LOCUS       NM_138421               1573 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens serum amyloid A like 1 (SAAL1), mRNA.
ACCESSION   NM_138421
VERSION     NM_138421.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1573)
  AUTHORS   Sato,T., Fujii,R., Konomi,K., Yagishita,N., Aratani,S., Araya,N.,
            Aono,H., Yudoh,K., Suzuki,N., Beppu,M., Yamano,Y., Nishioka,K. and
            Nakajima,T.
  TITLE     Overexpression of SPACIA1/SAAL1, a newly identified gene that is
            involved in synoviocyte proliferation, accelerates the progression
            of synovitis in mice and humans
  JOURNAL   Arthritis Rheum 63 (12), 3833-3842 (2011)
   PUBMED   22127701
  REMARK    GeneRIF: Overexpression of SPACIA1/SAAL1, a newly identified gene
            that is involved in synoviocyte proliferation, accelerates the
            progression of synovitis in mice and humans.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR155913.1, BC012010.1, BU150462.1 and AC090099.14.
            
            On Nov 23, 2018 this sequence version replaced NM_138421.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB489136.1, BC012010.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000524803.6/ ENSP00000432487.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               DR155913.1         10-185
            177-894             BC012010.1         168-885
            895-1083            BU150462.1         475-663
            1084-1522           BC012010.1         1075-1513
            1523-1573           AC090099.14        170833-170883
FEATURES             Location/Qualifiers
     source          1..1573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..1573
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /note="serum amyloid A like 1"
                     /db_xref="GeneID:113174"
                     /db_xref="HGNC:HGNC:25158"
     exon            1..176
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1466
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /note="synoviocyte proliferation-associated in
                     collagen-induced arthritis 1; synoviocyte
                     proliferation-associated in collagen-induced arthritis
                     protein 1"
                     /codon_start=1
                     /product="protein SAAL1"
                     /protein_id="NP_612430.2"
                     /db_xref="CCDS:CCDS31439.1"
                     /db_xref="GeneID:113174"
                     /db_xref="HGNC:HGNC:25158"
                     /translation="MDRNPSPPPPGRDKEEEEEVAGGDCIGSTVYSKHWLFGVLSGLI
                     QIVSPENTKSSSDDEEQLTELDEEMENEICRVWDMSMDEDVALFLQEFNAPDIFMGVL
                     AKSKCPRLREICVGILGNMACFQEICVSISSDKNLGQVLLHCLYDSDPPTLLETSRLL
                     LTCLSQAEVASVWVERIQEHPAIYDSICFIMSSSTNVDLLVKVGEVVDKLFDLDEKLM
                     LEWVRNGAAQPLDQPQEESEEQPVFRLVPCILEAAKQVRSENPEWLDVYMHILQLLTT
                     VDDGIQAIVHCPDTGKDIWNLLFDLVCHEFCQSDDPPIILQEQKTVLASVFSVLSAIY
                     ASQTEQEYLKIEKVDLPLIDSLIRVLQNMEQCQKKPENSAESNTEETKRTDLTQDDFH
                     LKILKDILCEFLSNIFQALTKETVAQGVKEGQLSKQKCSSAFQNLLPFYSPVVEDFIK
                     ILREVDKALADDLEKNFPSLKVQT"
     exon            177..290
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..374
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            375..454
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..514
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            515..630
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..811
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..894
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1083
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1280
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1373
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1573
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1497..1502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /note="hexamer: AATAAA"
     polyA_site      1522
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /note="major polyA site"
     regulatory      1550..1555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
                     /note="hexamer: ACTAAA"
     polyA_site      1573
                     /gene="SAAL1"
                     /gene_synonym="SPACIA1"
ORIGIN      
        1 agcttccggc acggccttca agcgcgggac gcgacaaagt catggaccgc aacccctcgc
       61 cgccgccgcc gggtcgcgac aaggaggagg aggaggaggt ggccggtgga gactgcatag
      121 ggagcacggt ctacagcaaa cactggctct tcggcgtcct cagcggactc atccagattg
      181 ttagccctga aaacaccaaa tctagctcag atgatgagga gcagctgacg gagcttgatg
      241 aagaaatgga gaatgaaatt tgcagagtat gggatatgtc aatggatgag gacgtggctt
      301 tatttctcca agaatttaat gctcctgata tattcatggg agtactggcc aagtccaagt
      361 gtcctcgatt aagagaaatc tgtgtgggaa ttttaggtaa tatggcctgt ttccaggaga
      421 tatgtgtgtc catcagcagt gataaaaatc ttgggcaggt gttattgcac tgtttgtatg
      481 attcagaccc acctactctg ctggaaacaa gcaggttgtt gcttacttgc ctttcccagg
      541 cagaagtggc cagtgtttgg gttgaaagga tccaggaaca tccagctatt tatgatagca
      601 tttgcttcat tatgtcaagt tcaacaaatg ttgacttgct ggtgaaggtg ggggaggttg
      661 tggacaagct ctttgatttg gatgagaaac taatgttaga atgggtcaga aatggggctg
      721 ctcagcctct ggaccaaccc caggaagagt ctgaagagca gccagtgttt cggcttgtgc
      781 cctgtatact tgaagctgcc aaacaagtac gttctgaaaa tccagaatgg cttgatgttt
      841 acatgcacat tttacaactg cttactacag tggatgatgg aattcaagca attgtacatt
      901 gtcctgacac tggaaaagac atttggaatt tactttttga cctggtctgc catgaattct
      961 gccagtctga tgatccaccc atcattcttc aagaacagaa aacagtgcta gcctctgttt
     1021 tttcagtgtt gtctgccatc tatgcctcac agactgagca agagtatcta aagatagaaa
     1081 aagtagatct tcctctaatt gacagcctca ttcgggtctt acaaaatatg gaacagtgtc
     1141 agaaaaaacc agagaactcg gcagagtcta acacagagga aactaaaagg actgatttaa
     1201 cccaagatga tttccacttg aaaatcttaa aggatatttt atgtgaattt ctttctaata
     1261 tttttcaggc attaacaaag gagacggtgg ctcagggagt aaaggaaggc cagttgagca
     1321 aacagaagtg ttcctctgca tttcaaaacc ttcttccttt ctatagccct gtggtggaag
     1381 attttattaa aatcctacgt gaagttgata aggcgcttgc tgatgacttg gaaaaaaact
     1441 tcccaagttt gaaggttcag acttaaaacc tgaattggaa ttacttctgt acaagaaata
     1501 aactttattt ttctcactga cagttgaaat tgacttattg gaaatattaa ctaaagccca
     1561 tattagacca taa
//
