LOCUS       NM_014649               3167 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens scaffold attachment factor B2 (SAFB2), mRNA.
ACCESSION   NM_014649 XM_375559
VERSION     NM_014649.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3167)
  AUTHORS   Zhen,H., Yao,Y. and Yang,H.
  TITLE     SAFB2 Inhibits the Progression of Breast Cancer by Suppressing the
            Wnt/beta-Catenin Signaling Pathway via NFAT5
  JOURNAL   Mol Biotechnol 65 (9), 1465-1475 (2023)
   PUBMED   36652182
  REMARK    GeneRIF: SAFB2 Inhibits the Progression of Breast Cancer by
            Suppressing the Wnt/beta-Catenin Signaling Pathway via NFAT5.
REFERENCE   2  (bases 1 to 3167)
  AUTHORS   Hutter,K., Lohmuller,M., Jukic,A., Eichin,F., Avci,S., Labi,V.,
            Szabo,T.G., Hoser,S.M., Huttenhofer,A., Villunger,A. and Herzog,S.
  TITLE     SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in
            Clustered Primary miRNA Transcripts
  JOURNAL   Mol Cell 78 (5), 876-889 (2020)
   PUBMED   32502422
  REMARK    GeneRIF: SAFB2 Enables the Processing of Suboptimal Stem-Loop
            Structures in Clustered Primary miRNA Transcripts.
REFERENCE   3  (bases 1 to 3167)
  AUTHORS   Hong,E., Best,A., Gautrey,H., Chin,J., Razdan,A., Curk,T.,
            Elliott,D.J. and Tyson-Capper,A.J.
  TITLE     Unravelling the RNA-Binding Properties of SAFB Proteins in Breast
            Cancer Cells
  JOURNAL   Biomed Res Int 2015, 395816 (2015)
   PUBMED   26273616
  REMARK    GeneRIF: Single depletion of either SAFB1 or SAFB2 leads to an
            increase in expression of the other SAFB protein.
REFERENCE   4  (bases 1 to 3167)
  AUTHORS   Hashimoto,T., Matsuda,K. and Kawata,M.
  TITLE     Scaffold attachment factor B (SAFB)1 and SAFB2 cooperatively
            inhibit the intranuclear mobility and function of ERalpha
  JOURNAL   J Cell Biochem 113 (9), 3039-3050 (2012)
   PUBMED   22566185
  REMARK    GeneRIF: Results indicate that SAFB1 and SAFB2 are crucial
            repressors for ERalpha dynamics in association with the nuclear
            matrix and that their synergistic regulation of ERalpha mobility is
            sufficient for inhibiting ERalpha function.
REFERENCE   5  (bases 1 to 3167)
  AUTHORS   Hammerich-Hille,S., Bardout,V.J., Hilsenbeck,S.G., Osborne,C.K. and
            Oesterreich,S.
  TITLE     Low SAFB levels are associated with worse outcome in breast cancer
            patients
  JOURNAL   Breast Cancer Res Treat 121 (2), 503-509 (2010)
   PUBMED   19137425
  REMARK    GeneRIF: This study shows that low SAFB protein levels predict poor
            prognosis of breast cancer patients, suggesting critical functions
            of SAFB1 and SAFB2 in breast cancer cells.
REFERENCE   6  (bases 1 to 3167)
  AUTHORS   Hammerich-Hille,S., Kaipparettu,B.A., Tsimelzon,A., Creighton,C.J.,
            Jiang,S., Polo,J.M., Melnick,A., Meyer,R. and Oesterreich,S.
  TITLE     SAFB1 mediates repression of immune regulators and apoptotic genes
            in breast cancer cells
  JOURNAL   J Biol Chem 285 (6), 3608-3616 (2010)
   PUBMED   19901029
  REMARK    GeneRIF: Study confirms the primary role of SAFB1/SAFB2 as
            corepressors and also uncovers a previously unknown role for SAFB1
            in the regulation of immune genes and in estrogen-mediated
            repression of genes.
REFERENCE   7  (bases 1 to 3167)
  AUTHORS   Tsianou,D., Nikolakaki,E., Tzitzira,A., Bonanou,S., Giannakouros,T.
            and Georgatsou,E.
  TITLE     The enzymatic activity of SR protein kinases 1 and 1a is negatively
            affected by interaction with scaffold attachment factors B1 and 2
  JOURNAL   FEBS J 276 (18), 5212-5227 (2009)
   PUBMED   19674106
  REMARK    GeneRIF: The enzymatic activity of SR protein kinases 1 and 1a is
            negatively affected by interaction with scaffold attachment factors
            B1 and 2.
REFERENCE   8  (bases 1 to 3167)
  AUTHORS   Bergman,A., Abel,F., Behboudi,A., Yhr,M., Mattsson,J.,
            Svensson,J.H., Karlsson,P. and Nordling,M.
  TITLE     No germline mutations in supposed tumour suppressor genes SAFB1 and
            SAFB2 in familial breast cancer with linkage to 19p
  JOURNAL   BMC Med Genet 9, 108 (2008)
   PUBMED   19077293
  REMARK    GeneRIF: SAFB2 is not likely to be causative of the hereditary
            breast cancer syndrome in west Swedish breast cancer families
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3167)
  AUTHORS   Oesterreich,S.
  TITLE     Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or
            critical players in breast tumorigenesis?
  JOURNAL   J Cell Biochem 90 (4), 653-661 (2003)
   PUBMED   14587024
  REMARK    GeneRIF: REVIEW: possibility that SAFB1 and SAFB2 are novel breast
            tumor suppressor genes, and how they might function in this role,
            are discussed
            Review article
REFERENCE   10 (bases 1 to 3167)
  AUTHORS   Townson,S.M., Dobrzycka,K.M., Lee,A.V., Air,M., Deng,W., Kang,K.,
            Jiang,S., Kioka,N., Michaelis,K. and Oesterreich,S.
  TITLE     SAFB2, a new scaffold attachment factor homolog and estrogen
            receptor corepressor
  JOURNAL   J Biol Chem 278 (22), 20059-20068 (2003)
   PUBMED   12660241
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB475007.1, D50928.1 and
            AW136754.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014649.2.
            
            Summary: The protein encoded by this gene, along with its paralog
            (scaffold attachment factor B1), is a repressor of estrogen
            receptor alpha. The encoded protein binds scaffold/matrix
            attachment region (S/MAR) DNA and is involved in cell cycle
            regulation, apoptosis, differentiation, the stress response, and
            regulation of immune genes. [provided by RefSeq, May 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: D50928.1, SRR1660807.108917.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252542.9/ ENSP00000252542.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DB475007.1         152-176
            26-2936             D50928.1           1-2911
            2937-3167           AW136754.1         17-247              c
FEATURES             Location/Qualifiers
     source          1..3167
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3167
                     /gene="SAFB2"
                     /note="scaffold attachment factor B2"
                     /db_xref="GeneID:9667"
                     /db_xref="HGNC:HGNC:21605"
                     /db_xref="MIM:608066"
     exon            1..247
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2923
                     /gene="SAFB2"
                     /codon_start=1
                     /product="scaffold attachment factor B2"
                     /protein_id="NP_055464.1"
                     /db_xref="CCDS:CCDS32879.1"
                     /db_xref="GeneID:9667"
                     /db_xref="HGNC:HGNC:21605"
                     /db_xref="MIM:608066"
                     /translation="MAETLPGSGDSGPGTASLGPGVAETGTRRLSELRVIDLRAELKK
                     RNLDTGGNKSVLMERLKKAVKEEGQDPDEIGIELEATSKKSAKRCVKGLKMEEEGTED
                     NGLEDDSRDGQEDMEASLENLQNMGMMDMSVLDETEVANSSAPDFGEDGTDGLLDSFC
                     DSKEYVAAQLRQLPAQPPEHAVDGEGFKNTLETSSLNFKVTPDIEESLLEPENEKILD
                     ILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASES
                     TAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEEL
                     AEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSFKEEKDIKP
                     IIKDEKGRVGSGSGRNLWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCY
                     GFVTMSTSDEATKCISHLHRTELHGRMISVEKAKNEPAGKKLSDRKECEVKKEKLSSV
                     DRHHSVEIKIEKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSR
                     GMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERE
                     RQRQREREIRETERRREREQREREQRLEAFHERKEKARLQRERLQLECQRQRLERERM
                     ERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDA
                     YWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRREGSRPMMGDHRDGQ
                     HYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPPPRGGRDWGEHNQRLEE
                     HQARAWQGAMDAGAASREHARWQGGERGLSGPSGPGHMASRGGVAGRGGFAQGGHSQG
                     HVVPGGGLEGGGVASQDRGSRVPHPHPHPPPYPHFTRRY"
     exon            248..335
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            336..400
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            401..604
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..667
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            668..695
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..1206
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1256
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1357
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1507
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1620
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1751
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1843
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1980
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2268
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2409
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2455
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2586
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2699
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2766
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..3167
                     /gene="SAFB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3079..3084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAFB2"
                     /note="hexamer: AATAAA"
     polyA_site      3110
                     /gene="SAFB2"
     regulatory      3148..3153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAFB2"
                     /note="hexamer: AATAAA"
     polyA_site      3167
                     /gene="SAFB2"
                     /note="major polyA site"
ORIGIN      
        1 agagccgcta tagctgccgg cggtgtgcga ctgagtcggt ggcgaagacg ggaacgcgac
       61 gatggcggag actctgcccg ggtcgggcga ctcgggccct ggcacggctt ctctcggccc
      121 gggcgttgcg gagactggga cgaggcggct cagcgagctg cgggtgatcg atctgcgggc
      181 ggagctgaag aagcggaacc tggacacggg cggcaacaag agcgtcctga tggagcggct
      241 caagaaggcg gttaaagaag aggggcaaga tcctgatgaa attggcatcg agttagaagc
      301 caccagcaag aagtcagcca agagatgtgt taaaggactg aagatggagg aggaaggcac
      361 agaagataat ggcctggaag acgattccag agacgggcag gaggacatgg aagcaagtct
      421 ggagaacctg cagaatatgg gcatgatgga catgagtgtg ctagacgaaa ctgaagtggc
      481 gaatagcagt gctccagatt ttggggagga tggcacggac ggccttctcg attccttttg
      541 tgatagtaaa gaatacgtgg ctgcacagct gagacagctc ccggctcagc ccccagagca
      601 tgctgtggat ggggaaggat ttaagaacac tttggaaact tcatcgttga acttcaaagt
      661 aactccggac attgaagaat cccttttgga gccagaaaat gagaaaatac tcgacatttt
      721 gggggaaact tgtaaatctg agccagtaaa agaagaaagt tccgagctgg agcagccatt
      781 tgcacaggac acaagtagcg tggggccaga cagaaagctt gcggaggaag aggacctatt
      841 tgacagcgcc catccggaag agggtgattt agatttggcc agcgagtcaa cagcacacgc
      901 tcagtcgagc aaggcagaca gcctgttagc ggtagtgaaa agggagcccg cggagcagcc
      961 aggcgatggc gagaggacgg actgtgagcc tgtagggcta gagccggcag ttgagcagag
     1021 tagtgcggcc tccgagctcg cggaggcctc tagcgaggag ctcgcagaag cacccacgga
     1081 agccccaagc ccagaagcca gagatagcaa agaagacggg aggaagtttg attttgacgc
     1141 ttgtaatgaa gtccctccgg ctcctaaaga gtcctcaacc agtgagggcg ctgatcagaa
     1201 aatgagctct tttaaggaag aaaaagatat aaagccaatc attaaagatg aaaaaggtcg
     1261 ggtcggcagc ggttctggtc ggaacctgtg ggtcagcggg ctgtcctcca caacacgcgc
     1321 tacggatctc aagaaccttt tcagcaagta tgggaaggtt gtcggggcca aagtggtaac
     1381 gaacgcccgc agcccggggg ctcgatgcta tggattcgtc accatgtcga catctgacga
     1441 ggcgaccaag tgcatcagcc atctccacag aactgagctg catggacgaa tgatctccgt
     1501 agagaaggcc aaaaatgagc ctgctgggaa aaagctttcc gacagaaaag agtgcgaagt
     1561 gaagaaggaa aaattatcga gtgtcgacag acatcattct gtggagatca aaattgaaaa
     1621 aactgtaatt aagaaggaag agaagattga gaagaaggag gaaaaaaagc ctgaagacat
     1681 taagaaggaa gaaaaagacc aggatgagct gaaacccgga cctacaaatc ggtctagagt
     1741 caccaaatca ggaagcagag gaatggagcg gacggtcgtg atggataaat cgaaaggaga
     1801 gcccgtcatt agcgtgaaaa ccacaagcag gtccaaagag agaagctcca agagtcagga
     1861 tcgcaagtca gaaagcaaag aaaagagaga catcttgtcg tttgataaaa tcaaagaaca
     1921 aagggagaga gagcgccaga ggcagcggga acgggagatc cgcgaaacgg agaggcggcg
     1981 ggagcgcgag cagcgggagc gggagcaacg cctcgaggcc ttccatgagc ggaaggagaa
     2041 ggcccggcta cagcgggaac gcctgcagct cgagtgccag cgccagcggc tggagcggga
     2101 gcgcatggag cgggagcggc tggagcgcga gcgcatgcgc gtggagcgtg agcgcaggaa
     2161 ggagcaggag cgcatccacc gcgagcgcga ggagctgcgg cgccagcagg agcagctgcg
     2221 ttacgagcag gagcggcggc ccgggcggag gccctacgac ctggaccgac gagatgatgc
     2281 ctattggcca gaaggaaagc gtgtggcaat ggaggaccga tatcgtgcag actttccccg
     2341 gccagaccac cgctttcacg acttcgatca tcgagaccgg ggccagtacc aggaccacgc
     2401 catcgacagg cgggagggtt cgaggccaat gatgggagac caccgggatg ggcagcacta
     2461 tggagatgac cgccatggcc acggaggacc cccagagcgc cacggccggg actcccgtga
     2521 tggctggggg ggctacggct ccgacaagag gctgagtgaa ggccgggggc tgccccctcc
     2581 ccccaggggt ggccgtgact ggggagagca caaccagcgg ctagaggagc accaggcacg
     2641 cgcctggcag ggtgccatgg acgcaggcgc ggctagccgg gagcacgcca ggtggcaagg
     2701 tggcgagagg ggcctgtctg ggccctcggg gccggggcac atggcaagcc gcggtggagt
     2761 ggcggggcga ggcggctttg cacaaggtgg acattcccag ggccacgtgg tgccaggtgg
     2821 cggactggaa ggtggcggag tggccagcca ggaccggggc agcagagtcc ctcacccaca
     2881 ccctcatccc cccccgtacc cccacttcac ccgccgctac taagtcccac tcgctgcgag
     2941 ttttcgggtg ggcagacgca ctgttgaatc tggtagccag ggttccctcg aacttggggg
     3001 atctttttaa aagcaaagta aatcctgcca ccatgttgta gctcaataca atgtgaactc
     3061 actttttttt tttttttaaa taaatgtgtt cttgttctgc catttttaaa tcaaggtttc
     3121 tgttaacgag gcattccatt ttccattaat aaagtttacc attcgca
//
