LOCUS       NM_002963                429 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens S100 calcium binding protein A7 (S100A7), mRNA.
ACCESSION   NM_002963
VERSION     NM_002963.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 429)
  AUTHORS   Kurtovic,M., Pitesa,N., Conkas,J., Hajpek,H., Vucic,M., Musani,V.,
            Ozretic,P. and Sabol,M.
  TITLE     GLI Transcriptional Targets S100A7 and KRT16 Show Upregulated
            Expression Patterns in Epidermis Overlying the Tumor Mass in
            Melanoma Samples
  JOURNAL   Int J Mol Sci 25 (11), 6084 (2024)
   PUBMED   38892279
  REMARK    GeneRIF: GLI Transcriptional Targets S100A7 and KRT16 Show
            Upregulated Expression Patterns in Epidermis Overlying the Tumor
            Mass in Melanoma Samples.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 429)
  AUTHORS   Stolte,K.N., Danker,K., Witt,M., Ebhardt,H. and Dommisch,H.
  TITLE     Upregulation of psoriasin/S100A7 correlates with clinical severity
            in patients with oral lichen planus
  JOURNAL   Clin Oral Investig 28 (6), 318 (2024)
   PUBMED   38750317
  REMARK    GeneRIF: Upregulation of psoriasin/S100A7 correlates with clinical
            severity in patients with oral lichen planus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 429)
  AUTHORS   Li,Y., Yang,X., Jin,T., Li,Q., Li,X. and Ma,L.
  TITLE     Correlation between S100A7 and immune characteristics, methylation,
            tumor stemness and tumor heterogeneity in pan-cancer and its role
            in chemotherapy resistance in breast cancer
  JOURNAL   Aging (Albany NY) 16 (6), 5581-5600 (2024)
   PUBMED   38499391
  REMARK    GeneRIF: Correlation between S100A7 and immune characteristics,
            methylation, tumor stemness and tumor heterogeneity in pan-cancer
            and its role in chemotherapy resistance in breast cancer.
REFERENCE   4  (bases 1 to 429)
  AUTHORS   Reddi,K.K., Zhang,W., Shahrabi-Farahani,S., Anderson,K.M., Liu,M.,
            Kakhniashvili,D., Wang,X. and Zhang,Y.H.
  TITLE     Tetraspanin CD82 Correlates with and May Regulate S100A7 Expression
            in Oral Cancer
  JOURNAL   Int J Mol Sci 25 (5), 2659 (2024)
   PUBMED   38473906
  REMARK    GeneRIF: Tetraspanin CD82 Correlates with and May Regulate S100A7
            Expression in Oral Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 429)
  AUTHORS   Wang,H., Liu,J., Tang,R., Hu,J., Liu,M., Wang,J., Zhang,J. and
            Hou,H.
  TITLE     Deciphering the significance of anoikis in bladder cancer and
            systematic analysis of S100A7 as a potential therapeutic target
  JOURNAL   Eur J Med Res 29 (1), 52 (2024)
   PUBMED   38217031
  REMARK    GeneRIF: Deciphering the significance of anoikis in bladder cancer
            and systematic analysis of S100A7 as a potential therapeutic
            target.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 429)
  AUTHORS   Hattori,F., Kiatsurayanon,C., Okumura,K., Ogawa,H., Ikeda,S.,
            Okamoto,K. and Niyonsaba,F.
  TITLE     The antimicrobial protein S100A7/psoriasin enhances the expression
            of keratinocyte differentiation markers and strengthens the skin's
            tight junction barrier
  JOURNAL   Br J Dermatol 171 (4), 742-753 (2014)
   PUBMED   24842328
  REMARK    GeneRIF: The antimicrobial peptide psoriasin has immunoregulatory
            activities and is involved in skin innate immunity.
REFERENCE   7  (bases 1 to 429)
  AUTHORS   Schafer,B.W., Wicki,R., Engelkamp,D., Mattei,M.G. and Heizmann,C.W.
  TITLE     Isolation of a YAC clone covering a cluster of nine S100 genes on
            human chromosome 1q21: rationale for a new nomenclature of the S100
            calcium-binding protein family
  JOURNAL   Genomics 25 (3), 638-643 (1995)
   PUBMED   7759097
REFERENCE   8  (bases 1 to 429)
  AUTHORS   Hoffmann,H.J., Olsen,E., Etzerodt,M., Madsen,P., Thogersen,H.C.,
            Kruse,T. and Celis,J.E.
  TITLE     Psoriasin binds calcium and is upregulated by calcium to levels
            that resemble those observed in normal skin
  JOURNAL   J Invest Dermatol 103 (3), 370-375 (1994)
   PUBMED   8077703
REFERENCE   9  (bases 1 to 429)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   10 (bases 1 to 429)
  AUTHORS   Madsen,P., Rasmussen,H.H., Leffers,H., Honore,B., Dejgaard,K.,
            Olsen,E., Kiil,J., Walbum,E., Andersen,A.H., Basse,B. et al.
  TITLE     Molecular cloning, occurrence, and expression of a novel partially
            secreted protein 'psoriasin' that is highly up-regulated in
            psoriatic skin
  JOURNAL   J Invest Dermatol 97 (4), 701-712 (1991)
   PUBMED   1940442
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF090388.1, AW238300.1 and
            BX476368.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002963.3.
            
            Summary: The protein encoded by this gene is a member of the S100
            family of proteins containing 2 EF-hand calcium-binding motifs.
            S100 proteins are localized in the cytoplasm and/or nucleus of a
            wide range of cells, and involved in the regulation of a number of
            cellular processes such as cell cycle progression and
            differentiation. S100 genes include at least 13 members which are
            located as a cluster on chromosome 1q21. This protein differs from
            the other S100 proteins of known structure in its lack of calcium
            binding ability in one EF-hand at the N-terminus. The protein is
            overexpressed in hyperproliferative skin diseases, exhibits
            antimicrobial activities against bacteria and induces
            immunomodulatory activities. [provided by RefSeq, Nov 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX280362.1, BX476368.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000368723.4/
                                                  ENSP00000357712.3
            Protein has antimicrobial activity :: PMID: 24842328
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               BF090388.1         62-205
            145-239             AW238300.1         232-326             c
            240-429             BX476368.1         211-400
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..429
                     /gene="S100A7"
                     /gene_synonym="PSOR1; S100A7c"
                     /note="S100 calcium binding protein A7"
                     /db_xref="GeneID:6278"
                     /db_xref="HGNC:HGNC:10497"
                     /db_xref="MIM:600353"
     exon            1..44
                     /gene="S100A7"
                     /gene_synonym="PSOR1; S100A7c"
                     /inference="alignment:Splign:2.1.0"
     exon            45..202
                     /gene="S100A7"
                     /gene_synonym="PSOR1; S100A7c"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..367
                     /gene="S100A7"
                     /gene_synonym="PSOR1; S100A7c"
                     /note="psoriasin 1"
                     /codon_start=1
                     /product="protein S100-A7"
                     /protein_id="NP_002954.2"
                     /db_xref="CCDS:CCDS1039.1"
                     /db_xref="GeneID:6278"
                     /db_xref="HGNC:HGNC:10497"
                     /db_xref="MIM:600353"
                     /translation="MSNTQAERSIIGMIDMFHKYTRRDDKIEKPSLLTMMKENFPNFL
                     SACDKKGTNYLADVFEKKDKNEDKKIDFSEFLSLLGDIATDYHKQSHGAAPCSGGSQ"
     exon            203..429
                     /gene="S100A7"
                     /gene_synonym="PSOR1; S100A7c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      406..411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100A7"
                     /gene_synonym="PSOR1; S100A7c"
                     /note="hexamer: AATAAA"
     polyA_site      429
                     /gene="S100A7"
                     /gene_synonym="PSOR1; S100A7c"
                     /note="major polyA site"
ORIGIN      
        1 acacatctca ctcatccttc tactcgtgac gcttcccagc tctggctttt tgaaagcaaa
       61 gatgagcaac actcaagctg agaggtccat aataggcatg atcgacatgt ttcacaaata
      121 caccagacgt gatgacaaga ttgagaagcc aagcctgctg acgatgatga aggagaactt
      181 ccccaacttc cttagtgcct gtgacaaaaa gggcacaaat tacctcgccg atgtctttga
      241 gaaaaaggac aagaatgagg ataagaagat tgatttttct gagtttctgt ccttgctggg
      301 agacatagcc acagactacc acaagcagag ccatggagca gcgccctgtt ccgggggcag
      361 ccagtgaccc agccccacca atgggcctcc agagacccca ggaacaataa aatgtcttct
      421 cccaccaga
//
