LOCUS       NM_002964                408 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens S100 calcium binding protein A8 (S100A8), transcript
            variant 4, mRNA.
ACCESSION   NM_002964
VERSION     NM_002964.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 408)
  AUTHORS   Zhang,Y., Zhao,Y., Zhang,J., Gao,Y., Gao,X., Li,S., Chang,C. and
            Yang,G.
  TITLE     Proteomics of plasma-derived extracellular vesicles reveals S100A8
            as a novel biomarker for Alzheimer's disease: A preliminary study
  JOURNAL   J Proteomics 308, 105279 (2024)
   PUBMED   39159863
  REMARK    GeneRIF: Proteomics of plasma-derived extracellular vesicles
            reveals S100A8 as a novel biomarker for Alzheimer's disease: A
            preliminary study.
REFERENCE   2  (bases 1 to 408)
  AUTHORS   De Luca,G., Goette,N.P., Lev,P.R., Baroni Pietto,M.C., Marin
            Oyarzun,C.P., Castro Rios,M.A., Moiraghi,B., Sackmann,F.,
            Kamiya,L.J., Verri,V., Caula,V., Fernandez,V., Vicente,A., Pose
            Cabarcos,J., Caruso,V., Camacho,M.F., Larripa,I.B., Khoury,M.,
            Marta,R.F., Glembotsky,A.C. and Heller,P.G.
  TITLE     Elevated levels of damage-associated molecular patterns HMGB1 and
            S100A8/A9 coupled with toll-like receptor-triggered monocyte
            activation are associated with inflammation in patients with
            myelofibrosis
  JOURNAL   Front Immunol 15, 1365015 (2024)
   PUBMED   39391311
  REMARK    GeneRIF: Elevated levels of damage-associated molecular patterns
            HMGB1 and S100A8/A9 coupled with toll-like receptor-triggered
            monocyte activation are associated with inflammation in patients
            with myelofibrosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 408)
  AUTHORS   Ding,L., Lu,L., Zheng,S., Zhang,Z., Huang,X., Ma,R., Zhang,M.,
            Xu,Z., Chen,M., Guo,Z., Zhu,S., Gong,J., Mao,H., Zhang,W. and Xu,P.
  TITLE     Usp14 deficiency removes alpha-synuclein by regulating S100A8/A9 in
            Parkinson's disease
  JOURNAL   Cell Mol Life Sci 81 (1), 232 (2024)
   PUBMED   38780644
  REMARK    GeneRIF: Usp14 deficiency removes alpha-synuclein by regulating
            S100A8/A9 in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 408)
  AUTHORS   Munoz-Grajales,C., Barraclough,M.L., Diaz-Martinez,J.P., Su,J.,
            Bingham,K., Kakvan,M., Kretzmann,R.P., Tartaglia,M.C., Ruttan,L.,
            Choi,M.Y., Appenzeller,S., Marzouk,S., Bonilla,D., Katz,P.,
            Beaton,D., Green,R., Gladman,D.D., Wither,J. and Touma,Z.
  TITLE     Serum S100A8/A9 and MMP-9 levels are elevated in systemic lupus
            erythematosus patients with cognitive impairment
  JOURNAL   Front Immunol 14, 1326751 (2024)
   PUBMED   38332909
  REMARK    GeneRIF: Serum S100A8/A9 and MMP-9 levels are elevated in systemic
            lupus erythematosus patients with cognitive impairment.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 408)
  AUTHORS   Cho,S.B., Kim,I.K., Yeo,C.D. and Lee,S.H.
  TITLE     Association Between Clinicopathological Parameters and S100A8/A9
            Expression According to Smoking History in Patients With Non-small
            Cell Lung Cancer
  JOURNAL   In Vivo 38 (1), 474-481 (2024)
   PUBMED   38148054
  REMARK    GeneRIF: Association Between Clinicopathological Parameters and
            S100A8/A9 Expression According to Smoking History in Patients With
            Non-small Cell Lung Cancer.
REFERENCE   6  (bases 1 to 408)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   7  (bases 1 to 408)
  AUTHORS   Lemarchand,P., Vaglio,M., Mauel,J. and Markert,M.
  TITLE     Translocation of a small cytosolic calcium-binding protein (MRP-8)
            to plasma membrane correlates with human neutrophil activation
  JOURNAL   J Biol Chem 267 (27), 19379-19382 (1992)
   PUBMED   1326551
REFERENCE   8  (bases 1 to 408)
  AUTHORS   Schafer,T., Sachse,G.E. and Gassen,H.G.
  TITLE     The calcium-binding protein MRP-8 is produced by human pulmonary
            tumor cells
  JOURNAL   Biol Chem Hoppe Seyler 372 (1), 1-4 (1991)
   PUBMED   2039599
REFERENCE   9  (bases 1 to 408)
  AUTHORS   Dorin,J.R., Emslie,E. and van Heyningen,V.
  TITLE     Related calcium-binding proteins map to the same subregion of
            chromosome 1q and to an extended region of synteny on mouse
            chromosome 3
  JOURNAL   Genomics 8 (3), 420-426 (1990)
   PUBMED   2149559
REFERENCE   10 (bases 1 to 408)
  AUTHORS   Wilkinson,M.M., Busuttil,A., Hayward,C., Brock,D.J., Dorin,J.R. and
            Van Heyningen,V.
  TITLE     Expression pattern of two related cystic fibrosis-associated
            calcium-binding proteins in normal and abnormal tissues
  JOURNAL   J Cell Sci 91 (Pt 2), 221-230 (1988)
   PUBMED   3267695
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291328.1 and X06234.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002964.4.
            
            Summary: The protein encoded by this gene is a member of the S100
            family of proteins containing 2 EF-hand calcium-binding motifs.
            S100 proteins are localized in the cytoplasm and/or nucleus of a
            wide range of cells, and involved in the regulation of a number of
            cellular processes such as cell cycle progression and
            differentiation. S100 genes include at least 13 members which are
            located as a cluster on chromosome 1q21. This protein may function
            in the inhibition of casein kinase and as a cytokine. Altered
            expression of this protein is associated with the disease cystic
            fibrosis. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (4) uses an alternate splice
            junction compared to variant 1. The resulting isoform (d) is
            shorter at the N-terminus compared to isoform a. Variants 4 and 5
            both encode the same isoform (d).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X06234.1, BP225716.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368733.4/ ENSP00000357722.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-406               AK291328.1         1-406
            407-408             X06234.1           408-409
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..408
                     /gene="S100A8"
                     /gene_synonym="60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag;
                     MA387; MIF; MRP8; NIF; P8; S100-A8"
                     /note="S100 calcium binding protein A8"
                     /db_xref="GeneID:6279"
                     /db_xref="HGNC:HGNC:10498"
                     /db_xref="MIM:123885"
     exon            1..33
                     /gene="S100A8"
                     /gene_synonym="60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag;
                     MA387; MIF; MRP8; NIF; P8; S100-A8"
                     /inference="alignment:Splign:2.1.0"
     exon            34..196
                     /gene="S100A8"
                     /gene_synonym="60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag;
                     MA387; MIF; MRP8; NIF; P8; S100-A8"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..337
                     /gene="S100A8"
                     /gene_synonym="60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag;
                     MA387; MIF; MRP8; NIF; P8; S100-A8"
                     /note="isoform d is encoded by transcript variant 4;
                     protein S100-A8; calgranulin A; cystic fibrosis antigen;
                     calprotectin L1L subunit; urinary stone protein band A;
                     leukocyte L1 complex light chain; migration inhibitory
                     factor-related protein 8"
                     /codon_start=1
                     /product="protein S100-A8 isoform d"
                     /protein_id="NP_002955.2"
                     /db_xref="CCDS:CCDS1038.1"
                     /db_xref="GeneID:6279"
                     /db_xref="HGNC:HGNC:10498"
                     /db_xref="MIM:123885"
                     /translation="MLTELEKALNSIIDVYHKYSLIKGNFHAVYRDDLKKLLETECPQ
                     YIRKKGADVWFKELDINTDGAVNFQEFLILVIKMGVAAHKKSHEESHKE"
     exon            197..408
                     /gene="S100A8"
                     /gene_synonym="60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag;
                     MA387; MIF; MRP8; NIF; P8; S100-A8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      388..393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100A8"
                     /gene_synonym="60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag;
                     MA387; MIF; MRP8; NIF; P8; S100-A8"
                     /note="hexamer: AATAAA"
     polyA_site      408
                     /gene="S100A8"
                     /gene_synonym="60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag;
                     MA387; MIF; MRP8; NIF; P8; S100-A8"
                     /note="major polyA site"
ORIGIN      
        1 atgtctcttg tcagctgtct ttcagaagac ctggtggggc aagtccgtgg gcatcatgtt
       61 gaccgagctg gagaaagcct tgaactctat catcgacgtc taccacaagt actccctgat
      121 aaaggggaat ttccatgccg tctacaggga tgacctgaag aaattgctag agaccgagtg
      181 tcctcagtat atcaggaaaa agggtgcaga cgtctggttc aaagagttgg atatcaacac
      241 tgatggtgca gttaacttcc aggagttcct cattctggtg ataaagatgg gcgtggcagc
      301 ccacaaaaaa agccatgaag aaagccacaa agagtagctg agttactggg cccagaggct
      361 gggcccctgg acatgtacct gcagaataat aaagtcatca atacctca
//
