,D., Shianna,K.V., Colombo,S., Ledergerber,B.,
            Cirulli,E.T., Urban,T.J., Zhang,K., Gumbs,C.E., Smith,J.P.,
            Castagna,A., Cozzi-Lepri,A., De Luca,A., Easterbrook,P.,
            Gunthard,H.F., Mallal,S., Mussini,C., Dalmau,J.,
            Martinez-Picado,J., Miro,J.M., Obel,N., Wolinsky,S.M.,
            Martinson,J.J., Detels,R., Margolick,J.B., Jacobson,L.P.,
            Descombes,P., Antonarakis,S.E., Beckmann,J.S., O'Brien,S.J.,
            Letvin,N.L., McMichael,A.J., Haynes,B.F., Carrington,M., Feng,S.,
            Telenti,A. and Goldstein,D.B.
  CONSRTM   NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
  TITLE     Common genetic variation and the control of HIV-1 in humans
  JOURNAL   PLoS Genet 5 (12), e1000791 (2009)
   PUBMED   20041166
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL354880.12, CB988162.1, BX642659.1 and AL034350.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001030060.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX642679.1, BX642659.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367474.2/ ENSP00000356444.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL354880.12        7879-7880
            3-635               CB988162.1         30-662
            636-1121            BX642659.1         2-487
            1122-6326           AL034350.2         44828-50032
FEATURES             Location/Qualifiers
     source          1..6326
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.3"
     gene            1..6326
                     /gene="SAMD5"
                     /gene_synonym="dJ875H10.1"
                     /note="sterile alpha motif domain containing 5"
                     /db_xref="GeneID:389432"
                     /db_xref="HGNC:HGNC:21180"
                     /db_xref="MIM:620517"
     exon            1..698
                     /gene="SAMD5"
                     /gene_synonym="dJ875H10.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..761
                     /gene="SAMD5"
                     /gene_synonym="dJ875H10.1"
                     /note="SAM domain containing 1; SAM domain-containing
                     protein 5"
                     /codon_start=1
                     /product="sterile alpha motif domain-containing protein 5"
                     /protein_id="NP_001025231.1"
                     /db_xref="CCDS:CCDS34548.1"
                     /db_xref="GeneID:389432"
                     /db_xref="HGNC:HGNC:21180"
                     /db_xref="MIM:620517"
                     /translation="MCTNIVYEWLKALQLPQYAESFVDNGYDDLEVCKQIGDPDLDAI
                     GVLAPAHRRRILEAVRRLREQDANAAGLYFTLEPQPAPPGPPADAVPTGRRGEPCGGP
                     AQGTRGDSRGHTTAPRSRELVSYPKLKLKIMIRDKLVRDGIHLSKPPYSRKVPMAGIL
                     EYLMNWPKSSQSR"
     exon            699..6326
                     /gene="SAMD5"
                     /gene_synonym="dJ875H10.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6302..6307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAMD5"
                     /gene_synonym="dJ875H10.1"
                     /note="hexamer: AATAAA"
     polyA_site      6326
                     /gene="SAMD5"
                     /gene_synonym="dJ875H10.1"
                     /note="major polyA site"
ORIGIN      
        1 agtgcctgcg agctccgctg ctgcttgggg aattcacttt gctgcttgtt cgcttctccc
       61 ttcctcaggc ttcttctgat ggttttccgt ctcctgcccg agcctttcct ttaaaaggaa
      121 aactttactg cgataccctt ttccccttgg aggagaggat taaaagttcc aagaactggt
      181 gccgcccgtg ccatttgggc gctgggaagg tgctcggcgg cggggttccc ggtcccacca
      241 tgtgcaccaa catagtttac gagtggctca aagcgctgca gcttccgcag tacgcggagt
      301 ccttcgtgga taacggctac gatgacctgg aggtgtgcaa gcagatcggg gacccggacc
      361 tggatgccat cggggtgctg gcgcccgcgc accgccgccg tatcctggag gccgtgcgcc
      421 ggctgcggga gcaggacgcc aacgccgccg gcctctactt cacgcttgag ccgcagccgg
      481 cgccccccgg gccgcccgcc gacgccgtcc ccaccggccg ccggggggag ccgtgcggcg
      541 gcccggccca gggcacccgc ggggactctc gcggccacac gaccgccccc cgcagcaggg
      601 agctggtgag ctaccccaaa ctgaagctga agatcatgat cagggataag ctcgtccgtg
      661 acggcatcca cctgagcaag cccccgtact cccgcaaggt cccaatggct ggcatcctag
      721 agtacttaat gaattggccg aagtcatcac agagccgcta gatatcattt ttgagacctc
      781 gtggaggact gatgaggtgc ctgaagactg gaaaagggca tatttagaac cttctttcaa
      841 aaagggaaat ggatgatgac cctggaaata ctcatcagct taactttttg cttggacaaa
      901 ttctggaata atcaacttag taaactgggt aactggctta taacagctag aaataaggca
      961 gtgaactatc acgcataaag aagtattgag ttcatttttt taagaagata tcatgatgag
     1021 atacagtctt atgcatttct tggcattctc ccttccattc ttaatgaaaa cagatgaggt
     1081 tggctaaggc atttgagtca taacttagtt taagtacaat ataacaaaaa ggtagatttc
     1141 tgacagtaag tagtaattat attatttcca aatttgcttt taacttgaga acagtagctt
     1201 taatttttat attcaagcat acattctact tcatttcata taggaccatg tttttataag
     1261 ataagataca taattctatg tagaatagtt tggtgaagga attcttattt taaggtgctt
     1321 ttatatagtt attttgtata ttggtacaat gttaaaggtg atgaattaag gaacatcacc
     1381 aagagaggac aatttcttct aacttctctt tttaaattta atctggctga ggtttagtat
     1441 taggactaat acaagtgtct tgctctgaca tgcatcaagc aagagctagc tattttactt
     1501 catagctagt ttcttgcact ctgtggagac tgccagggcc gcagctcaca gcctgttctg
     1561 agctgcagtg ctttatccca ccttgctctc caggcttctg acttcaggcc tgtgggggcc
     1621 gggaggtggg cagcggcagt ggcctgagga gccctgtaga actacggctg aaaaagaaag
     1681 tagattgagg tggggggagg aaattaacag gaatctagag tttttctaat tcttatcgtc
     1741 ttatcgttct tgtgtttgga tgctggtagt tttttttttt ttagacagag tctcgctctg
     1801 tcacccaggc tggagtgtag tggcacaatc ttggctcaca gtgactttcg cctcccaggt
     1861 tcaaggaatt ctcctgcctc ggcctcttgg tagctgggat tacaggcacg catcaccaca
     1921 cccagctaat ttttttgtat ttttagtaga gatggggttt taccatgttg gccaggctgt
     1981 tcttgaactc ctggcctcaa atgatccact cgccgtggcc tccagtagcg ctgggattac
     2041 aggcgtgagc catcacaccc ggcctggatg ctggtagttt tattttctgc ttagaaaacg
     2101 caaccatgtt gatgggacca aaaacttagt tgaaagaagc catggcaaaa gatgttgacg
     2161 tacaactggc tcctgaggct gtcaattgtt tagagctccc aagtagtact gcattacgga
     2221 atctactact tagaagaatg tacaagatgt aagttcccat cggcaccgtc atggtaagaa
     2281 gaataagaaa ctctcaaagg aaaagaaact tacattcact ttttcctggt ccattttggt
     2341 tcctaagaat agataggcca ttaagaagga tattaggttt ctaaggacaa ttttaacaca
     2401 atactgcttt aaaaatctga agtttaaata gtttagctat ttctgtaggt taattcaggc
     2461 actgactaaa atcagtctca ttatcatata caaatgtaag gaagttaaat tttaaaagca
     2521 tgtataggtt gtccttaaat tatacaaaag cttttagttt catcaggatt atattccagt
     2581 taacctttca tctttttttt ttttccaaat gaactagggt ctttaaaatt cctaagtaga
     2641 ttcttttgag tggtagggga gtctgtatag attacagata taatttattg tgataacaaa
     2701 tggcttcctg tttgacctca tttccaggtg tcgcatccgt ggctgattta tttcacagat
     2761 gtacatttgc atgtacttgt tgaactttgc taggaaggac tcaatttttg aaaaatctgt
     2821 tattttcact gtgggcctta tgaggcaatc tactgcaatg gaaaaagggt tccttggtca
     2881 tttcaagttt tattttctat tagagtaata tctaacttca attattttgc caggtttaaa
     2941 ccttctctct gtgtctgtgg ttagaatttg aaaataacaa tgctctgctt aaagtaagag
     3001 tcacagtcag caaaaaaagc caatggattt taaaaagaca tcttagttaa agctagagga
     3061 agaaaacttc aaataagcaa agaagtattg aaggatgccc acgaattcct ttgcattaaa
     3121 atcaagatga ggtaagaggt agaatataag agaaagggat tatttttacc atgaattgta
     3181 tctggggaca gttagtctta gaaggagtaa ttttttcagc gtttttcctc tgtatctaaa
     3241 caccaataat atacttaatt tttgaatata aaagaagtag caattgacta agaataaata
     3301 tgttataaaa actaggggat tatcttgatt tacatttcct agagtattaa aagagattaa
     3361 ttacagactt tcacttgata atattgagga gtctggaggg tcatagcaaa attttcttta
     3421 gttcatctta aaatttaggg aggtaaaaaa agattttatt cacataaaag atttcttggc
     3481 atagggaagg cgtaatgtta agggcttctt ccttacccaa gtgggagctg aaccagtaat
     3541 tgtggggaaa actgaattta tagcaacaaa ggatagtagt ttctcaactg ggagcatacg
     3601 agcaatttct cagttcagag atatttatag catcttggtg ttatgcaata aacaatgaca
     3661 acaacaagca ttgagctttc actttggagt tactcagatc tgagtttaaa ttctaaaatt
     3721 attctagtag tattttcctg cggtgaatct gttaaggatg taagctatag tgtagcttgg
     3781 ggaatcatct tgaacagtta tgaaactcat taaagcttct tttcccttgt ctgtaaaatg
     3841 ggaaaaataa atacctctat agctcttaag aggcttaaga gttctatggc ttacacccac
     3901 atacagtcct tggctcagtg ctaggcatgt agcaggtgct gactgcctct ctcccttccc
     3961 ttctttactc tcagttgtct tatttcttct tatgcagaag agattacctt aaagctgact
     4021 agaaaactca gacataaatt gacatttcct tatcattgcc tgaaacccac tgaataagtc
     4081 ccctttgatt tctctcagga aggataaaaa aggctacagt acctgctcat aggagttcag
     4141 taaatgttta ttgattgaat gaaaagaatt tgatttaagg aaacaataac actccatcct
     4201 gggcaacaga gcaagatccc gtctcaaaac aaaacaaaac aaaacaaaac agcaaattca
     4261 taaaggccag cagttttcaa gtctggggaa ataggcacat ggacagatta tatgaaggta
     4321 tttcattagc tttcttctct ttatggcagc ttcagattga tgaatttgag gtacaaatga
     4381 gtgagtgaca tatgtatatt ttcctctgat tttatgactg atttacaaat taggagtgca
     4441 aatgggctgt tccccgatag catcttctgg gaagaatcca accaagatac aaagcagatg
     4501 atggtggatc ggcaaactct tttctatgaa aagaaaaacc agatatacca gggactggaa
     4561 agcacctgct tgaaaattga tatgagcatg tctgaatttt tcccttataa gagcctgagt
     4621 attgtaacag gtctcttgca cagggggttg aaaaataaaa aaagaagtta acataattaa
     4681 aatgcttgga caaaacattt gctttatata gattcttaca agtaatattt gattaggtat
     4741 caaaataggt ttaggcaggt ggaagttctg aatttcaagg caaataaggc atgaagggtg
     4801 gaacattgca tctagggaaa ataagagaaa taagtgaaag tctgacccta cattgccaat
     4861 tctcagacca agtacaaagt attaggaatt ttttatatca gctgacatct tgtgcttaca
     4921 gtaaagccat atagatgcac acatagtgac tttattaaat caaatgagtt gtgcagagca
     4981 gagcaaatct attaggcttt ctcttttaga gttttctaat tttactctta ttagctccct
     5041 cagttgtcat caattacata ttcctacatc agatatttta cactatcaga ttctttgatt
     5101 aaaaaatcat cttcagcttt acattattaa tctctgagga cataaaatca aataactttc
     5161 tagtccatga tcattaatcc ctactatttt agatatttcc ataaaaggct taaagggaaa
     5221 aaaaaatggt aggtagttca gaaaaaaatg gctgggcacg gtggctcacg cctgtaatcc
     5281 cagcactttg ggaggccggg gtgggcagat catttgaggt caggagtttg agaccagcct
     5341 ggccaacatg gtgaaaccct gtgtctacta aaaatacaaa aaaaattagc tgagtgtggt
     5401 ggtgtgcgcc tgtaatccca gctactaagg caggagaatg gcttgaaccc aggaggtgga
     5461 ggtcgcagtg agctgagatc gcgccagtgc gctccagcct gggcaacaga gtgagactct
     5521 gtctaaaaaa aaaaaaaaaa gaaaagaaaa aagaaaaatt gaagaacata acttttctac
     5581 ttatgaaata gataattttt taaaattgtt taaactcctg gaaattaagt gttatttttt
     5641 attactgcag ttgagagata ccttttcaga ggaaaacaag aggctaaatt ccatgttaag
     5701 agctaagtag tatttttttc ttaacaattt tgccaaaatt tcttctactg gaccaaaagg
     5761 aaataaatct acaataaatc tactttctaa atattattta agatgggaaa tgtcttttat
     5821 aggtatattc tgtataatac ccttaattag atgaattatc ccttatcatt ccaaaaatga
     5881 aatgctgtgt taaatatctc cagggcaaag tggtatgttg actgggacaa acgttagaaa
     5941 ttgtattgtt cattgcactt gttgccctgt tccccaagct tgtcaatgtt tagagatact
     6001 attcgggttg ctaaagccat tattcataga aaatttctgc ccctacagaa gtgtgtgcat
     6061 gggccttgga aaatctacat gtgtatatct gagtagcgaa gcacagattc actctaattg
     6121 aaagcagcag tttggttttg taaatgtaat tgcaattgac actttctttt ccctttcagt
     6181 tattattttt tttaaaggac gttatgagaa ggcactatga aaagcctaat tggaatagca
     6241 ttatgaacca tgtaatgcat gcccatgcac actgtgattt gcaaacatat gtccgctctt
     6301 caataaatgt tacggctttc acagcg
//
