LOCUS       NM_002960                742 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens S100 calcium binding protein A3 (S100A3), mRNA.
ACCESSION   NM_002960
VERSION     NM_002960.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 742)
  AUTHORS   Simon,M.A., Ecsedi,P., Kovacs,G.M., Poti,A.L., Remenyi,A.,
            Kardos,J., Gogl,G. and Nyitray,L.
  TITLE     High-throughput competitive fluorescence polarization assay reveals
            functional redundancy in the S100 protein family
  JOURNAL   FEBS J 287 (13), 2834-2846 (2020)
   PUBMED   31837246
REFERENCE   2  (bases 1 to 742)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 742)
  AUTHORS   Al-Mutairy,E.A., Imtiaz,F.A., Khalid,M., Al Qattan,S., Saleh,S.,
            Mahmoud,L.M., Al-Saif,M.M., Al-Haj,L., Al-Enazi,A., AlJebreen,A.M.,
            Mohammed,S.F., Mobeireek,A.F., Alkattan,K., Chisti,M.A.,
            Luzina,I.G., Al-Owain,M., Weheba,I., Abdelsayed,A.M., Ramzan,K.,
            Janssen,L.J., Conca,W., Alaiya,A., Collison,K.S., Meyer,B.F.,
            Atamas,S.P., Khabar,K.S., Hasday,J.D. and Al-Mohanna,F.
  TITLE     An atypical pulmonary fibrosis is associated with co-inheritance of
            mutations in the calcium binding protein genes S100A3 and S100A13
  JOURNAL   Eur Respir J 54 (1), 1802041 (2019)
   PUBMED   31073086
  REMARK    GeneRIF: An atypical pulmonary fibrosis is associated with
            co-inheritance of mutations in the calcium binding protein genes
            S100A3 and S100A13.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 742)
  AUTHORS   Gianni,M., Terao,M., Kurosaki,M., Paroni,G., Brunelli,L.,
            Pastorelli,R., Zanetti,A., Lupi,M., Acquavita,A., Bolis,M.,
            Fratelli,M., Rochette-Egly,C. and Garattini,E.
  TITLE     S100A3 a partner protein regulating the stability/activity of
            RARalpha and PML-RARalpha in cellular models of breast/lung cancer
            and acute myeloid leukemia
  JOURNAL   Oncogene 38 (14), 2482-2500 (2019)
   PUBMED   30532072
  REMARK    GeneRIF: Opposite effects on RARalpha/PML-RARalpha levels and
            ATRA-induced differentiation are observed upon S100A3
            overexpression.
            Erratum:[Oncogene. 2023 Jan;42(3):254-258. doi:
            10.1038/s41388-022-02564-8.. PMID: 36476834]
REFERENCE   5  (bases 1 to 742)
  AUTHORS   Izycka,N., Sterzynska,K., Januchowski,R. and Nowak-Markwitz,E.
  TITLE     Semaphorin 3A (SEMA3A), protocadherin 9 (PCdh9), and S100 calcium
            binding protein A3 (S100A3) as potential biomarkers of
            carcinogenesis and chemoresistance of different neoplasms,
            including ovarian cancer - review of literature
  JOURNAL   Ginekol Pol 90 (4), 223-227 (2019)
   PUBMED   31059116
  REMARK    GeneRIF: This review discusses the role and potential use as
            biomarkers of semaphorin 3A (SEMA3A), protocadherin 9 (PCDH9), and
            S100 calcium binding protein A3 (S100A3) in carcinogenesis and
            chemoresistance of various tumors, including ovarian cancer.
REFERENCE   6  (bases 1 to 742)
  AUTHORS   Kizawa,K., Uchiwa,H. and Murakami,U.
  TITLE     Highly-expressed S100A3, a calcium-binding protein, in human hair
            cuticle
  JOURNAL   Biochim Biophys Acta 1312 (2), 94-98 (1996)
   PUBMED   8672544
REFERENCE   7  (bases 1 to 742)
  AUTHORS   Schafer,B.W. and Heizmann,C.W.
  TITLE     The S100 family of EF-hand calcium-binding proteins: functions and
            pathology
  JOURNAL   Trends Biochem Sci 21 (4), 134-140 (1996)
   PUBMED   8701470
  REMARK    Review article
REFERENCE   8  (bases 1 to 742)
  AUTHORS   Fohr,U.G., Heizmann,C.W., Engelkamp,D., Schafer,B.W. and Cox,J.A.
  TITLE     Purification and cation binding properties of the recombinant human
            S100 calcium-binding protein A3, an EF-hand motif protein with high
            affinity for zinc
  JOURNAL   J Biol Chem 270 (36), 21056-21061 (1995)
   PUBMED   7673133
REFERENCE   9  (bases 1 to 742)
  AUTHORS   Schafer,B.W., Wicki,R., Engelkamp,D., Mattei,M.G. and Heizmann,C.W.
  TITLE     Isolation of a YAC clone covering a cluster of nine S100 genes on
            human chromosome 1q21: rationale for a new nomenclature of the S100
            calcium-binding protein family
  JOURNAL   Genomics 25 (3), 638-643 (1995)
   PUBMED   7759097
REFERENCE   10 (bases 1 to 742)
  AUTHORS   Engelkamp,D., Schafer,B.W., Mattei,M.G., Erne,P. and Heizmann,C.W.
  TITLE     Six S100 genes are clustered on human chromosome 1q21:
            identification of two genes coding for the two previously
            unreported calcium-binding proteins S100D and S100E
  JOURNAL   Proc Natl Acad Sci U S A 90 (14), 6547-6551 (1993)
   PUBMED   8341667
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z18948.1 and BX470102.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002960.1.
            
            Summary: The protein encoded by this gene is a member of the S100
            family of proteins containing 2 EF-hand calcium-binding motifs.
            S100 proteins are localized in the cytoplasm and/or nucleus of a
            wide range of cells, and involved in the regulation of a number of
            cellular processes such as cell cycle progression and
            differentiation. S100 genes include at least 13 members which are
            located as a cluster on chromosome 1q21. This protein has the
            highest content of cysteines of all S100 proteins, has a high
            affinity for Zinc, and is highly expressed in human hair cuticle.
            The precise function of this protein is unknown. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z18948.1, BC012893.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368713.8/ ENSP00000357702.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-738               Z18948.1           1-738
            739-742             BX470102.12        21427-21430         c
FEATURES             Location/Qualifiers
     source          1..742
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..742
                     /gene="S100A3"
                     /gene_synonym="S100E"
                     /note="S100 calcium binding protein A3"
                     /db_xref="GeneID:6274"
                     /db_xref="HGNC:HGNC:10493"
                     /db_xref="MIM:176992"
     exon            1..78
                     /gene="S100A3"
                     /gene_synonym="S100E"
                     /inference="alignment:Splign:2.1.0"
     exon            79..224
                     /gene="S100A3"
                     /gene_synonym="S100E"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..389
                     /gene="S100A3"
                     /gene_synonym="S100E"
                     /codon_start=1
                     /product="protein S100-A3"
                     /protein_id="NP_002951.1"
                     /db_xref="CCDS:CCDS1043.1"
                     /db_xref="GeneID:6274"
                     /db_xref="HGNC:HGNC:10493"
                     /db_xref="MIM:176992"
                     /translation="MARPLEQAVAAIVCTFQEYAGRCGDKYKLCQAELKELLQKELAT
                     WTPTEFRECDYNKFMSVLDTNKDCEVDFVEYVRSLACLCLYCHEYFKDCPSEPPCSQ"
     exon            225..742
                     /gene="S100A3"
                     /gene_synonym="S100E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      723..728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100A3"
                     /gene_synonym="S100E"
                     /note="hexamer: AATAAA"
     polyA_site      742
                     /gene="S100A3"
                     /gene_synonym="S100E"
                     /note="major polyA site"
ORIGIN      
        1 agtctcagat tggtaaacac ccgaactggt caactctcaa gagaccatct ggttcaggtt
       61 cctgactggg ccagcgagtg aggatggcca ggcctctgga gcaggcggta gctgccatcg
      121 tgtgcacctt ccaggaatac gcagggcgct gtggggacaa atacaagctc tgccaggcgg
      181 agctcaagga gctgctgcag aaggagctgg ccacctggac cccgactgag tttcgggaat
      241 gtgactacaa caaattcatg agtgttctgg acaccaacaa ggactgcgag gtggactttg
      301 tggagtatgt gcgctcactt gcctgcctct gtctctactg ccacgagtac ttcaaggact
      361 gcccctcaga gcccccctgc tcccagtagc ctctgctcca gggggtgcgc tggctgtcgg
      421 gggctgggca tgtctcccac accccctcct accctctctc ctgtacccct ttcaatctgg
      481 acttgcccag gtcttctgcg atcagttaac ccattttacc taggaggccc agagatgtga
      541 gggctccttc ctcaggatgc ccagcgaatg aggggtagag ccactctggg gcccagcctg
      601 cctgccgcac ccctgtggcc tcccttgtgg atgggaggag gcgggatctg ctctgaggcc
      661 ctcgaggctc agcagagcgt gcaccaatga gaccacgatg ggaaagggcc tatttaactc
      721 ctaataaaaa actggcatca gc
//
