LOCUS       NM_001394232             756 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens S100 calcium binding protein A5 (S100A5), transcript
            variant 2, mRNA.
ACCESSION   NM_001394232
VERSION     NM_001394232.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 756)
  AUTHORS   Wheeler,L.C. and Harms,M.J.
  TITLE     Were Ancestral Proteins Less Specific?
  JOURNAL   Mol Biol Evol 38 (6), 2227-2239 (2021)
   PUBMED   33528559
  REMARK    GeneRIF: Were Ancestral Proteins Less Specific?
REFERENCE   2  (bases 1 to 756)
  AUTHORS   Simon,M.A., Ecsedi,P., Kovacs,G.M., Poti,A.L., Remenyi,A.,
            Kardos,J., Gogl,G. and Nyitray,L.
  TITLE     High-throughput competitive fluorescence polarization assay reveals
            functional redundancy in the S100 protein family
  JOURNAL   FEBS J 287 (13), 2834-2846 (2020)
   PUBMED   31837246
REFERENCE   3  (bases 1 to 756)
  AUTHORS   Wheeler,L.C., Anderson,J.A., Morrison,A.J., Wong,C.E. and
            Harms,M.J.
  TITLE     Conservation of Specificity in Two Low-Specificity Proteins
  JOURNAL   Biochemistry 57 (5), 684-695 (2018)
   PUBMED   29240404
  REMARK    GeneRIF: Isothermal titration calorimetry measured the binding of
            peptides with diverse sequence and biochemistry to human S100A5 and
            S110A6. These proteins bound distinct, but overlapping, sets of
            peptide targets.  A single historical mutation, when reverted in
            human S100A5, gave it the ability to bind an S100A6-specific
            peptide. The specificity of S100 peptide interfaces is likely
            important for the biology of these proteins.
REFERENCE   4  (bases 1 to 756)
  AUTHORS   Kim,I., Lee,K.O., Yun,Y.J., Jeong,J.Y., Kim,E.H., Cheong,H.,
            Ryu,K.S., Kim,N.K. and Suh,J.Y.
  TITLE     Biophysical characterization of Ca2+-binding of S100A5 and
            Ca2+-induced interaction with RAGE
  JOURNAL   Biochem Biophys Res Commun 483 (1), 332-338 (2017)
   PUBMED   28017722
  REMARK    GeneRIF: S100A5 employs the periphery of the dimer interface to
            interact with RAGE-v
REFERENCE   5  (bases 1 to 756)
  AUTHORS   Bertini,I., Das Gupta,S., Hu,X., Karavelas,T., Luchinat,C.,
            Parigi,G. and Yuan,J.
  TITLE     Solution structure and dynamics of S100A5 in the apo and Ca2+-bound
            states
  JOURNAL   J Biol Inorg Chem 14 (7), 1097-1107 (2009)
   PUBMED   19536568
  REMARK    GeneRIF: Homodimeric solution structures of S100A5 in both apo &
            Ca(II)-loaded forms were obtained & show conformational
            rearrangement on Ca binding. Also, large mobility was observed in
            hinge loop of apo-S100A5; this mobility was not quenched in Ca
            form.
REFERENCE   6  (bases 1 to 756)
  AUTHORS   Schafer,B.W., Fritschy,J.M., Murmann,P., Troxler,H., Durussel,I.,
            Heizmann,C.W. and Cox,J.A.
  TITLE     Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding
            protein of the EF-hand superfamily
  JOURNAL   J Biol Chem 275 (39), 30623-30630 (2000)
   PUBMED   10882717
REFERENCE   7  (bases 1 to 756)
  AUTHORS   Ridinger,K., Ilg,E.C., Niggli,F.K., Heizmann,C.W. and Schafer,B.W.
  TITLE     Clustered organization of S100 genes in human and mouse
  JOURNAL   Biochim Biophys Acta 1448 (2), 254-263 (1998)
   PUBMED   9920416
REFERENCE   8  (bases 1 to 756)
  AUTHORS   Schafer,B.W. and Heizmann,C.W.
  TITLE     The S100 family of EF-hand calcium-binding proteins: functions and
            pathology
  JOURNAL   Trends Biochem Sci 21 (4), 134-140 (1996)
   PUBMED   8701470
  REMARK    Review article
REFERENCE   9  (bases 1 to 756)
  AUTHORS   Schafer,B.W., Wicki,R., Engelkamp,D., Mattei,M.G. and Heizmann,C.W.
  TITLE     Isolation of a YAC clone covering a cluster of nine S100 genes on
            human chromosome 1q21: rationale for a new nomenclature of the S100
            calcium-binding protein family
  JOURNAL   Genomics 25 (3), 638-643 (1995)
   PUBMED   7759097
REFERENCE   10 (bases 1 to 756)
  AUTHORS   Engelkamp,D., Schafer,B.W., Mattei,M.G., Erne,P. and Heizmann,C.W.
  TITLE     Six S100 genes are clustered on human chromosome 1q21:
            identification of two genes coding for the two previously
            unreported calcium-binding proteins S100D and S100E
  JOURNAL   Proc Natl Acad Sci U S A 90 (14), 6547-6551 (1993)
   PUBMED   8341667
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX470102.12.
            
            Summary: The protein encoded by this gene is a member of the S100
            family of proteins containing 2 EF-hand calcium-binding motifs.
            S100 proteins are localized in the cytoplasm and/or nucleus of a
            wide range of cells, and involved in the regulation of a number of
            cellular processes such as cell cycle progression and
            differentiation. S100 genes include at least 13 members which are
            located as a cluster on chromosome 1q21. This protein has a Ca2+
            affinity 20- to 100-fold higher than the other S100 proteins
            studied under identical conditions. This protein also binds Zn2+
            and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This
            protein is expressed in very restricted regions of the adult brain.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA810909.1, DRR138512.131274.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000368717.3/
                                                ENSP00000357706.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               BX470102.12        14719-15032         c
            315-466             BX470102.12        14152-14303         c
            467-756             BX470102.12        11245-11534         c
FEATURES             Location/Qualifiers
     source          1..756
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..756
                     /gene="S100A5"
                     /gene_synonym="S100D"
                     /note="S100 calcium binding protein A5"
                     /db_xref="GeneID:6276"
                     /db_xref="HGNC:HGNC:10495"
                     /db_xref="MIM:176991"
     exon            1..314
                     /gene="S100A5"
                     /gene_synonym="S100D"
                     /inference="alignment:Splign:2.1.0"
     exon            315..466
                     /gene="S100A5"
                     /gene_synonym="S100D"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..607
                     /gene="S100A5"
                     /gene_synonym="S100D"
                     /codon_start=1
                     /product="protein S100-A5"
                     /protein_id="NP_001381161.1"
                     /db_xref="CCDS:CCDS1041.2"
                     /db_xref="GeneID:6276"
                     /db_xref="HGNC:HGNC:10495"
                     /db_xref="MIM:176991"
                     /translation="METPLEKALTTMVTTFHKYSGREGSKLTLSRKELKELIKKELCL
                     GEMKESSIDDLMKSLDKNSDQEIDFKEYSVFLTMLCMAYNDFFLEDNK"
     exon            467..756
                     /gene="S100A5"
                     /gene_synonym="S100D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      729..734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100A5"
                     /gene_synonym="S100D"
                     /note="hexamer: AATAAA"
     polyA_site      756
                     /gene="S100A5"
                     /gene_synonym="S100D"
                     /note="major polyA site"
ORIGIN      
        1 atctgtctct tcccttggct gagggtggct gtgctattgg aatccaggcc cttattcaag
       61 cgtagcctct ggatccaggt tttggaatga tcctggagat ttcaagaggc cccctgccct
      121 ccctgcccgc tgacccgtct ctgtgtgcac tgctctgggc cagagtctgg agaccagctg
      181 ggccagctca gctcacctcc ctgctgctcc ttgttgagac cccatcaccc agttccagcc
      241 cagccccctc tcagccctgg actctctctt tgccctgtcc ccgactttaa taatgggaca
      301 ctcctcgata tcagagctgc acactgtgat ggagactcct ctggagaagg ccctgaccac
      361 tatggtgacc acgtttcaca aatattcggg gagagagggt agcaaactga ccctgagtag
      421 gaaggaactc aaggagctga tcaagaaaga gctgtgtctt ggggagatga aggagagcag
      481 catcgatgac ttgatgaaga gcctggacaa gaacagcgac caggagatcg acttcaagga
      541 gtactcggtg ttcctgacca tgctgtgcat ggcctacaac gacttctttc tagaggacaa
      601 caagtgacca gggctgccct ccaccctcac cctccaccct ttgctgctga cctcggctgc
      661 tcctctcaca gaccctcttt ggccccctgc cctcctctcc ctcccagatg gacccttcca
      721 tgggaggaaa taaagtttcc atcgcaggtg ctggga
//
