LOCUS       NM_001381902            2946 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens sarcoma antigen 1 (SAGE1), transcript variant 1, mRNA.
ACCESSION   NM_001381902 XM_017029621
VERSION     NM_001381902.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2946)
  AUTHORS   Zhang,Y., Yu,X., Liu,Q., Gong,H., Chen,A.A., Zheng,H., Zhong,S. and
            Li,Y.
  TITLE     SAGE1: a Potential Target Antigen for Lung Cancer T-Cell
            Immunotherapy
  JOURNAL   Mol Cancer Ther 20 (11), 2302-2313 (2021)
   PUBMED   34465596
  REMARK    GeneRIF: SAGE1: a Potential Target Antigen for Lung Cancer T-Cell
            Immunotherapy.
REFERENCE   2  (bases 1 to 2946)
  AUTHORS   Ishihara,M., Kageyama,S., Miyahara,Y., Ishikawa,T., Ueda,S.,
            Soga,N., Naota,H., Mukai,K., Harada,N., Ikeda,H. and Shiku,H.
  TITLE     MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co-expression
            relationships in solid tumours
  JOURNAL   BMC Cancer 20 (1), 606 (2020)
   PUBMED   32600281
  REMARK    GeneRIF: MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and
            co-expression relationships in solid tumours.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2946)
  AUTHORS   Pineau,C., Hikmet,F., Zhang,C., Oksvold,P., Chen,S., Fagerberg,L.,
            Uhlen,M. and Lindskog,C.
  TITLE     Cell Type-Specific Expression of Testis Elevated Genes Based on
            Transcriptomics and Antibody-Based Proteomics
  JOURNAL   J Proteome Res 18 (12), 4215-4230 (2019)
   PUBMED   31429579
REFERENCE   4  (bases 1 to 2946)
  AUTHORS   Maheswaran,E., Pedersen,C.B., Ditzel,H.J. and Gjerstorff,M.F.
  TITLE     Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in
            Lung and Breast Cancer
  JOURNAL   PLoS One 10 (8), e0134967 (2015)
   PUBMED   26252478
  REMARK    GeneRIF: ADAM2, CALR3 and SAGE1 cancer/testis antigens are not
            promising targets for immunotherapy of breast and lung cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2946)
  AUTHORS   Miyahara,Y., Naota,H., Wang,L., Hiasa,A., Goto,M., Watanabe,M.,
            Kitano,S., Okumura,S., Takemitsu,T., Yuta,A., Majima,Y.,
            Lemonnier,F.A., Boon,T. and Shiku,H.
  TITLE     Determination of cellularly processed HLA-A2402-restricted novel
            CTL epitopes derived from two cancer germ line genes, MAGE-A4 and
            SAGE
  JOURNAL   Clin Cancer Res 11 (15), 5581-5589 (2005)
   PUBMED   16061876
  REMARK    GeneRIF: MAGE-A4(143-151) and SAGE(715-723) are
            HLA-A2402-restricted CTL epitopes
REFERENCE   6  (bases 1 to 2946)
  AUTHORS   Martelange,V., De Smet,C., De Plaen,E., Lurquin,C. and Boon,T.
  TITLE     Identification on a human sarcoma of two new genes with
            tumor-specific expression
  JOURNAL   Cancer Res 60 (14), 3848-3855 (2000)
   PUBMED   10919659
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC240441.2 and AL953870.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 20, 2020 this sequence version replaced XM_017029621.1.
            
            Summary: This gene belongs to a class of genes that are activated
            in tumors. These genes are expressed in tumors of different
            histologic types but not in normal tissues, except for
            spermatogenic cells and, for some, placenta. The proteins encoded
            by these genes appear to be strictly tumor specific, and hence may
            be excellent sources of antigens for cancer immunotherapy. This
            gene is expressed in sarcomas. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.4458371.1,
                                           SRR14038195.1639024.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370709.4/ ENSP00000359743.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AC240441.2         159395-159460
            67-153              AC240441.2         161922-162008
            154-286             AC240441.2         167238-167370
            287-379             AC240441.2         170156-170248
            380-520             AC240441.2         170931-171071
            521-661             AC240441.2         171703-171843
            662-802             AC240441.2         172090-172230
            803-943             AC240441.2         172605-172745
            944-1084            AC240441.2         172992-173132
            1085-1225           AC240441.2         173380-173520
            1226-1366           AC240441.2         173768-173908
            1367-1507           AC240441.2         174156-174296
            1508-1648           AC240441.2         174543-174683
            1649-1789           AC240441.2         175318-175458
            1790-1930           AC240441.2         175709-175849
            1931-2071           AC240441.2         176094-176234
            2072-2212           AC240441.2         176871-177011
            2213-2587           AC240441.2         177258-177632
            2588-2681           AC240441.2         178000-178093
            2682-2880           AC240441.2         178477-178675
            2881-2946           AL953870.2         17726-17791
FEATURES             Location/Qualifiers
     source          1..2946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..2946
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /note="sarcoma antigen 1"
                     /db_xref="GeneID:55511"
                     /db_xref="HGNC:HGNC:30369"
                     /db_xref="MIM:300359"
     exon            1..66
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..2781
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /note="cancer/testis antigen 14; putative tumor antigen"
                     /codon_start=1
                     /product="sarcoma antigen 1"
                     /protein_id="NP_001368831.1"
                     /db_xref="CCDS:CCDS14652.1"
                     /db_xref="GeneID:55511"
                     /db_xref="HGNC:HGNC:30369"
                     /db_xref="MIM:300359"
                     /translation="MQASPLQTSQPTPPEELHAAAYVFTNDGQQMRSDEVNLVATGHQ
                     SKKKHSRKSKRHSSSKRRKSMSSWLDKQEDAAVTHSICEERINNGQPVADNVLSTAPP
                     WPDATIAHNIREERMENGQSRTDKVLSTAPPQLVHMAAAGIPSMSTRDLHSTVTHNIR
                     EERMENGQPQPDNVLSTGPTGLINMAATPIPAMSARDLYATVTHNVCEQKMENVQPAP
                     DNVLLTLRPRRINMTDTGISPMSTRDPYATITYNVPEEKMEKGQPQPDNILSTASTGL
                     INVAGAGTPAISTNGLYSTVPHNVCEEKMENDQPQPNNVLSTVQPVIIYLTATGIPGM
                     NTRDQYATITHNVCEERVVNNQPLPSNALSTVLPGLAYLATADMPAMSTRDQHATIIH
                     NLREEKKDNSQPTPDNVLSAVTPELINLAGAGIPPMSTRDQYATVNHHVHEARMENGQ
                     RKQDNVLSNVLSGLINMAGASIPAMSSRDLYATITHSVREEKMESGKPQTDKVISNDA
                     PQLGHMAAGGIPSMSTKDLYATVTQNVHEERMENNQPQPSYDLSTVLPGLTYLTVAGI
                     PAMSTRDQYATVTHNVHEEKIKNGQAASDNVFSTVPPAFINMAATGVSSMSTRDQYAA
                     VTHNIREEKINNSQPAPGNILSTAPPWLRHMAAAGISSTITRDLYVTATHSVHEEKMT
                     NGQQAPDNSLSTVPPGCINLSGAGISCRSTRDLYATVIHDIQEEEMENDQTPPDGFLS
                     NSDSPELINMTGHCMPPNALDSFSHDFTSLSKDELLYKPDSNEFAVGTKNYSVSAGDP
                     PVTVMSLVETVPNTPQISPAMAKKINDDIKYQLMKEVRRFGQNYERIFILLEEVQGSM
                     KVKRQFVEFTIKEAARFKKVVLIQQLEKALKEIDSHCHLRKVKHMRKR"
     exon            67..153
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            154..286
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            287..379
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            380..520
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            521..661
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            662..802
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            803..943
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1084
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1225
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1366
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1507
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1648
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1789
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1930
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2071
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2212
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2587
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2681
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2946
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2919..2924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /note="hexamer: AATAAA"
     polyA_site      2946
                     /gene="SAGE1"
                     /gene_synonym="CT14; SAGE"
                     /note="major polyA site"
ORIGIN      
        1 actatcaact gcacagcggg cagaggcaga ggaacacaga accttctcac acagcgggat
       61 aaaaggatgc aggcttctcc acttcaaacg agtcaaccaa ctccacctga agaacttcat
      121 gctgctgcct atgtgtttac aaatgatggg cagcaaatga ggagtgatga agtaaatctg
      181 gttgcaacag ggcatcaaag caaaaagaaa cattccagaa aatccaagag acactcttca
      241 tctaagagaa ggaagagtat gtcctcgtgg ttagacaaac aggaagatgc tgcagtcact
      301 cacagcattt gtgaagagag gataaataac ggccaaccag tagctgataa tgtcttgtca
      361 actgctccac catggcctga tgctaccatc gctcacaata tccgtgaaga gaggatggaa
      421 aatggccaat ctcgaactga caaagtcttg tcaactgctc caccacagct tgttcatatg
      481 gctgcagctg gtattccatc catgagtacc agggatctgc attctaccgt cactcacaat
      541 atccgtgaag agagaatgga aaatggccaa ccccaacctg ataacgtctt gtcaactggt
      601 cccacagggc ttattaatat ggcagcaact cctattccag ccatgagtgc cagagatctc
      661 tatgctacag tcactcacaa tgtctgtgaa cagaagatgg aaaatgtcca accagcacct
      721 gataacgtgt tgttgactct tcgaccacgg cgtattaata tgacagacac tggtatttca
      781 cccatgagta ccagggatcc atatgctacc atcacttaca atgtccctga ggagaagatg
      841 gaaaagggcc aaccccaacc tgataacatc ttgtcaactg cttcaacagg gcttattaat
      901 gtggcaggag ctggtactcc agccatcagc accaatggcc tgtattccac cgtccctcac
      961 aatgtctgtg aagagaagat ggaaaatgac caaccgcaac ctaataacgt attgtcaact
     1021 gttcaaccag tgattattta tttgacagca actggtattc cgggcatgaa taccagggat
     1081 cagtatgcta ccatcactca caatgtctgt gaagagagag tggtaaataa ccaaccacta
     1141 cctagtaacg ccttgtcaac tgttctacca gggcttgctt atttggcaac agctgatatg
     1201 ccagccatga gtaccaggga tcagcatgct accatcattc acaatctgcg tgaagagaag
     1261 aaagataaca gccaaccaac ccctgataac gtcttgtcag ctgttacacc agagcttatt
     1321 aacttggcag gagctggtat tccacccatg agtaccaggg atcagtatgc taccgtcaat
     1381 caccatgtcc atgaagcaag gatggaaaat ggccaacgaa aacaggataa cgtcttgtca
     1441 aatgttctat ccgggcttat taatatggca ggagctagta ttccagcaat gagttccagg
     1501 gatctgtatg ctaccattac tcacagtgtt cgtgaagaga agatggaaag tggcaaaccc
     1561 caaactgata aggtcatatc aaatgatgca ccacagcttg gtcatatggc tgcaggtggt
     1621 attccatcca tgagtaccaa ggatctgtat gctaccgtca ctcaaaatgt ccatgaagag
     1681 aggatggaaa ataaccaacc acaacctagt tatgacttgt caactgttct accaggactt
     1741 acttatttga cagtagctgg tattccggcc atgagtacca gggatcagta tgctaccgtc
     1801 actcacaatg tccatgaaga gaagattaaa aatggccaag cagcatccga taatgtcttc
     1861 tcgactgttc caccagcatt tattaatatg gcagcaactg gtgtttcatc catgagtacc
     1921 agggatcagt atgctgcagt cactcacaac atccgtgaag agaagataaa taacagccaa
     1981 ccagcacctg gtaacatctt gtcaactgct cctccatggc ttcgtcatat ggcagcagct
     2041 ggaatttcat ccacgattac cagggatctg tatgtcaccg ccactcacag tgtccatgag
     2101 gagaagatga caaatggcca acaggcacct gataactcct tgtcaacggt tccacctggt
     2161 tgtattaatc tgtcaggagc tggtatttca tgcagaagta ccagggatct gtatgctact
     2221 gtcattcacg atatccagga ggaggagatg gaaaatgatc aaacccctcc tgatggcttc
     2281 ctgtcaaatt ctgattcacc agagctgata aatatgacag gacattgtat gccacccaat
     2341 gcattggatt ctttctctca cgacttcaca agtctcagca aagatgagct gctttacaaa
     2401 cctgatagta atgaatttgc ggtaggcacc aaaaactaca gtgtctctgc aggtgaccca
     2461 ccagttacag taatgtcttt ggtggaaact gtgccaaata caccacaaat atctcctgcc
     2521 atggcaaaga aaattaatga tgatataaaa tatcaattaa tgaaagaagt tcgaaggttt
     2581 gggcaaaatt atgaaagaat tttcattttg cttgaagagg tacaaggatc tatgaaagtc
     2641 aagagacaat ttgttgaatt taccatcaag gaagcagcaa ggtttaaaaa agttgtctta
     2701 attcagcaac tcgagaaggc gcttaaagaa atagattccc actgccatct cagaaaagtt
     2761 aagcacatga gaaaaagata attgtgttag tgcaaagacc aaggagaaac aaggacatat
     2821 gctgtaggat ggaacaggtt attgctgaag ctccctataa tcctgaaatg aagagaattc
     2881 ccttccagaa gctacgaaaa agggagctgt ttaaatttaa taaatctctg ttagtaaaag
     2941 ctgcac
//
