LOCUS       NM_006512                630 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens serum amyloid A4, constitutive (SAA4), mRNA.
ACCESSION   NM_006512
VERSION     NM_006512.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 630)
  AUTHORS   Li,S., Kong,D., Zhang,W., Li,Y., Wang,H., Yang,R., Sun,Q., Wang,Z.
            and Zhang,Z.
  TITLE     Low SAA4 gene expression is associated with advanced HCC stage and
            a poor prognosis
  JOURNAL   Clin Exp Med 24 (1), 31 (2024)
   PUBMED   38300370
  REMARK    GeneRIF: Low SAA4 gene expression is associated with advanced HCC
            stage and a poor prognosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 630)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 630)
  AUTHORS   Jumeau,C., Awad,F., Assrawi,E., Cobret,L., Duquesnoy,P.,
            Giurgea,I., Valeyre,D., Grateau,G., Amselem,S., Bernaudin,J.F. and
            Karabina,S.A.
  TITLE     Expression of SAA1, SAA2 and SAA4 genes in human primary monocytes
            and monocyte-derived macrophages
  JOURNAL   PLoS One 14 (5), e0217005 (2019)
   PUBMED   31100086
  REMARK    GeneRIF: after stimulation by various pro-inflammatory conditions,
            changes in SAA1, SAA2 and SAA4 gene expression at both the
            transcriptional and protein levels were evaluated during maturation
            of freshly collected human monocytes into macrophages.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 630)
  AUTHORS   Seok,A., Lee,H.J., Lee,S., Lee,J., Mun,S., Park,A., Chun,Y.T.,
            Lee,J.H., Lim,H.J. and Kang,H.G.
  TITLE     Identification and Validation of SAA4 as a Rheumatoid Arthritis
            Prescreening Marker by Liquid Chromatography Tandem-mass
            Spectrometry
  JOURNAL   Molecules 22 (5), 805 (2017)
   PUBMED   28505104
  REMARK    GeneRIF: Data identified SAA4 as a protein that was positively
            correlated with RF and RA. SAA4 may represent a novel prescreening
            marker for the diagnosis of RA.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 630)
  AUTHORS   Rossmann,C., Hammer,A., Koyani,C.N., Kovacevic,A., Siwetz,M.,
            Desoye,G., Poehlmann,T.G., Markert,U.R., Huppertz,B., Sattler,W.
            and Malle,E.
  TITLE     Expression of serum amyloid A4 in human trophoblast-like
            choriocarcinoma cell lines and human first trimester/term
            trophoblast cells
  JOURNAL   Placenta 35 (8), 661-664 (2014)
   PUBMED   24951172
  REMARK    GeneRIF: expressed in invasive trophoblast cells
REFERENCE   6  (bases 1 to 630)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 630)
  AUTHORS   Steel,D.M., Sellar,G.C., Uhlar,C.M., Simon,S., DeBeer,F.C. and
            Whitehead,A.S.
  TITLE     A constitutively expressed serum amyloid A protein gene (SAA4) is
            closely linked to, and shares structural similarities with, an
            acute-phase serum amyloid A protein gene (SAA2)
  JOURNAL   Genomics 16 (2), 447-454 (1993)
   PUBMED   7686132
REFERENCE   8  (bases 1 to 630)
  AUTHORS   Watson,G., Coade,S. and Woo,P.
  TITLE     Analysis of the genomic and derived protein structure of a novel
            human serum amyloid A gene, SAA4
  JOURNAL   Scand J Immunol 36 (5), 703-712 (1992)
   PUBMED   1439582
REFERENCE   9  (bases 1 to 630)
  AUTHORS   Whitehead,A.S., de Beer,M.C., Steel,D.M., Rits,M., Lelias,J.M.,
            Lane,W.S. and de Beer,F.C.
  TITLE     Identification of novel members of the serum amyloid A protein
            superfamily as constitutive apolipoproteins of high density
            lipoprotein
  JOURNAL   J Biol Chem 267 (6), 3862-3867 (1992)
   PUBMED   1740433
REFERENCE   10 (bases 1 to 630)
  AUTHORS   Bausserman,L.L., Herbert,P.N., Forte,T., Klausner,R.D.,
            McAdam,K.P., Osborne,J.C. Jr. and Rosseneu,M.
  TITLE     Interaction of the serum amyloid A proteins with phospholipid
  JOURNAL   J Biol Chem 258 (17), 10681-10688 (1983)
   PUBMED   6411718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG569210.1, AV699045.1 and BC007026.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006512.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.134134.1,
                                           SRR5189664.138919.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278222.7/ ENSP00000278222.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                BG569210.1         37-103
            68-68               AV699045.1         46-46
            69-355              BC007026.1         36-322
            356-630             AV699045.1         334-608
FEATURES             Location/Qualifiers
     source          1..630
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..630
                     /gene="SAA4"
                     /gene_synonym="C-SAA; CSAA"
                     /note="serum amyloid A4, constitutive"
                     /db_xref="GeneID:6291"
                     /db_xref="HGNC:HGNC:10516"
                     /db_xref="MIM:104752"
     exon            1..86
                     /gene="SAA4"
                     /gene_synonym="C-SAA; CSAA"
                     /inference="alignment:Splign:2.1.0"
     exon            87..181
                     /gene="SAA4"
                     /gene_synonym="C-SAA; CSAA"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..483
                     /gene="SAA4"
                     /gene_synonym="C-SAA; CSAA"
                     /note="serum amyloid A-4 protein; constitutively expressed
                     serum amyloid A protein"
                     /codon_start=1
                     /product="serum amyloid A-4 protein precursor"
                     /protein_id="NP_006503.2"
                     /db_xref="CCDS:CCDS7832.1"
                     /db_xref="GeneID:6291"
                     /db_xref="HGNC:HGNC:10516"
                     /db_xref="MIM:104752"
                     /translation="MRLFTGIVFCSLVMGVTSESWRSFFKEALQGVGDMGRAYWDIMI
                     SNHQNSNRYLYARGNYDAAQRGPGGVWAAKLISRSRVYLQGLIDCYLFGNSSTVLEDS
                     KSNEKAEEWGRSGKDPDRFRPDGLPKKY"
     exon            182..320
                     /gene="SAA4"
                     /gene_synonym="C-SAA; CSAA"
                     /inference="alignment:Splign:2.1.0"
     exon            321..630
                     /gene="SAA4"
                     /gene_synonym="C-SAA; CSAA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      609..614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAA4"
                     /gene_synonym="C-SAA; CSAA"
                     /note="hexamer: AATAAA"
     polyA_site      630
                     /gene="SAA4"
                     /gene_synonym="C-SAA; CSAA"
                     /note="major polyA site"
ORIGIN      
        1 agcagaggta ccaactatag ctccacggcc agaagatacc agcagctctg cctttactga
       61 aatttcatct ggagaaaggt ccacagcaca atgaggcttt tcacaggcat tgttttctgc
      121 tccttggtca tgggagtcac cagtgaaagc tggcgttcgt ttttcaagga ggctctccaa
      181 ggggttgggg acatgggcag agcctattgg gacataatga tatccaatca ccaaaattca
      241 aacagatatc tctatgctcg gggaaactat gatgctgccc aaagaggacc tgggggtgtc
      301 tgggctgcta aactcatcag ccgttccagg gtctatcttc agggattaat agactgctat
      361 ttatttggaa acagcagcac tgtattggag gactcgaagt ccaacgagaa agctgaggaa
      421 tggggccgga gtggcaaaga ccccgaccgc ttcagacctg acggcctgcc taagaaatac
      481 tgagcttcct gctcctctgc tctcagggaa actgggctgt gagccacaca cttctccccc
      541 cagacaggga cacagggtca ctgagctttg tgtccccagg aactggtata gggcacctag
      601 aggtgttcaa taaatgtttg tcaaattgaa
//
