LOCUS       NM_001257359            4763 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens sterile alpha motif domain containing 14 (SAMD14),
            transcript variant 2, mRNA.
ACCESSION   NM_001257359
VERSION     NM_001257359.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4763)
  AUTHORS   Xu,X., Chang,X., Xu,Y., Deng,P., Wang,J., Zhang,C., Zhu,X., Chen,S.
            and Dai,D.
  TITLE     SAMD14 promoter methylation is strongly associated with gene
            expression and poor prognosis in gastric cancer
  JOURNAL   Int J Clin Oncol 25 (6), 1105-1114 (2020)
   PUBMED   32206938
  REMARK    GeneRIF: SAMD14 promoter hyper-methylation was significantly
            associated with a poor prognosis in gastric cancer.
REFERENCE   2  (bases 1 to 4763)
  AUTHORS   Thurner,L., Preuss,K.D., Bewarder,M., Kemele,M., Fadle,N.,
            Regitz,E., Altmeyer,S., Schormann,C., Poeschel,V., Ziepert,M.,
            Walter,S., Roth,P., Weller,M., Szczepanowski,M., Klapper,W.,
            Monoranu,C., Rosenwald,A., Moller,P., Hartmann,S., Hansmann,M.L.,
            Mackensen,A., Schafer,H., Schorb,E., Illerhaus,G., Buslei,R.,
            Bohle,R.M., Stilgenbauer,S., Kim,Y.J. and Pfreundschuh,M.
  TITLE     Hyper-N-glycosylated SAMD14 and neurabin-I as driver autoantigens
            of primary central nervous system lymphoma
  JOURNAL   Blood 132 (26), 2744-2753 (2018)
   PUBMED   30249786
  REMARK    GeneRIF: Hyper-N-glycosylated SAMD14 and neurabin-I as driver
            autoantigens of primary central nervous system lymphoma.
REFERENCE   3  (bases 1 to 4763)
  AUTHORS   Shen,Y., Takahashi,M., Byun,H.M., Link,A., Sharma,N., Balaguer,F.,
            Leung,H.C., Boland,C.R. and Goel,A.
  TITLE     Boswellic acid induces epigenetic alterations by modulating DNA
            methylation in colorectal cancer cells
  JOURNAL   Cancer Biol Ther 13 (7), 542-552 (2012)
   PUBMED   22415137
REFERENCE   4  (bases 1 to 4763)
  AUTHORS   Fehrmann,R.S., Jansen,R.C., Veldink,J.H., Westra,H.J., Arends,D.,
            Bonder,M.J., Fu,J., Deelen,P., Groen,H.J., Smolonska,A.,
            Weersma,R.K., Hofstra,R.M., Buurman,W.A., Rensen,S., Wolfs,M.G.,
            Platteel,M., Zhernakova,A., Elbers,C.C., Festen,E.M., Trynka,G.,
            Hofker,M.H., Saris,C.G., Ophoff,R.A., van den Berg,L.H., van
            Heel,D.A., Wijmenga,C., Te Meerman,G.J. and Franke,L.
  TITLE     Trans-eQTLs reveal that independent genetic variants associated
            with a complex phenotype converge on intermediate genes, with a
            major role for the HLA
  JOURNAL   PLoS Genet 7 (8), e1002197 (2011)
   PUBMED   21829388
REFERENCE   5  (bases 1 to 4763)
  AUTHORS   Sun,W., Iijima,T., Kano,J., Kobayashi,H., Li,D., Morishita,Y.,
            Okubo,C., Anami,Y. and Noguchi,M.
  TITLE     Frequent aberrant methylation of the promoter region of sterile
            alpha motif domain 14 in pulmonary adenocarcinoma
  JOURNAL   Cancer Sci 99 (11), 2177-2184 (2008)
   PUBMED   18823374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002401.2, CN369613.1, AK094209.1, AF035306.1 and BM973393.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001257359.1.
            
            Transcript Variant: This variant (2) lacks an exon in the coding
            region, but maintains the reading frame, compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK094209.1, BC141822.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330175.9/ ENSP00000329144.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               AC002401.2         25388-25665
            279-347             CN369613.1         3-71
            348-2213            AK094209.1         1-1866
            2214-3411           AF035306.1         808-2005
            3412-3494           BM973393.1         17-99               c
            3495-4763           AC002401.2         44240-45508
FEATURES             Location/Qualifiers
     source          1..4763
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..4763
                     /gene="SAMD14"
                     /note="sterile alpha motif domain containing 14"
                     /db_xref="GeneID:201191"
                     /db_xref="HGNC:HGNC:27312"
                     /db_xref="MIM:619233"
     exon            1..644
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            645..699
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     CDS             657..1910
                     /gene="SAMD14"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sterile alpha motif domain-containing protein 14; SAM
                     domain-containing protein 14"
                     /codon_start=1
                     /product="sterile alpha motif domain-containing protein 14
                     isoform 2"
                     /protein_id="NP_001244288.1"
                     /db_xref="CCDS:CCDS58562.1"
                     /db_xref="GeneID:201191"
                     /db_xref="HGNC:HGNC:27312"
                     /db_xref="MIM:619233"
                     /translation="MASSKLREPVDEVFDLDLAVPETARLDSSLHKARAQLLAKGRRH
                     RPSRSRLRDSASSAEDGEGSDGPGGKVTDGCGSPLHRLRSPLHSGPGSPAGGSFCLDP
                     PGLRRSLDEDEPPPSPLTRYRPLHNAASHEGLAAASCSPPRSAPSSDSSPSFVRRHPR
                     AEPHSEDDSRDASPPEPASPTIGLDKKTRRKFLDLGVTLRRASTGKSRKEKGSNRLSM
                     GSRESVEGSGRSGGSPFLPFSWFTDSGKGSASSGSTTSPTCSPKHEGFSPKKSASQES
                     TLSDDSTPPSSSPKIPSGPWQEAKCSYPYHTLSQSSDEFLDEPLPPVHHWTSQQVGQW
                     LQSLNLEQYAAEFAARQVDGPQLLQLDGSKLKSLGLSNSHDRALVKRKLKEMAAAAEK
                     ERKAQEKAARQREKLRRREQEAKKS"
     exon            700..866
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1155
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1243
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1318
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1478
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1598
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1754
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..4763
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3463..3468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAMD14"
                     /note="hexamer: AATAAA"
     polyA_site      3494
                     /gene="SAMD14"
                     /note="major polyA site"
ORIGIN      
        1 gcgccgcgtc tcccgcgggc agagaagtag ctgcaactcc gctccccggc cccagccgcc
       61 tcctccccgc cgccctcccc cgcccccgcc ccctcgctcc ctcccgctct ttgtctcctg
      121 ggcgcccggc ttctccgcca cgcgcccccc accccgacgc cccttccccg gagacccccg
      181 cggacccctg ccgacgcgac gccgcgcgaa tcggccctgc caggcggggg ccccgcgtcc
      241 ggccaggcct ggcgggcggc aggggcgggg agggaggtgg cgctcgctct tcgctcttct
      301 ctctctctct ctctctgtca cacacacaca cacgcacacg cacacgcaca cacacacgga
      361 gcatcctccc gtcaggtctc ctggtccagc cccgcccgcg cctcctgctt ccagcgaacc
      421 tgttccctct ccccacatcc cccgccctcc atctcccccg gctctgggac ccttcccgcc
      481 gacctcaccc ccacccccgg gatggagcgg ctcgagcccg cccggagccc cccgcggccg
      541 gggtgacggt ccccccaccc ctctcctgcc cggcccccgc ctcgagcacc atgggcctga
      601 ggggttcccg gggcgccaga cgctgaagat gaccgatgcc ggagctctct tgagtcatgg
      661 cttcttcaaa gctccgagaa cccgtggatg aagtttttga cctggacttg gctgtgccag
      721 agacggccag actggacagc agtttacaca aggcccgggc ccaactgttg gccaagggcc
      781 ggagacaccg gccatcccgc tccaggcttc gggacagtgc cagctccgcg gaggatggtg
      841 aaggctcgga tgggcccgga ggcaaggtga ccgatggctg cgggagcccc ctgcaccggc
      901 tgcgctcgcc tttgcactca ggcccggggt ccccggccgg gggctctttc tgcctggatc
      961 ctccggggtt gcggcgcagc ctggacgagg acgagccgcc gccctcgccg ctcacacgct
     1021 accggcccct gcacaacgct gcgtcgcacg agggcctggc cgccgcctcc tgctctccgc
     1081 cgcgctccgc gccctcctcc gacagctccc ccagcttcgt gcgccgccac ccgcgcgcag
     1141 agccgcacag cgaagatgac agccgtgacg ccagtcctcc tgagcccgcc agccccacca
     1201 tcggcctcga taagaagact cgccgaaagt tcctggacct gggggtcacc ctgcgccgag
     1261 catccacggg caagagccgg aaggagaaag gcagcaaccg actgtccatg ggcagcaggg
     1321 agtcagtgga ggggtccggc aggtcagggg gctccccgtt cctgcctttt tcctggttca
     1381 cggacagcgg caagggctca gcatcctcgg gtagcaccac ctcccccacc tgctccccta
     1441 aacacgaggg cttcagccct aagaagtcag cttcccagga atccactctg agtgatgact
     1501 ccacgccccc cagcagcagc cccaagatcc ccagtgggcc ctggcaggag gccaaatgtt
     1561 cttaccccta ccacacgctg tctcagtctt cagatgagtt cctggatgaa cccctccccc
     1621 ctgtccacca ctggaccagc cagcaggtgg gccagtggct gcagagcctc aacctggaac
     1681 agtatgctgc tgagtttgct gcacggcagg tagacgggcc gcagctgctg cagctggacg
     1741 gaagcaaact aaagagcctg gggctcagca actctcatga ccgggcactg gtgaagcgca
     1801 agttgaagga gatggcagca gctgccgaga aggagcgcaa ggcccaggag aaggctgcgc
     1861 ggcagcggga gaagctccgg cgccgagagc aggaggccaa gaagagctag gggagggtgc
     1921 acaggcgctg gcacccggca ggggcagcca ctggctccgc gggcacaggc ctcaccaggg
     1981 aggctggacc tgggcgctgc acttgggcta gcctggtccc acgctctcag gggggacatg
     2041 ctctctctta ccctgtcact tggtctagac ccagagaccc cagaaaggga gaccccaggg
     2101 agagggccta gtaataaatc ctattttgag gacttgtttg gcacagagtt cctgggggag
     2161 gagcagatga aggggagagg gcagagaggc cagggctgag gcaagtctgg gaggctgggt
     2221 caggctgtcc cattgccctc aggccatcgt ggggctgggg tggaggggag ctaggaggcc
     2281 tgcctgcctg cttgcctgcc agaggccctg aggccgggcc ccagggctca gagctgggct
     2341 gggcatttca gcaggagccc atgtgggagc ggctcctctc cactcttcca gggggctgtg
     2401 tggtgggaga gctctgtcct gctcccccaa gaggccagtg ggcgctgcag caagtcgcac
     2461 tcagggtaga ctcccagcca aactcctcaa caggagcgca gagaaagcag cctggggcga
     2521 gtgcagtctt tgccaggact caagagggga ggatgaacat ccccttctcc ctctcccctc
     2581 ctctgtcctg tgggtcccag ggggcgagat gacaccacac aggtctgcct ctcagggccc
     2641 attcaagacc tggtctttga cccattctcc aagccaggac tcccttcact tcctgctgct
     2701 tcctcagagg gcacctaagt cctctttggg agctgagcaa acaggaactg atagggacag
     2761 aggacaccac ttccaccagc caaggcctag gagctgctga cctggtcagc cctcacccca
     2821 gccaggcaga gaggcaaaac ctgggggtcc ccggcagcta cgagattgga aaggttcatc
     2881 agccctcccc catctgcccc aggcattgtc agggaatcag tgggctcaga actggcaggc
     2941 ggtgcaagct ctgcttccct gggccacact gagggctggg gccagctccc tggatggggg
     3001 tggagtttac cagcagcctg gggacagcat gtgtcctttt taggaaatgt ccttggagga
     3061 agtgttcatg tgtggcgctg gtcagcagct agtcccgctt ccaggacact ggtcagagtt
     3121 accgatgagg cctgggggct cccgcttgga aacccctcca gctcctccca tctgcccaga
     3181 cagagcggca gatggcacca atgcatgctg gctccctcat tcctgcccag gggctgtggc
     3241 ttacggccag caccctgtac ctgggactca gcccttatcc cccctctgct atctgtgctg
     3301 ggagaggggc ttcggaggga aacagatatg aggacactgg caccatctgg gcctggtggc
     3361 agggccatgg gaggttggaa ggcacccaca tccttaaagc catcagtagc tatagtgggt
     3421 gcccacctgc atgtgaaggg gaggcagttc tcaatttatt tcaataaatc cttatgatgt
     3481 gccagtgacc agaatttctg tctgctccag ttgttgggtt ggccggactc tgctgggccc
     3541 tgagtatggt gggacaacag gtctgtcacc aggtgctggg ccatccggcg ttctgaacag
     3601 atggctttgc ccagtgtttt actcacagtc ctgagctggg ccggacgtcc ccggtgcgtc
     3661 atgtggtggt cacagggcac cgcagtgtgc gtgtgtacgt gcgcacgtgt gggtcccctc
     3721 ccccagggat gcagccaggc cagtctcatt cagtctcctc tttactgtgg gtgtgggtgt
     3781 cactgtcact gccacagcca ctgggaggga cacacagctt taacccctgt gtgcttaggg
     3841 gaagggtggg ggcattcagg gttataaaac taactatata cacagaaggt cctagggaga
     3901 aagccaccct gagcacacat gtctgggcac agtgggggct gggggctgga gctcaggcag
     3961 gatggactag gcttgtggag gagcgggtgg gcatgagcat gtgaggacat gctgggaggg
     4021 ctcaggaggt ggcacagaca ttgccaaggc cactgcaggg cctcgagcag cttggctgga
     4081 tggcaagctc tcggtctaac aaggttcttc cactttagag ttgggccctg tgagagccac
     4141 cccctccgcc accgaccttc aagccctgag cggagggaga ggctgcagga ccagcctcat
     4201 tccccactca cgggtgtaac tcctttcccc actcagtccc caggtctgga gggcacccac
     4261 cctcttccta acacttcagc aggccaaggc cagggtgcct ttgtgggctg ggggaataag
     4321 gcaacgggac atccacttgg aaggcctgtg ctgtggaggg tgctgagggg gacccagtac
     4381 ccctggcaga aaagtgacag ccctggtctc agagaggagg actgccatgg gaaaatgtct
     4441 ctgggacacc ccatcagggt ggagacatcc ctaaccctca ggcatcgccc acagagatag
     4501 ggaggccacc gaggggtctc cacagagatg gactggcact tagggaccat cacagaccta
     4561 tcaccgcagt gacttccata gagacagaac ctggtcatca gggagaaccc accccctgct
     4621 cccccaggag gatggtgagg ggcaccacgg tggggggacc cagaggcggc agtccgtcct
     4681 ctcaggtgca gatgcacggc ggcccttagc tgacgcggta cgtggacgtg ttcttgggct
     4741 ccgtgctggg cacacaccag tcg
//
