LOCUS       NM_014624                434 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens S100 calcium binding protein A6 (S100A6), mRNA.
ACCESSION   NM_014624
VERSION     NM_014624.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 434)
  AUTHORS   Yang,F., Duan,Y., Li,Y., Zhu,D., Wang,Z., Luo,Z., Zhang,Y.,
            Zhang,G., He,X. and Kang,X.
  TITLE     S100A6 Regulates nucleus pulposus cell apoptosis via
            Wnt/beta-catenin signaling pathway: an in vitro and in vivo study
  JOURNAL   Mol Med 30 (1), 87 (2024)
   PUBMED   38877413
  REMARK    GeneRIF: S100A6 Regulates nucleus pulposus cell apoptosis via
            Wnt/beta-catenin signaling pathway: an in vitro and in vivo study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 434)
  AUTHORS   Chen,T., Ruan,Y., Ji,L., Cai,J., Tong,M., Xue,Y., Zhao,H., Cai,X.
            and Xu,J.
  TITLE     S100A6 drives lymphatic metastasis of liver cancer via activation
            of the RAGE/NF-kB/VEGF-D pathway
  JOURNAL   Cancer Lett 587, 216709 (2024)
   PUBMED   38350547
  REMARK    GeneRIF: S100A6 drives lymphatic metastasis of liver cancer via
            activation of the RAGE/NF-kB/VEGF-D pathway.
REFERENCE   3  (bases 1 to 434)
  AUTHORS   Zhou,R., Pei,B., Li,X. and Zhang,X.
  TITLE     Involvement of S100A6/S100A11 in T-Cell Immune Regulatory in HCC
            Revealed by Single Cell RNA-seq
  JOURNAL   Technol Cancer Res Treat 23, 15330338241252610 (2024)
   PUBMED   38766816
  REMARK    GeneRIF: Involvement of S100A6/S100A11 in T-Cell Immune Regulatory
            in HCC Revealed by Single Cell RNA-seq.
REFERENCE   4  (bases 1 to 434)
  AUTHORS   Kazakov,A.S., Deryusheva,E.I., Rastrygina,V.A., Sokolov,A.S.,
            Permyakova,M.E., Litus,E.A., Uversky,V.N., Permyakov,E.A. and
            Permyakov,S.E.
  TITLE     Interaction of S100A6 Protein with the Four-Helical Cytokines
  JOURNAL   Biomolecules 13 (9), 1345 (2023)
   PUBMED   37759746
  REMARK    GeneRIF: Interaction of S100A6 Protein with the Four-Helical
            Cytokines.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 434)
  AUTHORS   Du,Q., Zhu,T., Wen,G., Jin,H., An,J., Xu,J., Xie,R., Zhu,J.,
            Yang,X., Zhang,T., Liu,Q., Yao,S., Yang,X., Tuo,B. and Ma,X.
  TITLE     The S100 calcium-binding protein A6 plays a crucial role in hepatic
            steatosis by mediating lipophagy
  JOURNAL   Hepatol Commun 7 (9), e0232 (2023)
   PUBMED   37655980
  REMARK    GeneRIF: The S100 calcium-binding protein A6 plays a crucial role
            in hepatic steatosis by mediating lipophagy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 434)
  AUTHORS   Tomida,Y., Terasawa,M., Kobayashi,R. and Hidaka,H.
  TITLE     Calcyclin and calvasculin exist in human platelets
  JOURNAL   Biochem Biophys Res Commun 189 (3), 1310-1316 (1992)
   PUBMED   1482346
REFERENCE   7  (bases 1 to 434)
  AUTHORS   Engelkamp,D., Schafer,B.W., Erne,P. and Heizmann,C.W.
  TITLE     S100 alpha, CAPL, and CACY: molecular cloning and expression
            analysis of three calcium-binding proteins from human heart
  JOURNAL   Biochemistry 31 (42), 10258-10264 (1992)
   PUBMED   1384693
REFERENCE   8  (bases 1 to 434)
  AUTHORS   Minami,H., Tokumitsu,H., Mizutani,A., Watanabe,Y., Watanabe,M. and
            Hidaka,H.
  TITLE     Specific binding of CAP-50 to calcyclin
  JOURNAL   FEBS Lett 305 (3), 217-219 (1992)
   PUBMED   1299619
REFERENCE   9  (bases 1 to 434)
  AUTHORS   Filipek,A., Gerke,V., Weber,K. and Kuznicki,J.
  TITLE     Characterization of the cell-cycle-regulated protein calcyclin from
            Ehrlich ascites tumor cells. Identification of two binding proteins
            obtained by Ca2(+)-dependent affinity chromatography
  JOURNAL   Eur J Biochem 195 (3), 795-800 (1991)
   PUBMED   1999197
REFERENCE   10 (bases 1 to 434)
  AUTHORS   Murphy,L.C., Murphy,L.J., Tsuyuki,D., Duckworth,M.L. and Shiu,R.P.
  TITLE     Cloning and characterization of a cDNA encoding a highly conserved,
            putative calcium binding protein, identified by an anti-prolactin
            receptor antiserum
  JOURNAL   J Biol Chem 263 (5), 2397-2401 (1988)
   PUBMED   2448309
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC001431.2 and BX470102.12.
            
            On Nov 22, 2018 this sequence version replaced NM_014624.3.
            
            Summary: The protein encoded by this gene is a member of the S100
            family of proteins containing 2 EF-hand calcium-binding motifs.
            S100 proteins are localized in the cytoplasm and/or nucleus of a
            wide range of cells, and involved in the regulation of a number of
            cellular processes such as cell cycle progression and
            differentiation. S100 genes include at least 13 members which are
            located as a cluster on chromosome 1q21. This protein may function
            in stimulation of Ca2+-dependent insulin release, stimulation of
            prolactin secretion, and exocytosis. Chromosomal rearrangements and
            altered expression of this gene have been implicated in melanoma.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP291443.1, BP343734.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368719.9/ ENSP00000357708.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-433               BC001431.2         56-488
            434-434             BX470102.12        8697-8697           c
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..434
                     /gene="S100A6"
                     /gene_synonym="2A9; 5B10; CABP; CACY; PRA; S10A6"
                     /note="S100 calcium binding protein A6"
                     /db_xref="GeneID:6277"
                     /db_xref="HGNC:HGNC:10496"
                     /db_xref="MIM:114110"
     exon            1..43
                     /gene="S100A6"
                     /gene_synonym="2A9; 5B10; CABP; CACY; PRA; S10A6"
                     /inference="alignment:Splign:2.1.0"
     exon            44..202
                     /gene="S100A6"
                     /gene_synonym="2A9; 5B10; CABP; CACY; PRA; S10A6"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..337
                     /gene="S100A6"
                     /gene_synonym="2A9; 5B10; CABP; CACY; PRA; S10A6"
                     /note="prolactin receptor-associated protein; calcyclin;
                     MLN 4; growth factor-inducible protein 2A9"
                     /codon_start=1
                     /product="protein S100-A6"
                     /protein_id="NP_055439.1"
                     /db_xref="CCDS:CCDS1040.1"
                     /db_xref="GeneID:6277"
                     /db_xref="HGNC:HGNC:10496"
                     /db_xref="MIM:114110"
                     /translation="MACPLDQAIGLLVAIFHKYSGREGDKHTLSKKELKELIQKELTI
                     GSKLQDAEIARLMEDLDRNKDQEVNFQEYVTFLGALALIYNEALKG"
     exon            203..434
                     /gene="S100A6"
                     /gene_synonym="2A9; 5B10; CABP; CACY; PRA; S10A6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      410..415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100A6"
                     /gene_synonym="2A9; 5B10; CABP; CACY; PRA; S10A6"
                     /note="hexamer: AATAAA"
     polyA_site      434
                     /gene="S100A6"
                     /gene_synonym="2A9; 5B10; CABP; CACY; PRA; S10A6"
                     /note="major polyA site"
ORIGIN      
        1 atcccctcga ccgctcgcgt cgcatttggc cgcctcccta ccgctccaag cccagccctc
       61 agccatggca tgccccctgg atcaggccat tggcctcctc gtggccatct tccacaagta
      121 ctccggcagg gagggtgaca agcacaccct gagcaagaag gagctgaagg agctgatcca
      181 gaaggagctc accattggct cgaagctgca ggatgctgaa attgcaaggc tgatggaaga
      241 cttggaccgg aacaaggacc aggaggtgaa cttccaggag tatgtcacct tcctgggggc
      301 cttggctttg atctacaatg aagccctcaa gggctgaaaa taaataggga agatggagac
      361 accctctggg ggtcctctct gagtcaaatc cagtggtggg taattgtaca ataaattttt
      421 tttggtcaaa ttta
//
