LOCUS       NM_030760               2338 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens sphingosine-1-phosphate receptor 5 (S1PR5), transcript
            variant 1, mRNA.
ACCESSION   NM_030760
VERSION     NM_030760.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2338)
  AUTHORS   Hong,H., Yoon,B. and Ghil,S.
  TITLE     Interactions between lysophosphatidylinositol receptor GPR55 and
            sphingosine-1-phosphate receptor S1P5 in live cells
  JOURNAL   Biochem Biophys Res Commun 570, 53-59 (2021)
   PUBMED   34271437
  REMARK    GeneRIF: Interactions between lysophosphatidylinositol receptor
            GPR55 and sphingosine-1-phosphate receptor S1P5 in live cells.
REFERENCE   2  (bases 1 to 2338)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2338)
  AUTHORS   Drouillard,A., Mathieu,A.L., Marcais,A., Belot,A., Viel,S.,
            Mingueneau,M., Guckian,K. and Walzer,T.
  TITLE     S1PR5 is essential for human natural killer cell migration toward
            sphingosine-1 phosphate
  JOURNAL   J Allergy Clin Immunol 141 (6), 2265-2268 (2018)
   PUBMED   29248494
  REMARK    GeneRIF: our findings establish that S1PR5 is of central importance
            for human NK-cell response to sphingosine-1-phosphate and suggest
            that it is required for their egress from the bone marrow and
            secondary lymphoid organs.
REFERENCE   4  (bases 1 to 2338)
  AUTHORS   Andrieu,G., Ledoux,A., Branka,S., Bocquet,M., Gilhodes,J.,
            Walzer,T., Kasahara,K., Inagaki,M., Sabbadini,R.A., Cuvillier,O.
            and Hatzoglou,A.
  TITLE     Sphingosine 1-phosphate signaling through its receptor S1P5
            promotes chromosome segregation and mitotic progression
  JOURNAL   Sci Signal 10 (472) (2017)
   PUBMED   28351953
  REMARK    GeneRIF: Data indicate that the mitotic kinase Polo-like kinase 1
            (PLK1) was an important effector of S1P-S1P5 signaling, and a new
            function of the SphK1-S1P pathway specifically in the control of
            mitosis in HeLa cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2338)
  AUTHORS   Barnawi,J., Jersmann,H., Haberberger,R., Hodge,S. and Meech,R.
  TITLE     Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in
            alveolar macrophages in COPD: A potential link to failed
            efferocytosis
  JOURNAL   Respirology 22 (2), 315-321 (2017)
   PUBMED   27868302
  REMARK    GeneRIF: Reduced DNA methylation may underlie the increased
            expression of the S1PR5 gene in alveolar macrophages and associated
            defective efferocytosis in COPD.
REFERENCE   6  (bases 1 to 2338)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   7  (bases 1 to 2338)
  AUTHORS   Im,D.S., Clemens,J., Macdonald,T.L. and Lynch,K.R.
  TITLE     Characterization of the human and mouse sphingosine 1-phosphate
            receptor, S1P5 (Edg-8): structure-activity relationship of
            sphingosine1-phosphate receptors
  JOURNAL   Biochemistry 40 (46), 14053-14060 (2001)
   PUBMED   11705398
  REMARK    GeneRIF: The molecular identity, functional properties, and
            expression profile of the S1P5 (Edg-8) receptor have been
            characterized.
REFERENCE   8  (bases 1 to 2338)
  AUTHORS   Malek,R.L., Toman,R.E., Edsall,L.C., Wong,S., Chiu,J.,
            Letterle,C.A., Van Brocklyn,J.R., Milstien,S., Spiegel,S. and
            Lee,N.H.
  TITLE     Nrg-1 belongs to the endothelial differentiation gene family of G
            protein-coupled sphingosine-1-phosphate receptors
  JOURNAL   J Biol Chem 276 (8), 5692-5699 (2001)
   PUBMED   11069896
REFERENCE   9  (bases 1 to 2338)
  AUTHORS   Im,D.S., Heise,C.E., Ancellin,N., O'Dowd,B.F., Shei,G.J.,
            Heavens,R.P., Rigby,M.R., Hla,T., Mandala,S., McAllister,G.,
            George,S.R. and Lynch,K.R.
  TITLE     Characterization of a novel sphingosine 1-phosphate receptor, Edg-8
  JOURNAL   J Biol Chem 275 (19), 14281-14286 (2000)
   PUBMED   10799507
REFERENCE   10 (bases 1 to 2338)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA747912.1, BC034703.1, AC011461.5 and AF331840.1.
            
            On Nov 23, 2018 this sequence version replaced NM_030760.4.
            
            Summary: The lysosphingolipid sphingosine 1-phosphate (S1P)
            regulates cell proliferation, apoptosis, motility, and neurite
            retraction. Its actions may be both intracellular as a second
            messenger and extracellular as a receptor ligand. S1P and the
            structurally related lysolipid mediator lysophosphatidic acid (LPA)
            signal cells through a set of G protein-coupled receptors known as
            EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P
            receptors; others (e.g., EDG2; MIM 602282) are LPA
            receptors.[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA931194.1, BC034703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333430.6/ ENSP00000328472.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA747912.1         5-15
            12-688              BC034703.1         1-677
            689-2125            AC011461.5         56865-58301         c
            2126-2154           AF331840.1         2067-2095
            2155-2338           AF331840.1         2103-2286
FEATURES             Location/Qualifiers
     source          1..2338
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2338
                     /gene="S1PR5"
                     /gene_synonym="Edg-8; EDG8; S1P5; SPPR-1; SPPR-2"
                     /note="sphingosine-1-phosphate receptor 5"
                     /db_xref="GeneID:53637"
                     /db_xref="HGNC:HGNC:14299"
                     /db_xref="MIM:605146"
     exon            1..50
                     /gene="S1PR5"
                     /gene_synonym="Edg-8; EDG8; S1P5; SPPR-1; SPPR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            51..2338
                     /gene="S1PR5"
                     /gene_synonym="Edg-8; EDG8; S1P5; SPPR-1; SPPR-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1265
                     /gene="S1PR5"
                     /gene_synonym="Edg-8; EDG8; S1P5; SPPR-1; SPPR-2"
                     /note="endothelial differentiation, sphingolipid
                     G-protein-coupled receptor, 8; sphingosine 1-phosphate
                     receptor EDG8; S1P receptor 5; S1P receptor Edg-8;
                     sphingosine 1-phosphate receptor Edg-8; endothelial
                     differentiation G-protein-coupled receptor 8"
                     /codon_start=1
                     /product="sphingosine 1-phosphate receptor 5"
                     /protein_id="NP_110387.1"
                     /db_xref="CCDS:CCDS12240.1"
                     /db_xref="GeneID:53637"
                     /db_xref="HGNC:HGNC:14299"
                     /db_xref="MIM:605146"
                     /translation="MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCL
                     AVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLK
                     LSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWG
                     VSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQ
                     VRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVA
                     CPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSG
                     SQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLV
                     SEPAAD"
     regulatory      2111..2116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S1PR5"
                     /gene_synonym="Edg-8; EDG8; S1P5; SPPR-1; SPPR-2"
                     /note="hexamer: AATAAA"
     polyA_site      2134
                     /gene="S1PR5"
                     /gene_synonym="Edg-8; EDG8; S1P5; SPPR-1; SPPR-2"
                     /note="major polyA site"
     regulatory      2318..2323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S1PR5"
                     /gene_synonym="Edg-8; EDG8; S1P5; SPPR-1; SPPR-2"
                     /note="hexamer: AATAAA"
     polyA_site      2338
                     /gene="S1PR5"
                     /gene_synonym="Edg-8; EDG8; S1P5; SPPR-1; SPPR-2"
ORIGIN      
        1 actcggttca aggcagcgcg actgcgggtg gcgcacgacc agggcgcaga ccttggggcg
       61 cgcggcccat ggagtcgggg ctgctgcggc cggcgccggt gagcgaggtc atcgtcctgc
      121 attacaacta caccggcaag ctccgcggtg cgcgctacca gccgggtgcc ggcctgcgcg
      181 ccgacgccgt ggtgtgcctg gcggtgtgcg ccttcatcgt gctagagaat ctagccgtgt
      241 tgttggtgct cggacgccac ccgcgcttcc acgctcccat gttcctgctc ctgggcagcc
      301 tcacgttgtc ggatctgctg gcaggcgccg cctacgccgc caacatccta ctgtcggggc
      361 cgctcacgct gaaactgtcc cccgcgctct ggttcgcacg ggagggaggc gtcttcgtgg
      421 cactcactgc gtccgtgctg agcctcctgg ccatcgcgct ggagcgcagc ctcaccatgg
      481 cgcgcagggg gcccgcgccc gtctccagtc gggggcgcac gctggcgatg gcagccgcgg
      541 cctggggcgt gtcgctgctc ctcgggctcc tgccagcgct gggctggaat tgcctgggtc
      601 gcctggacgc ttgctccact gtcttgccgc tctacgccaa ggcctacgtg ctcttctgcg
      661 tgctcgcctt cgtgggcatc ctggccgcta tctgtgcact ctacgcgcgc atctactgcc
      721 aggtacgcgc caacgcgcgg cgcctgccgg cacggcccgg gactgcgggg accacctcga
      781 cccgggcgcg tcgcaagccg cgctcgctgg ccttgctgcg cacgctcagc gtggtgctcc
      841 tggcctttgt ggcatgttgg ggccccctct tcctgctgct gttgctcgac gtggcgtgcc
      901 cggcgcgcac ctgtcctgta ctcctgcagg ccgatccctt cctgggactg gccatggcca
      961 actcacttct gaaccccatc atctacacgc tcaccaaccg cgacctgcgc cacgcgctcc
     1021 tgcgcctggt ctgctgcgga cgccactcct gcggcagaga cccgagtggc tcccagcagt
     1081 cggcgagcgc ggctgaggct tccgggggcc tgcgccgctg cctgcccccg ggccttgatg
     1141 ggagcttcag cggctcggag cgctcatcgc cccagcgcga cgggctggac accagcggct
     1201 ccacaggcag ccccggtgca cccacagccg cccggactct ggtatcagaa ccggctgcag
     1261 actgacaccc tcggcccacg actgtcttcc caagttttac agacttgttc tttttacata
     1321 aaggaatttg taggaaatgc agccaaaggt gcagtcggaa aagatgcagg ggaaatgtat
     1381 ttatgcagcg acaccccaca atgtgaacaa acagacaaaa aatctgtgcc ctcgtggaat
     1441 tgacgttctg cttgggaaca cagaaaagaa ctcggtgatg aaataatgga gatgattcca
     1501 gtgacaaacg acagagatgg tgatggtggt cagggaagac ctctctgcag aggtagtgac
     1561 ttgtgatgtg agctgagacc tctgtcctgg gaagaccaaa agaaaagcat ttcaggatga
     1621 gggaatggca tgcgcaaagg ccctgaggct gaaatgtgcc catgtgttct aagaaatgca
     1681 gcgatgctgg tgtgcctgga gcagggacgg agggggagaa tgggaggaga caaggagctg
     1741 aaggagtagt tcccgaagga ccttgtgggt gatatagagg acttcgcttt tgctctgagt
     1801 gaggtgggag ccatagaagc ttctaagcag aagagggact tgccctaatt caggtgatca
     1861 caggtgtctt gtggcctcca tgggaggttg aaaaccagag aaggtgaagg ggggctgcac
     1921 tgagccacag gaacaatgat ggagattcca gctaagccca gaccccgtgg attctagata
     1981 gattttagag gcagcagaca gaattactga ggaattgagt gtaagagtgg aataaagtta
     2041 tcaaggacaa tgccaagggt ggggcacccc caaatttgac tctgggagac tcagccaaat
     2101 cctatctggt aataaaattt cttttttatt tttcttttct ttctttcttt cttttttttt
     2161 tttttgagtt gggatcttgt gctctgtcac ccaggctgga gtgcaatggg cacaattata
     2221 gctcactgca gcctggaact cctgggatca agcctggagt tcctgcttca gcctccctag
     2281 tagctgggac tacaggcatg caccaccatg cccagttaat aaaatttctt caaatgca
//
