LOCUS       NM_005226               4330 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens sphingosine-1-phosphate receptor 3 (S1PR3), mRNA.
ACCESSION   NM_005226 NM_182599
VERSION     NM_005226.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4330)
  AUTHORS   Piao,J., Su,Z., He,J., Zhu,T., Fan,F., Wang,X., Yang,Z., Zhan,H.
            and Luo,D.
  TITLE     SphK1 deficiency ameliorates the development of atherosclerosis by
            inhibiting the S1P/S1PR3/Rhoa/ROCK pathway
  JOURNAL   Cell Signal 121, 111252 (2024)
   PUBMED   38852936
  REMARK    GeneRIF: SphK1 deficiency ameliorates the development of
            atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway.
REFERENCE   2  (bases 1 to 4330)
  AUTHORS   Velagapudi,S., Wang,D., Poti,F., Feuerborn,R., Robert,J.,
            Schlumpf,E., Yalcinkaya,M., Panteloglou,G., Potapenko,A.,
            Simoni,M., Rohrer,L., Nofer,J.R. and von Eckardstein,A.
  TITLE     Sphingosine-1-phosphate receptor 3 regulates the transendothelial
            transport of high-density lipoproteins and low-density lipoproteins
            in opposite ways
  JOURNAL   Cardiovasc Res 120 (5), 476-489 (2024)
   PUBMED   38109696
  REMARK    GeneRIF: Sphingosine-1-phosphate receptor 3 regulates the
            transendothelial transport of high-density lipoproteins and
            low-density lipoproteins in opposite ways.
REFERENCE   3  (bases 1 to 4330)
  AUTHORS   Nishida,S., Matovelo,S.A., Kajimoto,T., Nakamura,S.I. and Okada,T.
  TITLE     Extracellular alpha-synuclein impairs sphingosine 1-phosphate
            receptor type 3 (S1PR3)-regulated lysosomal delivery of cathepsin D
            in HeLa cells
  JOURNAL   Genes Cells 29 (3), 207-216 (2024)
   PUBMED   38163647
  REMARK    GeneRIF: Extracellular alpha-synuclein impairs sphingosine
            1-phosphate receptor type 3 (S1PR3)-regulated lysosomal delivery of
            cathepsin D in HeLa cells.
REFERENCE   4  (bases 1 to 4330)
  AUTHORS   Saurabh,K., Mbadhi,M.N., Prifti,K.K., Martin,K.T. and Frolova,A.I.
  TITLE     Sphingosine 1-Phosphate Activates S1PR3 to Induce a Proinflammatory
            Phenotype in Human Myometrial Cells
  JOURNAL   Endocrinology 164 (6) (2023)
   PUBMED   37120767
  REMARK    GeneRIF: Sphingosine 1-Phosphate Activates S1PR3 to Induce a
            Proinflammatory Phenotype in Human Myometrial Cells.
REFERENCE   5  (bases 1 to 4330)
  AUTHORS   Li,F., Zhang,Y., Lin,Z., Yan,L., Liu,Q., Li,Y., Pei,X., Feng,Y.,
            Han,X., Yang,J., Zheng,F., Li,T., Zhang,Y., Fu,Z., Shao,D., Yu,J.
            and Li,C.
  TITLE     Targeting SPHK1/S1PR3-regulated S-1-P metabolic disorder triggers
            autophagic cell death in pulmonary lymphangiomyomatosis (LAM)
  JOURNAL   Cell Death Dis 13 (12), 1065 (2022)
   PUBMED   36543771
  REMARK    GeneRIF: Targeting SPHK1/S1PR3-regulated S-1-P metabolic disorder
            triggers autophagic cell death in pulmonary lymphangiomyomatosis
            (LAM).
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4330)
  AUTHORS   Van Brocklyn,J.R., Tu,Z., Edsall,L.C., Schmidt,R.R. and Spiegel,S.
  TITLE     Sphingosine 1-phosphate-induced cell rounding and neurite
            retraction are mediated by the G protein-coupled receptor H218
  JOURNAL   J Biol Chem 274 (8), 4626-4632 (1999)
   PUBMED   9988698
REFERENCE   7  (bases 1 to 4330)
  AUTHORS   An,S., Bleu,T., Huang,W., Hallmark,O.G., Coughlin,S.R. and
            Goetzl,E.J.
  TITLE     Identification of cDNAs encoding two G protein-coupled receptors
            for lysosphingolipids
  JOURNAL   FEBS Lett 417 (3), 279-282 (1997)
   PUBMED   9409733
REFERENCE   8  (bases 1 to 4330)
  AUTHORS   Yamaguchi,F., Tokuda,M., Hatase,O. and Brenner,S.
  TITLE     Molecular cloning of the novel human G protein-coupled receptor
            (GPCR) gene mapped on chromosome 9
  JOURNAL   Biochem Biophys Res Commun 227 (2), 608-614 (1996)
   PUBMED   8878560
REFERENCE   9  (bases 1 to 4330)
  AUTHORS   Van Koppen,C.J., Meyer Zu Heringdorf,D., Zhang,C., Laser,K.T. and
            Jakobs,K.H.
  TITLE     A distinct G(i) protein-coupled receptor for
            sphingosylphosphorylcholine in human leukemia HL-60 cells and human
            neutrophils
  JOURNAL   Mol Pharmacol 49 (6), 956-961 (1996)
   PUBMED   8649355
REFERENCE   10 (bases 1 to 4330)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC060827.1, DR763542.1 and
            BM990167.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005226.3.
            
            Summary: This gene encodes a member of the EDG family of receptors,
            which are G protein-coupled receptors. This protein has been
            identified as a functional receptor for sphingosine 1-phosphate and
            likely contributes to the regulation of angiogenesis and vascular
            endothelial cell function. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.202639.1, BC060827.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358157.3/ ENSP00000350878.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1918              BC060827.1         22-1939
            1919-2596           DR763542.1         154-831
            2597-4185           BC060827.1         2618-4206
            4186-4280           BM990167.1         67-161              c
            4281-4330           BM990167.1         16-65               c
FEATURES             Location/Qualifiers
     source          1..4330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.1"
     gene            1..4330
                     /gene="S1PR3"
                     /gene_synonym="bA791O21.3; C9orf108; C9orf47; EDG-3; EDG3;
                     LPB3; S1P3"
                     /note="sphingosine-1-phosphate receptor 3"
                     /db_xref="GeneID:1903"
                     /db_xref="HGNC:HGNC:3167"
                     /db_xref="MIM:601965"
     exon            1..228
                     /gene="S1PR3"
                     /gene_synonym="bA791O21.3; C9orf108; C9orf47; EDG-3; EDG3;
                     LPB3; S1P3"
                     /inference="alignment:Splign:2.1.0"
     exon            229..4330
                     /gene="S1PR3"
                     /gene_synonym="bA791O21.3; C9orf108; C9orf47; EDG-3; EDG3;
                     LPB3; S1P3"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..1512
                     /gene="S1PR3"
                     /gene_synonym="bA791O21.3; C9orf108; C9orf47; EDG-3; EDG3;
                     LPB3; S1P3"
                     /note="S1P receptor EDG3; endothelial differentiation,
                     sphingolipid G-protein-coupled receptor, 3; G
                     protein-coupled receptor, endothelial differentiation
                     gene-3; S1P receptor 3; S1P receptor Edg-3; sphingosine
                     1-phosphate receptor Edg-3; endothelial differentiation
                     G-protein coupled receptor 3; uncharacterized protein
                     C9orf47"
                     /codon_start=1
                     /product="sphingosine 1-phosphate receptor 3"
                     /protein_id="NP_005217.2"
                     /db_xref="CCDS:CCDS6680.1"
                     /db_xref="GeneID:1903"
                     /db_xref="HGNC:HGNC:3167"
                     /db_xref="MIM:601965"
                     /translation="MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTV
                     LFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKK
                     TFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGM
                     CWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARI
                     YFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPI
                     LFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDP
                     SRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN"
     regulatory      4156..4161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S1PR3"
                     /gene_synonym="bA791O21.3; C9orf108; C9orf47; EDG-3; EDG3;
                     LPB3; S1P3"
                     /note="hexamer: AATAAA"
     polyA_site      4185
                     /gene="S1PR3"
                     /gene_synonym="bA791O21.3; C9orf108; C9orf47; EDG-3; EDG3;
                     LPB3; S1P3"
                     /note="major polyA site"
     regulatory      4306..4311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S1PR3"
                     /gene_synonym="bA791O21.3; C9orf108; C9orf47; EDG-3; EDG3;
                     LPB3; S1P3"
                     /note="hexamer: ATTAAA"
     polyA_site      4330
                     /gene="S1PR3"
                     /gene_synonym="bA791O21.3; C9orf108; C9orf47; EDG-3; EDG3;
                     LPB3; S1P3"
ORIGIN      
        1 agaggccgag gaagccggtt ccggggacgg gcaacaggga ctcagggacc agaaggcggc
       61 tgcaggacgc gaccgagcag gaccccaggc ccgggaacga cgtcgcgagc gctgagactg
      121 ccgggcctcc cagcccatct ggcattcgag cgcaggaccg ggcgccccgg caccgccgcg
      181 cgccacccgc taggatgccg gtggccccag cgccctcagc cgacggagga gccctttttc
      241 aacgccctcg ctggagtctg gcctgcacgc cttgctgaat gaagccggaa cctcagcccc
      301 gcttcccttt gaaatgaatg ttcctggggc gccctctcgt ggattttgga gctaatcgtc
      361 tgtgaatgcc aagtgatggc aactgccctc ccgccgcgtc tccagccggt gcgggggaac
      421 gagaccctgc gggagcatta ccagtacgtg gggaagttgg cgggcaggct gaaggaggcc
      481 tccgagggca gcacgctcac caccgtgctc ttcttggtca tctgcagctt catcgtcttg
      541 gagaacctga tggttttgat tgccatctgg aaaaacaata aatttcacaa ccgcatgtac
      601 tttttcattg gcaacctggc tctctgcgac ctgctggccg gcatcgctta caaggtcaac
      661 attctgatgt ctggcaagaa gacgttcagc ctgtctccca cggtctggtt cctcagggag
      721 ggcagtatgt tcgtggccct tggggcgtcc acctgcagct tactggccat cgccatcgag
      781 cggcacttga caatgatcaa aatgaggcct tacgacgcca acaagaggca ccgcgtcttc
      841 ctcctgatcg ggatgtgctg gctcattgcc ttcacgctgg gcgccctgcc cattctgggc
      901 tggaactgcc tgcacaatct ccctgactgc tctaccatcc tgcccctcta ctccaagaag
      961 tacattgcct tctgcatcag catcttcacg gccatcctgg tgaccatcgt gatcctctac
     1021 gcacgcatct acttcctggt gaagtccagc agccgtaagg tggccaacca caacaactcg
     1081 gagcggtcca tggcactgct gcggaccgtg gtgattgtgg tgagcgtgtt catcgcctgc
     1141 tggtccccac tcttcatcct cttcctcatt gatgtggcct gcagggtgca ggcgtgcccc
     1201 atcctcttca aggctcagtg gttcatcgtg ttggctgtgc tcaactccgc catgaacccg
     1261 gtcatctaca cgctggccag caaggagatg cggcgggcct tcttccgtct ggtctgcaac
     1321 tgcctggtca ggggacgggg ggcccgcgcc tcacccatcc agcctgcgct cgacccaagc
     1381 agaagtaaat caagcagcag caacaatagc agccactctc cgaaggtcaa ggaagacctg
     1441 ccccacacag ccccctcatc ctgcatcatg gacaagaacg cagcacttca gaatgggatc
     1501 ttctgcaact gatcgtctcc atgcgccctg ctctgcggct gtgttcttat ttattgcatg
     1561 cgtcgcttcc acaggggccc ctcaagagct gtgactcggg agagctacct tactttgacc
     1621 aacagcctgc ccagtgtgga tgtctcttac agagggggcc caaggaatca ccaccccgct
     1681 tcagtgtaaa caacgtgcct tgtccacttt gggctccaga gtctttcaga tgtactaagc
     1741 tgctgacatc atccactgcc ttctgctgca tcctagacac cctccctgtt gttcacagag
     1801 agggaaggtc gtgggccaca caatgctgtg tgaccctctc cgtgtgcctc tgaatggtgt
     1861 tttgatgatt ttacactaca tttcctgtgc gtagaatgga tgcttgtata ttcgtacatc
     1921 tctatgttac acagaatttg tgttgcaggt gtttgccatg tggtacctac atagaatctc
     1981 catacaacac acaggtaaca ggttatacaa gtggattcag actgaacccc cagtacaagg
     2041 acattgtttt gaactaggtg gacatgccat ccctggtctc cttagactga catgattctc
     2101 atgttaacca agttttaaaa gttcaaattc cccaaaaagg cttgtccaag gctggcccca
     2161 gatgtgtggg tctgacccac accagccctg tgtcctgtcc tttcagtcat ttgtccctgc
     2221 gtaattttaa tcgtattcca aagcccaatt atgtgatggt tttcaggttt ctgcaaatta
     2281 cagaagagcc agccaagatc acccaggagc ttgtgccccc agatgggcca aagaaagagc
     2341 ctatgaagga gaagcagaag cagacggctg gcctggctca ccttcccacg ccagtggggc
     2401 aggggtctgc ttcaggaaat ggaagctgtc caggaaatga gcagagattc acaagacagc
     2461 actttgattc tatgttgagt ttgtttctat attagaaaag cagcaagtca gtaatccccc
     2521 gtggcatcac agctaagtag ctgtggccac cggcagtttc acagcatcct gaaagctggc
     2581 actgatcgtg actatcagtg aaagaagttt aattttcagg ttagaaaatg tgatctggca
     2641 gtttatgcat tcttcagagt aatgtaataa tacctatgtg atgctgtaat tttacttttc
     2701 aacataagtt gaacccgtag cagtctgttt accttgtaaa gggattactt agaagacatt
     2761 tttgtacatg ctcttcccca aggattgtac gtattataca aatagatgga aagaaaagtg
     2821 aacacgtttg tagaactttc ataagcacac agttgctgtg ttgagttctc tttaaaaaca
     2881 aggacaaaac caaccagcgt tcaaaggaac ctcccatcag agtcccctaa agtattttag
     2941 gttcagtgag catttgcctg aataaaacct aaaagagtag tcttaacaca ttactaactt
     3001 tttctaagag aaattgattc ctgttttgtc atctgatgca atttgctctt ataaagagac
     3061 attttcatag gttcagagta actcacctcc atgggctgac caaaggcttt tctaattttt
     3121 gttactgatg agatgaaacc tatttgtaag gagatcttcc ccaggagcat ttctgttgcc
     3181 ttcttgacat caatgaaaag tagcatattc tcttatgaaa tagcatgaga aaacacaggg
     3241 catttctagg acagtaaaac gttaaagtac tggattaaga aaacaacaac aggctgggcg
     3301 cagtggctca cacctgtaat cccagcactt tgggaggctg aggcgggtgg atcacctgag
     3361 gtcaggagtt tgtgaccagc ctggccaaca tagtgaaatc ctgtttctac taaaaataca
     3421 aaaattagct ggatgcgata gcacgtgcct gtagtcccag ctactcggga ggctgaggct
     3481 ggagagttgc tcaaacccgg gaggcggaga ttgcagtgag ccaagatcgc accgctgcac
     3541 tccagcctgg gtgacagagc gaccctctgt ctcaaaaaat aataataata ataaataaaa
     3601 caacaacaaa atgcatcaga gagccaaaac attcagtatt gcattttcac ataggtgatg
     3661 aaatgacttt ggaactttat ctgtgttata gttatgagtt gctttgggag acttggagct
     3721 ctctgtagct attgttcata acactttgct ccataaccct gatgtccgca gtatctaagt
     3781 atctcagcct tcatccatta actctactag ggagcccaca gccaccattt ccactaggag
     3841 gtatcaatat ttgtggtatg acataaggct cccttgaaat aacaagactt ttgagcaatc
     3901 tgaattaaaa atacatcaaa aaagtaatag cgctcatttg ctaaatgcaa aaaataatca
     3961 cctttgatac caatgtgcac caatatgcct aactagctag ccagctggag ataatttacc
     4021 agggaatgtt tcaaagccct aaccttgaag tttggaaaca ggtggtcttc tatgctgcag
     4081 agaaactatg cattaggtct cttttcaatt agaaaccttt actatttcca atgtatgttt
     4141 gttaaaaata ataataataa aaccaaaagc ctttgtggaa acccactctt cgtagtccat
     4201 gtgatgggat tgttttatcg ttttcaccgg gtgccctccc cactgcaggg gtgcgcactg
     4261 ttgttgcagg cttgctaccc acctgtgttt cttagcattt caggaattaa accacattca
     4321 gaaccccaaa
//
