LOCUS       NM_001134663            1459 bp    mRNA    linear   PRI 29-APR-2024
DEFINITION  Homo sapiens sterile alpha motif domain containing 13 (SAMD13),
            transcript variant 2, mRNA.
ACCESSION   NM_001134663
VERSION     NM_001134663.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1459)
  AUTHORS   Yoo,W., Kim,S. and Noh,K.
  TITLE     SAMD13 serves as a useful prognostic biomarker for hepatocellular
            carcinoma
  JOURNAL   Eur J Med Res 28 (1), 514 (2023)
   PUBMED   37968735
  REMARK    GeneRIF: SAMD13 serves as a useful prognostic biomarker for
            hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1459)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359273.11.
            
            On Dec 22, 2018 this sequence version replaced NM_001134663.1.
            
            Transcript Variant: This variant (2) has multiple differences in
            the 5' UTR and 5' coding region, which results in the use of a
            downstream AUG start codon, compared to variant 1. Variants 2 and 3
            both encode the same protein (isoform 2).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.194920.1,
                                           SRR5189667.398382.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394834.8/ ENSP00000378311.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AL359273.11        43792-43885
            95-179              AL359273.11        45287-45371
            180-291             AL359273.11        67721-67832
            292-1459            AL359273.11        91715-92882
FEATURES             Location/Qualifiers
     source          1..1459
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..1459
                     /gene="SAMD13"
                     /gene_synonym="DJL; HSD-41; HSD-42"
                     /note="sterile alpha motif domain containing 13"
                     /db_xref="GeneID:148418"
                     /db_xref="HGNC:HGNC:24582"
                     /db_xref="MIM:620800"
     exon            1..94
                     /gene="SAMD13"
                     /gene_synonym="DJL; HSD-41; HSD-42"
                     /inference="alignment:Splign:2.1.0"
     exon            95..179
                     /gene="SAMD13"
                     /gene_synonym="DJL; HSD-41; HSD-42"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..435
                     /gene="SAMD13"
                     /gene_synonym="DJL; HSD-41; HSD-42"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sterile alpha motif domain-containing protein 13;
                     dnaj-like protein (LOC148418); SAM domain-containing
                     protein 13"
                     /codon_start=1
                     /product="sterile alpha motif domain-containing protein 13
                     isoform 2"
                     /protein_id="NP_001128135.1"
                     /db_xref="CCDS:CCDS44166.1"
                     /db_xref="GeneID:148418"
                     /db_xref="HGNC:HGNC:24582"
                     /db_xref="MIM:620800"
                     /translation="MLSVDMENKENGSVGVKNSMENGRPPDPADWAVMDVVNYFRTVG
                     FEEQASAFQEQEIDGKSLLLMTRNDVLTGLQLKLGPALKIYEYHVKPLQTKHLKNNSS
                     "
     exon            180..291
                     /gene="SAMD13"
                     /gene_synonym="DJL; HSD-41; HSD-42"
                     /inference="alignment:Splign:2.1.0"
     exon            292..1459
                     /gene="SAMD13"
                     /gene_synonym="DJL; HSD-41; HSD-42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1438..1443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAMD13"
                     /gene_synonym="DJL; HSD-41; HSD-42"
                     /note="hexamer: AATAAA"
     polyA_site      1459
                     /gene="SAMD13"
                     /gene_synonym="DJL; HSD-41; HSD-42"
                     /note="major polyA site"
ORIGIN      
        1 cctttgccag cctactttgt gaaagaaaac attggggttt ctttggctgt tcttgataag
       61 cctataaaaa atgatatttt ttagttgctt atagttgctg aagtaaagga accctgcagc
      121 cttcccatgc tatctgttga catggaaaac aaggaaaatg gctctgtcgg tgtaaaaaat
      181 tccatggaaa atgggagacc acctgatcct gcagactggg ccgtgatgga tgtcgtcaat
      241 tatttccgaa ccgtgggatt tgaggagcaa gctagtgctt ttcaggaaca ggaaattgat
      301 ggaaaatccc tgctattgat gacaagaaat gatgtgttga caggacttca gttaaaattg
      361 gggcctgctc tgaaaatcta cgaatatcat gtaaaacctc tgcagacaaa gcatttaaag
      421 aacaactctt catagtacag tcaaattggg gtcttcgacc tcaaaaaata cataatgaca
      481 taatttagtt tcatgtaatg aaactttgta aacagaatac atacatgtgt atatgtaaag
      541 aatttcaatc aaatgaaacg ttatcctatt ggatagacta ggcaattcat cagctcacct
      601 gaaatcagcc aggaggagca aggacaagat gcgcacaggg tggttttcct catggatttt
      661 gtcaaataga tgatctttga cacgattaga cactcctccc cacaaaggct ttgaaatcat
      721 aaggattttc ctcatctctt tatagctttc ccaaaatctt ttaaaaaaga atttaattaa
      781 atgacagtct tttggttaca gacttaggat gagtaaaaac aagaaaattt ggggaggggg
      841 agaaagaaga aagggattgc tgtctccctt gaattcctct gttccttaga gcttgtgtta
      901 cttggacgga attgccaaca ccctttttta tagagggttc tccacttgac cttattaagg
      961 ttttattggg atatgctgca gtgtttgaaa tgaacatgca tcatggcccc ttcaggagca
     1021 gaatcatagc tctgaaaaga gaagctccgt tgtgtactga ggatatccat ccatattcag
     1081 ctagctttca aatggggtaa cgatattttc tgcatagatt ttcttttaaa ttggttcttt
     1141 gtttctgaag aaagaatttt ttttaacttc atggttttat ttataataat ttgtttctga
     1201 agaaatttgc cgagagttac aggtcaaaaa gccttgttac tagtacagaa tatttttata
     1261 tatattcctt catgatggtg taattttttt taattgtcct atgctttgtt cggttcctgg
     1321 gttaagtact tgtttttaag agcttggaaa aagtgggctt gctacatctc tgttcaaaga
     1381 gacatttgtt caatctctgt gtgtcaacgc cttgttgaat tggtgctttg tggttgcaat
     1441 aaagcattgc ttcagttta
//
