LOCUS       NM_022753               4220 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens S100P binding protein (S100PBP), transcript variant 1,
            mRNA.
ACCESSION   NM_022753
VERSION     NM_022753.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4220)
  AUTHORS   Srivastava,K., Lines,K.E., Jach,D. and Crnogorac-Jurcevic,T.
  TITLE     S100PBP is regulated by mutated KRAS and plays a tumour suppressor
            role in pancreatic cancer
  JOURNAL   Oncogene 42 (46), 3422-3434 (2023)
   PUBMED   37794133
  REMARK    GeneRIF: S100PBP is regulated by mutated KRAS and plays a tumour
            suppressor role in pancreatic cancer.
REFERENCE   2  (bases 1 to 4220)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4220)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4220)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 4220)
  AUTHORS   Xie,H., Lee,L., Scicluna,P., Kavak,E., Larsson,C., Sandberg,R. and
            Lui,W.O.
  TITLE     Novel functions and targets of miR-944 in human cervical cancer
            cells
  JOURNAL   Int J Cancer 136 (5), E230-E241 (2015)
   PUBMED   25156441
  REMARK    GeneRIF: Low S100PBP expression is associated with cervical cancer.
REFERENCE   6  (bases 1 to 4220)
  AUTHORS   Lines,K.E., Chelala,C., Dmitrovic,B., Wijesuriya,N., Kocher,H.M.,
            Marshall,J.F. and Crnogorac-Jurcevic,T.
  TITLE     S100P-binding protein, S100PBP, mediates adhesion through
            regulation of cathepsin Z in pancreatic cancer cells
  JOURNAL   Am J Pathol 180 (4), 1485-1494 (2012)
   PUBMED   22330678
  REMARK    GeneRIF: S100P-binding protein mediates adhesion through regulation
            of cathepsin Z in pancreatic cancer cells.
REFERENCE   7  (bases 1 to 4220)
  AUTHORS   Deng,H., Shi,J., Wilkerson,M., Meschter,S., Dupree,W. and Lin,F.
  TITLE     Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on
            fine-needle aspiration biopsy specimens
  JOURNAL   Am J Clin Pathol 129 (1), 81-88 (2008)
   PUBMED   18089492
  REMARK    GeneRIF: S100P is a sensitive and specific marker for the detection
            of pancreatic ductal adenocarcinoma on FNAB specimens on cell-block
            and smear preparations.
REFERENCE   8  (bases 1 to 4220)
  AUTHORS   Dowen,S.E., Crnogorac-Jurcevic,T., Gangeswaran,R., Hansen,M.,
            Eloranta,J.J., Bhakta,V., Brentnall,T.A., Luttges,J., Kloppel,G.
            and Lemoine,N.R.
  TITLE     Expression of S100P and its novel binding partner S100PBPR in early
            pancreatic cancer
  JOURNAL   Am J Pathol 166 (1), 81-92 (2005)
   PUBMED   15632002
  REMARK    GeneRIF: can be added to the genetic progression model for
            pancreatic ductal adenocarcinoma.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX647916.1 and AK022965.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022753.3.
            
            Summary: This gene encodes a protein that was originally identified
            by its interaction with S100 calcium-binding protein P. Expression
            of this protein has been reported to be associated with pancreatic
            ductal adenocarcinoma. Alternatively spliced transcript variants
            have been described. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 3 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647916.1, SRR1803613.236731.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373475.10/ ENSP00000362574.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1903              BX647916.1         100-2002
            1904-2024           AK022965.1         1374-1494
            2025-4220           BX647916.1         2123-4318
FEATURES             Location/Qualifiers
     source          1..4220
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..4220
                     /gene="S100PBP"
                     /gene_synonym="S100PBPR"
                     /note="S100P binding protein"
                     /db_xref="GeneID:64766"
                     /db_xref="HGNC:HGNC:25768"
                     /db_xref="MIM:611889"
     exon            1..37
                     /gene="S100PBP"
                     /gene_synonym="S100PBPR"
                     /inference="alignment:Splign:2.1.0"
     exon            38..154
                     /gene="S100PBP"
                     /gene_synonym="S100PBPR"
                     /inference="alignment:Splign:2.1.0"
     exon            155..987
                     /gene="S100PBP"
                     /gene_synonym="S100PBPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1383
                     /gene="S100PBP"
                     /gene_synonym="S100PBPR"
                     /note="S100P binding protein 1"
                     /codon_start=1
                     /product="S100P-binding protein"
                     /protein_id="NP_073590.2"
                     /db_xref="CCDS:CCDS30666.1"
                     /db_xref="GeneID:64766"
                     /db_xref="HGNC:HGNC:25768"
                     /db_xref="MIM:611889"
                     /translation="MMCSRVPSEQSSGTSLLPKDGAPFSWDSLDEDGLDDSLLELSEG
                     EEDDGDVNYTEEEIDALLKEDDPSYEQSSGEDDGGHVEKGERGSQILLDTPREKNSSY
                     SLGPVAETPDLFKLPQLSTSSGHGPAHTKPLNRRSVLEKNLIKVTVAPFNPTVCDALL
                     DKDETDSSKDTEKLSSLGEEMREDGLSPNESKLCTESEGISPNNSAWNGPQLSSSNNN
                     FQQTVSDKNMPDSENPTSVFSRISDHSETPNMELSCRNGGSHKSSCEMRSLVVSTSSN
                     KQDVLNKDSGKMKGHERRLGKVIPVLQTKTRTNVPTFSQSNLEQQKQLYLRSVIAHIE
                     DPEDTNQGISGELCALMDQVHHMQHSKWQHPSDLTTRNYARRQKHLQRYSLTQWVDRN
                     MRSHHRFQRLPDFSYS"
     exon            988..1076
                     /gene="S100PBP"
                     /gene_synonym="S100PBPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1180
                     /gene="S100PBP"
                     /gene_synonym="S100PBPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1268
                     /gene="S100PBP"
                     /gene_synonym="S100PBPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..4220
                     /gene="S100PBP"
                     /gene_synonym="S100PBPR"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1531
                     /gene="S100PBP"
                     /gene_synonym="S100PBPR"
                     /note="major polyA site"
     regulatory      4199..4204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100PBP"
                     /gene_synonym="S100PBPR"
                     /note="hexamer: AATAAA"
     polyA_site      4220
                     /gene="S100PBP"
                     /gene_synonym="S100PBPR"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcgttc gcccaggctt tggcccggct tccggaggaa ggtgggagtc aatcattttg
       61 acaagtctcc tgaaaggaac agctagcagg aactgaaacc tttttccatt tggtctcgtg
      121 gcaaaggcag agattgctcc agcagctcca cacaaaatga tgtgctcacg ggtgccctct
      181 gaacagtctt ctggtacctc tctcttgcct aaagacggtg ccccattttc ttgggattcc
      241 ttggatgagg atggattgga tgactccttg ctggagctgt cagagggaga agaagatgat
      301 ggtgatgtaa attacacaga ggaagagatt gatgcactgt tgaaggaaga tgacccatca
      361 tatgagcagt cttctgggga agatgatggt gggcatgttg agaagggaga aagagggagt
      421 caaattctac ttgatactcc ccgagagaaa aattcatcgt acagcctggg accagtagct
      481 gagactcctg acctcttcaa actacctcag ctaagtacat caagtggtca tggaccagct
      541 catactaaac cattaaacag acgctctgta ctagaaaaga atcttataaa agtaactgtt
      601 gcaccattta atccaacagt ttgtgatgct ctgcttgata aggacgagac tgattcgtcc
      661 aaagatactg aaaaactctc ttcccttgga gaagagatga gagaagatgg tcttagccca
      721 aatgaaagca aactttgtac tgaatctgaa gggatcagcc ccaataactc tgcctggaat
      781 gggccccagc tctcttcttc aaacaataac tttcaacaga ctgtctctga taaaaatatg
      841 cctgacagtg agaaccctac gtctgtattc tctcggatct cagaccattc agagactcct
      901 aatatggagt tatcctgcag aaatggtggt tcacacaagt caagttgtga aatgagatct
      961 ctggttgttt ccacctcatc aaacaaacag gatgttctta acaaggattc tgggaagatg
     1021 aaaggccatg agagaagact aggcaaagtc attcctgttc tacaaactaa gaccaggact
     1081 aatgttccga cgttttcaca gtcaaatcta gaacagcaga agcagcttta tctcaggagt
     1141 gtcattgctc atatagaaga cccagaggac actaaccaag gtatctcggg ggagctttgt
     1201 gccttgatgg atcaagttca tcatatgcag cactcaaaat ggcagcatcc ttcggacctc
     1261 accacgcgaa actacgcccg ccgacagaaa catctgcaaa gatacagtct gactcagtgg
     1321 gttgacagga acatgcgaag ccaccatcgg ttccagcgtc tcccagactt ctcgtacagt
     1381 taatttgtgt catcccatca gcaatgaagg tccctatcca gggtcctgct tggagcagca
     1441 tttcatgttc ttttgctgtt ttgtgctttg ccgattttgg attttatttt tcacaaaatt
     1501 tttatttaaa aaactcgtca ccttttggaa atgcccattg ccgacttgaa tttttttgta
     1561 tgaagtccct cctgattttg tgtgtgtgtg tctgtgttta agcaagcgtt cggttggtat
     1621 agtttttttt tgttttttta atttaaattg aaggtagctg cctcctgaaa gccagcatta
     1681 agccagaaca cccaggttca agcaaaagac ccacctctct gcagaggcaa agtctacttt
     1741 ctggtacctc aaagaaatca ttgttcaatc ttccataagg aagagattct ttaccaggct
     1801 gtgagccagt gttagataac ttgtgaatgg atataagtta cttttaacaa cccctcttac
     1861 ttttttattt gaatcctctg aatacctgtc agtattttaa agttggcaat ccaggacatt
     1921 ataagtagga tggagcagga gaagaatcct attgaaagga caaattaaaa tagtaaatcc
     1981 tctcctctcc cttctgtagg tactagctgc cttgattttt ttttgtgggt gggggggatt
     2041 ttttcattcc ttattgaact tattttgcac aatagtgttt acaaatctta tacatcttac
     2101 tttgacagaa gacttataat accttgtggt cttgagactg gttgtctcct ttgcctttct
     2161 tcaaggattt tcctttttct ttttaccccc cagtgaccac tctgctcttt aggattctag
     2221 tggcagtatt cttgtaacct gttagacgtg gatatacctc ttcaggatgg cctccttgct
     2281 gtctttattg aagagctgcc cacccagagt cttgactcta gggcaggcta gtgctattgt
     2341 ggtgtcagtt gatatttagt ttcatttgct gaaccccaaa tttgagtgtt agttagggag
     2401 cctccattct gtgggagagt gtggaaaggc actctttttt ctccatatta gttaacaaga
     2461 ggtgtcttta ggccctggat gttaccatct catttggtca agcccctgat acctagtttc
     2521 acatggatgc taacgtggat gtaatatagt tgtgacagcc tatgcacaaa agcattacct
     2581 gatcttaagg tttggtattc taaccaaagt tgacagactg tgcgtctgtc ttaatggatg
     2641 tcttaggagt tggttattct ctcttttttt tttgagacgg agtttcgctg ttgttgccca
     2701 ggctggagtg caatggcgta tctccactca ccacaacctc cgcctcctgg gttcaaggga
     2761 ttctcctgtc ttagcctcct gagtagctgt gattacaggc atgcgccacc atgcctggct
     2821 aatttcatat tttttagtag agacaggatt tctccatgtt ggtcaggctg gtcttgaact
     2881 cctgacctca ggtgatctgc ccacctcggc ctcctaaagt gctgggatta caggcatgag
     2941 ccactgcacc tggccggtta ttctctcttt acagatagct atagacatca ttttaggaag
     3001 tgttgcagtc tggcatttgt gctattgttc attctctgtg aaggctgttc atagttgcta
     3061 tagcctgtgt ttagttttgt gatttcatca atcccatctt tctgtgtgag taatgcattc
     3121 taaacatcct accccacttt agaaacggac gtggggaacg cttggtcatt taagccaaca
     3181 ataaatttag gtgaatgtcc ctaagtgttt actgttttta tccagtcaag gatttgcttt
     3241 tccttgaaca tttgttttaa attctggggc caaaatgcaa aggagaagtt ctattcaaag
     3301 gcagtagttg aaatctatta ttttagttag cctacttggc atttactaca tcggtcactt
     3361 ctccaggctg ccctaaatta ggttgatgga gtgagacatg ccaaacatcc acctttggga
     3421 ccatagcata gttaaaatta aatgtagttg gaatagctag cattgcagct acagtaggga
     3481 actgtagtct agttccctac agaaaaccca aggagtgaag ggacaggatt ttgcctaggc
     3541 aaaaatctaa gactcgtgcc ctcctggtac atggggtttt aagactgaat gtgtaatagg
     3601 agcactgcct ttgccaaatc aaatgagtga caggttaact agaaaatgtg acaatcacat
     3661 ttcctcttag ctcaaataat tctgtttttc caaagcttta gcagcttaat taaatctgtt
     3721 ggactggggg aggagagagc tgttctctag tggttaacat ggtattcttt aagaagaaaa
     3781 aacaaagcca aagaaaactc attatctggc atgttcgcct taaagatggt actgggtaga
     3841 atctggagtt ttcatctctt ttcaaagctg catatctctt atatttggta ttggcctcta
     3901 agtctaatat tgcagttgga attcttgctg tattattttt taagcaagtg ttaggtgcat
     3961 ttaactgctt tcttcatcca tgacgacatt cccaccatgg gggtcttgac aaagcagagt
     4021 aaaaatatgc tgtttacatt gtttacttac aagtaaggag cctgaaataa cctgtagttt
     4081 cgaatgcagg ccctgattta ctggcgttgt cagtttcaat tatgaaactg aagtttggtg
     4141 cctcctcttt atcatgtttt ttcccttgta gcagttgtgt ttaatgtcat taaaaagaaa
     4201 taaaagttct ttgtcagtga
//
