LOCUS       NM_004230               3643 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sphingosine-1-phosphate receptor 2 (S1PR2), mRNA.
ACCESSION   NM_004230
VERSION     NM_004230.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3643)
  AUTHORS   Zheng,Y.S., Liu,Y.L., Xu,Z.G., He,C. and Guo,Z.Y.
  TITLE     Is myeloid-derived growth factor a ligand of the
            sphingosine-1-phosphate receptor 2?
  JOURNAL   Biochem Biophys Res Commun 706, 149766 (2024)
   PUBMED   38484568
  REMARK    GeneRIF: Is myeloid-derived growth factor a ligand of the
            sphingosine-1-phosphate receptor 2?
REFERENCE   2  (bases 1 to 3643)
  AUTHORS   Gong,C., Jin,Y., Wang,X., Mao,J., Wang,D., Yu,X., Chen,S., Wang,Y.,
            Ma,D., Fang,X., Zhang,K. and Shu,Q.
  TITLE     Lack of S1PR2 in Macrophage Ameliorates Sepsis-associated Lung
            Injury through Inducing IL-33-mediated Type 2 Immunity
  JOURNAL   Am J Respir Cell Mol Biol 70 (3), 215-225 (2024)
   PUBMED   38061028
  REMARK    GeneRIF: Lack of S1PR2 in Macrophage Ameliorates Sepsis-associated
            Lung Injury through Inducing IL-33-mediated Type 2 Immunity.
REFERENCE   3  (bases 1 to 3643)
  AUTHORS   Lam,B.W.S., Xiang,P., Peng,B., Soon,L.J.J., Yam,A.T.Y., Lim,C.M.H.,
            Zheng,Y., Nguyen,L.N., Herr,D.R. and Le,M.T.N.
  TITLE     Activation of S1P2 is protective against cisplatin-induced
            peripheral neuropathy
  JOURNAL   Cell Prolif 57 (2), e13549 (2024)
   PUBMED   37727014
  REMARK    GeneRIF: Activation of S1P2 is protective against cisplatin-induced
            peripheral neuropathy.
REFERENCE   4  (bases 1 to 3643)
  AUTHORS   Lyssy,F., Guettler,J., Brugger,B.A., Stern,C., Forstner,D.,
            Nonn,O., Fischer,C., Herse,F., Wernitznig,S., Hirschmugl,B.,
            Wadsack,C. and Gauster,M.
  TITLE     Platelet-derived factors dysregulate placental
            sphingosine-1-phosphate receptor 2 in human trophoblasts
  JOURNAL   Reprod Biomed Online 47 (2), 103215 (2023)
   PUBMED   37301709
  REMARK    GeneRIF: Platelet-derived factors dysregulate placental
            sphingosine-1-phosphate receptor 2 in human trophoblasts.
REFERENCE   5  (bases 1 to 3643)
  AUTHORS   Wang,X., Huang,R., Huang,B. and Li,X.
  TITLE     S1PR2 Regulates Autophagy Through the AKT/mTOR Pathway to Promote
            Pathological Damage in Alzheimer's Disease
  JOURNAL   J Alzheimers Dis 96 (4), 1489-1504 (2023)
   PUBMED   38007654
  REMARK    GeneRIF: S1PR2 Regulates Autophagy Through the AKT/mTOR Pathway to
            Promote Pathological Damage in Alzheimer's Disease.
REFERENCE   6  (bases 1 to 3643)
  AUTHORS   Windh,R.T., Lee,M.J., Hla,T., An,S., Barr,A.J. and Manning,D.R.
  TITLE     Differential coupling of the sphingosine 1-phosphate receptors
            Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families
            of heterotrimeric G proteins
  JOURNAL   J Biol Chem 274 (39), 27351-27358 (1999)
   PUBMED   10488065
REFERENCE   7  (bases 1 to 3643)
  AUTHORS   Ancellin,N. and Hla,T.
  TITLE     Differential pharmacological properties and signal transduction of
            the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5
  JOURNAL   J Biol Chem 274 (27), 18997-19002 (1999)
   PUBMED   10383399
REFERENCE   8  (bases 1 to 3643)
  AUTHORS   Van Brocklyn,J.R., Tu,Z., Edsall,L.C., Schmidt,R.R. and Spiegel,S.
  TITLE     Sphingosine 1-phosphate-induced cell rounding and neurite
            retraction are mediated by the G protein-coupled receptor H218
  JOURNAL   J Biol Chem 274 (8), 4626-4632 (1999)
   PUBMED   9988698
REFERENCE   9  (bases 1 to 3643)
  AUTHORS   Yamaguchi,F., Tokuda,M., Hatase,O. and Brenner,S.
  TITLE     Molecular cloning of the novel human G protein-coupled receptor
            (GPCR) gene mapped on chromosome 9
  JOURNAL   Biochem Biophys Res Commun 227 (2), 608-614 (1996)
   PUBMED   8878560
REFERENCE   10 (bases 1 to 3643)
  AUTHORS   MacLennan,A.J., Browe,C.S., Gaskin,A.A., Lado,D.C. and Shaw,G.
  TITLE     Cloning and characterization of a putative G-protein coupled
            receptor potentially involved in development
  JOURNAL   Mol Cell Neurosci 5 (3), 201-209 (1994)
   PUBMED   8087418
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011511.12, BF513287.1,
            BC069598.1 and BG055846.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004230.3.
            
            Summary: This gene encodes a member of the G protein-coupled
            receptors, as well as the EDG family of proteins. The encoded
            protein is a receptor for sphingosine 1-phosphate, which
            participates in cell proliferation, survival, and transcriptional
            activation. Defects in this gene have been associated with
            congenital profound deafness. [provided by RefSeq, Mar 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF513287.1, AI218191.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267767 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000646641.1/ ENSP00000496438.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC011511.12        45916-45974         c
            60-522              BF513287.1         1-463
            523-1232            BC069598.1         353-1062
            1233-3252           AC011511.12        36467-38486         c
            3253-3643           BG055846.1         6-396               c
FEATURES             Location/Qualifiers
     source          1..3643
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..3643
                     /gene="S1PR2"
                     /gene_synonym="AGR16; DFNB68; EDG-5; EDG5; Gpcr13; H218;
                     LPB2; S1P2"
                     /note="sphingosine-1-phosphate receptor 2"
                     /db_xref="GeneID:9294"
                     /db_xref="HGNC:HGNC:3169"
                     /db_xref="MIM:605111"
     exon            1..128
                     /gene="S1PR2"
                     /gene_synonym="AGR16; DFNB68; EDG-5; EDG5; Gpcr13; H218;
                     LPB2; S1P2"
                     /inference="alignment:Splign:2.1.0"
     exon            129..3643
                     /gene="S1PR2"
                     /gene_synonym="AGR16; DFNB68; EDG-5; EDG5; Gpcr13; H218;
                     LPB2; S1P2"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1232
                     /gene="S1PR2"
                     /gene_synonym="AGR16; DFNB68; EDG-5; EDG5; Gpcr13; H218;
                     LPB2; S1P2"
                     /note="S1P receptor EDG5; endothelial differentiation,
                     sphingolipid G-protein-coupled receptor, 5; S1P receptor
                     2; S1P receptor Edg-5; sphingosine 1-phosphate receptor
                     Edg-5; endothelial differentiation G-protein coupled
                     receptor 5; CTD-2369P2.2; deafness, autosomal recessive
                     68"
                     /codon_start=1
                     /product="sphingosine 1-phosphate receptor 2"
                     /protein_id="NP_004221.3"
                     /db_xref="CCDS:CCDS12229.1"
                     /db_xref="GeneID:9294"
                     /db_xref="HGNC:HGNC:3169"
                     /db_xref="MIM:605111"
                     /translation="MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILC
                     CAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTP
                     VQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISL
                     VLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRS
                     SHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAV
                     STLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSL
                     ERGMHMPTSPTFLEGNTVV"
     regulatory      3622..3627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S1PR2"
                     /gene_synonym="AGR16; DFNB68; EDG-5; EDG5; Gpcr13; H218;
                     LPB2; S1P2"
                     /note="hexamer: AATAAA"
     polyA_site      3643
                     /gene="S1PR2"
                     /gene_synonym="AGR16; DFNB68; EDG-5; EDG5; Gpcr13; H218;
                     LPB2; S1P2"
                     /note="major polyA site"
ORIGIN      
        1 gtccctcgtc ccagccccgg gacttagccg agcccggctg gcaaccccag ccccagccgc
       61 ggccgccctg gggacgcaga cgccaaggcc cctccggcca gggccgggag ccgggccggc
      121 ctagccagtt ctgaaagccc catggcccca gcaggcctct gagccccacc atgggcagct
      181 tgtactcgga gtacctgaac cccaacaagg tccaggaaca ctataattat accaaggaga
      241 cgctggaaac gcaggagacg acctcccgcc aggtggcctc ggccttcatc gtcatcctct
      301 gttgcgccat tgtggtggaa aaccttctgg tgctcattgc ggtggcccga aacagcaagt
      361 tccactcggc aatgtacctg tttctgggca acctggccgc ctccgatcta ctggcaggcg
      421 tggccttcgt agccaatacc ttgctctctg gctctgtcac gctgaggctg acgcctgtgc
      481 agtggtttgc ccgggagggc tctgccttca tcacgctctc ggcctctgtc ttcagcctcc
      541 tggccatcgc cattgagcgc cacgtggcca ttgccaaggt caagctgtat ggcagcgaca
      601 agagctgccg catgcttctg ctcatcgggg cctcgtggct catctcgctg gtcctcggtg
      661 gcctgcccat ccttggctgg aactgcctgg gccacctcga ggcctgctcc actgtcctgc
      721 ctctctacgc caagcattat gtgctgtgcg tggtgaccat cttctccatc atcctgttgg
      781 ccatcgtggc cctgtacgtg cgcatctact gcgtggtccg ctcaagccac gctgacatgg
      841 ccgccccgca gacgctagcc ctgctcaaga cggtcaccat cgtgctaggc gtctttatcg
      901 tctgctggct gcccgccttc agcatcctcc ttctggacta tgcctgtccc gtccactcct
      961 gcccgatcct ctacaaagcc cactactttt tcgccgtctc caccctgaat tccctgctca
     1021 accccgtcat ctacacgtgg cgcagccggg acctgcggcg ggaggtgctt cggccgctgc
     1081 agtgctggag gccgggggtg ggggtgcaag gacggaggcg gggcgggacc ccgggccacc
     1141 acctcctgcc actccgcagc tccagctccc tggagagggg catgcacatg cccacgtcac
     1201 ccacgtttct ggagggcaac acggtggtct gagggtgggg gtggaccaac aaccaggcca
     1261 gggcagaggg gttcatggag aggccactgg gtgaccccag atagagactt ggggctactg
     1321 agccagatgc ccccgcccca cagacctggg tgatgttgca aatatttcac acctggaaag
     1381 gccagataag gcactgacta gtcacatagc agtgttgcag tgcggtcctg agggccagtc
     1441 cagtggctag tgtgacccct ttagaactgg atcctgggga ggccagggca ggggacctgt
     1501 gaagagccag ggtgagggca ggcagcattt aaggggagct cagggcagga gcactttacc
     1561 acctggtaca aaggattttt tttttttttt gagacggaat cttgcactgc tgcccaggct
     1621 ggagtgcagt ggcgtgatct cggctcaccg caagctccgc ctcctgggtt catgtcgttc
     1681 tcctgcctca gcctcccaag tagctgggac tataggcgcc tgccaccaca cctggctaat
     1741 tttttgtacc tttagtagag atggggtttc accgtgttag ccaggatggt cttgatctcc
     1801 tgacctcgtg atccgcccgc ctcggcctcc caaagtgctg ggattacagg cgtgagccac
     1861 cgtgcccggc tttttttttt tttttttttt tttttttttt tttttttgag atgaagtctc
     1921 gctctgttgc ccaggctgga gagtgcagtg gtacggtctc agctcactgc aacctccacc
     1981 tcccaggttc aagcgattct ccagcctgag cctcctgagt agctgggatt acaggtgcct
     2041 accaccacgc ccaggtaatt tttttttttt ttgtattttt agtagagacg gggtttcacc
     2101 atgttggcca ggctggtctc gaactcctga cctcatgatc cgcccgtgtt ggcctcccaa
     2161 agtgtgggat tacaggcgta agccacctca cctggcggta caaagaattt ctgcattttc
     2221 ttccctggcc cctagtcctg caccgatttc tccttttcga atgtattcct cctgccacct
     2281 tctctgggca acttcgtgcg actacagaac cactgtcctg aggagctaga ggcctcctct
     2341 ctgaccatcc agagcccaaa tccacagctt ccccaaattt catcagctgc cacttgacga
     2401 cttctccccg tctctctgag gcccggaaac cacggctgga ggtggggagg ggatggcggc
     2461 tgaggtccat tcctcattct cagacctcat tgctcagttg cactatttgg ggcacagaat
     2521 aatcaccaaa agtgagaaaa acgagtttgg gtggctgggg aggactttgg gactcttgat
     2581 gcaaggcgca acttgagaaa attctgggtg tgatatttgc acagacaccc tcctttcaaa
     2641 aacagccacc ccccaagcta ttctcagctc cacacctgca gccccagcta aggtaccagg
     2701 tctcctgagc aaggcagaga gaagccttga gccttctctg tgtcttcttt caagaacccc
     2761 gctgtgtctt ctttcaagat tttttttttg agacagtttc aagatttttg ttttgttttt
     2821 gagatggagt ctcactgtgt cacccaggct gaggtggcag tggttcaatc tccgttcact
     2881 gccacctcca cctcccgggt tcaagcgatt ctcctgcttc agcctctcga gtagctggga
     2941 ctacaggcac ctgccaccat gtctggctaa tttttgtatt tttagtagag acagggtttc
     3001 actacgttgg ccaggctggt ctcaaactcc tgacctcaag tgatccgccc gcctcggcct
     3061 ccccaattgc tgggattaca ggcgtgagcc actgtgcccg gccttcttct ttcaagttat
     3121 atagaatgga gcatgggggt ggcagtggct agggacattt cctggggaca ctctccccta
     3181 accccccaga aggacttcac aaaaacctgt ggataatgga agggatgtta cggtacaaac
     3241 gtatatttat gtgtgtgtgt gtgtatgtgt gtgcgcgcgc gcgtgtgcac ataggcgtga
     3301 tgtctgtgac cctcctctcc tcgtcacatt tcccccagaa tgaatgctgt cctgtctgct
     3361 catgtttgtg ttgaagctgc caaagtcggg gagctctggt cctgcccaga cccctttgga
     3421 attgctggcc catcctccca ctggagagct ggggtgcagc tcaccttggg gaaggaaacc
     3481 tcatgcctca gagtaatttc ttgtgaatgc aaagcctggg ggagcgggtc tttggggggc
     3541 aaggagccag tcaggggctt gtttcccctc atagagctcc ccagacgtgc ctccgcaatg
     3601 cctgaaaccc agacctaggc taataaacgg ttcaatttct gtt
//
