LOCUS       NM_006272               1109 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens S100 calcium binding protein B (S100B), mRNA.
ACCESSION   NM_006272
VERSION     NM_006272.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1109)
  AUTHORS   Shi,H., Zhang,Y., Yang,Y., Zhang,H., Li,W., Zhong,Z. and Lv,L.
  TITLE     Serum S100B protein and white matter changes in schizophrenia
            before and after medication
  JOURNAL   Brain Res Bull 210, 110927 (2024)
   PUBMED   38485004
  REMARK    GeneRIF: Serum S100B protein and white matter changes in
            schizophrenia before and after medication.
REFERENCE   2  (bases 1 to 1109)
  AUTHORS   Yan,A.
  TITLE     Application value of serum S100B combined with glucose metabolism
            indexes in predicting adverse pregnancy outcomes of patients with
            severe preeclampsia
  JOURNAL   J Hum Hypertens 38 (3), 232-237 (2024)
   PUBMED   38160207
  REMARK    GeneRIF: Application value of serum S100B combined with glucose
            metabolism indexes in predicting adverse pregnancy outcomes of
            patients with severe preeclampsia.
REFERENCE   3  (bases 1 to 1109)
  AUTHORS   Michetti,F., Di Sante,G., Clementi,M.E., Valeriani,F.,
            Mandarano,M., Ria,F., Di Liddo,R., Rende,M. and Romano Spica,V.
  TITLE     The Multifaceted S100B Protein: A Role in Obesity and Diabetes?
  JOURNAL   Int J Mol Sci 25 (2), 776 (2024)
   PUBMED   38255850
  REMARK    GeneRIF: The Multifaceted S100B Protein: A Role in Obesity and
            Diabetes?
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1109)
  AUTHORS   Elhady,M.M., Adly,S.A., Elshebiny,H.A. and Moselhy,S.S.
  TITLE     Detection the severity of organophosphate intoxication using
            sensitive serum biomarkers S100B and amyloid beta (Abeta) in
            Egyptian subjects
  JOURNAL   Environ Sci Pollut Res Int 30 (48), 105194-105201 (2023)
   PUBMED   37713081
  REMARK    GeneRIF: Detection the severity of organophosphate intoxication
            using sensitive serum biomarkers S100B and amyloid beta (Abeta) in
            Egyptian subjects.
REFERENCE   5  (bases 1 to 1109)
  AUTHORS   Yue,P., Zhang,L. and Wang,B.
  TITLE     Effects of interventional vascular embolization at different timing
            on prognosis and serum S100 calcium-binding protein B level of
            patients with aneurysmal subarachnoid hemorrhage
  JOURNAL   Afr Health Sci 23 (3), 561-568 (2023)
   PUBMED   38357151
  REMARK    GeneRIF: Effects of interventional vascular embolization at
            different timing on prognosis and serum S100 calcium-binding
            protein B level of patients with aneurysmal subarachnoid
            hemorrhage.
REFERENCE   6  (bases 1 to 1109)
  AUTHORS   Morii,K., Tanaka,R., Takahashi,Y., Minoshima,S., Fukuyama,R.,
            Shimizu,N. and Kuwano,R.
  TITLE     Structure and chromosome assignment of human S100 alpha and beta
            subunit genes
  JOURNAL   Biochem Biophys Res Commun 175 (1), 185-191 (1991)
   PUBMED   1998503
  REMARK    Erratum:[Biochem Biophys Res Commun 1991 Jun 14;177(2):894]
REFERENCE   7  (bases 1 to 1109)
  AUTHORS   Allore,R.J., Friend,W.C., O'Hanlon,D., Neilson,K.M., Baumal,R.,
            Dunn,R.J. and Marks,A.
  TITLE     Cloning and expression of the human S100 beta gene
  JOURNAL   J Biol Chem 265 (26), 15537-15543 (1990)
   PUBMED   2394738
REFERENCE   8  (bases 1 to 1109)
  AUTHORS   Duncan,A.M., Higgins,J., Dunn,R.J., Allore,R. and Marks,A.
  TITLE     Refined sublocalization of the human gene encoding the beta subunit
            of the S100 protein (S100B) and confirmation of a subtle t(9;21)
            translocation using in situ hybridization
  JOURNAL   Cytogenet Cell Genet 50 (4), 234-235 (1989)
   PUBMED   2530061
REFERENCE   9  (bases 1 to 1109)
  AUTHORS   Baudier,J. and Cole,R.D.
  TITLE     Interactions between the microtubule-associated tau proteins and
            S100b regulate tau phosphorylation by the Ca2+/calmodulin-dependent
            protein kinase II
  JOURNAL   J Biol Chem 263 (12), 5876-5883 (1988)
   PUBMED   2833519
REFERENCE   10 (bases 1 to 1109)
  AUTHORS   Allore,R., O'Hanlon,D., Price,R., Neilson,K., Willard,H.F.,
            Cox,D.R., Marks,A. and Dunn,R.J.
  TITLE     Gene encoding the beta subunit of S100 protein is on chromosome 21:
            implications for Down syndrome
  JOURNAL   Science 239 (4845), 1311-1313 (1988)
   PUBMED   2964086
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA310307.1, BC001766.1,
            EB386131.1 and AP000339.2.
            
            On Nov 23, 2018 this sequence version replaced NM_006272.2.
            
            Summary: The protein encoded by this gene is a member of the S100
            family of proteins containing 2 EF-hand calcium-binding motifs.
            S100 proteins are localized in the cytoplasm and/or nucleus of a
            wide range of cells, and involved in the regulation of a number of
            cellular processes such as cell cycle progression and
            differentiation. S100 genes include at least 13 members which are
            located as a cluster on chromosome 1q21; however, this gene is
            located at 21q22.3. This protein may function in Neurite extension,
            proliferation of melanoma cells, stimulation of Ca2+ fluxes,
            inhibition of PKC-mediated phosphorylation, astrocytosis and axonal
            proliferation, and inhibition of microtubule assembly. Chromosomal
            rearrangements and altered expression of this gene have been
            implicated in several neurological, neoplastic, and other types of
            diseases, including Alzheimer's disease, Down's syndrome, epilepsy,
            amyotrophic lateral sclerosis, melanoma, and type I diabetes.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.311408.1,
                                           SRR1660807.308821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291700.9/ ENSP00000291700.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AA310307.1         127-135
            10-169              BC001766.1         1-160
            170-734             EB386131.1         159-723
            735-1095            AP000339.2         21217-21577         c
            1096-1109           AP000339.2         21203-21216         c
FEATURES             Location/Qualifiers
     source          1..1109
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..1109
                     /gene="S100B"
                     /gene_synonym="NEF; S100; S100-B; S100beta"
                     /note="S100 calcium binding protein B"
                     /db_xref="GeneID:6285"
                     /db_xref="HGNC:HGNC:10500"
                     /db_xref="MIM:176990"
     exon            1..70
                     /gene="S100B"
                     /gene_synonym="NEF; S100; S100-B; S100beta"
                     /inference="alignment:Splign:2.1.0"
     exon            71..209
                     /gene="S100B"
                     /gene_synonym="NEF; S100; S100-B; S100beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..350
                     /gene="S100B"
                     /gene_synonym="NEF; S100; S100-B; S100beta"
                     /note="S100 calcium-binding protein, beta (neural); S-100
                     calcium-binding protein, beta chain; S-100 protein subunit
                     beta"
                     /codon_start=1
                     /product="protein S100-B"
                     /protein_id="NP_006263.1"
                     /db_xref="CCDS:CCDS13736.1"
                     /db_xref="GeneID:6285"
                     /db_xref="HGNC:HGNC:10500"
                     /db_xref="MIM:176990"
                     /translation="MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHF
                     LEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE"
     exon            210..1109
                     /gene="S100B"
                     /gene_synonym="NEF; S100; S100-B; S100beta"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      513
                     /gene="S100B"
                     /gene_synonym="NEF; S100; S100-B; S100beta"
     regulatory      733..738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100B"
                     /gene_synonym="NEF; S100; S100-B; S100beta"
                     /note="hexamer: AACAAA"
     polyA_site      762
                     /gene="S100B"
                     /gene_synonym="NEF; S100; S100-B; S100beta"
                     /note="major polyA site"
     polyA_site      779
                     /gene="S100B"
                     /gene_synonym="NEF; S100; S100-B; S100beta"
     regulatory      1087..1092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100B"
                     /gene_synonym="NEF; S100; S100-B; S100beta"
                     /note="hexamer: AATAAA"
     polyA_site      1109
                     /gene="S100B"
                     /gene_synonym="NEF; S100; S100-B; S100beta"
ORIGIN      
        1 gccgcccagg acccgcagca gagacgacgc ctgcagcaag gagaccagga aggggtgaga
       61 caaggaagag gatgtctgag ctggagaagg ccatggtggc cctcatcgac gttttccacc
      121 aatattctgg aagggaggga gacaagcaca agctgaagaa atccgaactg aaggagctca
      181 tcaacaatga gctttcccat ttcttagagg aaatcaaaga gcaggaggtt gtggacaaag
      241 tcatggaaac actggacaat gatggagacg gcgaatgtga cttccaggaa ttcatggcct
      301 ttgttgccat ggttactact gcctgccacg agttctttga acatgagtga gattagaaag
      361 cagccaaacc tttcctgtaa cagagacggt catgcaagaa agcagacagc aagggcttgc
      421 agcctagtag gagctgagct ttccagccgt gttgtagcta attaggaagc ttgatttgct
      481 ttgtgattga aaaattgaaa acctctttcc aaaggctgtt ttaacggcct gcatcattct
      541 ttctgctata ttaggcctgt gtgtaagctg actggcccca gggactcttg ttaacagtaa
      601 cttaggagtc aggtctcagt gataaagcgt gcaccgtgca gcccgccatg gccgtgtaga
      661 ccctaacccg gagggaaccc tgactacaga aattaccccg gggcaccctt aaaacttcca
      721 ctacctttaa aaaacaaagc cttatccagc attatttgaa aacactgctg ttctttaaat
      781 gcgttcctca tccatgcaga taacagctgg ttggccggtg tggccctgca agggcgtggt
      841 ggcttcggcc tgcttcccgg gatgcgcctg atcaccaggt gaacgctcag cgctggcagc
      901 gctcctggaa aaagcaactc catcagaact cgcaatccga gccagctctg ggggctccag
      961 cgtggcctcc gtgacccatg cgattcaagt cgcggctgca ggatccttgc ctccaacgtg
     1021 cctccagcac atgcggcttc cgagggcact accgggggct ctgagccacc gcgagggcct
     1081 gcgttcaata aaaagagcgc agcttggga
//
