LOCUS       NM_130772               1553 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens S100 calcium binding protein Z (S100Z), mRNA.
ACCESSION   NM_130772
VERSION     NM_130772.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1553)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1553)
  AUTHORS   Calderone,V., Fragai,M. and Luchinat,C.
  TITLE     Reviewing the Crystal Structure of S100Z and Other Members of the
            S100 Family: Implications in Calcium-Regulated Quaternary Structure
  JOURNAL   Methods Mol Biol 1929, 487-499 (2019)
   PUBMED   30710292
  REMARK    GeneRIF: Apo-S100Z has been compared to the structure of zebrafish
            calcium-S100Z with which it shares 70% sequence identity. It shows
            that the surface of interaction between the monomers in the dimers
            decreases; likewise, the surface among the dimers is lower, with
            the consequent absence of superhelical arrangement in the crystals.
            Also, calcium binding plays a fundamental role in triggering
            quaternary structure formation.
REFERENCE   3  (bases 1 to 1553)
  AUTHORS   Festen,E.A., Stokkers,P.C., van Diemen,C.C., van Bodegraven,A.A.,
            Boezen,H.M., Crusius,B.J., Hommes,D.W., van der Woude,C.J.,
            Balschun,T., Verspaget,H.W., Schreiber,S., de Jong,D.J., Franke,A.,
            Dijkstra,G., Wijmenga,C. and Weersma,R.K.
  TITLE     Genetic analysis in a Dutch study sample identifies more ulcerative
            colitis susceptibility loci and shows their additive role in
            disease risk
  JOURNAL   Am J Gastroenterol 105 (2), 395-402 (2010)
   PUBMED   19861958
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Am J Gastroenterol. 2010 Feb;105(2):479. van der Woude,
            Janneke C [corrected to van der Woude, C Janneke]]
REFERENCE   4  (bases 1 to 1553)
  AUTHORS   Gribenko,A.V., Hopper,J.E. and Makhatadze,G.I.
  TITLE     Molecular characterization and tissue distribution of a novel
            member of the S100 family of EF-hand proteins
  JOURNAL   Biochemistry 40 (51), 15538-15548 (2001)
   PUBMED   11747429
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC022320.1, BX281742.1, AF437876.1, CD368348.1 and AC027342.5.
            
            On Nov 23, 2018 this sequence version replaced NM_130772.3.
            
            Summary: Members of the S100 protein family contain 2
            calcium-binding EF-hands and exhibit cell-type specific expression
            patterns. For additional background information on S100 proteins,
            see MIM 114085.[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI766857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317593.9/ ENSP00000320430.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-384               BC022320.1         15-398
            385-600             BX281742.1         300-515
            601-890             AF437876.1         354-643
            891-1134            CD368348.1         18-261              c
            1135-1553           AC027342.5         6417-6835
FEATURES             Location/Qualifiers
     source          1..1553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.3"
     gene            1..1553
                     /gene="S100Z"
                     /gene_synonym="Gm625; S100-zeta"
                     /note="S100 calcium binding protein Z"
                     /db_xref="GeneID:170591"
                     /db_xref="HGNC:HGNC:30367"
                     /db_xref="MIM:610103"
     exon            1..142
                     /gene="S100Z"
                     /gene_synonym="Gm625; S100-zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            143..261
                     /gene="S100Z"
                     /gene_synonym="Gm625; S100-zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            262..458
                     /gene="S100Z"
                     /gene_synonym="Gm625; S100-zeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..617
                     /gene="S100Z"
                     /gene_synonym="Gm625; S100-zeta"
                     /note="S100 calcium binding protein, zeta"
                     /codon_start=1
                     /product="protein S100-Z"
                     /protein_id="NP_570128.2"
                     /db_xref="CCDS:CCDS43333.1"
                     /db_xref="GeneID:170591"
                     /db_xref="HGNC:HGNC:30367"
                     /db_xref="MIM:610103"
                     /translation="MPTQLEMAMDTMIRIFHRYSGKERKRFKLSKGELKLLLQRELTE
                     FLSCQKETQLVDKIVQDLDANKDNEVDFNEFVVMVAALTVACNDYFVEQLKKKGK"
     exon            459..619
                     /gene="S100Z"
                     /gene_synonym="Gm625; S100-zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            620..1553
                     /gene="S100Z"
                     /gene_synonym="Gm625; S100-zeta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1115..1120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100Z"
                     /gene_synonym="Gm625; S100-zeta"
                     /note="hexamer: AATATA"
     polyA_site      1134
                     /gene="S100Z"
                     /gene_synonym="Gm625; S100-zeta"
                     /note="major polyA site"
     regulatory      1267..1272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100Z"
                     /gene_synonym="Gm625; S100-zeta"
                     /note="hexamer: AATAAA"
     polyA_site      1290
                     /gene="S100Z"
                     /gene_synonym="Gm625; S100-zeta"
     regulatory      1529..1534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100Z"
                     /gene_synonym="Gm625; S100-zeta"
                     /note="hexamer: AATAAA"
     polyA_site      1553
                     /gene="S100Z"
                     /gene_synonym="Gm625; S100-zeta"
ORIGIN      
        1 gcagactcag aacagcacta ctcacagcag ggcctcttgc tcgctctagc tgctgggagg
       61 aaaacggctt gctaatctcc acgcccagaa attcagacaa gagcattctc cttatctcat
      121 ctgcacagga agcaggtcta agtgtaattt cacaagcccc tgactctgtg tagacaccca
      181 gctctccaga aaaatgcttt gaagacaaag gatacagcat acagtcccgt gtctcggctg
      241 agtcatcgca ttccttaata gtgtcttctc cccgggtttg gtggcctgct tctggagtgg
      301 tcagttctgc tgccgacatg cccacccagc tcgagatggc catggacacc atgattagaa
      361 tcttccaccg ctattctggc aaggaaagga agagattcaa gctcagcaag ggggaactga
      421 aactgctcct gcagcgagag ctcacggaat tcctctcgtg ccaaaaggaa acccagttgg
      481 ttgataagat agtgcaggac ctggatgcca ataaggacaa cgaagtggat tttaatgaat
      541 tcgtggtcat ggtggcagct ctgacagttg cttgtaatga ttactttgta gaacaattga
      601 agaagaaagg aaaataaagg aagttcgtga atgctaatca agggctaaat aaagtggaaa
      661 gcagcatcct tgaaaatcat cgctctcagg acggggtctg cctggaatag cactgaatgt
      721 gtttagtagt gcctttggct tgggggcttt ggagaaagct gcttgagccc ttcccatgct
      781 cataaattag gtaaggagca gtgaggaagt gtctacagca acctcagcca atgtgatgtg
      841 cctctacagc tgtatgaagt agattctctg attttatctt gaaatccaca acttccacaa
      901 aaaagaaaaa tcttttacca tttctcatta aaaaagtaat ataagtttat tgtaggggga
      961 aataatcaaa tgtaatctca ttacccagat ataatcactg ttaacttctt cattcgaatt
     1021 ttccctaggt ccatgtatct atatatctat ggttcataaa aatgagatta caccaaaaaa
     1081 tatcttttgt tatctatata gttccagctt aataaatata caactgtatt attatttttg
     1141 tctgaatagt attttcattg atatatcaca atatatttac tccaattccc tattgcatat
     1201 agattatttc taatttttct attaataata ctaagggagc ttttaagtca atacatctga
     1261 atcttgaata aaattcttgt tccttctctt tggatgggta ttcagactct taattttaca
     1321 aatgaagaaa taaagtccca gaaggtaaca gagatagaac taggcacgat tttctattct
     1381 tctttccttc ctttctttgt gagagttaac gattatttaa aagtattcat aattttctga
     1441 taataaaagt aagacatggc attatgacac tggatattca aaaaccacga tgtcctttta
     1501 cttgaagatt ttaaaaggaa atgattacaa taaataccca gagtcaacaa tta
//
