LOCUS       NM_002961                513 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens S100 calcium binding protein A4 (S100A4), transcript
            variant 1, mRNA.
ACCESSION   NM_002961
VERSION     NM_002961.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Ren,W. and Ouyang,L.
  TITLE     Long noncoding RNA VPS9D1-AS1 promotes the progression of
            endometrial cancer via regulation of the miR-187-3p/S100A4 axis
  JOURNAL   Environ Toxicol 39 (9), 4447-4458 (2024)
   PUBMED   38953363
  REMARK    GeneRIF: Long noncoding RNA VPS9D1-AS1 promotes the progression of
            endometrial cancer via regulation of the miR-187-3p/S100A4 axis.
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Tan,X., He,Y., Yu,P., Deng,Y., Xie,Z., Guo,J., Hou,Q., Li,P.,
            Lin,X., Ouyang,S., Ma,W., Xie,Y., Guo,Z., Chen,D., Zhang,Z.,
            Zhu,Y., Huang,F., Zhao,Z., Zhang,C., Guo,Z., Chen,X., Peng,T.,
            Li,L. and Xie,W.
  TITLE     The dual role of FSP1 in programmed cell death: resisting
            ferroptosis in the cell membrane and promoting necroptosis in the
            nucleus of THP-1 cells
  JOURNAL   Mol Med 30 (1), 102 (2024)
   PUBMED   39009982
  REMARK    GeneRIF: The dual role of FSP1 in programmed cell death: resisting
            ferroptosis in the cell membrane and promoting necroptosis in the
            nucleus of THP-1 cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 513)
  AUTHORS   Hua,D., Zhou,X.X., Wang,Q., Sun,C.Y., Shi,C.J., Luo,W.J.,
            Jiang,Z.D. and Yu,S.Z.
  TITLE     [SRSF2 promotes glioblastoma cell proliferation by inducing
            alternative splicing of FSP1 and inhibiting ferroptosis]
  JOURNAL   Zhonghua Bing Li Xue Za Zhi 53 (5), 430-438 (2024)
   PUBMED   38678322
  REMARK    GeneRIF: [SRSF2 promotes glioblastoma cell proliferation by
            inducing alternative splicing of FSP1 and inhibiting ferroptosis].
REFERENCE   4  (bases 1 to 513)
  AUTHORS   Zhou,X., Zhao,J., Yan,T., Ye,D., Wang,Y., Zhou,B., Liu,D., Wang,X.,
            Zheng,W., Zheng,B., Qian,F., Li,Y., Li,D. and Fang,L.
  TITLE     ANXA9 facilitates S100A4 and promotes breast cancer progression
            through modulating STAT3 pathway
  JOURNAL   Cell Death Dis 15 (4), 260 (2024)
   PUBMED   38609357
  REMARK    GeneRIF: ANXA9 facilitates S100A4 and promotes breast cancer
            progression through modulating STAT3 pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 513)
  AUTHORS   Yang,L., Liu,J., Yin,J., Li,Y., Liu,J., Liu,D., Wang,Z.,
            DiSanto,M.E., Zhang,W. and Zhang,X.
  TITLE     S100A4 modulates cell proliferation, apoptosis and fibrosis in the
            hyperplastic prostate
  JOURNAL   Int J Biochem Cell Biol 169, 106551 (2024)
   PUBMED   38360265
  REMARK    GeneRIF: S100A4 modulates cell proliferation, apoptosis and
            fibrosis in the hyperplastic prostate.
REFERENCE   6  (bases 1 to 513)
  AUTHORS   Ambartsumian,N., Tarabykina,S., Grigorian,M., Tulchinsky,E.,
            Hulgaard,E., Georgiev,G. and Lukanidin,E.
  TITLE     Characterization of two splice variants of metastasis-associated
            human mts1 gene
  JOURNAL   Gene 159 (1), 125-130 (1995)
   PUBMED   7607566
REFERENCE   7  (bases 1 to 513)
  AUTHORS   Tomida,Y., Terasawa,M., Kobayashi,R. and Hidaka,H.
  TITLE     Calcyclin and calvasculin exist in human platelets
  JOURNAL   Biochem Biophys Res Commun 189 (3), 1310-1316 (1992)
   PUBMED   1482346
REFERENCE   8  (bases 1 to 513)
  AUTHORS   Engelkamp,D., Schafer,B.W., Erne,P. and Heizmann,C.W.
  TITLE     S100 alpha, CAPL, and CACY: molecular cloning and expression
            analysis of three calcium-binding proteins from human heart
  JOURNAL   Biochemistry 31 (42), 10258-10264 (1992)
   PUBMED   1384693
REFERENCE   9  (bases 1 to 513)
  AUTHORS   Tulchinsky,E., Ford,H.L., Kramerov,D., Reshetnyak,E., Grigorian,M.,
            Zain,S. and Lukanidin,E.
  TITLE     Transcriptional analysis of the mts1 gene with specific reference
            to 5' flanking sequences
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9146-9150 (1992)
   PUBMED   1329089
REFERENCE   10 (bases 1 to 513)
  AUTHORS   Stoler,A. and Bouck,N.
  TITLE     Identification of a single chromosome in the normal human genome
            essential for suppression of hamster cell transformation
  JOURNAL   Proc Natl Acad Sci U S A 82 (2), 570-574 (1985)
   PUBMED   3155863
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX470102.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 26, 2018 this sequence version replaced NM_002961.2.
            
            Summary: The protein encoded by this gene is a member of the S100
            family of proteins containing 2 EF-hand calcium-binding motifs.
            S100 proteins are localized in the cytoplasm and/or nucleus of a
            wide range of cells, and involved in the regulation of a number of
            cellular processes such as cell cycle progression and
            differentiation. S100 genes include at least 13 members which are
            located as a cluster on chromosome 1q21. This protein may function
            in motility, invasion, and tubulin polymerization. Chromosomal
            rearrangements and altered expression of this gene have been
            implicated in tumor metastasis. Multiple alternatively spliced
            variants, encoding the same protein, have been identified.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) has an alternate 5' UTR,
            compared to variant 2. Both variants 1 and 2 encode the same
            isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB106939.1, AK292083.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368716.9/ ENSP00000357705.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BX470102.12        19851-19904         c
            55-210              BX470102.12        18752-18907         c
            211-513             BX470102.12        17719-18021         c
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..513
                     /gene="S100A4"
                     /gene_synonym="18A2; 42A; CAPL; FSP1; MTS1; P9KA; PEL98"
                     /note="S100 calcium binding protein A4"
                     /db_xref="GeneID:6275"
                     /db_xref="HGNC:HGNC:10494"
                     /db_xref="MIM:114210"
     exon            1..54
                     /gene="S100A4"
                     /gene_synonym="18A2; 42A; CAPL; FSP1; MTS1; P9KA; PEL98"
                     /inference="alignment:Splign:2.1.0"
     exon            55..210
                     /gene="S100A4"
                     /gene_synonym="18A2; 42A; CAPL; FSP1; MTS1; P9KA; PEL98"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..375
                     /gene="S100A4"
                     /gene_synonym="18A2; 42A; CAPL; FSP1; MTS1; P9KA; PEL98"
                     /note="fibroblast-specific protein-1; metastasin 1; S100
                     calcium-binding protein A4 (calcium protein, calvasculin,
                     metastasin, murine placental homolog); malignant
                     transformation suppression 1; leukemia multidrug
                     resistance associated protein; protein Mts1; placental
                     calcium-binding protein; calcium placental protein"
                     /codon_start=1
                     /product="protein S100-A4"
                     /protein_id="NP_002952.1"
                     /db_xref="CCDS:CCDS1042.1"
                     /db_xref="GeneID:6275"
                     /db_xref="HGNC:HGNC:10494"
                     /db_xref="MIM:114210"
                     /translation="MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPS
                     FLGKRTDEAAFQKLMSNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK"
     exon            211..513
                     /gene="S100A4"
                     /gene_synonym="18A2; 42A; CAPL; FSP1; MTS1; P9KA; PEL98"
                     /inference="alignment:Splign:2.1.0"
     regulatory      492..497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100A4"
                     /gene_synonym="18A2; 42A; CAPL; FSP1; MTS1; P9KA; PEL98"
                     /note="hexamer: AATAAA"
     polyA_site      513
                     /gene="S100A4"
                     /gene_synonym="18A2; 42A; CAPL; FSP1; MTS1; P9KA; PEL98"
                     /note="major polyA site"
ORIGIN      
        1 attcttcccc tctctacaac cctctctcct cagcgcttct tctttcttgg tttgatcctg
       61 actgctgtca tggcgtgccc tctggagaag gccctggatg tgatggtgtc caccttccac
      121 aagtactcgg gcaaagaggg tgacaagttc aagctcaaca agtcagaact aaaggagctg
      181 ctgacccggg agctgcccag cttcttgggg aaaaggacag atgaagctgc tttccagaag
      241 ctgatgagca acttggacag caacagggac aacgaggtgg acttccaaga gtactgtgtc
      301 ttcctgtcct gcatcgccat gatgtgtaac gaattctttg aaggcttccc agataagcag
      361 cccaggaaga aatgaaaact cctctgatgt ggttgggggg tctgccagct ggggccctcc
      421 ctgtcgccag tgggcacttt tttttttcca ccctggctcc ttcagacacg tgcttgatgc
      481 tgagcaagtt caataaagat tcttggaagt ttt
//
