LOCUS       NM_004057                455 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens S100 calcium binding protein G (S100G), mRNA.
ACCESSION   NM_004057
VERSION     NM_004057.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Fukushima,A., Aizaki,Y. and Sakuma,K.
  TITLE     Short-chain fatty acids increase the level of calbindin-D9k
            messenger RNA in Caco-2 cells
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 58 (4), 287-291 (2012)
   PUBMED   23132313
  REMARK    GeneRIF: Addition of short-chain fatty acids to cultured Caco-2
            cells results in elevation of calbindin-D9k mRNA.
REFERENCE   3  (bases 1 to 455)
  AUTHORS   Halhali,A., Figueras,A.G., Diaz,L., Avila,E., Barrera,D.,
            Hernandez,G. and Larrea,F.
  TITLE     Effects of calcitriol on calbindins gene expression and lipid
            peroxidation in human placenta
  JOURNAL   J Steroid Biochem Mol Biol 121 (1-2), 448-451 (2010)
   PUBMED   20214988
  REMARK    GeneRIF: cultured syncytiotrophoblast cells express calbindin-D9k
            and calbindin-D28k genes, which are stimulated by calcitriol
REFERENCE   4  (bases 1 to 455)
  AUTHORS   Mao,X., Mao,Z. and Huo,Z.
  TITLE     [Effect of parathyroid hormone and 1,25-(OH)2-D3 on the expression
            of the mRNA of calbindin D9k in Caco-2 cells]
  JOURNAL   Wei Sheng Yan Jiu 36 (3), 372-375 (2007)
   PUBMED   17712966
  REMARK    GeneRIF: Parathyroid hormone may inhibit or counteract the increase
            in CaBP-D9k mRNA caused by 1,25-(OH)2-D3 in Caco-2 cells.
REFERENCE   5  (bases 1 to 455)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   6  (bases 1 to 455)
  AUTHORS   Fleet,J.C. and Hock,J.M.
  TITLE     Identification of osteocalcin mRNA in nonosteoid tissue of rats and
            humans by reverse transcription-polymerase chain reaction
  JOURNAL   J Bone Miner Res 9 (10), 1565-1573 (1994)
   PUBMED   7817802
REFERENCE   7  (bases 1 to 455)
  AUTHORS   Miller,E.K., Word,R.A., Goodall,C.A. and Iacopino,A.M.
  TITLE     Calbindin-D9K gene expression in human myometrium during pregnancy
            and labor
  JOURNAL   J Clin Endocrinol Metab 79 (2), 609-615 (1994)
   PUBMED   8045984
REFERENCE   8  (bases 1 to 455)
  AUTHORS   Jeung,E.B., Krisinger,J., Dann,J.L. and Leung,P.C.
  TITLE     Molecular cloning of the full-length cDNA encoding the human
            calbindin-D9k
  JOURNAL   FEBS Lett 307 (2), 224-228 (1992)
   PUBMED   1379540
REFERENCE   9  (bases 1 to 455)
  AUTHORS   Howard,A., Legon,S., Spurr,N.K. and Walters,J.R.
  TITLE     Molecular cloning and chromosomal assignment of human calbindin-D9k
  JOURNAL   Biochem Biophys Res Commun 185 (2), 663-669 (1992)
   PUBMED   1610358
REFERENCE   10 (bases 1 to 455)
  AUTHORS   Balmain,N.
  TITLE     Calbindin-D9k. A vitamin-D-dependent, calcium-binding protein in
            mineralized tissues
  JOURNAL   Clin Orthop Relat Res (265), 265-276 (1991)
   PUBMED   2009668
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L13220.1 and AL445467.6.
            
            On May 17, 2019 this sequence version replaced NM_004057.2.
            
            Summary: This gene encodes calbindin D9K, a vitamin D-dependent
            calcium-binding protein. This cytosolic protein belongs to a family
            of calcium-binding proteins that includes calmodulin, parvalbumin,
            troponin C, and S100 protein. In the intestine, the protein is
            vitamin D-dependent and its expression correlates with calcium
            transport activity. The protein may increase Ca2+ absorption by
            buffering Ca2+ in the cytoplasm and increase ATP-dependent Ca2+
            transport in duodenal basolateral membrane vesicles. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X65869.1, L13220.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380200.3/ ENSP00000369547.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-453               L13220.1           4-456
            454-455             AL445467.6         52666-52667
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..455
                     /gene="S100G"
                     /gene_synonym="CABP; CABP1; CABP9K; CALB3"
                     /note="S100 calcium binding protein G"
                     /db_xref="GeneID:795"
                     /db_xref="HGNC:HGNC:1436"
                     /db_xref="MIM:302020"
     exon            1..46
                     /gene="S100G"
                     /gene_synonym="CABP; CABP1; CABP9K; CALB3"
                     /inference="alignment:Splign:2.1.0"
     exon            47..189
                     /gene="S100G"
                     /gene_synonym="CABP; CABP1; CABP9K; CALB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..294
                     /gene="S100G"
                     /gene_synonym="CABP; CABP1; CABP9K; CALB3"
                     /note="calbindin D9K; calbindin 3, (vitamin D-dependent
                     calcium-binding protein); vitamin D-dependent
                     calcium-binding protein, intestinal; calbindin-D9k"
                     /codon_start=1
                     /product="protein S100-G"
                     /protein_id="NP_004048.1"
                     /db_xref="CCDS:CCDS14176.1"
                     /db_xref="GeneID:795"
                     /db_xref="HGNC:HGNC:1436"
                     /db_xref="MIM:302020"
                     /translation="MSTKKSPEELKRIFEKYAAKEGDPDQLSKDELKLLIQAEFPSLL
                     KGPNTLDDLFQELDKNGDGEVSFEEFQVLVKKISQ"
     exon            190..455
                     /gene="S100G"
                     /gene_synonym="CABP; CABP1; CABP9K; CALB3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaactcctct ttgattcttc tagctgtttc actattgggc aaccagacac cagaatgagt
       61 actaaaaagt ctcctgagga actgaagagg atttttgaaa aatatgcagc caaagaaggt
      121 gatccagacc agttgtcaaa ggatgaactg aagctattga ttcaggctga attccccagt
      181 ttactcaaag gtccaaacac cctagatgat ctctttcaag aactggacaa gaatggagat
      241 ggagaagtta gttttgaaga attccaagta ttagtaaaaa agatatccca gtgaaggaga
      301 aaacaaaata gaaccctgag cactggagga agagcgcctg tgctgtggtc ttatcctatg
      361 tggaatcccc caaagtctct ggtttaattc tttgcaatta taataacctg gctgtgaggt
      421 tcagttatta ttaataaaga aattattaga catac
//
