LOCUS       NM_005980                471 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens S100 calcium binding protein P (S100P), mRNA.
ACCESSION   NM_005980
VERSION     NM_005980.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Gao,L., Bai,Y., Zhou,J., Liang,C., Dong,Y., Han,T., Liu,Y., Guo,J.,
            Wu,J. and Hu,D.
  TITLE     S100P facilitates LUAD progression via PKA/c-Jun-mediated
            tumor-associated macrophage recruitment and polarization
  JOURNAL   Cell Signal 120, 111179 (2024)
   PUBMED   38640980
  REMARK    GeneRIF: S100P facilitates LUAD progression via PKA/c-Jun-mediated
            tumor-associated macrophage recruitment and polarization.
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Sun,Y., Chen,D., Sun,S., Ren,M., Zhou,L., Chen,C., Zhao,J., Wei,H.,
            Zhao,Q., Qi,Y., Zhang,J., Zhang,G., Liu,H., Yang,Q., Liu,Q.,
            Wang,Y. and Zhang,W.
  TITLE     RBMS1 Coordinates with the m6A Reader YTHDF1 to Promote NSCLC
            Metastasis through Stimulating S100P Translation
  JOURNAL   Adv Sci (Weinh) 11 (15), e2307122 (2024)
   PUBMED   38342601
  REMARK    GeneRIF: RBMS1 Coordinates with the m[6]A Reader YTHDF1 to Promote
            NSCLC Metastasis through Stimulating S100P Translation.
REFERENCE   3  (bases 1 to 471)
  AUTHORS   Hao,W., Zhang,Y., Dou,J., Cui,P. and Zhu,J.
  TITLE     S100P as a potential biomarker for immunosuppressive
            microenvironment in pancreatic cancer: a bioinformatics analysis
            and in vitro study
  JOURNAL   BMC Cancer 23 (1), 997 (2023)
   PUBMED   37853345
  REMARK    GeneRIF: S100P as a potential biomarker for immunosuppressive
            microenvironment in pancreatic cancer: a bioinformatics analysis
            and in vitro study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 471)
  AUTHORS   Xuan,Z., Liu,L., Zhang,G., Zheng,X., Jiang,J., Wang,K. and Huang,P.
  TITLE     Novel cell subtypes of SPP1 + S100P+, MS4A1-SPP1 + S100P+ were key
            subpopulations in intrahepatic cholangiocarcinoma
  JOURNAL   Biochim Biophys Acta Gen Subj 1867 (9), 130420 (2023)
   PUBMED   37433400
  REMARK    GeneRIF: Novel cell subtypes of SPP1 + S100P+, MS4A1-SPP1 + S100P+
            were key subpopulations in intrahepatic cholangiocarcinoma.
REFERENCE   5  (bases 1 to 471)
  AUTHORS   Lancaster,T., Tabrizi,M.E.A., Repici,M., Gupta,J. and Gross,S.R.
  TITLE     An Extracellular/Membrane-Bound S100P Pool Regulates Motility and
            Invasion of Human Extravillous Trophoblast Lines and Primary Cells
  JOURNAL   Biomolecules 13 (8), 1231 (2023)
   PUBMED   37627296
  REMARK    GeneRIF: An Extracellular/Membrane-Bound S100P Pool Regulates
            Motility and Invasion of Human Extravillous Trophoblast Lines and
            Primary Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 471)
  AUTHORS   Schafer,B.W. and Heizmann,C.W.
  TITLE     The S100 family of EF-hand calcium-binding proteins: functions and
            pathology
  JOURNAL   Trends Biochem Sci 21 (4), 134-140 (1996)
   PUBMED   8701470
  REMARK    Review article
REFERENCE   7  (bases 1 to 471)
  AUTHORS   Schafer,B.W., Wicki,R., Engelkamp,D., Mattei,M.G. and Heizmann,C.W.
  TITLE     Isolation of a YAC clone covering a cluster of nine S100 genes on
            human chromosome 1q21: rationale for a new nomenclature of the S100
            calcium-binding protein family
  JOURNAL   Genomics 25 (3), 638-643 (1995)
   PUBMED   7759097
REFERENCE   8  (bases 1 to 471)
  AUTHORS   Engelkamp,D., Schafer,B.W., Mattei,M.G., Erne,P. and Heizmann,C.W.
  TITLE     Six S100 genes are clustered on human chromosome 1q21:
            identification of two genes coding for the two previously
            unreported calcium-binding proteins S100D and S100E
  JOURNAL   Proc Natl Acad Sci U S A 90 (14), 6547-6551 (1993)
   PUBMED   8341667
REFERENCE   9  (bases 1 to 471)
  AUTHORS   Becker,T., Gerke,V., Kube,E. and Weber,K.
  TITLE     S100P, a novel Ca(2+)-binding protein from human placenta. cDNA
            cloning, recombinant protein expression and Ca2+ binding properties
  JOURNAL   Eur J Biochem 207 (2), 541-547 (1992)
   PUBMED   1633809
REFERENCE   10 (bases 1 to 471)
  AUTHORS   Emoto,Y., Kobayashi,R., Akatsuka,H. and Hidaka,H.
  TITLE     Purification and characterization of a new member of the S-100
            protein family from human placenta
  JOURNAL   Biochem Biophys Res Commun 182 (3), 1246-1253 (1992)
   PUBMED   1540168
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093323.3 and KF495696.1.
            
            On Aug 25, 2018 this sequence version replaced NM_005980.2.
            
            Summary: The protein encoded by this gene is a member of the S100
            family of proteins containing 2 EF-hand calcium-binding motifs.
            S100 proteins are localized in the cytoplasm and/or nucleus of a
            wide range of cells, and involved in the regulation of a number of
            cellular processes such as cell cycle progression and
            differentiation. S100 genes include at least 13 members which are
            located as a cluster on chromosome 1q21; however, this gene is
            located at 4p16. This protein, in addition to binding Ca2+, also
            binds Zn2+ and Mg2+. This protein may play a role in the etiology
            of prostate cancer. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM783029.1, BM854679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296370.4/ ENSP00000296370.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AC093323.3         160801-160993
            194-280             KF495696.1         120-206
            281-471             AC093323.3         163903-164093
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..471
                     /gene="S100P"
                     /gene_synonym="MIG9"
                     /note="S100 calcium binding protein P"
                     /db_xref="GeneID:6286"
                     /db_xref="HGNC:HGNC:10504"
                     /db_xref="MIM:600614"
     exon            1..193
                     /gene="S100P"
                     /gene_synonym="MIG9"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..343
                     /gene="S100P"
                     /gene_synonym="MIG9"
                     /note="protein S100-E; migration-inducing gene 9 protein"
                     /codon_start=1
                     /product="protein S100-P"
                     /protein_id="NP_005971.1"
                     /db_xref="CCDS:CCDS3391.1"
                     /db_xref="GeneID:6286"
                     /db_xref="HGNC:HGNC:10504"
                     /db_xref="MIM:600614"
                     /translation="MTELETAMGMIIDVFSRYSGSEGSTQTLTKGELKVLMEKELPGF
                     LQSGKDKDAVDKLLKDLDANGDAQVDFSEFIVFVAAITSACHKYFEKAGLK"
     exon            194..471
                     /gene="S100P"
                     /gene_synonym="MIG9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      452..457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100P"
                     /gene_synonym="MIG9"
                     /note="hexamer: AATAAA"
     polyA_site      471
                     /gene="S100P"
                     /gene_synonym="MIG9"
                     /note="major polyA site"
ORIGIN      
        1 acattttctc ggccctgcca gcccccagga ggaaggtggg tctgaatcta gcaccatgac
       61 ggaactagag acagccatgg gcatgatcat agacgtcttt tcccgatatt cgggcagcga
      121 gggcagcacg cagaccctga ccaaggggga gctcaaggtg ctgatggaga aggagctacc
      181 aggcttcctg cagagtggaa aagacaagga tgccgtggat aaattgctca aggacctgga
      241 cgccaatgga gatgcccagg tggacttcag tgagttcata gtgttcgtgg ctgcaatcac
      301 gtctgcctgt cacaagtact ttgagaaggc aggactcaaa tgatgccctg gagatgtcac
      361 agattcctgg cagagccatg gtcccaggct tcccaaaagt gtttgttggc aattattccc
      421 ctaggctgag cctgctcatg tacctctgat taataaatgc ttatgaaatg a
//
