LOCUS       NM_014363              15635 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens sacsin molecular chaperone (SACS), transcript variant
            1, mRNA.
ACCESSION   NM_014363
VERSION     NM_014363.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15635)
  AUTHORS   Dabbaghizadeh,A., Pare,A., Cheng-Boivin,Z., Dagher,R., Minotti,S.,
            Dicaire,M.J., Brais,B., Young,J.C., Durham,H.D. and Gentil,B.J.
  TITLE     The J Domain of Sacsin Disrupts Intermediate Filament Assembly
  JOURNAL   Int J Mol Sci 23 (24), 15742 (2022)
   PUBMED   36555380
  REMARK    GeneRIF: The J Domain of Sacsin Disrupts Intermediate Filament
            Assembly.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15635)
  AUTHORS   Francis,V., Alshafie,W., Kumar,R., Girard,M., Brais,B. and
            McPherson,P.S.
  TITLE     The ARSACS disease protein sacsin controls lysosomal positioning
            and reformation by regulating microtubule dynamics
  JOURNAL   J Biol Chem 298 (9), 102320 (2022)
   PUBMED   35933016
  REMARK    GeneRIF: The ARSACS disease protein sacsin controls lysosomal
            positioning and reformation by regulating microtubule dynamics.
            Erratum:[J Biol Chem. 2022 Dec;298(12):102718. doi:
            10.1016/j.jbc.2022.102718.. PMID: 36446242]
REFERENCE   3  (bases 1 to 15635)
  AUTHORS   Bouhlal,Y., Amouri,R., El Euch-Fayeche,G. and Hentati,F.
  TITLE     Autosomal recessive spastic ataxia of Charlevoix-Saguenay: an
            overview
  JOURNAL   Parkinsonism Relat Disord 17 (6), 418-422 (2011)
   PUBMED   21450511
  REMARK    Review article
REFERENCE   4  (bases 1 to 15635)
  AUTHORS   Parfitt,D.A., Michael,G.J., Vermeulen,E.G., Prodromou,N.V.,
            Webb,T.R., Gallo,J.M., Cheetham,M.E., Nicoll,W.S., Blatch,G.L. and
            Chapple,J.P.
  TITLE     The ataxia protein sacsin is a functional co-chaperone that
            protects against polyglutamine-expanded ataxin-1
  JOURNAL   Hum Mol Genet 18 (9), 1556-1565 (2009)
   PUBMED   19208651
REFERENCE   5  (bases 1 to 15635)
  AUTHORS   Takiyama,Y.
  TITLE     Sacsinopathies: sacsin-related ataxia
  JOURNAL   Cerebellum 6 (4), 353-359 (2007)
   PUBMED   17853117
  REMARK    GeneRIF: As more SACS mutations are identified worldwide, the
            clinical spectrum of 'sacsinopathies' will expand
REFERENCE   6  (bases 1 to 15635)
  AUTHORS   Ouyang,Y., Takiyama,Y., Sakoe,K., Shimazaki,H., Ogawa,T.,
            Nagano,S., Yamamoto,Y. and Nakano,I.
  TITLE     Sacsin-related ataxia (ARSACS): expanding the genotype upstream
            from the gigantic exon
  JOURNAL   Neurology 66 (7), 1103-1104 (2006)
   PUBMED   16606928
  REMARK    GeneRIF: Japanese autosomal recessive spastic ataxia of
            Charlevoix-Saguenay (ARSACS) patient with a compound heterozygous
            mutation in a new exon of the SACS gene.
REFERENCE   7  (bases 1 to 15635)
  AUTHORS   Engert,J.C., Dore,C., Mercier,J., Ge,B., Betard,C., Rioux,J.D.,
            Owen,C., Berube,P., Devon,K., Birren,B., Melancon,S.B., Morgan,K.,
            Hudson,T.J. and Richter,A.
  TITLE     Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS):
            high-resolution physical and transcript map of the candidate region
            in chromosome region 13q11
  JOURNAL   Genomics 62 (2), 156-164 (1999)
   PUBMED   10610707
REFERENCE   8  (bases 1 to 15635)
  AUTHORS   Vermeer,S., van de Warrenburg,B.P., Kamsteeg,E.J., Brais,B. and
            Synofzik,M.
  TITLE     ARSACS
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301432
REFERENCE   9  (bases 1 to 15635)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
REFERENCE   10 (bases 1 to 15635)
  AUTHORS   Richter,A., Morgan,K., Bouchard,J.P., Poirier,J., Mercier,J.,
            Gosselin,F. and Melancon,S.B.
  TITLE     Clinical and molecular genetic studies on autosomal recessive
            spastic ataxia of Charlevoix-Saguenay (ARSACS)
  JOURNAL   Adv Neurol 61, 97-103 (1993)
   PUBMED   8421971
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB213398.1, AW296712.1,
            AW295072.1, AL157766.9, AK125458.1 and DB309987.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014363.5.
            
            Summary: This gene encodes the sacsin protein, which includes a UbL
            domain at the N-terminus, a DnaJ domain, and a HEPN domain at the
            C-terminus. The gene is highly expressed in the central nervous
            system, also found in skin, skeletal muscles and at low levels in
            the pancreas. This gene includes a very large exon spanning more
            than 12.8 kb. Mutations in this gene result in autosomal recessive
            spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative
            disorder characterized by early-onset cerebellar ataxia with
            spasticity and peripheral neuropathy. The authors of a publication
            on the effects of siRNA-mediated sacsin knockdown concluded that
            sacsin protects against mutant ataxin-1 and suggest that 'the large
            multi-domain sacsin protein is able to recruit Hsp70 chaperone
            action and has the potential to regulate the effects of other
            ataxia proteins' (Parfitt et al., PubMed: 19208651). A pseudogene
            associated with this gene is located on chromosome 11. Alternative
            splicing of this gene results in multiple transcript variants.
            [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on alignment of partial transcripts
            and data in published reports.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.61912.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382292.9/ ENSP00000371729.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-549               DB213398.1         27-575
            550-756             AW296712.1         1-207               c
            757-1215            AW295072.1         7-465
            1216-1339           AL157766.9         33070-33193         c
            1340-1737           AK125458.1         835-1232
            1738-2682           AL157766.9         31727-32671         c
            2683-2774           AL157766.9         30993-31084         c
            2775-15575          AL157766.9         6098-18898          c
            15576-15635         DB309987.1         8-67                c
FEATURES             Location/Qualifiers
     source          1..15635
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.12"
     gene            1..15635
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /note="sacsin molecular chaperone"
                     /db_xref="GeneID:26278"
                     /db_xref="HGNC:HGNC:10519"
                     /db_xref="MIM:604490"
     exon            1..88
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /inference="alignment:Splign:2.1.0"
     exon            89..609
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /inference="alignment:Splign:2.1.0"
     CDS             590..14329
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /note="isoform 1 is encoded by transcript variant 1; dnaJ
                     homolog subfamily C member 29; spastic ataxia of
                     Charlevoix-Saguenay (sacsin); protein phosphatase 1,
                     regulatory subunit 138"
                     /codon_start=1
                     /product="sacsin isoform 1"
                     /protein_id="NP_055178.3"
                     /db_xref="CCDS:CCDS9300.2"
                     /db_xref="GeneID:26278"
                     /db_xref="HGNC:HGNC:10519"
                     /db_xref="MIM:604490"
                     /translation="METKENRWVPVTVLPGCVGCRTVAALASWTVRDVKERIFAETGF
                     PVSEQRLWRGGRELSDWIKIGDLTSKNCHLFVNLQSKGLKGGGRFGQTTPPLVDFLKD
                     ILRRYPEGGQILKELIQNAEDAGATEVKFLYDETQYGTETLWSKDMAPYQGPALYVYN
                     NAVFTPEDWHGIQEIARSRKKDDPLKVGRFGIGFNSVYHITDVPCIFSGDQIGMLDPH
                     QTLFGPHESGQCWNLKDDSKEISELSDQFAPFVGIFGSTKETFINGNFPGTFFRFPLR
                     LQPSQLSSNLYNKQKVLELFESFRADADTVLLFLKSVQDVSLYVREADGTEKLVFRVT
                     SSESKALKHERPNSIKILGTAISNYCKKTPSNNITCVTYHVNIVLEEESTKDAQKTSW
                     LVCNSVGGRGISSKLDSLADELKFVPIIGIAMPLSSRDDEAKGATSDFSGKAFCFLPL
                     PPGEESSTGLPVHISGFFGLTDNRRSIKWRELDQWRDPAALWNEFLVMNVVPKAYATL
                     ILDSIKRLEMEKSSDFPLSVDVIYKLWPEASKVKVHWQPVLEPLFSELLQNAVIYSIS
                     CDWVRLEQVYFSELDENLEYTKTVLNYLQSSGKQIAKVPGNVDAAVQLTAASGTTPVR
                     KVTPAWVRQVLRKCAHLGCAEEKLHLLEFVLSDQAYSELLGLELLPLQNGNFVPFSSS
                     VSDQDVIYITSAEYPRSLFPSLEGRFILDNLKPHLVAALKEAAQTRGRPCTQLQLLNP
                     ERFARLIKEVMNTFWPGRELIVQWYPFDENRNHPSVSWLKMVWKNLYIHFSEDLTLFD
                     EMPLIPRTILEEGQTCVELIRLRIPSLVILDDESEAQLPEFLADIVQKLGGFVLKKLD
                     ASIQHPLIKKYIHSPLPSAVLQIMEKMPLQKLCNQITSLLPTHKDALRKFLASLTDSS
                     EKEKRIIQELAIFKRINHSSDQGISSYTKLKGCKVLHHTAKLPADLRLSISVIDSSDE
                     ATIRLANMLKIEQLKTTSCLKLVLKDIENAFYSHEEVTQLMLWVLENLSSLKNENPNV
                     LEWLTPLKFIQISQEQMVSAGELFDPDIEVLKDLFCNEEGTYFPPSVFTSPDILHSLR
                     QIGLKNEASLKEKDVVQVAKKIEALQVGACPDQDVLLKKAKTLLLVLNKNHTLLQSSE
                     GKMTLKKIKWVPACKERPPNYPGSLVWKGDLCNLCAPPDMCDVGHAILIGSSLPLVES
                     IHVNLEKALGIFTKPSLSAVLKHFKIVVDWYSSKTFSDEDYYQFQHILLEIYGFMHDH
                     LNEGKDSFRALKFPWVWTGKKFCPLAQAVIKPIHDLDLQPYLHNVPKTMAKFHQLFKV
                     CGSIEELTSDHISMVIQKIYLKSDQDLSEQESKQNLHLMLNIIRWLYSNQIPASPNTP
                     VPIHHSKNPSKLIMKPIHECCYCDIKVDDLNDLLEDSVEPIILVHEDIPMKTAEWLKV
                     PCLSTRLINPENMGFEQSGQREPLTVRIKNILEEYPSVSDIFKELLQNADDANATECS
                     FLIDMRRNMDIRENLLDPGMAACHGPALWSFNNSQFSDSDFVNITRLGESLKRGEVDK
                     VGKFGLGFNSVYHITDIPIIMSREFMIMFDPNINHISKHIKDKSNPGIKINWSKQQKR
                     LRKFPNQFKPFIDVFGCQLPLTVEAPYSYNGTLFRLSFRTQQEAKVSEVSSTCYNTAD
                     IYSLVDEFSLCGHRLIIFTQSVKSMYLKYLKIEETNPSLAQDTVIIKKKSCSSKALNT
                     PVLSVLKEAAKLMKTCSSSNKKLPSDEPKSSCILQITVEEFHHVFRRIADLQSPLFRG
                     PDDDPAALFEMAKSGQSKKPSDELSQKTVECTTWLLCTCMDTGEALKFSLSESGRRLG
                     LVPCGAVGVQLSEIQDQKWTVKPHIGEVFCYLPLRIKTGLPVHINGCFAVTSNRKEIW
                     KTDTKGRWNTTFMRHVIVKAYLQVLSVLRDLATSGELMDYTYYAVWPDPDLVHDDFSV
                     ICQGFYEDIAHGKGKELTKVFSDGSTWVSMKNVRFLDDSILKRRDVGSAAFKIFLKYL
                     KKTGSKNLCAVELPSSVKLGFEEAGCKQILLENTFSEKQFFSEVFFPNIQEIEAELRD
                     PLMIFVLNEKVDEFSGVLRVTPCIPCSLEGHPLVLPSRLIHPEGRVAKLFDIKDGRFP
                     YGSTQDYLNPIILIKLVQLGMAKDDILWDDMLERAVSVAEINKSDHVAACLRSSILLS
                     LIDEKLKIRDPRAKDFAAKYQTIRFLPFLTKPAGFSLDWKGNSFKPETMFAATDLYTA
                     EHQDIVCLLQPILNENSHSFRGCGSVSLAVKEFLGLLKKPTVDLVINQLKEVAKSVDD
                     GITLYQENITNACYKYLHEALMQNEITKMSIIDKLKPFSFILVENAYVDSEKVSFHLN
                     FEAAPYLYQLPNKYKNNFRELFETVGVRQSCTVEDFALVLESIDQERGTKQITEENFQ
                     LCRRIISEGIWSLIREKKQEFCEKNYGKILLPDTNLMLLPAKSLCYNDCPWIKVKDTT
                     VKYCHADIPREVAVKLGAVPKRHKALERYASNVCFTTLGTEFGQKEKLTSRIKSILNA
                     YPSEKEMLKELLQNADDAKATEICFVFDPRQHPVDRIFDDKWAPLQGPALCVYNNQPF
                     TEDDVRGIQNLGKGTKEGNPYKTGQYGIGFNSVYHITDCPSFISGNDILCIFDPHARY
                     APGATSISPGRMFRDLDADFRTQFSDVLDLYLGTHFKLDNCTMFRFPLRNAEMAKVSE
                     ISSVPASDRMVQNLLDKLRSDGAELLMFLNHMEKISICEIDKSTGALNVLYSVKGKIT
                     DGDRLKRKQFHASVIDSVTKKRQLKDIPVQQITYTMDTEDSEGNLTTWLICNRSGFSS
                     MEKVSKSVISAHKNQDITLFPRGGVAACITHNYKKPHRAFCFLPLSLETGLPFHVNGH
                     FALDSARRNLWRDDNGVGVRSDWNNSLMTALIAPAYVELLIQLKKRYFPGSDPTLSVL
                     QNTPIHVVKDTLKKFLSFFPVNRLDLQPDLYCLVKALYNCIHEDMKRLLPVVRAPNID
                     GSDLHSAVIITWINMSTSNKTRPFFDNLLQDELQHLKNADYNITTRKTVAENVYRLKH
                     LLLEIGFNLVYNCDETANLYHCLIDADIPVSYVTPADIRSFLMTFSSPDTNCHIGKLP
                     CRLQQTNLKLFHSLKLLVDYCFKDAEENEIEVEGLPLLITLDSVLQTFDAKRPKFLTT
                     YHELIPSRKDLFMNTLYLKYSNILLNCKVAKVFDISSFADLLSSVLPREYKTKSCTKW
                     KDNFASESWLKNAWHFISESVSVKEDQEETKPTFDIVVDTLKDWALLPGTKFTVSANQ
                     LVVPEGDVLLPLSLMHIAVFPNAQSDKVFHALMKAGCIQLALNKICSKDSAFVPLLSC
                     HTANIESPTSILKALHYMVQTSTFRAEKLVENDFEALLMYFNCNLNHLMSQDDIKILK
                     SLPCYKSISGRYVSIGKFGTCYVLTKSIPSAEVEKWTQSSSSAFLEEKIHLKELYEVI
                     GCVPVDDLEVYLKHLLPKIENLSYDAKLEHLIYLKNRLSSAEELSEIKEQLFEKLESL
                     LIIHDANSRLKQAKHFYDRTVRVFEVMLPEKLFIPNDFFKKLEQLIKPKNHVTFMTSW
                     VEFLRNIGLKYILSQQQLLQFAKEISVRANTENWSKETLQNTVDILLHHIFQERMDLL
                     SGNFLKELSLIPFLCPERAPAEFIRFHPQYQEVNGTLPLIKFNGAQVNPKFKQCDVLQ
                     LLWTSCPILPEKATPLSIKEQEGSDLGPQEQLEQVLNMLNVNLDPPLDKVINNCRNIC
                     NITTLDEEMVKTRAKVLRSIYEFLSAEKREFRFQLRGVAFVMVEDGWKLLKPEEVVIN
                     LEYESDFKPYLYKLPLELGTFHQLFKHLGTEDIISTKQYVEVLSRIFKNSEGKQLDPN
                     EMRTVKRVVSGLFRSLQNDSVKVRSDLENVRDLALYLPSQDGRLVKSSILVFDDAPHY
                     KSRIQGNIGVQMLVDLSQCYLGKDHGFHTKLIMLFPQKLRPRLLSSILEEQLDEETPK
                     VCQFGALCSLQGRLQLLLSSEQFITGLIRIMKHENDNAFLANEEKAIRLCKALREGLK
                     VSCFEKLQTTLRVKGFNPIPHSRSETFAFLKRFGNAVILLYIQHSDSKDINFLLALAM
                     TLKSATDNLISDTSYLIAMLGCNDIYRIGEKLDSLGVKYDSSEPSKLELPMPGTPIPA
                     EIHYTLLMDPMNVFYPGEYVGYLVDAEGGDIYGSYQPTYTYAIIVQEVEREDADNSSF
                     LGKIYQIDIGYSEYKIVSSLDLYKFSRPEESSQSRDSAPSTPTSPTEFLTPGLRSIPP
                     LFSGRESHKTSSKHQSPKKLKVNSLPEILKEVTSVVEQAWKLPESERKKIIRRLYLKW
                     HPDKNPENHDIANEVFKHLQNEINRLEKQAFLDQNADRASRRTFSTSASRFQSDKYSF
                     QRFYTSWNQEATSHKSERQQQNKEKCPPSAGQTYSQRFFVPPTFKSVGNPVEARRWLR
                     QARANFSAARNDLHKNANEWVCFKCYLSTKLALIAADYAVRGKSDKDVKPTALAQKIE
                     EYSQQLEGLTNDVHTLEAYGVDSLKTRYPDLLPFPQIPNDRFTSEVAMRVMECTACII
                     IKLENFMQQKV"
     exon            610..760
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /inference="alignment:Splign:2.1.0"
     exon            761..848
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /inference="alignment:Splign:2.1.0"
     exon            849..934
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1046
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1193
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..2682
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2774
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..15635
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15611..15616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /note="hexamer: AATAAA"
     polyA_site      15635
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /note="major polyA site"
ORIGIN      
        1 agtgcggctg cgggacagtc acgctgggaa ctgctgatgg cactggagga aaacaaaggc
       61 cgagagaccc tgatgcccac agcccccaga tcacagaagt gaggccaaga tgcccatgtc
      121 accagagcca gaagaaaggc tcctaccaaa gaatatttta catctgctga gatgagggtg
      181 agaaacaaaa tccaagaatt tctgcgacgt tttccccaag aaccttcaaa aagaaataca
      241 gaaaattctc agatgaaaat aaattgattt tgctctgggg gaaagccaaa aacctttagc
      301 gaatccacac tgttttatcc tgagaacttc catgggtcgc tggatcagca ggcaaccatt
      361 atcagactgg agagtcatac tttaaggaat acaaatgcaa cacacgacaa tgtttcctga
      421 catcagatga tgaatggaca ctgaagggaa aaacaggctt tttttccacc tggcaggaag
      481 agctgaactt ggagtacaca tttaaaggaa gcacagaggg aagacttaaa cagaagaaag
      541 aagcgtactt tcatggtttt cacaaacaaa tatcccagga gaagtgatca tggagaccaa
      601 ggagaacagg tgggtcccgg tgaccgtgct ccccggctgc gtgggctgca ggaccgtcgc
      661 ggcgctggcg tcctggaccg tgcgcgatgt gaaggaacgt atcttcgcgg agactggctt
      721 cccggtgtcg gagcagcggc tgtggcgcgg cggccgcgag ttatctgact ggatcaagat
      781 tggagatctg acttccaaaa attgtcatct ttttgtaaac cttcaatcaa aaggcttaaa
      841 agggggaggt cgatttggtc agacaacgcc accacttgtt gattttctca aggacatttt
      901 gagaagatat ccagaaggag gacagattct taaggaatta attcagaatg cagaagatgc
      961 tggggcgaca gaagttaaat ttttatatga tgaaactcaa tacggaacag agactctttg
     1021 gtcaaaagat atggcgccat atcaggggcc agctctctat gtgtacaaca acgcggtttt
     1081 caccccagag gactggcacg gcattcaaga aatagcaaga agcaggaaaa aggatgatcc
     1141 tctgaaggtc ggaagatttg gaattgggtt taattctgtc tatcatataa cagatgttcc
     1201 ttgtatcttt agtggtgacc aaatcgggat gctagatcct catcaaacac tttttggccc
     1261 acatgaatca ggccaatgtt ggaatctcaa agatgacagc aaagaaatta gtgaactttc
     1321 agaccagttt gcaccatttg ttggcatttt tggaagcacc aaggaaacat ttataaacgg
     1381 caattttcca ggaacatttt tccgtttccc tcttcgccta caaccttcac aacttagtag
     1441 taacctctac aataagcaga aggttcttga gttgtttgag tcttttaggg cagatgcaga
     1501 cacagtgctg ctctttctga aaagtgtgca ggatgtttcc ttatatgtcc gagaggctga
     1561 cggaacagag aaactggtgt ttagagtgac ttcgagtgag agtaaggcac tgaaacatga
     1621 gcggccgaat tctataaaga ttctgggaac tgctataagt aactattgta aaaagactcc
     1681 aagcaataac atcacctgtg taacatatca cgtaaatatt gttttagaag aggagagtac
     1741 taaggatgca cagaaaacat cttggttggt gtgtaacagt gtgggtgggc gagggatcag
     1801 tagtaagctt gactctttag ctgatgaact gaaatttgtc ccaatcattg gaatagccat
     1861 gcctttatca agcagagatg atgaagcaaa aggagcaacg tctgatttct caggaaaagc
     1921 attttgtttc cttcctttac cacctggtga ggaaagcagc acaggcctcc cagttcacat
     1981 cagtgggttc tttggcctta ctgataaccg caggagcata aaatggagag agctggacca
     2041 gtggagagac ccggcagcct tatggaatga gtttcttgtc atgaatgttg tccccaaagc
     2101 ttatgctact ctgatcttag attcaataaa acgtctggag atggaaaaga gctctgattt
     2161 ccccttgtca gttgatgtta tctataagct ttggccggag gcgagcaaag tcaaggtgca
     2221 ctggcaaccg gtgttagagc ctctattcag cgagctgttg cagaatgcag tgatttattc
     2281 aattagctgt gactgggtca ggttggagca ggtgtacttc tcagaacttg atgaaaattt
     2341 agaatacaca aaaactgtgc tcaactacct ccagagctca gggaagcaga ttgccaaggt
     2401 accagggaat gtggatgctg ctgttcagct cacagctgcc tctggcacaa cacctgtgag
     2461 gaaggtgacg cccgcgtggg tgcggcaggt gctgcggaag tgtgcacacc tgggctgtgc
     2521 tgaagaaaag cttcaccttc tagaatttgt gctttctgac caagcctaca gtgagctgct
     2581 tgggctggag ctgctccctt tacaaaatgg caattttgtc cccttctcct catctgtatc
     2641 agaccaagat gtcatttata ttacctcagc agaatatcca aggtcccttt tcccaagtct
     2701 tgaaggaaga tttattttgg ataacttgaa acctcacctt gtggctgctt taaaggaagc
     2761 tgcccaaacc cgaggaagac catgtactca gctgcagctt ctaaatccag aacgatttgc
     2821 acgtcttatc aaggaagtaa tgaatacatt ctggcctggc agagaattga ttgttcaatg
     2881 gtatccattt gatgaaaaca gaaatcaccc atctgtttca tggcttaaga tggtttggaa
     2941 aaatctttat atacattttt cagaggattt gactttattt gatgagatgc cacttatccc
     3001 cagaactata ctagaggaag gtcagacatg tgtggaactc attagactca ggattccatc
     3061 gttagtcatt ttagacgatg aatctgaagc acagcttcca gaatttttag cagacattgt
     3121 acaaaaactt ggagggtttg tccttaaaaa attagatgca tctatacaac atccgcttat
     3181 taaaaaatat attcattcac cattaccaag tgctgttttg cagataatgg agaagatgcc
     3241 attgcagaaa ttgtgtaatc aaataacttc gctacttcca acacacaaag atgccctgag
     3301 gaagttcttg gctagtttaa ccgatagcag tgagaaagag aaaagaatta ttcaagaatt
     3361 ggcaatattc aagcgcatta accattcttc tgatcaggga atttcctctt atacaaaatt
     3421 gaaaggttgt aaagtcttac accatactgc caaactccca gcagatctgc gactttctat
     3481 ttcagtaata gacagtagtg atgaagctac tattcgtctg gcaaacatgt tgaaaataga
     3541 acagttaaag accactagct gcttaaagct tgttttaaaa gatattgaaa atgcatttta
     3601 ttcacatgaa gaggtaacac agcttatgtt atgggtcctt gagaatctat cttctcttaa
     3661 aaatgagaat ccaaatgtgc ttgagtggtt aacaccatta aaattcatcc agatatcaca
     3721 ggaacagatg gtatcagctg gtgaactctt tgaccctgat atagaagtac taaaggatct
     3781 cttttgtaat gaagaaggaa cctatttccc accctcagtt tttacctcac cagatattct
     3841 tcactcctta agacagattg gtttaaaaaa cgaagccagt ctcaaagaaa aggatgttgt
     3901 gcaagtggca aaaaaaattg aagccttaca ggtcggtgct tgtcctgatc aagatgttct
     3961 tctgaagaaa gccaaaaccc tcttactggt tttaaataag aatcacacac tgttgcaatc
     4021 atctgaagga aagatgacat tgaagaaaat aaaatgggtt ccagcctgca aggaaaggcc
     4081 tccaaattat ccaggctctt tggtctggaa aggagatctc tgtaatctct gtgcaccacc
     4141 agatatgtgt gatgtaggcc atgcaattct cattggctcc tcacttcctc ttgttgaaag
     4201 tatccatgta aacctggaaa aagcattagg gatcttcaca aaacctagcc ttagtgctgt
     4261 cttaaaacac tttaaaattg ttgttgattg gtattcttca aaaaccttta gtgatgaaga
     4321 ctactatcaa ttccagcata ttttgcttga gatttacgga ttcatgcatg atcatctaaa
     4381 tgaagggaaa gattctttta gagccttaaa atttccatgg gtttggactg gcaaaaagtt
     4441 ttgtccactt gcccaggctg tgattaaacc aatccatgat cttgaccttc agccttattt
     4501 gcataatgta cctaaaacca tggcaaaatt ccaccaacta tttaaggtct gtggttcaat
     4561 agaggagttg acatcagatc atatttccat ggttattcag aagatatatc tcaaaagtga
     4621 ccaagatctc agtgaacaag aaagcaaaca aaatcttcat cttatgttga atattatcag
     4681 atggctgtat agcaatcaga ttccagcaag ccccaacaca ccagttccta tacatcatag
     4741 caaaaatcct tctaaactta tcatgaagcc aattcacgaa tgctgttatt gtgacattaa
     4801 agttgatgac cttaatgact tacttgaaga ttctgtggaa ccaatcattt tggtgcatga
     4861 ggacataccc atgaaaactg cagaatggct aaaagttcca tgccttagta caagactgat
     4921 aaatcctgaa aacatgggat ttgagcagtc aggacaaaga gagccactta ctgtaagaat
     4981 taaaaatatt ctggaagaat acccttcagt gtcagatatt tttaaagaac tacttcaaaa
     5041 cgctgatgat gcaaatgcaa cagaatgcag tttcttgatt gatatgagaa gaaatatgga
     5101 cataagagag aatctcctag acccagggat ggcagcttgt catggacctg ctttgtggtc
     5161 attcaacaat tctcaattct cagattcaga ttttgtgaac ataactaggt taggagaatc
     5221 tttaaaaagg ggagaagttg acaaagttgg aaaatttggt cttggattta attctgtgta
     5281 ccatatcact gacattccca tcattatgag tcgggaattc atgataatgt tcgatccaaa
     5341 cataaatcat atcagtaaac acattaaaga caaatccaat cctgggatca aaattaattg
     5401 gagtaaacaa cagaaaagac ttagaaaatt tcctaatcag ttcaaaccat ttatagatgt
     5461 atttggctgt cagttacctt tgactgtaga agcaccttac agctataatg gaaccctttt
     5521 ccgactgtcc tttagaactc aacaggaagc aaaagtgagt gaagttagta gtacgtgcta
     5581 caatacagca gatatttatt ctcttgtgga tgaatttagt ctctgtggac acaggcttat
     5641 cattttcact cagagtgtaa agtcaatgta tttgaagtac ttgaaaattg aggaaaccaa
     5701 ccccagttta gcacaagata cagtaataat taaaaaaaaa tcctgctctt ccaaagcatt
     5761 gaacacacct gtcttaagtg ttttaaaaga ggctgctaag ctcatgaaga cttgcagcag
     5821 cagtaataaa aagcttccca gtgatgaacc aaagtcatct tgcattcttc agatcacagt
     5881 ggaagaattt caccatgtgt tcagaaggat tgctgattta cagtcgccac tttttagagg
     5941 tccagatgat gacccagctg ctctctttga aatggctaag tctggccaat caaaaaagcc
     6001 atcagatgag ttgtcacaga aaacagtaga gtgtaccacg tggcttctgt gtacttgcat
     6061 ggacacagga gaggctctga agttttccct gagtgagagt ggaagaagac taggactggt
     6121 tccatgtggg gcagtaggag ttcagctgtc agaaatccag gaccagaagt ggacagtgaa
     6181 accacacatt ggagaggtgt tttgctattt acctttacga ataaaaacag gcttgccagt
     6241 tcatatcaat gggtgctttg ctgttacatc aaataggaaa gaaatctgga aaacagatac
     6301 aaaaggacga tggaatacca cgttcatgag acatgttatt gtgaaagctt acttacaggt
     6361 actgagtgtc ttacgggacc tggccactag tggggagcta atggattata cttactatgc
     6421 agtatggccc gatcctgatt tagttcatga tgatttttct gtaatttgcc aaggatttta
     6481 tgaagatata gctcatggaa aagggaaaga actgaccaaa gtcttctctg atggatctac
     6541 ttgggtttcc atgaagaacg taagatttct agatgactct atacttaaaa gaagagatgt
     6601 tggttcagca gccttcaaga tatttttgaa atacctcaag aagactgggt ccaaaaacct
     6661 ttgtgctgtt gaacttcctt cttcggtaaa attaggattt gaagaagctg gctgcaaaca
     6721 gatactactt gaaaacacat tttcagagaa acagtttttt tctgaagtgt tttttccaaa
     6781 tattcaagaa attgaagcag aacttagaga tcctttaatg atctttgttc taaatgaaaa
     6841 agttgatgag ttctcgggag ttcttcgtgt tactccatgt attccttgtt ccttggaggg
     6901 gcatcctttg gttttgccat caagattgat ccaccccgaa ggacgagttg caaagttatt
     6961 tgatattaaa gatgggagat tcccttatgg ttctactcag gattatctca atcctattat
     7021 tttgattaaa ctagttcagt taggtatggc aaaagatgat attttatggg atgatatgct
     7081 agaacgtgca gtgtcagtag ctgaaattaa taaaagtgat catgttgctg catgcctaag
     7141 aagtagtatc ttattgagtc ttatcgatga gaaactaaaa ataagggatc ctagagcaaa
     7201 ggattttgct gcaaaatatc aaacaatccg cttccttcca tttctgacaa aaccagcagg
     7261 tttttctttg gactggaaag gcaacagttt taagcctgaa accatgtttg cagcaactga
     7321 cctttataca gctgaacatc aagatatagt ttgtcttttg caaccaattc taaatgaaaa
     7381 ttcccattct tttagaggtt gtggttcagt gtcattggct gttaaagagt ttttgggatt
     7441 actcaagaag ccaacagttg atctggttat aaaccaattg aaagaagtag caaaatcagt
     7501 tgatgatgga attacactgt accaggagaa tatcaccaat gcttgctaca aataccttca
     7561 tgaagccttg atgcaaaatg aaatcactaa gatgtcaatt attgataagt taaaaccctt
     7621 tagcttcatt ctagttgaga atgcatatgt tgactcagaa aaggtttctt ttcatttaaa
     7681 ttttgaggcg gcaccatacc tttatcagtt gcctaataag tataaaaata atttccgcga
     7741 actttttgaa accgtgggtg tgaggcagtc atgcactgtt gaagattttg ctcttgtttt
     7801 ggaatctatt gatcaagaaa gaggaacaaa gcaaataaca gaagagaatt ttcagctttg
     7861 ccgacgaata atcagtgaag gaatatggag tctcattaga gaaaagaaac aagaattttg
     7921 tgagaaaaat tatggcaaga tattattgcc agatactaat cttatgcttc tccctgctaa
     7981 atcgttatgc tacaatgatt gcccttggat aaaagtaaag gataccactg taaaatattg
     8041 tcatgctgac atacccaggg aagtagcagt aaaactagga gcagtcccaa agcgacacaa
     8101 agccttagaa agatatgcat ccaatgtctg ttttacaaca cttggcacag aatttgggca
     8161 gaaagaaaaa ttgaccagca gaattaagag catccttaat gcatatcctt ctgaaaagga
     8221 aatgttgaaa gagcttcttc aaaatgctga tgatgcaaag gcgacagaaa tctgttttgt
     8281 gtttgatcct agacagcatc cagttgatag aatatttgat gataagtggg ccccattgca
     8341 agggccagca ctttgtgtgt acaacaacca gccatttaca gaagatgatg ttagaggaat
     8401 tcagaatctt ggaaaaggca cgaaagaggg aaatccttat aaaactggac agtatggaat
     8461 aggattcaat tctgtgtatc atatcacaga ctgcccatct tttatttctg gcaatgacat
     8521 cctgtgtatt tttgatcctc atgccagata tgcaccaggg gccacatcca ttagtcccgg
     8581 acgcatgttt agagatttgg atgcagattt taggacacag ttctcagatg ttctggatct
     8641 ttatctggga acccatttta aactggataa ttgcacaatg ttcagatttc ctcttcgtaa
     8701 tgcagaaatg gcaaaagttt cggaaatttc gtctgttcca gcatcagaca gaatggtcca
     8761 gaatcttttg gacaaactgc gctcagatgg ggcagaactt ctaatgtttc ttaatcacat
     8821 ggaaaaaatt tctatttgtg aaatagataa gagtactgga gctctaaatg tgctgtattc
     8881 agtaaagggc aaaatcacag atggagacag attgaaaagg aaacaatttc atgcatctgt
     8941 aattgatagt gttactaaaa agaggcagct caaagacata ccagttcaac aaataaccta
     9001 tactatggat actgaggact ctgaaggaaa tcttactacg tggctaattt gtaatagatc
     9061 aggcttttca agtatggaga aagtatctaa aagtgtcata tcagctcaca agaaccaaga
     9121 tattactctt ttcccacgtg gtggagtagc tgcctgcatt actcacaact ataaaaaacc
     9181 ccatagggcc ttctgttttt tgcctctttc tttggagact gggctgccat ttcatgtgaa
     9241 tggccacttt gcactggatt cagccagaag gaacctgtgg cgtgatgata atggagttgg
     9301 tgttcgaagt gactggaata acagtttaat gacagcatta atagctcctg catatgttga
     9361 attgctaata cagttaaaaa aacggtattt ccctggttct gatccaacat tatcagtgtt
     9421 acagaacacc cctattcatg ttgtaaagga cactttaaag aagtttttat cgtttttccc
     9481 agttaaccgt cttgatctac agccagattt atattgtcta gtgaaagcac tttacaattg
     9541 cattcacgaa gacatgaaac gtcttttacc tgttgtgcgg gctccaaata ttgatggctc
     9601 tgacttgcac tctgcagtta taattacttg gatcaatatg tctacttcta ataaaactag
     9661 accatttttt gacaatttac tacaggatga attacaacac cttaaaaatg cagattataa
     9721 tatcaccaca cgcaaaacag tagcagagaa tgtctatagg ctgaaacatc tccttttaga
     9781 aattggtttc aacttggttt ataactgtga tgaaactgct aatctttacc actgtcttat
     9841 agatgcagat attcctgtta gttatgtgac ccctgctgat atcagatctt ttttaatgac
     9901 attttcctct cctgacacta attgccatat tgggaagctg ccttgtcgtc tgcagcagac
     9961 taatctaaaa ctttttcata gtttaaaact tttagttgat tattgtttta aagatgcaga
    10021 agaaaatgag attgaagttg agggattgcc ccttctcatc acactggaca gtgttttgca
    10081 aacttttgat gcaaaacgac ccaagtttct aacaacatat catgaattga ttccatcccg
    10141 caaagacttg tttatgaata cattatattt gaaatatagt aatattttat tgaactgtaa
    10201 agttgcaaaa gtgtttgaca tttccagctt tgctgatttg ttatcctctg tgttgcctcg
    10261 agaatataag accaaaagtt gcacaaagtg gaaagacaat tttgcaagtg agtcttggct
    10321 taagaatgca tggcatttta ttagtgaatc tgtaagtgtg aaagaagatc aggaagaaac
    10381 aaaaccaaca tttgacattg ttgttgatac tctaaaagac tgggcattgc ttccaggaac
    10441 aaagtttact gtttcagcca accagcttgt ggttcctgaa ggagatgttc tgcttcctct
    10501 cagccttatg cacattgcag tttttccaaa tgcccagagt gataaagttt ttcatgctct
    10561 aatgaaagct ggctgtattc agcttgcttt gaacaaaatc tgttccaaag acagtgcatt
    10621 tgttcctttg ttgtcatgtc acacagcaaa tatagagagc cccacaagca tcttgaaggc
    10681 tctacattat atggtccaaa cttcaacatt tagagcagaa aaattagtag aaaatgattt
    10741 tgaggcactt ttgatgtatt tcaactgcaa tttgaatcat ttgatgtccc aagatgatat
    10801 aaaaattcta aagtcacttc cgtgctataa atccatcagt ggccgctatg taagcattgg
    10861 aaaatttgga acatgctacg tacttacaaa aagtatccct tcagctgaag tggagaaatg
    10921 gacacagtca tcatcatctg catttcttga agaaaaaata cacttaaaag aactatatga
    10981 ggtgattggt tgtgtacctg tagatgatct tgaggtatat ttgaaacacc tcttaccaaa
    11041 aattgaaaat ctctcttatg atgcaaaatt agagcacttg atctacctta agaatagatt
    11101 atcaagtgct gaggaattat cagagattaa ggaacaactt tttgaaaaac tggaaagttt
    11161 attgataatc catgatgcta acagtagact aaagcaagca aagcatttct atgatagaac
    11221 tgtgagagtt tttgaagtta tgcttcctga aaaattgttt attcctaatg atttctttaa
    11281 gaaattggaa caacttataa aacccaaaaa tcatgttaca tttatgacat cctgggtgga
    11341 attcttaaga aatattggac taaaatacat actttctcag cagcagttgt tacagtttgc
    11401 taaggaaatc agtgtgaggg ctaatacaga aaactggtcc aaagaaacat tgcaaaatac
    11461 agttgatatc cttctgcatc atatattcca agaacgaatg gatttgttat ctggaaattt
    11521 tctgaaagaa ctatctttaa taccattctt atgtcctgag cgggcccccg cggaattcat
    11581 tagatttcat cctcaatatc aagaggtaaa tggaacactt cctcttataa agttcaatgg
    11641 agcacaggta aatccaaaat tcaagcaatg tgatgtactc cagctgttat ggacatcctg
    11701 ccctattctt ccagagaaag ctacaccctt aagcattaaa gaacaagaag gtagtgacct
    11761 tggtccacaa gaacagcttg aacaagtttt aaatatgctt aatgttaacc tggatcctcc
    11821 tcttgataag gtaatcaata actgcagaaa catatgcaac ataacgacgt tggatgaaga
    11881 aatggtaaaa actagagcaa aagtcttaag gagcatatat gaattcctca gtgcagaaaa
    11941 aagggaattt cgttttcagt tgcgaggggt tgcttttgtg atggtagaag atggttggaa
    12001 acttctgaag cctgaggagg tagtcataaa cctagaatat gaatctgatt ttaaacctta
    12061 tttgtacaag ctacctttag aacttggcac atttcaccag ttgttcaaac acttaggtac
    12121 tgaagatatt atttcaacta agcaatatgt tgaagtgttg agccgcatat ttaaaaattc
    12181 tgagggcaaa caattagatc ctaatgaaat gcgtacagtt aagagagtag tttctggtct
    12241 gttcaggagt ctacagaatg attcagtcaa ggtgaggagt gatctcgaga atgtacgaga
    12301 ccttgcgctt tacctcccaa gccaggatgg tagattggta aagtcaagca tcttagtgtt
    12361 tgacgatgcg ccacattata aaagtagaat ccaggggaat attggtgtgc aaatgttagt
    12421 tgatctcagc cagtgctact tagggaaaga ccatggattt cacactaagt tgataatgct
    12481 ctttcctcaa aaacttagac ctcgattatt gagcagtata cttgaagaac aattagatga
    12541 agagactccc aaagtttgtc agtttggagc gttgtgttct cttcaaggaa gattgcagtt
    12601 actcttgtct tctgaacagt tcattacagg actgattaga attatgaagc atgaaaatga
    12661 taatgctttt ctggccaatg aagaaaaagc cataagactt tgcaaagccc taagagaagg
    12721 attgaaagta tcctgctttg aaaagcttca aacaacatta agagttaaag gttttaatcc
    12781 tattccccac agcagaagtg aaacttttgc ttttttgaag cgatttggta atgcagtcat
    12841 cttgctctac attcaacatt cagacagtaa agacattaat ttcctgttag cattggcaat
    12901 gactcttaaa tcagcaactg acaatttgat ttctgacact tcatatttaa ttgctatgct
    12961 aggatgcaat gatatttaca ggattggtga gaaacttgac agtttaggag tgaaatatga
    13021 ctcttcggag ccatcaaaac tggaacttcc aatgcctggc acaccaattc ctgctgaaat
    13081 tcattacact ctgcttatgg acccaatgaa tgttttttac ccgggagaat atgttgggta
    13141 ccttgttgat gctgaaggtg gtgatatcta tggatcatac cagccaacat acacatatgc
    13201 aattattgta caagaagttg aaagagaaga tgctgacaat tctagttttc taggaaagat
    13261 atatcagata gatattggtt atagtgaata taaaatagtt agctctcttg atctgtataa
    13321 gttttcaaga cctgaggaaa gctctcaaag cagggacagt gctccttcta caccaaccag
    13381 ccccactgag ttcctcaccc ctggcctgag aagcattcct cctcttttct ctggtagaga
    13441 gagccacaag acttcttcca aacatcagtc ccccaaaaag cttaaggtta attctttacc
    13501 agaaatctta aaagaagtga catctgtggt ggagcaagca tggaagcttc cagaatcgga
    13561 acgaaaaaag attattaggc ggttgtattt gaaatggcat cctgacaaaa atccagagaa
    13621 ccatgacatt gccaatgaag tttttaaaca tttgcagaat gaaatcaaca gattagaaaa
    13681 acaggctttt ctagatcaaa atgcagacag ggcctccaga cgaacatttt caacctcagc
    13741 atcccgattt cagtcagaca aatactcatt tcagagattc tatacttcat ggaatcaaga
    13801 agcaacgagc cataaatctg aaagacagca acagaacaaa gaaaaatgcc ccccttcagc
    13861 cggacagact tactctcaaa ggttctttgt tcctcccact ttcaagtcgg ttggcaatcc
    13921 agtggaagca cgcagatggc taagacaagc cagagcaaac ttctcagctg ccaggaatga
    13981 ccttcataaa aatgccaatg agtgggtgtg ctttaaatgt tacctttcta ccaagttagc
    14041 tttgattgca gctgactatg ctgtgagggg aaagtctgat aaagatgtaa aaccaactgc
    14101 acttgctcag aaaatagagg aatatagtca gcaacttgaa ggactgacaa atgatgttca
    14161 cacattggaa gcttatggtg tagacagttt aaaaacaaga taccctgatt tgcttccctt
    14221 tcctcagatc ccaaatgaca ggttcacttc tgaggttgct atgagggtga tggaatgtac
    14281 tgcctgtatc ataataaaac ttgaaaattt tatgcaacaa aaagtgtgaa gatatttaac
    14341 gaaaaaaaag gtagatcttg aatgtgttgt agcacgaata aattgctgta cttcattaag
    14401 cttcattgcc aattagctag gaattgttaa gcacattgca gattgttctt ggagaattct
    14461 ggagttgtta tgaacatgaa taccaacgga aaaccttaac tgaatctaaa agaaaactat
    14521 tttgaagatg gtggtgagct gcaaaatagc tggatggatt tgaatgattg ggatgataca
    14581 tcattgaact gcactttata taaccaaagc ttagcagttt gttagataag agtctatgta
    14641 tgtctctggt taggatgaag ttaattttat gtttttaaca tggtattttt gaaggagcta
    14701 atgaaacact ggacatataa ttggtttaaa cataagggga attaagtctt tgtagtctgt
    14761 cattttttta agtggatcct cttggatgcg ttattttctc atcagctggc tctgatcatg
    14821 aatttgttgt aattttatgt tgtactcagt gcatttaaga aatggtagag tattttaatc
    14881 ctattacttg actaagagtg tgaaggtagt actttttaga gtgcactgag tgcactttac
    14941 atctttattt aaattttttt ttaacatctt atgtttacag gcttcctgtt tgatgaagat
    15001 agcaacggaa aactcaaaat ggtggcagtt cttattacca gttgttagta ttgtttctgg
    15061 aaactgcttg ccaagacaac atttattaac tgttagaaca cttgctttat gtttgtgtgt
    15121 acatattttc cacaaatgtt ataatttata tagtgtggtt gaacaggatg caatcttttg
    15181 ttgtctaaag gtgctgcagt taaaaaaaaa acaacctttt ctttcaatat ggcatgtagt
    15241 ggagtttttt taactttaaa aacatcaaaa attgttaaaa tcattgtgtt atctagtagt
    15301 ttataattat cggcttatat ttccccatga atgatcagaa ctgacattta attcatgttt
    15361 gtctcgccat gcttctttac tttaacatat ttcttttgca gaatgtaaaa ggtaatgata
    15421 attagtttat ataagtgtac tggctgtaaa tgatgctaaa tatactttat gcaattaagg
    15481 gcttacagaa catgttgaaa ctttttttac ttttattggg aataaggaat gtttgcacct
    15541 ccacatttta ttgcttctgg atgtgaaatc atgtaattat ttctgctgtt atataaagtg
    15601 ccatactttt aataaaggaa aatgtacata tgaaa
//
