LOCUS       NM_003775               1564 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sphingosine-1-phosphate receptor 4 (S1PR4), mRNA.
ACCESSION   NM_003775
VERSION     NM_003775.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1564)
  AUTHORS   Zhang,P., Zhang,Q. and Shao,Z.
  TITLE     Silence of S1PR4 Represses the Activation of Fibroblast-like
            Synoviocytes by Regulating IL-17/STAT3 Signaling Pathway
  JOURNAL   Inflammation 46 (1), 234-243 (2023)
   PUBMED   36068391
  REMARK    GeneRIF: Silence of S1PR4 Represses the Activation of
            Fibroblast-like Synoviocytes by Regulating IL-17/STAT3 Signaling
            Pathway.
REFERENCE   2  (bases 1 to 1564)
  AUTHORS   Pitman,M.R., Lewis,A.C., Davies,L.T., Moretti,P.A.B., Anderson,D.,
            Creek,D.J., Powell,J.A. and Pitson,S.M.
  TITLE     The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits
            off-target effects on sphingolipid metabolism
  JOURNAL   Sci Rep 12 (1), 454 (2022)
   PUBMED   35013382
  REMARK    GeneRIF: The sphingosine 1-phosphate receptor 2/4 antagonist
            JTE-013 elicits off-target effects on sphingolipid metabolism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1564)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1564)
  AUTHORS   Mo,X.G., Liu,W., Yang,Y., Imani,S., Lu,S., Dan,G., Nie,X., Yan,J.,
            Zhan,R., Li,X., Deng,Y., Chen,B. and Cai,Y.
  TITLE     NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive diagnostic
            biomarkers in patients with obstructive coronary artery: A weighted
            gene co-expression network analysis
  JOURNAL   J Cell Biochem 120 (10), 18219-18235 (2019)
   PUBMED   31245869
  REMARK    GeneRIF: NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive
            diagnostic biomarkers in patients with obstructive coronary artery:
            A weighted gene co-expression network analysis.
REFERENCE   5  (bases 1 to 1564)
  AUTHORS   Xiong,Y., Piao,W., Brinkman,C.C., Li,L., Kulinski,J.M., Olivera,A.,
            Cartier,A., Hla,T., Hippen,K.L., Blazar,B.R., Schwab,S.R. and
            Bromberg,J.S.
  TITLE     CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and
            endothelial S1PR2 regulate afferent lymphatic migration
  JOURNAL   Sci Immunol 4 (33) (2019)
   PUBMED   30877143
  REMARK    GeneRIF: T cell S1PR1 and S1PR4, and lymphatic endothelial cell
            (LEC) S1PR2, were required for migration across LECs and into
            lymphatic vessels and lymph nodes. S1PR1 and S1PR4 differentially
            regulated T cell motility and vascular cell adhesion molecule-1
            (VCAM-1) binding. S1PR2 regulated LEC layer structure,
            permeability, and expression of the junction molecules VE-cadherin,
            occludin, and zonulin-1 through the ERK pathway.
REFERENCE   6  (bases 1 to 1564)
  AUTHORS   Idzko,M., Panther,E., Corinti,S., Morelli,A., Ferrari,D.,
            Herouy,Y., Dichmann,S., Mockenhaupt,M., Gebicke-Haerter,P., Di
            Virgilio,F., Girolomoni,G. and Norgauer,J.
  TITLE     Sphingosine 1-phosphate induces chemotaxis of immature and
            modulates cytokine-release in mature human dendritic cells for
            emergence of Th2 immune responses
  JOURNAL   FASEB J 16 (6), 625-627 (2002)
   PUBMED   11919175
REFERENCE   7  (bases 1 to 1564)
  AUTHORS   Van Brocklyn,J.R., Graler,M.H., Bernhardt,G., Hobson,J.P., Lipp,M.
            and Spiegel,S.
  TITLE     Sphingosine-1-phosphate is a ligand for the G protein-coupled
            receptor EDG-6
  JOURNAL   Blood 95 (8), 2624-2629 (2000)
   PUBMED   10753843
REFERENCE   8  (bases 1 to 1564)
  AUTHORS   Yamazaki,Y., Kon,J., Sato,K., Tomura,H., Sato,M., Yoneya,T.,
            Okazaki,H., Okajima,F. and Ohta,H.
  TITLE     Edg-6 as a putative sphingosine 1-phosphate receptor coupling to
            Ca(2+) signaling pathway
  JOURNAL   Biochem Biophys Res Commun 268 (2), 583-589 (2000)
   PUBMED   10679247
REFERENCE   9  (bases 1 to 1564)
  AUTHORS   Graler,M.H., Bernhardt,G. and Lipp,M.
  TITLE     EDG6, a novel G-protein-coupled receptor related to receptors for
            bioactive lysophospholipids, is specifically expressed in lymphoid
            tissue
  JOURNAL   Genomics 53 (2), 164-169 (1998)
   PUBMED   9790765
REFERENCE   10 (bases 1 to 1564)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC014970.1.
            
            On May 17, 2019 this sequence version replaced NM_003775.3.
            
            Summary: This gene is a member of the endothelial differentiation,
            G-protein-coupled (EDG)) receptor gene family. EDG receptors bind
            lysophospholipids or lysosphingolipids as ligands, and are involved
            in cell signalling in many different cell types. This EDG receptor
            gene is intronless and is specifically expressed in the lymphoid
            tissue. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC014970.1, SRR1163655.348672.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246115.5/ ENSP00000246115.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1564              BC014970.1         2-1565
FEATURES             Location/Qualifiers
     source          1..1564
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1564
                     /gene="S1PR4"
                     /gene_synonym="EDG6; LPC1; S1P4; SLP4"
                     /note="sphingosine-1-phosphate receptor 4"
                     /db_xref="GeneID:8698"
                     /db_xref="HGNC:HGNC:3170"
                     /db_xref="MIM:603751"
     exon            1..1564
                     /gene="S1PR4"
                     /gene_synonym="EDG6; LPC1; S1P4; SLP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1179
                     /gene="S1PR4"
                     /gene_synonym="EDG6; LPC1; S1P4; SLP4"
                     /note="endothelial differentiation, lysophosphatidic acid
                     G-protein-coupled receptor, 6; sphingosine 1-phosphate
                     receptor Edg-6; S1P receptor 4; S1P receptor Edg-6;
                     endothelial differentiation G-protein coupled receptor 6"
                     /codon_start=1
                     /product="sphingosine 1-phosphate receptor 4 precursor"
                     /protein_id="NP_003766.1"
                     /db_xref="CCDS:CCDS12105.1"
                     /db_xref="GeneID:8698"
                     /db_xref="HGNC:HGNC:3170"
                     /db_xref="MIM:603751"
                     /translation="MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDG
                     GLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLAN
                     VLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTS
                     RVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLAT
                     IMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVF
                     GSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGP
                     GDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI"
     polyA_site      1564
                     /gene="S1PR4"
                     /gene_synonym="EDG6; LPC1; S1P4; SLP4"
                     /note="major polyA site"
ORIGIN      
        1 ctcagtcagc ccccggggga ggccatgaac gccacgggga ccccggtggc ccccgagtcc
       61 tgccaacagc tggcggccgg cgggcacagc cggctcattg ttctgcacta caaccactcg
      121 ggccggctgg ccgggcgcgg ggggccggag gatggcggcc tgggggccct gcgggggctg
      181 tcggtggccg ccagctgcct ggtggtgctg gagaacttgc tggtgctggc ggccatcacc
      241 agccacatgc ggtcgcgacg ctgggtctac tattgcctgg tgaacatcac gctgagtgac
      301 ctgctcacgg gcgcggccta cctggccaac gtgctgctgt cgggggcccg caccttccgt
      361 ctggcgcccg cccagtggtt cctacgggag ggcctgctct tcaccgccct ggccgcctcc
      421 accttcagcc tgctcttcac tgcaggggag cgctttgcca ccatggtgcg gccggtggcc
      481 gagagcgggg ccaccaagac cagccgcgtc tacggcttca tcggcctctg ctggctgctg
      541 gccgcgctgc tggggatgct gcctttgctg ggctggaact gcctgtgcgc ctttgaccgc
      601 tgctccagcc ttctgcccct ctactccaag cgctacatcc tcttctgcct ggtgatcttc
      661 gccggcgtcc tggccaccat catgggcctc tatggggcca tcttccgcct ggtgcaggcc
      721 agcgggcaga aggccccacg cccagcggcc cgccgcaagg cccgccgcct gctgaagacg
      781 gtgctgatga tcctgctggc cttcctggtg tgctggggcc cactcttcgg gctgctgctg
      841 gccgacgtct ttggctccaa cctctgggcc caggagtacc tgcggggcat ggactggatc
      901 ctggccctgg ccgtcctcaa ctcggcggtc aaccccatca tctactcctt ccgcagcagg
      961 gaggtgtgca gagccgtgct cagcttcctc tgctgcgggt gtctccggct gggcatgcga
     1021 gggcccgggg actgcctggc ccgggccgtc gaggctcact ccggagcttc caccaccgac
     1081 agctctctga ggccaaggga cagctttcgc ggctcccgct cgctcagctt tcggatgcgg
     1141 gagcccctgt ccagcatctc cagcgtgcgg agcatctgaa gttgcagtct tgcgtgtgga
     1201 tggtgcagcc accgggtgcg tgccaggcag gccctcctgg ggtacaggaa gctgtgtgca
     1261 cgcagcctcg cctgtatggg gagcagggaa cgggacaggc ccccatggtc ttcccggtgg
     1321 cctctcgggg cttctgacgc caaatgggct tcccatggtc accctggaca aggaggcaac
     1381 caccccacct ccccgtagga gcagagagca ccctggtgtg ggggcgagtg ggttccccac
     1441 aaccccgctt ctgtgtgatt ctggggaagt cccggcccct ctctgggcct cagtagggct
     1501 cccaggctgc aaggggtgga ctgtgggatg catgccctgg caacattgaa gttcgatcat
     1561 ggta
//
