LOCUS       NM_002965                573 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens S100 calcium binding protein A9 (S100A9), mRNA.
ACCESSION   NM_002965
VERSION     NM_002965.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 573)
  AUTHORS   De Luca,G., Goette,N.P., Lev,P.R., Baroni Pietto,M.C., Marin
            Oyarzun,C.P., Castro Rios,M.A., Moiraghi,B., Sackmann,F.,
            Kamiya,L.J., Verri,V., Caula,V., Fernandez,V., Vicente,A., Pose
            Cabarcos,J., Caruso,V., Camacho,M.F., Larripa,I.B., Khoury,M.,
            Marta,R.F., Glembotsky,A.C. and Heller,P.G.
  TITLE     Elevated levels of damage-associated molecular patterns HMGB1 and
            S100A8/A9 coupled with toll-like receptor-triggered monocyte
            activation are associated with inflammation in patients with
            myelofibrosis
  JOURNAL   Front Immunol 15, 1365015 (2024)
   PUBMED   39391311
  REMARK    GeneRIF: Elevated levels of damage-associated molecular patterns
            HMGB1 and S100A8/A9 coupled with toll-like receptor-triggered
            monocyte activation are associated with inflammation in patients
            with myelofibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 573)
  AUTHORS   Franz,S., Torregrossa,M., Anderegg,U., Ertel,A. and Saalbach,A.
  TITLE     Dysregulated S100A9 Expression Impairs Matrix Deposition in Chronic
            Wounds
  JOURNAL   Int J Mol Sci 25 (18), 9980 (2024)
   PUBMED   39337466
  REMARK    GeneRIF: Dysregulated S100A9 Expression Impairs Matrix Deposition
            in Chronic Wounds.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 573)
  AUTHORS   Ozbay Kurt,F.G., Cicortas,B.A., Balzasch,B.M., De la Torre,C.,
            Ast,V., Tavukcuoglu,E., Ak,C., Wohlfeil,S.A., Cerwenka,A.,
            Utikal,J. and Umansky,V.
  TITLE     S100A9 and HMGB1 orchestrate MDSC-mediated immunosuppression in
            melanoma through TLR4 signaling
  JOURNAL   J Immunother Cancer 12 (9), e009552 (2024)
   PUBMED   39266214
  REMARK    GeneRIF: S100A9 and HMGB1 orchestrate MDSC-mediated
            immunosuppression in melanoma through TLR4 signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 573)
  AUTHORS   Chen,J.M., He,J., Qiu,J.M., Yang,G.G., Wang,D. and Shen,Z.
  TITLE     Netrin-1-CD146 and netrin-1-S100A9 are associated with early stage
            of lymph node metastasis in colorectal cancer
  JOURNAL   BMC Gastroenterol 24 (1), 308 (2024)
   PUBMED   39261771
  REMARK    GeneRIF: Netrin-1-CD146 and netrin-1-S100A9 are associated with
            early stage of lymph node metastasis in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 573)
  AUTHORS   Ding,L., Lu,L., Zheng,S., Zhang,Z., Huang,X., Ma,R., Zhang,M.,
            Xu,Z., Chen,M., Guo,Z., Zhu,S., Gong,J., Mao,H., Zhang,W. and Xu,P.
  TITLE     Usp14 deficiency removes alpha-synuclein by regulating S100A8/A9 in
            Parkinson's disease
  JOURNAL   Cell Mol Life Sci 81 (1), 232 (2024)
   PUBMED   38780644
  REMARK    GeneRIF: Usp14 deficiency removes alpha-synuclein by regulating
            S100A8/A9 in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 573)
  AUTHORS   Lusitani,D., Malawista,S.E. and Montgomery,R.R.
  TITLE     Calprotectin, an abundant cytosolic protein from human
            polymorphonuclear leukocytes, inhibits the growth of Borrelia
            burgdorferi
  JOURNAL   Infect Immun 71 (8), 4711-4716 (2003)
   PUBMED   12874352
  REMARK    GeneRIF: Calprotectin, an antimicrobial peptide with antibacterial
            activity inhibits the growth of Borrelia burgdorferi.
REFERENCE   7  (bases 1 to 573)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   8  (bases 1 to 573)
  AUTHORS   Longbottom,D., Sallenave,J.M. and van Heyningen,V.
  TITLE     Subunit structure of calgranulins A and B obtained from sputum,
            plasma, granulocytes and cultured epithelial cells
  JOURNAL   Biochim Biophys Acta 1120 (2), 215-222 (1992)
   PUBMED   1562590
REFERENCE   9  (bases 1 to 573)
  AUTHORS   Dorin,J.R., Emslie,E. and van Heyningen,V.
  TITLE     Related calcium-binding proteins map to the same subregion of
            chromosome 1q and to an extended region of synteny on mouse
            chromosome 3
  JOURNAL   Genomics 8 (3), 420-426 (1990)
   PUBMED   2149559
REFERENCE   10 (bases 1 to 573)
  AUTHORS   Edgeworth,J., Freemont,P. and Hogg,N.
  TITLE     Ionomycin-regulated phosphorylation of the myeloid calcium-binding
            protein p14
  JOURNAL   Nature 342 (6246), 189-192 (1989)
   PUBMED   2478889
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X06233.1 and BC047681.2.
            
            On Nov 23, 2018 this sequence version replaced NM_002965.3.
            
            Summary: The protein encoded by this gene is a member of the S100
            family of proteins containing 2 EF-hand calcium-binding motifs.
            S100 proteins are localized in the cytoplasm and/or nucleus of a
            wide range of cells, and involved in the regulation of a number of
            cellular processes such as cell cycle progression and
            differentiation. S100 genes include at least 13 members which are
            located as a cluster on chromosome 1q21. This protein may function
            in the inhibition of casein kinase and altered expression of this
            protein is associated with the disease cystic fibrosis. This
            antimicrobial protein exhibits antifungal and antibacterial
            activity. [provided by RefSeq, Nov 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA620137.1, DA767554.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000368738.4/
                                                  ENSP00000357727.3
            Protein has antimicrobial activity :: PMID: 12874352
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                X06233.1           2-19
            19-573              BC047681.2         1-555
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..573
                     /gene="S100A9"
                     /gene_synonym="60B8AG; CAGB; CFAG; CGLB; L1AG; LIAG;
                     MAC387; MIF; MRP14; NIF; P14; S100-A9"
                     /note="S100 calcium binding protein A9"
                     /db_xref="GeneID:6280"
                     /db_xref="HGNC:HGNC:10499"
                     /db_xref="MIM:123886"
     exon            1..28
                     /gene="S100A9"
                     /gene_synonym="60B8AG; CAGB; CFAG; CGLB; L1AG; LIAG;
                     MAC387; MIF; MRP14; NIF; P14; S100-A9"
                     /inference="alignment:Splign:2.1.0"
     exon            29..193
                     /gene="S100A9"
                     /gene_synonym="60B8AG; CAGB; CFAG; CGLB; L1AG; LIAG;
                     MAC387; MIF; MRP14; NIF; P14; S100-A9"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..388
                     /gene="S100A9"
                     /gene_synonym="60B8AG; CAGB; CFAG; CGLB; L1AG; LIAG;
                     MAC387; MIF; MRP14; NIF; P14; S100-A9"
                     /note="calgranulin B; MRP-14; calprotectin L1H subunit;
                     leukocyte L1 complex heavy chain; migration inhibitory
                     factor-related protein 14"
                     /codon_start=1
                     /product="protein S100-A9"
                     /protein_id="NP_002956.1"
                     /db_xref="CCDS:CCDS1036.1"
                     /db_xref="GeneID:6280"
                     /db_xref="HGNC:HGNC:10499"
                     /db_xref="MIM:123886"
                     /translation="MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVRKD
                     LQNFLKKENKNEKVIEHIMEDLDTNADKQLSFEEFIMLMARLTWASHEKMHEGDEGPG
                     HHHKPGLGEGTP"
     exon            194..573
                     /gene="S100A9"
                     /gene_synonym="60B8AG; CAGB; CFAG; CGLB; L1AG; LIAG;
                     MAC387; MIF; MRP14; NIF; P14; S100-A9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      554..559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100A9"
                     /gene_synonym="60B8AG; CAGB; CFAG; CGLB; L1AG; LIAG;
                     MAC387; MIF; MRP14; NIF; P14; S100-A9"
                     /note="hexamer: AATAAA"
     polyA_site      573
                     /gene="S100A9"
                     /gene_synonym="60B8AG; CAGB; CFAG; CGLB; L1AG; LIAG;
                     MAC387; MIF; MRP14; NIF; P14; S100-A9"
                     /note="major polyA site"
ORIGIN      
        1 aaacactctg tgtggctcct cggctttgac agagtgcaag acgatgactt gcaaaatgtc
       61 gcagctggaa cgcaacatag agaccatcat caacaccttc caccaatact ctgtgaagct
      121 ggggcaccca gacaccctga accaggggga attcaaagag ctggtgcgaa aagatctgca
      181 aaattttctc aagaaggaga ataagaatga aaaggtcata gaacacatca tggaggacct
      241 ggacacaaat gcagacaagc agctgagctt cgaggagttc atcatgctga tggcgaggct
      301 aacctgggcc tcccacgaga agatgcacga gggtgacgag ggccctggcc accaccataa
      361 gccaggcctc ggggagggca ccccctaaga ccacagtggc caagatcaca gtggccacgg
      421 ccacggccac agtcatggtg gccacggcca cagccactaa tcaggaggcc aggccaccct
      481 gcctctaccc aaccagggcc ccggggcctg ttatgtcaaa ctgtcttggc tgtggggcta
      541 ggggctgggg ccaaataaag tctcttcctc caa
//
