LOCUS       NM_176823               4280 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens S100 calcium binding protein A7A (S100A7A), mRNA.
ACCESSION   NM_176823
VERSION     NM_176823.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4280)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4280)
  AUTHORS   Murray,J.I., Tonkin,M.L., Whiting,A.L., Peng,F., Farnell,B.,
            Cullen,J.T., Hof,F. and Boulanger,M.J.
  TITLE     Structural characterization of S100A15 reveals a novel zinc
            coordination site among S100 proteins and altered surface chemistry
            with functional implications for receptor binding
  JOURNAL   BMC Struct Biol 12, 16 (2012)
   PUBMED   22747601
  REMARK    GeneRIF: S100A15 retains the ability to coordinate zinc through
            incorporation of an exogenous ligand resulting in a unique
            zinc-binding site among S100 proteins.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4280)
  AUTHORS   Wolf,R., Mascia,F., Dharamsi,A., Howard,O.M., Cataisson,C.,
            Bliskovski,V., Winston,J., Feigenbaum,L., Lichti,U., Ruzicka,T.,
            Chavakis,T. and Yuspa,S.H.
  TITLE     Gene from a psoriasis susceptibility locus primes the skin for
            inflammation
  JOURNAL   Sci Transl Med 2 (61), 61ra90 (2010)
   PUBMED   21148126
REFERENCE   4  (bases 1 to 4280)
  AUTHORS   Wolf,R., Howard,O.M., Dong,H.F., Voscopoulos,C., Boeshans,K.,
            Winston,J., Divi,R., Gunsior,M., Goldsmith,P., Ahvazi,B.,
            Chavakis,T., Oppenheim,J.J. and Yuspa,S.H.
  TITLE     Chemotactic activity of S100A7 (Psoriasin) is mediated by the
            receptor for advanced glycation end products and potentiates
            inflammation with highly homologous but functionally distinct
            S100A15
  JOURNAL   J Immunol 181 (2), 1499-1506 (2008)
   PUBMED   18606705
  REMARK    GeneRIF: study defines RAGE (receptor for advanced glycation end
            products) as the hS100A7 receptor, whereas hS100A15 functions
            through a Gi protein-coupled receptor
REFERENCE   5  (bases 1 to 4280)
  AUTHORS   Buchau,A.S., Hassan,M., Kukova,G., Lewerenz,V., Kellermann,S.,
            Wurthner,J.U., Wolf,R., Walz,M., Gallo,R.L. and Ruzicka,T.
  TITLE     S100A15, an antimicrobial protein of the skin: regulation by E.
            coli through Toll-like receptor 4
  JOURNAL   J Invest Dermatol 127 (11), 2596-2604 (2007)
   PUBMED   17625598
  REMARK    GeneRIF: E. coli modulates S100A15 and IL-8 expression of
            keratinocytes by recognition through TLR4.
REFERENCE   6  (bases 1 to 4280)
  AUTHORS   Boeshans,K.M., Wolf,R., Voscopoulos,C., Gillette,W., Esposito,D.,
            Mueser,T.C., Yuspa,S.H. and Ahvazi,B.
  TITLE     Purification, crystallization and preliminary X-ray diffraction of
            human S100A15
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 62 (Pt 5), 467-470
            (2006)
   PUBMED   16682778
  REMARK    GeneRIF: The S100A15 protein has been expressed & purified to
            homogeneity in 2 crystal forms. Crystals of form I are triclinic.
            Crystals of form II are monoclinic & have a solvent content of
            51.8%, corresponding to the presence of 1 monomer in the asymmetric
            unit.
REFERENCE   7  (bases 1 to 4280)
  AUTHORS   Wolf,R., Mirmohammadsadegh,A., Walz,M., Lysa,B., Tartler,U.,
            Remus,R., Hengge,U., Michel,G. and Ruzicka,T.
  TITLE     Molecular cloning and characterization of alternatively spliced
            mRNA isoforms from psoriatic skin encoding a novel member of the
            S100 family
  JOURNAL   FASEB J 17 (13), 1969-1971 (2003)
   PUBMED   12923069
  REMARK    GeneRIF: Molecular cloning and characterization of alternatively
            spliced S100A15 isoforms from psoriatic skin.
REFERENCE   8  (bases 1 to 4280)
  AUTHORS   Kulski,J.K., Lim,C.P., Dunn,D.S. and Bellgard,M.
  TITLE     Genomic and phylogenetic analysis of the S100A7 (Psoriasin) gene
            duplications within the region of the S100 gene cluster on human
            chromosome 1q21
  JOURNAL   J Mol Evol 56 (4), 397-406 (2003)
   PUBMED   12664160
REFERENCE   9  (bases 1 to 4280)
  AUTHORS   Marenholz,I., Zirra,M., Fischer,D.F., Backendorf,C., Ziegler,A. and
            Mischke,D.
  TITLE     Identification of human epidermal differentiation complex
            (EDC)-encoded genes by subtractive hybridization of entire YACs to
            a gridded keratinocyte cDNA library
  JOURNAL   Genome Res 11 (3), 341-355 (2001)
   PUBMED   11230159
REFERENCE   10 (bases 1 to 4280)
  AUTHORS   Madsen,P., Rasmussen,H.H., Leffers,H., Honore,B., Dejgaard,K.,
            Olsen,E., Kiil,J., Walbum,E., Andersen,A.H., Basse,B. et al.
  TITLE     Molecular cloning, occurrence, and expression of a novel partially
            secreted protein 'psoriasin' that is highly up-regulated in
            psoriatic skin
  JOURNAL   J Invest Dermatol 97 (4), 701-712 (1991)
   PUBMED   1940442
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591704.7, AY189118.1 and AJ243672.2.
            
            On Nov 22, 2018 this sequence version replaced NM_176823.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY189118.1, AY189119.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368729.9/ ENSP00000357718.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL591704.7         112160-112163
            5-1942              AY189118.1         1-1938
            1943-4280           AJ243672.2         68-2405
FEATURES             Location/Qualifiers
     source          1..4280
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..4280
                     /gene="S100A7A"
                     /gene_synonym="NICE-2; NICE2; S100A15; S100A7f; S100A7L1"
                     /note="S100 calcium binding protein A7A"
                     /db_xref="GeneID:338324"
                     /db_xref="HGNC:HGNC:21657"
                     /db_xref="MIM:617427"
     exon            1..44
                     /gene="S100A7A"
                     /gene_synonym="NICE-2; NICE2; S100A15; S100A7f; S100A7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            45..202
                     /gene="S100A7A"
                     /gene_synonym="NICE-2; NICE2; S100A15; S100A7f; S100A7L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..367
                     /gene="S100A7A"
                     /gene_synonym="NICE-2; NICE2; S100A15; S100A7f; S100A7L1"
                     /note="S100 calcium-binding protein A15; S100
                     calcium-binding protein A7-like 1; koebnerisin"
                     /codon_start=1
                     /product="protein S100-A7A"
                     /protein_id="NP_789793.1"
                     /db_xref="CCDS:CCDS30872.1"
                     /db_xref="GeneID:338324"
                     /db_xref="HGNC:HGNC:21657"
                     /db_xref="MIM:617427"
                     /translation="MSNTQAERSIIGMIDMFHKYTGRDGKIEKPSLLTMMKENFPNFL
                     SACDKKGIHYLATVFEKKDKNEDKKIDFSEFLSLLGDIAADYHKQSHGAAPCSGGSQ"
     exon            203..4280
                     /gene="S100A7A"
                     /gene_synonym="NICE-2; NICE2; S100A15; S100A7f; S100A7L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2548..2553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100A7A"
                     /gene_synonym="NICE-2; NICE2; S100A15; S100A7f; S100A7L1"
                     /note="hexamer: TATAAA"
     polyA_site      2568
                     /gene="S100A7A"
                     /gene_synonym="NICE-2; NICE2; S100A15; S100A7f; S100A7L1"
                     /note="major polyA site"
     regulatory      4258..4263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100A7A"
                     /gene_synonym="NICE-2; NICE2; S100A15; S100A7f; S100A7L1"
                     /note="hexamer: ATTAAA"
     polyA_site      4280
                     /gene="S100A7A"
                     /gene_synonym="NICE-2; NICE2; S100A15; S100A7f; S100A7L1"
                     /note="major polyA site"
ORIGIN      
        1 acacatctca ctcatccttc tactcgtgac acttcccagt tctggctttt tgaaagcaaa
       61 gatgagcaac actcaagctg agaggtccat aataggcatg atcgacatgt ttcacaaata
      121 caccggacgt gatggcaaga ttgagaagcc aagcctgctg acgatgatga aggagaactt
      181 ccccaatttc ctcagtgcct gtgacaaaaa gggcatacat tacctcgcca ctgtctttga
      241 gaaaaaggac aagaatgagg ataagaagat tgatttttct gagtttctgt ccttgctggg
      301 agacatagcc gcagactacc acaagcagag ccatggagcg gcgccctgtt ctgggggaag
      361 ccagtgatcc agccccacca aggggcctcc agagacccca ggaacaataa gtgtctcctc
      421 ccaccagaca cttgccttat ttcttcttct ctttggtgac ctacattgtc aaaactacca
      481 attccaggtt aactttgttg gagaatttcc cccaccccca tccagtgggt cacccaggag
      541 taatgtccct ccagcaacgt tccccctatg gcctccagca gagctgatct gcctctcaca
      601 caggtcctgg tgtctgcctc tgcaccgttc cctaaatgca gccaccttgg caggttccag
      661 gtggaagttg gtagaaggcc cctgccaggt cacagcaatg ctctccttgt caaggcatgg
      721 accagggtca ttcagacaca ttcagatact gcactgagaa ggagctggca tctctcagtg
      781 tgctcctgcc ctcccactcc tgccccagct gttctccagg gcttggggaa acagaaacca
      841 ctcacatagg gattcctgga tggcttcagg ttcagcgccc ttggggctat gaatgggagg
      901 ctcagcagtg ccctgaggat gggcttcctt gtcctgtggc ctctgctcca ggggcagtgt
      961 cctttccctg tgctgtgtgc ttgtgtgcat gtgcctatgt gggtgaccct gtggaagtga
     1021 gaaggagtca ctgtgatgct tagctgtcct aaatgatggt ttgctcaatg ccaggactgg
     1081 gtttctggtg atgaatgaat attccagatt ttgaggagct ctaagtggtc caggagtcca
     1141 agtaagcagt ctggctggaa taaggcagca tcacggaaat tctgtaagga ctgacacaga
     1201 gagctcatgc tgactgtgat gagaaattgc agcacctcta tctcgcaggt aatggagtag
     1261 tttgttattg gtagtctact ccaggccagg cagtgtgtta tgggctgagg atgcagaaac
     1321 aggcaggaca cagtgctgtc ctagcagtgc actggcgggt ctctccatgc aggccacaac
     1381 acagggtcag tgttcacctg gtgtcacttc caggcaatgt tctgtgcagc cgctcttagt
     1441 attcttcctt gaggctcaca tcatgtgtcc ctatcactct tactactctg gtcagtctcc
     1501 agctaacctc tcaatcaggc aaacattctt cttggaggaa tcaggcaaac atctcaaaaa
     1561 ttctctttcc atcctaccag cagcagtgtg taagatgggc tatttgttct ttggaatgac
     1621 tgctccactc cacactcaca cctctattca cagaccagca tctcctctcc ttatcaggaa
     1681 cattccttcc tgaacatatt ctgcacctcg tcagccttca ggactgatct gccattttca
     1741 cctctaaatc cccatgtctg accattagtt ttcttctctt tccttctctc cctttctcat
     1801 tctcattcca cctgttcttg gaactcacgg agacctacag tccctgggct ttcattttct
     1861 cctcccagcc ccctgctgcc ttctctatgc agcctgccct ccatcatcca ccccagaatt
     1921 gctctctttc ctctcttagc tctgttgccc actttccttg ggccatacct tccctgcaga
     1981 tctccagccc agaaccatct tcccctgttg tcctcctctc tcctccaccg ggactgctgg
     2041 tcactgctta gaaccgtcat gccagggtcc caaaagtgtg ggtgcctgac ttcctctctg
     2101 tgcagcactc tctgaatccc tcctattcac cttgctgctg ttattccccg aatgcgcaac
     2161 atacccccca tcaatatatc tcagtatttc atgtctcaat accaatcttt taaactactg
     2221 cctctaccag aaatgtcttt taatacttct tctgtctcat taacattaca tttcaaggct
     2281 gagctttaat gtcagtgtct cttagacatt cagagggtga accaccatcc cttcacccca
     2341 aagaaatgat ctctgcttca tttgtgcctc cctcaccatg accccactct taccatagtg
     2401 gctacattac ttcagattcc cctaatgtct ttccagccag acttggaatc atggagggaa
     2461 aacattgtta cctcggatct cctggttacc cagcacatag tagtactgga ttccagctca
     2521 taataagtac tctatatcat ttttcaatat aaaatgtatt tgtgcaaatt ctagtcaata
     2581 ctactttatg taaacagcag tgtaaaatcc aaaaacttcc agtcctggag gcaggttgtg
     2641 cagcttaggg gaggacccca gaatctggac cccagagtct ggaagcaggc cagaaaggat
     2701 aaggcaaatg actgaacagt tccctcagga ctcacgtact gatctcccaa aagaagagag
     2761 ggtctccctg gggtggggtt gctggacctt caatccatcg ctacagtcca gaaggcaatt
     2821 ggccactcct aatgtgggcc tgccctccct ttatttttcc agttcttatt tcacctgata
     2881 atattccgtc caattggcaa tggcacataa aaattaggat ggagtgtgtg gacaaatact
     2941 tcttcatctt cttgtctagg ttttagaaat caccttctca agggagcctt gtctaatgtt
     3001 cctgagacta tttcacactc tccatgctta tgtcaatgca ggactcatca catctattcg
     3061 gatattctgt ttacacaccc atgtcatccc agagaggtga tcacagggca gggacacatg
     3121 tgtggcatac agttcctagt taagatccca aatcctgaga tattgctgat ttgctatggc
     3181 aggtcgtcaa gagaactgtg tcattccaaa ctcaccaagg tggcttatag aacagaagca
     3241 gatggatatg aagaggagag gggaccagac catctccgca accacagccc agagctccag
     3301 tcaccagata gaaaattgat ttgatttcat ccaatattcc ttcgaaagag tgtcaaggaa
     3361 tagggtgggg caatgtgtca ttctgcattg gaaggaggac attttagagc aaggcctaag
     3421 ggcacaggta ttagtgtcat attgatcaga attcaacctt tgttctaaca catactagag
     3481 caagaattta cttgatttgg aataattaat agctactgga cattatattg gtactaaaga
     3541 gaaagaatac ttgacagctc tatgcccaca ctcacattac agctgatgtg aaagagattc
     3601 tggaaatcca aatgttcccc agaaattctg atatcaaaac attccaataa cttttttttt
     3661 tcaggcgcag tctcactctg tcgcccgggc tggagtgctg tgagctgtcc gtggtgctga
     3721 attcactgtg acgtcactcc tgtctctctt tgctttcttc tgactgacat ttattcagcc
     3781 ttctctacag gaatctctta tgttccccca catgcaggtg gtttttcagt aggctcctga
     3841 agagtgatct caactttcca ggaagaaaag agggcaaagg gaacaatgtg aaaagaagca
     3901 gaaaatcata aaagaccatg tgtttgataa acaaccagat tgtttctggt tccctgccac
     3961 tataaaaaca ccatgagagc atactcatac atgttccctt ataaatctgc gaggtagttt
     4021 ctttggtatt cttgcccagg aaatgggttg attcatcaca gattttatat atatactttt
     4081 ttttaactaa gtgtgagata atatcttatt gtttttgtaa cttgcatttt acaagagttc
     4141 tgaccagcac cagataagct tcagtgctct cctttctttg gccttaatat tattggatta
     4201 aagaattact gcctctcact aggagcatca tttatttacc attattttca atttcatatt
     4261 aaaactcaat ttctagtaga
//
