LOCUS       NM_001400               2778 bp    mRNA    linear   PRI 27-FEB-2025
DEFINITION  Homo sapiens sphingosine-1-phosphate receptor 1 (S1PR1), transcript
            variant 1, mRNA.
ACCESSION   NM_001400
VERSION     NM_001400.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2778)
  AUTHORS   Dixit,D., Hallisey,V.M., Zhu,E.Y., Okuniewska,M., Cadwell,K.,
            Chipuk,J.E., Axelrad,J.E. and Schwab,S.R.
  TITLE     S1PR1 inhibition induces proapoptotic signaling in T cells and
            limits humoral responses within lymph nodes
  JOURNAL   J Clin Invest 134 (4), e174984 (2024)
   PUBMED   38194271
  REMARK    GeneRIF: S1PR1 inhibition induces proapoptotic signaling in T cells
            and limits humoral responses within lymph nodes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2778)
  AUTHORS   Yu,B., Shen,K., Li,T., Li,J., Meng,M., Liu,W., Tang,Q., Zhu,T.,
            Wang,X., Leung,S.W.S. and Shi,Y.
  TITLE     Glycolytic enzyme PFKFB3 regulates sphingosine 1-phosphate receptor
            1 in proangiogenic glomerular endothelial cells under diabetic
            condition
  JOURNAL   Am J Physiol Cell Physiol 325 (5), C1354-C1368 (2023)
   PUBMED   37781737
  REMARK    GeneRIF: Glycolytic enzyme PFKFB3 regulates sphingosine 1-phosphate
            receptor 1 in proangiogenic glomerular endothelial cells under
            diabetic condition.
REFERENCE   3  (bases 1 to 2778)
  AUTHORS   Tao,Y.P., Zhu,H.Y., Shi,Q.Y., Wang,C.X., Hua,Y.X., Hu,H.Y.,
            Zhou,Q.Y., Zhou,Z.L., Sun,Y., Wang,X.M., Wang,Y., Zhang,Y.L.,
            Guo,Y.J., Wang,Z.Y., Che,X., Xu,C.W., Zhang,X.C., Heger,M.,
            Tao,S.P., Zheng,X., Xu,Y., Ao,L., Liu,A.J., Liu,S.B., Cheng,S.Q.
            and Pan,W.W.
  TITLE     S1PR1 regulates ovarian cancer cell senescence through the
            PDK1-LATS1/2-YAP pathway
  JOURNAL   Oncogene 42 (47), 3491-3502 (2023)
   PUBMED   37828220
  REMARK    GeneRIF: S1PR1 regulates ovarian cancer cell senescence through the
            PDK1-LATS1/2-YAP pathway.
REFERENCE   4  (bases 1 to 2778)
  AUTHORS   Jiang,Z., Li,S., Jia,Y., Wu,Q., Chen,X., Zhang,M., Miao,Q.,
            Zhong,Z., Zhai,Z., Ni,B., Xiao,J. and Tang,J.
  TITLE     CircPTPN22 modulates T-cell activation by sponging miR-4689 to
            regulate S1PR1 expression in patients with systemic lupus
            erythematosus
  JOURNAL   Arthritis Res Ther 25 (1), 206 (2023)
   PUBMED   37858140
  REMARK    GeneRIF: CircPTPN22 modulates T-cell activation by sponging
            miR-4689 to regulate S1PR1 expression in patients with systemic
            lupus erythematosus.
            Erratum:[Arthritis Res Ther. 2024 Jan 31;26(1):39. doi:
            10.1186/s13075-024-03270-4. PMID: 38297345]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2778)
  AUTHORS   Resop,R.S., Salvatore,B., Kim,S.J., Gordon,B.R., Blom,B.,
            Vatakis,D.N. and Uittenbogaart,C.H.
  TITLE     HIV-1 Infection Results in Sphingosine-1-Phosphate Receptor 1
            Dysregulation in the Human Thymus
  JOURNAL   Int J Mol Sci 24 (18), 13865 (2023)
   PUBMED   37762169
  REMARK    GeneRIF: HIV-1 Infection Results in Sphingosine-1-Phosphate
            Receptor 1 Dysregulation in the Human Thymus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2778)
  AUTHORS   Lee,M.J., Van Brocklyn,J.R., Thangada,S., Liu,C.H., Hand,A.R.,
            Menzeleev,R., Spiegel,S. and Hla,T.
  TITLE     Sphingosine-1-phosphate as a ligand for the G protein-coupled
            receptor EDG-1
  JOURNAL   Science 279 (5356), 1552-1555 (1998)
   PUBMED   9488656
  REMARK    Erratum:[Science. 2024 Aug 2;385(6708):eadr9977. doi:
            10.1126/science.adr9977. PMID: 39088640]
REFERENCE   7  (bases 1 to 2778)
  AUTHORS   An,S., Bleu,T., Huang,W., Hallmark,O.G., Coughlin,S.R. and
            Goetzl,E.J.
  TITLE     Identification of cDNAs encoding two G protein-coupled receptors
            for lysosphingolipids
  JOURNAL   FEBS Lett 417 (3), 279-282 (1997)
   PUBMED   9409733
REFERENCE   8  (bases 1 to 2778)
  AUTHORS   Lee,M.J., Evans,M. and Hla,T.
  TITLE     The inducible G protein-coupled receptor edg-1 signals via the
            G(i)/mitogen-activated protein kinase pathway
  JOURNAL   J Biol Chem 271 (19), 11272-11279 (1996)
   PUBMED   8626678
REFERENCE   9  (bases 1 to 2778)
  AUTHORS   Hla,T. and Maciag,T.
  TITLE     An abundant transcript induced in differentiating human endothelial
            cells encodes a polypeptide with structural similarities to
            G-protein-coupled receptors
  JOURNAL   J Biol Chem 265 (16), 9308-9313 (1990)
   PUBMED   2160972
REFERENCE   10 (bases 1 to 2778)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109741.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 25, 2019 this sequence version replaced NM_001400.4.
            
            Summary: The protein encoded by this gene is structurally similar
            to G protein-coupled receptors and is highly expressed in
            endothelial cells. It binds the ligand sphingosine-1-phosphate with
            high affinity and high specificity, and suggested to be involved in
            the processes that regulate the differentiation of endothelial
            cells. Activation of this receptor induces cell-cell adhesion.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.984011.1,
                                           SRR1660809.202652.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305352.7/ ENSP00000305416.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AL109741.19        36409-36489
            82-2778             AL109741.19        38212-40908
FEATURES             Location/Qualifiers
     source          1..2778
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.2"
     gene            1..2778
                     /gene="S1PR1"
                     /gene_synonym="CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1;
                     S1P1"
                     /note="sphingosine-1-phosphate receptor 1"
                     /db_xref="GeneID:1901"
                     /db_xref="HGNC:HGNC:3165"
                     /db_xref="MIM:601974"
     exon            1..81
                     /gene="S1PR1"
                     /gene_synonym="CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1;
                     S1P1"
                     /inference="alignment:Splign:2.1.0"
     exon            82..2778
                     /gene="S1PR1"
                     /gene_synonym="CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1;
                     S1P1"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1393
                     /gene="S1PR1"
                     /gene_synonym="CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1;
                     S1P1"
                     /note="sphingosine 1-phosphate receptor EDG1; endothelial
                     differentiation, sphingolipid G-protein-coupled receptor,
                     1; S1P receptor Edg-1; sphingosine 1-phosphate receptor
                     Edg-1; endothelial differentiation G-protein coupled
                     receptor 1"
                     /codon_start=1
                     /product="sphingosine 1-phosphate receptor 1"
                     /protein_id="NP_001391.2"
                     /db_xref="CCDS:CCDS777.1"
                     /db_xref="GeneID:1901"
                     /db_xref="HGNC:HGNC:3165"
                     /db_xref="MIM:601974"
                     /translation="MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENS
                     IKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANL
                     LLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRL
                     FLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIV
                     ILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILL
                     LLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSG
                     DSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS"
     regulatory      2757..2762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S1PR1"
                     /gene_synonym="CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1;
                     S1P1"
                     /note="hexamer: AATAAA"
     polyA_site      2778
                     /gene="S1PR1"
                     /gene_synonym="CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1;
                     S1P1"
                     /note="major polyA site"
ORIGIN      
        1 agtcgggggc agcagcaaga tgcgaagcga gccgtacaga tcccgggctc tccgaacgca
       61 acttcgccct gcttgagcga ggctgcggtt tccgaggccc tctccagcca aggaaaagct
      121 acacaaaaag cctggatcac tcatcgaacc acccctgaag ccagtgaagg ctctctcgcc
      181 tcgccctcta gcgttcgtct ggagtagcgc caccccggct tcctggggac acagggttgg
      241 caccatgggg cccaccagcg tcccgctggt caaggcccac cgcagctcgg tctctgacta
      301 cgtcaactat gatatcatcg tccggcatta caactacacg ggaaagctga atatcagcgc
      361 ggacaaggag aacagcatta aactgacctc ggtggtgttc attctcatct gctgctttat
      421 catcctggag aacatctttg tcttgctgac catttggaaa accaagaaat tccaccgacc
      481 catgtactat tttattggca atctggccct ctcagacctg ttggcaggag tagcctacac
      541 agctaacctg ctcttgtctg gggccaccac ctacaagctc actcccgccc agtggtttct
      601 gcgggaaggg agtatgtttg tggccctgtc agcctccgtg ttcagtctcc tcgccatcgc
      661 cattgagcgc tatatcacaa tgctgaaaat gaaactccac aacgggagca ataacttccg
      721 cctcttcctg ctaatcagcg cctgctgggt catctccctc atcctgggtg gcctgcctat
      781 catgggctgg aactgcatca gtgcgctgtc cagctgctcc accgtgctgc cgctctacca
      841 caagcactat atcctcttct gcaccacggt cttcactctg cttctgctct ccatcgtcat
      901 tctgtactgc agaatctact ccttggtcag gactcggagc cgccgcctga cgttccgcaa
      961 gaacatttcc aaggccagcc gcagctctga gaagtcgctg gcgctgctca agaccgtaat
     1021 tatcgtcctg agcgtcttca tcgcctgctg ggcaccgctc ttcatcctgc tcctgctgga
     1081 tgtgggctgc aaggtgaaga cctgtgacat cctcttcaga gcggagtact tcctggtgtt
     1141 agctgtgctc aactccggca ccaaccccat catttacact ctgaccaaca aggagatgcg
     1201 tcgggccttc atccggatca tgtcctgctg caagtgcccg agcggagact ctgctggcaa
     1261 attcaagcga cccatcatcg ccggcatgga attcagccgc agcaaatcgg acaattcctc
     1321 ccacccccag aaagacgaag gggacaaccc agagaccatt atgtcttctg gaaacgtcaa
     1381 ctcttcttcc tagaactgga agctgtccac ccaccggaag cgctctttac ttggtcgctg
     1441 gccaccccag tgtttggaaa aaaatctctg ggcttcgact gctgccaggg aggagctgct
     1501 gcaagccaga gggaggaagg gggagaatac gaacagcctg gtggtgtcgg gtgttggtgg
     1561 gtagagttag ttcctgtgaa caatgcactg ggaagggtgg agatcaggtc ccggcctgga
     1621 atatattttc tacccccctg gagctttgat tttgcactga gccaaaggtc tagcattgtc
     1681 aagctcctaa agggttcatt tggcccctcc tcaaagacta atgtccccat gtgaaagcgt
     1741 ctctttgtct ggagctttga ggagatgttt tccttcactt tagtttcaaa cccaagtgag
     1801 tgtgtgcact tctgcttctt tagggatgcc ctgtacatcc cacaccccac cctcccttcc
     1861 cttcataccc ctcctcaacg ttcttttact ttatacttta actacctgag agttatcaga
     1921 gctggggttg tggaatgatc gatcatctat agcaaatagg ctatgttgag tacgtaggct
     1981 gtgggaagat gaagatggtt tggaggtgta aaacaatgtc cttcgctgag gccaaagttt
     2041 ccatgtaagc gggatccgtt ttttggaatt tggttgaagt cactttgatt tctttaaaaa
     2101 acatcttttc aatgaaatgt gttaccattt catatccatt gaagccgaaa tctgcataag
     2161 gaagcccact ttatctaaat gatattagcc aggatccttg gtgtcctagg agaaacagac
     2221 aagcaaaaca aagtgaaaac cgaatggatt aacttttgca aaccaaggga gatttcttag
     2281 caaatgagtc taacaaatat gacatctgtc tttggcactt ttgttgatgt ttatttcaga
     2341 atgttgtgtg attcatttca agcaacaaca tggttgtatt ttgttgtgtt aaaagtactt
     2401 ttcttgattt ttgaatgtat ttgtttcagc agaagtcatt ttattggatt tttctaaccc
     2461 gtgttaacac cattgaatgt gtatttctta agaaaatacc accctcttgt gcccttaaaa
     2521 gcattacttt aactggtagg gaacgccaga aacttttcag tccagctatt cattagatag
     2581 taattgaaga tatgtataaa tattacaaag aataaaaata tattactgtc tctttagtat
     2641 ggttttcagt gcaattaaac cgagagatgt cttgtttttt taaaaagaat agtatttaat
     2701 aggtttctga cttttgtgga tcattttgca catagcttta tcaactttta aacattaata
     2761 aactgatttt tttaaaga
//
