LOCUS       NM_001384574            4680 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens sterile alpha motif domain containing 4B (SAMD4B),
            transcript variant 10, mRNA.
ACCESSION   NM_001384574 XM_011527063
VERSION     NM_001384574.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4680)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 4680)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4680)
  AUTHORS   Wu,C., Liu,X., Li,B., Sun,G., Peng,C. and Xiang,D.
  TITLE     miR-451 suppresses the malignant characteristics of colorectal
            cancer via targeting SAMD4B
  JOURNAL   Mol Med Rep 24 (2) (2021)
   PUBMED   34109425
  REMARK    GeneRIF: miR451 suppresses the malignant characteristics of
            colorectal cancer via targeting SAMD4B.
REFERENCE   4  (bases 1 to 4680)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4680)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4680)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   7  (bases 1 to 4680)
  AUTHORS   Baez,M.V. and Boccaccio,G.L.
  TITLE     Mammalian Smaug is a translational repressor that forms cytoplasmic
            foci similar to stress granules
  JOURNAL   J Biol Chem 280 (52), 43131-43140 (2005)
   PUBMED   16221671
REFERENCE   8  (bases 1 to 4680)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   9  (bases 1 to 4680)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 4680)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011445.6 and AC005239.1.
            
            On Apr 8, 2021 this sequence version replaced NM_001384574.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853559.17048.1,
                                           SRR11853558.12789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000610417.5/ ENSP00000484229.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC011445.6         123523-123678
            157-217             AC011445.6         135108-135168
            218-618             AC011445.6         137791-138191
            619-1089            AC005239.1         14277-14747
            1090-1329           AC005239.1         20272-20511
            1330-1439           AC005239.1         21059-21168
            1440-1526           AC005239.1         21327-21413
            1527-1866           AC005239.1         22107-22446
            1867-1952           AC005239.1         23126-23211
            1953-2071           AC005239.1         24588-24706
            2072-2270           AC005239.1         25209-25407
            2271-2394           AC005239.1         25612-25735
            2395-2478           AC005239.1         27830-27913
            2479-4680           AC005239.1         28121-30322
FEATURES             Location/Qualifiers
     source          1..4680
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..4680
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /note="sterile alpha motif domain containing 4B"
                     /db_xref="GeneID:55095"
                     /db_xref="HGNC:HGNC:25492"
                     /db_xref="MIM:619231"
     exon            1..156
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /inference="alignment:Splign:2.1.0"
     exon            157..217
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /inference="alignment:Splign:2.1.0"
     exon            218..618
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..2507
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /note="isoform a is encoded by transcript variant 10;
                     smaug homolog B; protein Smaug homolog 2; smaug 2; SAM
                     domain-containing protein 4B; sterile alpha motif
                     domain-containing protein 4B"
                     /codon_start=1
                     /product="protein Smaug homolog 2 isoform a"
                     /protein_id="NP_001371503.1"
                     /db_xref="CCDS:CCDS33020.1"
                     /db_xref="GeneID:55095"
                     /db_xref="HGNC:HGNC:25492"
                     /db_xref="MIM:619231"
                     /translation="MMFRDQVGILAGWFKGWNECEQTVALLSLLKRVTRTQARFLQLC
                     LEHSLADCNDIHLLESEANSAAIVSQWQQESKEKVVSLLLSHLPLLQPGNTEAKSEYM
                     RLLQKVLAYSIESNAFIEESRQLLSYALIHPATTLEDRNALALWLSHLEERLASGFRS
                     RPEPSYHSRQGSDEWGGPAELGPGEAGPGWQDKPPRENGHVPFHPSSSVPPAINSIGS
                     NANTGLPCQIHPSPLKRSMSLIPTSPQVPGEWPSPEELGARAAFTTPDHAPLSPQSSV
                     ASSGSEQTEEQGSSRNTFQEDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQ
                     HLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIK
                     AYSVLQATVAAATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPP
                     PAPAPTDGSEPAPAPVADGDIPSQFTRVMGKVCTQLLVSRPDEENITSYLQLIEKCLT
                     HEAFTETQKKRLLSWKQQVLKLLRTFPRKAALEMQNYRQQKGWAFGSNSLPIAGSVGM
                     GVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFANPG
                     GSNSMPSQSRSSVQRTHSLPVHSSPQAILMFPPDCPVPGPDLEINPTLESLCLSMTEH
                     ALGDGTDKTSTI"
     exon            619..1089
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1329
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1439
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1526
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1866
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1952
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2071
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2270
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2394
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2478
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..4680
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4666..4671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /note="hexamer: AACAAA"
     polyA_site      4680
                     /gene="SAMD4B"
                     /gene_synonym="Smaug2; SMGB"
                     /note="major polyA site"
ORIGIN      
        1 acggcgcggt gacgcagcgc gacggcggcg gcggcggcgg cggcggtggt cggtgcggga
       61 ggagggaggg gagcttgcgg gcccgagagg gggcgacggc ggcggcggtg gcctgaggag
      121 gcccgagcgg cggcggtggc ggcgaaggcc gaggcggatt cttctcatcg cagtgctcca
      181 ggcagccact accaatcgat tggagttagc ctgtgaggaa actggagagg cgtggctgga
      241 ccaagacctc cccccatgtg agcaggcttc ctcctccccc aacaaccgtt gccaccacgc
      301 ccagaaacgt ccttaagccc tggccctcag gggaaaggta acaggaggcc agagccggga
      361 ccatgtgacg gcgctggccc tcgccaccgc cgtcccccga ccctggcccc aggcccggca
      421 ccatgatgtt ccgagaccag gtgggcatcc tcgctggctg gttcaaaggc tggaatgagt
      481 gtgagcagac agtggccctc ctgtcacttc tgaaacgggt cacccgtacc caggcccgct
      541 tcctgcagct ctgcctggag cactcactgg cggactgcaa tgacatccac ctgctggagt
      601 cggaggccaa cagtgctgcc atcgtcagcc agtggcagca ggagtccaaa gagaaggtgg
      661 tgtccctcct gctgtcccac cttcccctgc ttcagccagg caacacagag gccaagtcgg
      721 agtacatgag gctactgcag aaagtgctgg cctactcaat cgagagcaat gctttcatcg
      781 aggagagtcg ccagctgctt tcctatgccc tcatccaccc agccaccaca ctggaggacc
      841 gcaacgcact ggccctctgg ctgagccacc tggaagagcg gttggctagt ggcttccgct
      901 cccggccaga gccctcctac cattcacgtc aaggctcaga tgagtggggg ggccctgcag
      961 agctaggccc tggggaggca gggccaggct ggcaggacaa gccaccccgg gaaaatggac
     1021 acgtgccctt ccacccatcc agctcagtgc cgccagccat caacagtatt gggagcaatg
     1081 caaacacagg tctcccctgc caaatccacc ctagcccact gaagcgctcc atgtcactca
     1141 tccctacaag cccccaggtc cctggtgagt ggccgagtcc agaggagctt ggggcccggg
     1201 ctgcttttac cacgcccgat cacgcacctc tctcgcccca gagcagcgtg gcctcctctg
     1261 gcagtgagca gacagaggag cagggctcca gccggaacac cttccaggag gatggcagtg
     1321 gcatgaaaga tgtgccctca tggctcaaga gcctccgttt gcacaagtat gcagccctct
     1381 tctcacagat gagctacgag gagatgatga cactgactga gcagcacctg gagtctcaga
     1441 acgtcaccaa aggtgcccgc cacaagatag ccctgagcat ccagaagctg cgtgagagac
     1501 agagcgtcct caagtcccta gagaaggatg tgctggaagg cgggaaccta cgaaacgctc
     1561 tgcaggagct gcagcagatc atcatcactc ccatcaaggc ctacagtgtc ctccaggcca
     1621 ccgtggctgc cgccaccacc acccctactg ccaaggatgg ggccccgggg gaaccaccgc
     1681 tgccaggtgc tgagcctccc ctagcccacc ccggcacaga caaaggcacc gaggccaagg
     1741 accctccagc tgtggagaac tacccacctc caccagctcc agctcccact gatggcagtg
     1801 agcctgcccc ggctcccgtc gccgacggag acatccccag ccagtttaca cgggtgatgg
     1861 gcaaagtgtg cacccaactg ctggtgtccc gaccagacga ggagaacatc accagttacc
     1921 tccagctcat cgaaaagtgc ctgactcatg aggctttcac ggagacgcag aagaaacggc
     1981 tgctatcctg gaaacagcaa gtgctgaagc tcctccggac attcccgcgc aaagccgcac
     2041 tagagatgca gaactaccgg cagcagaaag gctgggcatt cggctccaac tcgctcccca
     2101 tagctggctc tgtggggatg ggagtggccc ggcgtaccca gcggcagttc ccaatgcctc
     2161 cccgggccct cccacccggc cggatgggcc tcctgagccc ctcgggcatt gggggtgtct
     2221 cccctcgaca tgccctcacc agccccagcc ttggaggcca gggccgacag aacctgtggt
     2281 ttgccaaccc tggaggcagc aacagcatgc ccagtcagag ccgcagctct gtgcagcgca
     2341 cccactcgct cccggtccac tcgtcacccc aggccattct catgttccct ccagactgcc
     2401 cggttcctgg gcctgacctg gagatcaatc ccactctgga gtctctgtgt ctgagcatga
     2461 cagaacacgc cttgggtgat gggacagaca aaacctccac catctgacgg gacccacagc
     2521 ccagcgcacc cataggctcc ctgggcggcg ggcgggggcc aacccccaac gggcttctcc
     2581 gcgacagcga gagggtgggc tggctcagct atatattcta atatttttct actctcttac
     2641 cctcttaact tttgtttaac attggcacat gccttgctca ctcccaggcc cgtcgaggga
     2701 tctctgctga ggcccgggga gttgggggca gccaggataa agggggcagg gactggccag
     2761 actgcctgcc tctctccttt ccttcctcat ccccacctgg tcccatccca cccctgcctc
     2821 ctccagaccg ctgaccacct gcctctcccc aagggagcag actccccaga gacaaactga
     2881 ccactacctt gtggagcctg ctcagaaaca tttgacattt ggggtgacgc gcagggcaga
     2941 gaacctgccc tccagaatgt tattgagagg agctggggag aaggaagggg agcaaggaga
     3001 ggaagctctc tctcctctcc ctgcttcccc ttcaccattc cccacattct gcaaggacag
     3061 gagccacctt cctctctctc acctcccctg gccctgttca ccagaggttc tctatgatta
     3121 atttcttagg cctatttaag atacatattt atatagttct taacggtttt tctctgatca
     3181 tttcctctca tttttagaat ccccaggtct ctctcagcca agacagtggc agggagagcc
     3241 tgaactttat gaggggagag ggcagagccc cctcctccag accctcaagc tctaacccat
     3301 tttcctccag ccctggctac ccggatgaag aggttggagg tgggcagcca gggtagccag
     3361 tgaggtcagg aagtctgttg ccttaacgtc cccttcccca cgaacacaca cccttctccg
     3421 ctcccaggtc tggttggtga gacttgggag tcaggaataa gggaaagggg attgtttggt
     3481 ttttgggttt ttccctaagc ccctcccttt tctttcagcc tttttccttc ccccattatg
     3541 tcatgacctc acttaagtgg aacactatat cataacccag agattcgtcc cagccccaga
     3601 gtccgacaga ctgtctggtc cctattccta atgaggggtt gtgttggggc ccaggtggag
     3661 ggaggggatt tgggggttca gactgcgggg aagccagggt ctccctcttc aacgccctcc
     3721 tccccctcaa cccaccttcc caactgggac attctcaagc ttttcacacc gaaaaggaaa
     3781 aaaaatgtta tttttagata cattttatga ataacttttg ttatgaatat ggctggtaac
     3841 cattgtgtat gttattaaag atacaaaatg ttgggaaaaa aacaaaaaaa acaaaaaaaa
     3901 aaaaaatttt aaaaccacca ccctccctgc actatcaccc cattccccag accttcttgc
     3961 ccccgccctc ctggtctgtg gacttccctc tgctctgagc ccagggaggg ggaagaagcc
     4021 agggggtagg gtggccctgg gaacctggct ctgggtcccc acttcctctc ccagtgccgg
     4081 gctgggtggg gtgtcaggtt tatttatgta cctcttgcac actcatcaac ctatgcaagt
     4141 cccccacccc ggccctccat gtttctgtgc ctttgctcat cccctcaatc tcccagggct
     4201 tctccagtcc ccctcccact agctgcagga agtgggatgg atgggccacc tcgtttggaa
     4261 tcagcagggt gtccctctca tgggaccctc ccctctcccc agcctgtcct gtcttgttca
     4321 ctctccatca gggtgagctg actgtgcctg gcactgggag gtggtgaggg acaccgtctc
     4381 acacacacag ggaggcaaga gctgcccccc accccacctg acagcagagt gtgcaggacg
     4441 caggcggccc cactctgatg ggcaggaccc tgaccctctc ccgctccagc cccctcccca
     4501 ggccctcctc catgatttca ccctccctac ccacttctgt ccccggcccc actggcagaa
     4561 tcagctttga gtaactgtac agtttttctc gctgttggag aagacttatt tgttggagtt
     4621 tcacttgttt aatggtctgg gcttattttg gaaaaaaaaa aaacaaacaa aaaaaacgaa
//
