LOCUS       NM_080388               1172 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens S100 calcium binding protein A16 (S100A16), transcript
            variant 3, mRNA.
ACCESSION   NM_080388
VERSION     NM_080388.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1172)
  AUTHORS   Yang,L., Shen,A., Wang,R. and Zheng,Z.
  TITLE     S100A16 stabilizes the ITGA3-mediated ECM-receptor interaction
            pathway to drive the malignant properties of lung adenocarcinoma
            cells via binding MOV10
  JOURNAL   Mol Med Rep 31 (1) (2025)
   PUBMED   39450567
  REMARK    GeneRIF: S100A16 stabilizes the ITGA3-mediated ECM-receptor
            interaction pathway to drive the malignant properties of lung
            adenocarcinoma cells via binding MOV10.
REFERENCE   2  (bases 1 to 1172)
  AUTHORS   Yang,D., Zhao,F., Zhou,Y., Zhang,Y., Shen,J., Yu,B., Zhao,K. and
            Ding,Y.
  TITLE     S100A16 is a potential target for reshaping the tumor
            microenvironment in the hypoxic context of liver cancer
  JOURNAL   Int Immunopharmacol 134, 112076 (2024)
   PUBMED   38733818
  REMARK    GeneRIF: S100A16 is a potential target for reshaping the tumor
            microenvironment in the hypoxic context of liver cancer.
REFERENCE   3  (bases 1 to 1172)
  AUTHORS   Yu,S., Wang,M., Zhang,H., Guo,X. and Qin,R.
  TITLE     Resistance to gemcitabine is mediated by the
            circ_0036627/miR-145/S100A16 axis in pancreatic cancer
  JOURNAL   J Cell Mol Med 28 (12), e18444 (2024)
   PUBMED   38924205
  REMARK    GeneRIF: Resistance to gemcitabine is mediated by the
            circ_0036627/miR-145/S100A16 axis in pancreatic cancer.
REFERENCE   4  (bases 1 to 1172)
  AUTHORS   Basnet,S., Vallenari,E.M., Maharjan,U., Sharma,S., Schreurs,O. and
            Sapkota,D.
  TITLE     An Update on S100A16 in Human Cancer
  JOURNAL   Biomolecules 13 (7), 1070 (2023)
   PUBMED   37509106
  REMARK    GeneRIF: An Update on S100A16 in Human Cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1172)
  AUTHORS   Hu,Y., Zhang,R., Lu,S., Zhang,W., Wang,D., Ge,Y., Jiang,F., Qin,X.
            and Liu,Y.
  TITLE     S100 Calcium Binding Protein A16 Promotes Cell Proliferation by
            triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to
            inhibit Hippo pathway in Glioma development
  JOURNAL   Int J Biol Sci 19 (7), 2034-2052 (2023)
   PUBMED   37151881
  REMARK    GeneRIF: S100 Calcium Binding Protein A16 Promotes Cell
            Proliferation by triggering LATS1 ubiquitin degradation mediated by
            CUL4A ligase to inhibit Hippo pathway in Glioma development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1172)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   7  (bases 1 to 1172)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 1172)
  AUTHORS   Marenholz,I. and Heizmann,C.W.
  TITLE     S100A16, a ubiquitously expressed EF-hand protein which is
            up-regulated in tumors
  JOURNAL   Biochem Biophys Res Commun 313 (2), 237-244 (2004)
   PUBMED   14684152
REFERENCE   9  (bases 1 to 1172)
  AUTHORS   Reddy,P.H., Stockburger,E., Gillevet,P. and Tagle,D.A.
  TITLE     Mapping and characterization of novel (CAG)n repeat cDNAs from
            adult human brain derived by the oligo capture method
  JOURNAL   Genomics 46 (2), 174-182 (1997)
   PUBMED   9417904
REFERENCE   10 (bases 1 to 1172)
  AUTHORS   Yamagata,K., Takeda,J., Menzel,S., Chen,X., Eng,S., Lim,L.R.,
            Concannon,P., Hanis,C.L., Spielman,R.S., Cox,N.J. and Bell,G.I.
  TITLE     Searching for NIDDM susceptibility genes: studies of genes with
            triplet repeats expressed in skeletal muscle
  JOURNAL   Diabetologia 39 (6), 725-730 (1996)
   PUBMED   8781769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM739127.1, BC010541.1 and AI673616.1.
            
            On Nov 23, 2018 this sequence version replaced NM_080388.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.33451.1,
                                           SRR5189658.92690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368706.9/ ENSP00000357695.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                BM739127.1         34-132
            100-1167            BC010541.1         1-1068
            1168-1172           AI673616.1         10-14               c
FEATURES             Location/Qualifiers
     source          1..1172
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1172
                     /gene="S100A16"
                     /gene_synonym="AAG13; DT1P1A7; S100F"
                     /note="S100 calcium binding protein A16"
                     /db_xref="GeneID:140576"
                     /db_xref="HGNC:HGNC:20441"
                     /db_xref="MIM:617437"
     exon            1..186
                     /gene="S100A16"
                     /gene_synonym="AAG13; DT1P1A7; S100F"
                     /inference="alignment:Splign:2.1.0"
     exon            187..365
                     /gene="S100A16"
                     /gene_synonym="AAG13; DT1P1A7; S100F"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..524
                     /gene="S100A16"
                     /gene_synonym="AAG13; DT1P1A7; S100F"
                     /note="aging-associated protein 13; protein S100-F;
                     aging-associated gene 13 protein"
                     /codon_start=1
                     /product="protein S100-A16"
                     /protein_id="NP_525127.1"
                     /db_xref="CCDS:CCDS1045.1"
                     /db_xref="GeneID:140576"
                     /db_xref="HGNC:HGNC:20441"
                     /db_xref="MIM:617437"
                     /translation="MSDCYTELEKAVIVLVENFYKYVSKYSLVKNKISKSSFREMLQK
                     ELNHMLSDTGNRKAADKLIQNLDANHDGRISFDEYWTLIGGITGPIAKLIHEQEQQSS
                     S"
     exon            366..1172
                     /gene="S100A16"
                     /gene_synonym="AAG13; DT1P1A7; S100F"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1147..1152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100A16"
                     /gene_synonym="AAG13; DT1P1A7; S100F"
                     /note="hexamer: ATTAAA"
     polyA_site      1172
                     /gene="S100A16"
                     /gene_synonym="AAG13; DT1P1A7; S100F"
                     /note="major polyA site"
ORIGIN      
        1 aagaaggagc tcagccacta tctccccacc gagccagctc agcgggcagg gctgggaggg
       61 agtgggacag attctgggag tgcagcgggg aggagtcccg gctgggctga gcgcagggag
      121 ctgcttggca gtgccagagc ccaggcccca gagccctgct ggagaggagg cagactgagg
      181 cagcaggccc cgccagcagg cgaagcaggg agatgtcaga ctgctacacg gagctggaga
      241 aggcagtcat tgtcctggtg gaaaacttct acaaatatgt gtctaagtac agcctggtca
      301 agaacaagat cagcaagagc agcttccgcg agatgctcca gaaagagctg aaccacatgc
      361 tgtcggacac agggaaccgg aaggctgcgg ataagctcat ccagaacctg gatgccaatc
      421 atgatgggcg catcagcttc gatgagtact ggaccttgat aggcggcatc accggcccca
      481 tcgccaaact catccatgag caggagcagc agagcagcag ctagagaccc ctttggccac
      541 accttccagg cactggcctg atgccccgcc ctggtgctct ccccaggctc cctcctcagc
      601 ctcctgccca cccagggccc tttactctct tctccctcca gaccttcctc tgacccttgc
      661 tgaactgggg tccctttgtg agtgtctcag tctagaggta cctccctccc tggggggtct
      721 cagctcctgg agtcgcaggc ccttggggcc cctctgtgag atctcaatgc tgtctgggga
      781 ccctaagagt tttctcacct gttcagtctc atctaacctt ccaatgtctg atgttcctgc
      841 caaattcctg cctgattctg ggtccgtcct gacctccaaa ggtcagcttg gtgcttgagg
      901 tctccctgct cttggtggca gtggtagcag caacagcagc agcagcagca gcagcagcag
      961 cagagacctc tccactttcc cttagcccct ctgctgggta gagaggcact ttcagggact
     1021 tccctccagc tgcctcttca tctgggaatg agctaagcaa ggctgagcct cctcctgttg
     1081 cttgaaataa tgatgatata aaggctggat ttggagtttg tatcccctgg tccctctggg
     1141 atgctcatta aaaccttccc actccttgga aa
//
