LOCUS       NM_001199744             844 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens SAA2-SAA4 readthrough (SAA2-SAA4), mRNA.
ACCESSION   NM_001199744
VERSION     NM_001199744.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 844)
  AUTHORS   Wang KS, Liu XF and Aragam N.
  TITLE     A genome-wide meta-analysis identifies novel loci associated with
            schizophrenia and bipolar disorder
  JOURNAL   Schizophr Res 124 (1-3), 192-199 (2010)
   PUBMED   20889312
REFERENCE   2  (bases 1 to 844)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090099.14 and BG616641.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001199744.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring serum amyloid A2 and serum
            amyloid A4 genes on chromosome 11. The read-through transcript
            produces a fusion protein that shares sequence identity with each
            individual gene product. [provided by RefSeq, Dec 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279830.9405.1,
                                           SRR5189664.119046.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 6289, 6291
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC090099.14        2507-2539
            34-285              BG616641.1         2-253
            286-286             AC090099.14        5251-5251
            287-569             BG616641.1         255-537
            570-844             AC090099.14        19546-19820
FEATURES             Location/Qualifiers
     source          1..844
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..844
                     /gene="SAA2-SAA4"
                     /note="SAA2-SAA4 readthrough"
                     /db_xref="GeneID:100528017"
                     /db_xref="HGNC:HGNC:39550"
     exon            1..66
                     /gene="SAA2-SAA4"
                     /inference="alignment:Splign:2.1.0"
     exon            67..161
                     /gene="SAA2-SAA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..697
                     /gene="SAA2-SAA4"
                     /note="SAA2-SAA4 read-through transcript"
                     /codon_start=1
                     /product="SAA2-SAA4 protein precursor"
                     /protein_id="NP_001186673.1"
                     /db_xref="GeneID:100528017"
                     /db_xref="HGNC:HGNC:39550"
                     /translation="MKLLTGLVFCSLVLSVSSRSFFSFLGEAFDGARDMWRAYSDMRE
                     ANYIGSDKYFHARGNYDAAKRGPGGAWAAEVISTMRLFTGIVFCSLVMGVTSESWRSF
                     FKEALQGVGDMGRAYWDIMISNHQNSNRYLYARGNYDAAQRGPGGVWAAKLISRSRVY
                     LQGLIDCYLFGNSSTVLEDSKSNEKAEEWGRSGKDPDRFRPDGLPKKY"
     exon            162..300
                     /gene="SAA2-SAA4"
                     /inference="alignment:Splign:2.1.0"
     exon            301..395
                     /gene="SAA2-SAA4"
                     /inference="alignment:Splign:2.1.0"
     exon            396..534
                     /gene="SAA2-SAA4"
                     /inference="alignment:Splign:2.1.0"
     exon            535..844
                     /gene="SAA2-SAA4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      823..828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAA2-SAA4"
                     /note="hexamer: AATAAA"
     polyA_site      844
                     /gene="SAA2-SAA4"
                     /note="major polyA site"
ORIGIN      
        1 actataaata gcagccacct ctccctggca gacagggacc cgcagctcag ctacagcaca
       61 gatcagcacc atgaagcttc tcacgggcct ggttttctgc tccttggtcc tgagtgtcag
      121 cagccgaagc ttcttttcgt tccttggcga ggcttttgat ggggctcggg acatgtggag
      181 agcctactct gacatgagag aagccaatta catcggctca gacaaatact tccatgctcg
      241 ggggaactat gatgctgcca aaaggggacc tgggggtgcc tgggctgcag aagtgatcag
      301 cacaatgagg cttttcacag gcattgtttt ctgctccttg gtcatgggag tcaccagtga
      361 aagctggcgt tcgtttttca aggaggctct ccaaggggtt ggggacatgg gcagagccta
      421 ttgggacata atgatatcca atcaccaaaa ttcaaacaga tatctctatg ctcggggaaa
      481 ctatgatgct gcccaaagag gacctggggg tgtctgggct gctaaactca tcagccgttc
      541 cagggtctat cttcagggat taatagactg ctatttattt ggaaacagca gcactgtatt
      601 ggaggactcg aagtccaacg agaaagctga ggaatggggc cggagtggca aagaccccga
      661 ccgcttcaga cctgacggcc tgcctaagaa atactgagct tcctgctcct ctgctctcag
      721 ggaaactggg ctgtgagcca cacacttctc cccccagaca gggacacagg gtcactgagc
      781 tttgtgtccc caggaactgg tatagggcac ctagaggtgt tcaataaatg tttgtcaaat
      841 tgaa
//
