LOCUS       NM_080621               2178 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens sterile alpha motif domain containing 10 (SAMD10),
            mRNA.
ACCESSION   NM_080621
VERSION     NM_080621.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2178)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   2  (bases 1 to 2178)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   3  (bases 1 to 2178)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM839907.1 and BC067362.1.
            
            On Nov 23, 2018 this sequence version replaced NM_080621.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067362.1, SRR3476690.678229.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369886.8/ ENSP00000358902.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BM839907.1         1-3
            4-1579              BC067362.1         1-1576
            1580-2178           BC067362.1         1579-2177
FEATURES             Location/Qualifiers
     source          1..2178
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..2178
                     /gene="SAMD10"
                     /gene_synonym="C20orf136; dJ591C20; dJ591C20.7"
                     /note="sterile alpha motif domain containing 10"
                     /db_xref="GeneID:140700"
                     /db_xref="HGNC:HGNC:16129"
     exon            1..266
                     /gene="SAMD10"
                     /gene_synonym="C20orf136; dJ591C20; dJ591C20.7"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..784
                     /gene="SAMD10"
                     /gene_synonym="C20orf136; dJ591C20; dJ591C20.7"
                     /note="D930033N23Rik; SAM domain-containing protein 10"
                     /codon_start=1
                     /product="sterile alpha motif domain-containing protein
                     10"
                     /protein_id="NP_542188.1"
                     /db_xref="CCDS:CCDS13549.1"
                     /db_xref="GeneID:140700"
                     /db_xref="HGNC:HGNC:16129"
                     /translation="MFTELRSKLSPPRGRAGAVRAGFGERRDVDATAHFSFCRTLLEH
                     TVSAESIPCHLPRTPGTSLTWHDSRSQRAASSRPIKLLQQPGTDTPQGRLYSDHYGLY
                     HTSPSLGGLTRPVVLWSQQDVCKWLKKHCPHNYLVYVEAFSQHAITGRALLRLNAEKL
                     QRMGLAQEAQRQEVLQQVLRLQVREEGRSLQLLSQASFGKMS"
     exon            267..448
                     /gene="SAMD10"
                     /gene_synonym="C20orf136; dJ591C20; dJ591C20.7"
                     /inference="alignment:Splign:2.1.0"
     exon            449..620
                     /gene="SAMD10"
                     /gene_synonym="C20orf136; dJ591C20; dJ591C20.7"
                     /inference="alignment:Splign:2.1.0"
     exon            621..761
                     /gene="SAMD10"
                     /gene_synonym="C20orf136; dJ591C20; dJ591C20.7"
                     /inference="alignment:Splign:2.1.0"
     exon            762..2178
                     /gene="SAMD10"
                     /gene_synonym="C20orf136; dJ591C20; dJ591C20.7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2159..2164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAMD10"
                     /gene_synonym="C20orf136; dJ591C20; dJ591C20.7"
                     /note="hexamer: AATAAA"
     polyA_site      2178
                     /gene="SAMD10"
                     /gene_synonym="C20orf136; dJ591C20; dJ591C20.7"
                     /note="major polyA site"
ORIGIN      
        1 acacagggct cggcggcagg tgcctcgtcg cgcacactcg cgggccgcgg ggaccggctc
       61 gggcgcgggg ccggctgggg cggggcgggg cggcggcgcg cgttccccgc cggccacacc
      121 ggccgccctg cactcggcga ggggcgtgtg cgcgggcctg gcacccgcgg gccccatgtt
      181 caccgagctg aggtccaagc tgagcccccc gcgtggccgc gccggggccg tgcgcgcggg
      241 cttcggggag cgccgggatg tggacgccac tgcccacttc agcttctgcc ggaccctcct
      301 ggagcacacg gtgtcagctg agagcatccc ctgccacttg cctcggacac ctggcaccag
      361 cctcacgtgg catgactccc gcagccagag ggcggccagc agcaggccaa tcaagctcct
      421 gcagcagccc ggcacagaca ccccccaggg ccggctgtac tctgaccact atggcctgta
      481 ccatacaagc ccctcgctgg gtggcctgac ccggcccgtg gtcctgtgga gtcagcagga
      541 cgtctgcaag tggctcaaga agcactgtcc ccacaactac ctcgtctacg tggaggcctt
      601 ctcccagcat gccatcaccg gccgggcact gctgcggctg aatgcggaga agctgcagcg
      661 gatggggctg gcccaggagg cccagaggca ggaggtgctg cagcaggtgc tccgcctgca
      721 ggtgcgtgag gaggggcgga gcctgcagct gctcagccaa gcttccttcg ggaaaatgtc
      781 ctagctgctg ctgaggcttg aacccagacc ccagcactgt gatgggagtc cacggctagg
      841 gaggaggcca agctggcccc gcagcgcctc ttggaccctg cgggatgccg gggcggccag
      901 gctggcccaa cggacagaca ggaccaggat cacacctcca ggcgcctctg gttggacatt
      961 ccaggtcgtg ccctggggct gggtgggtag ggggctgctt gagtgtggcc ccacctcctg
     1021 ggacctgagc ccaagccctc ccctggtgca gctggcagca tgtggggcag ctgcctggag
     1081 ccagaaccgg tttggatgtc ccccctagac tcccagggag tctgtttatt tacattcccc
     1141 tctccacgtg atgtcggtcc cccatcgcct gctgagtcac ttgtctgtcc acccacccag
     1201 cccagttcta ggtcgttccc cagcacctcc aggttggccc acacaggtac cataagctgc
     1261 ctcggctccc tgtggcttgt gcccatgcac ctgccagggc ccagcaggcc aacccatcat
     1321 ctagagtagt ggccatcagc acccgcctaa cgggcaccat gccaagcact ttcatcatta
     1381 tttatacatc gtcaccacac cccctctatt catgagaagt aaagctgaga aaggaccaga
     1441 ttgaccaagc gccagagaca aaatgtggca caacgagaac cccagccctg tccaggtggc
     1501 tccgcgccca gggcccaggc ttagcagtgc tccctgccct atctttggga aaatcttgct
     1561 tttatggtct tcccccctcg ccctcaagaa caagggcctt gtgcgtgggc cttcccattg
     1621 ctgctttccc aagaaggcct ggattcaggg gagaggcctt cccagggcca ctccccttac
     1681 accctcccag aggcctgagc aacccctctc tgggtggttt ggggctggtg ctgcctggcg
     1741 gaaggacagt gagggcggcc ctagccgcct ccaccctctt gcgcctctgc cctctcccag
     1801 tccccctgtg gcttctgaaa atctcaggga cagatgaggc tgagccccta gtcccctctg
     1861 tgtgctttga gcctccagac tcgaggctgg tcactgcagg tcccaggtgg aatttggaca
     1921 actggcctgg ccgctcccat cctgtaagcc cccaccacgg ggagaccctc atccctgccc
     1981 ctgtgtggct gcgcaagtat tctgcccgcc tcccaccatc agccttcgcc caaggggccc
     2041 ttctgcctct gcttccctcc cttctcctct gtcttgccct ggcccacgca cgcctgtctc
     2101 gtcttccttg ttttgctgca ctcacttttt tatactctga caaaaaaaaa aaatcagaaa
     2161 taaagctggt tcccaagt
//
