LOCUS       NM_138352               2514 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sterile alpha motif domain containing 1 (SAMD1), mRNA.
ACCESSION   NM_138352
VERSION     NM_138352.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2514)
  AUTHORS   An,R., Yang,Y., Liu,L. and Li,P.
  TITLE     SAMD1 attenuates antiphospholipid syndrome-induced pregnancy
            complications
  JOURNAL   Immun Inflamm Dis 11 (10), e1006 (2023)
   PUBMED   37904675
  REMARK    GeneRIF: SAMD1 attenuates antiphospholipid syndrome-induced
            pregnancy complications.
REFERENCE   2  (bases 1 to 2514)
  AUTHORS   Tian,S., Cao,Y., Wang,J., Bi,Y., Zhong,J., Meng,X., Sun,W.,
            Yang,R., Gan,L., Wang,X., Li,H. and Wang,R.
  TITLE     The miR-378c-Samd1 circuit promotes phenotypic modulation of
            vascular smooth muscle cells and foam cells formation in
            atherosclerosis lesions
  JOURNAL   Sci Rep 11 (1), 10548 (2021)
   PUBMED   34006929
  REMARK    GeneRIF: The miR-378c-Samd1 circuit promotes phenotypic modulation
            of vascular smooth muscle cells and foam cells formation in
            atherosclerosis lesions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2514)
  AUTHORS   Stielow,B., Zhou,Y., Cao,Y., Simon,C., Pogoda,H.M., Jiang,J.,
            Ren,Y., Phanor,S.K., Rohner,I., Nist,A., Stiewe,T.,
            Hammerschmidt,M., Shi,Y., Bulyk,M.L., Wang,Z. and Liefke,R.
  TITLE     The SAM domain-containing protein 1 (SAMD1) acts as a repressive
            chromatin regulator at unmethylated CpG islands
  JOURNAL   Sci Adv 7 (20) (2021)
   PUBMED   33980486
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2514)
  AUTHORS   Baas,R., Sijm,A., van Teeffelen,H.A., van Es,R., Vos,H.R. and Marc
            Timmers,H.T.
  TITLE     Quantitative Proteomics of the SMAD (Suppressor of Mothers against
            Decapentaplegic) Transcription Factor Family Identifies Importin 5
            as a Bone Morphogenic Protein Receptor SMAD-specific Importin
  JOURNAL   J Biol Chem 291 (46), 24121-24132 (2016)
   PUBMED   27703004
  REMARK    GeneRIF: The nuclear importin IPO5 was identified as a novel
            interacting protein of SMAD1. Overexpression of IPO5 in various
            cell lines specifically increases nuclear localization of BMP
            receptor-activated SMADs (R-SMADs) confirming a functional
            relationship between IPO5 and BMP but not TGF-beta R-SMADs.
REFERENCE   5  (bases 1 to 2514)
  AUTHORS   Lees,A.M., Deconinck,A.E., Campbell,B.D. and Lees,R.S.
  TITLE     Atherin: a newly identified, lesion-specific, LDL-binding protein
            in human atherosclerosis
  JOURNAL   Atherosclerosis 182 (2), 219-230 (2005)
   PUBMED   16159594
  REMARK    GeneRIF: atherin is present only in atherosclerotic lesions, not in
            normal intima
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022098.9, AY453840.1 and BC065477.1.
            
            On May 17, 2019 this sequence version replaced NM_138352.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY453840.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000673075.2/ ENSP00000500116.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-331               AC022098.9         127798-128128       c
            332-1090            AY453840.1         1-759
            1091-2514           BC065477.1         1-1424
FEATURES             Location/Qualifiers
     source          1..2514
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..2514
                     /gene="SAMD1"
                     /note="sterile alpha motif domain containing 1"
                     /db_xref="GeneID:90378"
                     /db_xref="HGNC:HGNC:17958"
                     /db_xref="MIM:620206"
     exon            1..1285
                     /gene="SAMD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..1948
                     /gene="SAMD1"
                     /note="atherin; SAM domain containing 1"
                     /codon_start=1
                     /product="sterile alpha motif domain-containing protein 1"
                     /protein_id="NP_612361.1"
                     /db_xref="GeneID:90378"
                     /db_xref="HGNC:HGNC:17958"
                     /db_xref="MIM:620206"
                     /translation="MAGPPALPPPETAAAATTAAAASSSAASPHYQEWILDTIDSLRS
                     RKARPDLERICRMVRRRHGPEPERTRAELEKLIQQRAVLRVSYKGSISYRNAARVQPP
                     RRGATPPAPPRAPRGAPAAAAAAAPPPTPAPPPPPAPVAAAAPARAPRAAAAAATAPP
                     SPGPAQPGPRAQRAAPLAAPPPAPAAPPAVAPPAGPRRAPPPAVAAREPPLPPPPQPP
                     APPQQQQPPPPQPQPPPEGGAVRAGGAARPVSLREVVRYLGGSGGAGGRLTRGRVQGL
                     LEEEAAARGRLERTRLGALALPRGDRPGRAPPAASARPSRSKRGGEERVLEKEEEEDD
                     DEDEDEEDDVSEGSEVPESDRPAGAQHHQLNGERGPQSAKERVKEWTPCGPHQGQDEG
                     RGPAPGSGTRQVFSMAAMNKEGGTASVATGPDSPSPVPLPPGKPALPGADGTPFGCPP
                     GRKEKPSDPVEWTVMDVVEYFTEAGFPEQATAFQEQEIDGKSLLLMQRTDVLTGLSIR
                     LGPALKIYEHHIKVLQQGHFEDDDPDGFLG"
     exon            1286..1580
                     /gene="SAMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1677
                     /gene="SAMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1789
                     /gene="SAMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..2514
                     /gene="SAMD1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccccctcg catccccggc cccgcgcgcg cccagcagaa gcgggtctgt gtgtgcgtgc
       61 gtgcgagtga gtgagtgtgt gcatattttt ttctctcttt tctttctctc tcactgtttt
      121 ttcctctctc tctctctccc tctctctctc tttttttttt tttttttttt gcaaagaaac
      181 agcagcgccg ccgccgctcc gccgaggcgc tgcgcccccc ggggggggag gcggaggagg
      241 cgggcagcgg cggagggagg ggagccgggg aggggggcgc cgcgctggga gggaggcagc
      301 gcgcacggtg cagccgggcc gggcgggagg catggcgggg cccccggccc tacccccgcc
      361 ggagacggcg gcggccgcca ccacggcggc cgccgcctcg tcgtccgccg cttccccgca
      421 ctaccaagag tggatcctgg acaccatcga ctcgctgcgc tcgcgcaagg cgcggccgga
      481 cctggagcgc atctgccgga tggtgcggcg gcggcacggc ccggagccgg agcgcacgcg
      541 cgccgagctc gagaaactga tccagcagcg cgccgtgctc cgggtcagct acaaggggag
      601 catctcgtac cgcaacgcgg cgcgcgtcca gccgccccgg cgcggagcca ccccgccggc
      661 cccgccgcgc gccccccgcg gggcccccgc cgccgccgcc gccgccgcgc cgccgcccac
      721 gcccgccccg ccgccaccgc ccgcgcccgt cgccgccgcc gccccggccc gggcgccccg
      781 cgcggccgcc gccgccgcca cagcgccccc ctcgcctggc cccgcgcagc cgggcccccg
      841 cgcgcagcgg gccgcgcccc tggccgcgcc gccgcccgcg ccagccgctc ccccggcggt
      901 ggcgcccccg gccggcccgc gccgcgcccc cccgcccgcc gtcgccgccc gggagccgcc
      961 gctgccgccg ccgccacagc cgccggcgcc gccacagcag cagcagccgc cgccgccgca
     1021 gccacagccg ccgccggagg ggggcgcggt gcgggccggc ggcgcggcgc ggcccgtgag
     1081 cctgcgggaa gtcgtgcgct acctcggggg cagcggcggc gccggcggtc gcctaacccg
     1141 cggccgcgtg caggggctgc tggaggagga ggcggcggct cgaggccgtc tggagcgcac
     1201 ccgtctcgga gcgcttgcgc tgccccgcgg ggacaggccc ggacgggcgc cgccggccgc
     1261 cagcgcccgc ccgtctcgca gcaagagagg tggagaagag cgagtacttg agaaagaaga
     1321 ggaagaagat gatgatgaag atgaagatga agaagatgat gtgtcagagg gctctgaagt
     1381 gcccgagagt gaccgtcctg caggtgccca gcaccaccag cttaacggcg agcggggacc
     1441 tcagagtgcc aaggagaggg tcaaggagtg gaccccctgc ggaccgcacc agggccagga
     1501 tgaagggcgg gggccagccc cgggcagcgg cacccgccag gtgttctcca tggcagccat
     1561 gaacaaggaa gggggaacag cttctgttgc caccgggcca gactccccgt cccccgtgcc
     1621 tttgccccca ggcaaaccag ccctacctgg ggccgacggg accccctttg gctgtcctcc
     1681 cgggcgcaaa gagaagccat ctgatcccgt cgagtggacc gtgatggatg tcgtcgaata
     1741 ttttactgag gctggattcc cggagcaggc gacagctttc caagagcagg aaattgatgg
     1801 caaatctttg ctgctcatgc agcgcacaga tgtgctcacc ggcctgtcca tccgcctcgg
     1861 gccagccctg aaaatctacg agcaccacat caaggtgctt cagcaaggcc actttgagga
     1921 tgatgacccc gatggcttct taggctgagc gcccagcctc acccctgccc cagcccattc
     1981 cggcccccat ctcacccaag atcccccaga gtccaggagc tggacgggga caccctcagc
     2041 cctcataaca gattccaagg agagggcacc ctcttgtcct tatctttgcc ccttgtgtct
     2101 gtctcacaca catctgctcc tcagcacgtc ggtgtgggga ggggattgct ccttaaaccc
     2161 caggtggctg accctcccca cccagtccag gacattttag gaaaaaaaaa atgaaatgtg
     2221 gggggcttct catctcccca agatcctctt ccgttcagcc agatgtttcc tgtataaatg
     2281 tttggatctg cctgtttatt ttggtgggtg gtctttcctc cctcccctac cacccatgcc
     2341 ccccttctca gtctgcccct ggcctccagc ccctagggga ctagctgggt tggggttcct
     2401 cgggcctttt ctctcctccc tcttttcttt ctgttgattg tcgctccagc tggctgtatt
     2461 gctttttaat attgcaccga aggtttttta aataaaattt taaaaaaaga aaaa
//
