LOCUS       NM_020672               1054 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens S100 calcium binding protein A14 (S100A14), mRNA.
ACCESSION   NM_020672
VERSION     NM_020672.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1054)
  AUTHORS   Wu,G., Dong,Z., Dong,Y., Chen,Y., Zhu,H., Ding,D., Cui,Y., Wang,Y.,
            Xu,Y. and Chen,H.
  TITLE     LncRNA CTBP1-AS inhibits TP63-mediated activation of S100A14 during
            prostate cancer progression
  JOURNAL   Cancer Sci 115 (5), 1492-1504 (2024)
   PUBMED   38476086
  REMARK    GeneRIF: LncRNA CTBP1-AS inhibits TP63-mediated activation of
            S100A14 during prostate cancer progression.
REFERENCE   2  (bases 1 to 1054)
  AUTHORS   Selimovic,D., Kharouf,N., Carrouel,F., Hassan,S.Y., Flanagan,T.W.,
            Hassan,S.L., Megahed,M., Haikel,Y., Santourlidis,S. and Hassan,M.
  TITLE     Induction of Antimicrobial Protein S100A15 Expression by Oral
            Microbial Pathogens Is Toll-like Receptors-Dependent Activation of
            c-Jun-N-Terminal Kinase (JNK), p38, and NF-kappaB Pathways
  JOURNAL   Int J Mol Sci 24 (6), 5348 (2023)
   PUBMED   36982421
  REMARK    GeneRIF: Induction of Antimicrobial Protein S100A15 Expression by
            Oral Microbial Pathogens Is Toll-like Receptors-Dependent
            Activation of c-Jun-N-Terminal Kinase (JNK), p38, and NF-kappaB
            Pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1054)
  AUTHORS   Wang,C., Chen,Y., Xinpeng,Y., Xu,R., Song,J., Ruze,R., Xu,Q. and
            Zhao,Y.
  TITLE     Construction of immune-related signature and identification of
            S100A14 determining immune-suppressive microenvironment in
            pancreatic cancer
  JOURNAL   BMC Cancer 22 (1), 879 (2022)
   PUBMED   35953822
  REMARK    GeneRIF: Construction of immune-related signature and
            identification of S100A14 determining immune-suppressive
            microenvironment in pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1054)
  AUTHORS   Chi,X., Gu,X., Chen,S. and Shen,X.
  TITLE     Circ_0003221 Downregulation Restrains Cervical Cancer Cell Growth,
            Metastasis and Angiogenesis by Governing the miR-139-3p/S100A14
            Pathway
  JOURNAL   Reprod Sci 29 (6), 1822-1835 (2022)
   PUBMED   35023052
  REMARK    GeneRIF: Circ_0003221 Downregulation Restrains Cervical Cancer Cell
            Growth, Metastasis and Angiogenesis by Governing the
            miR-139-3p/S100A14 Pathway.
REFERENCE   5  (bases 1 to 1054)
  AUTHORS   Jiang,S., Zhu,Y., Chen,Z., Huang,Z., Liu,B., Xu,Y., Li,Z., Lin,Z.
            and Li,M.
  TITLE     S100A14 inhibits cell growth and epithelial-mesenchymal transition
            (EMT) in prostate cancer through FAT1-mediated Hippo signaling
            pathway
  JOURNAL   Hum Cell 34 (4), 1215-1226 (2021)
   PUBMED   33890248
  REMARK    GeneRIF: S100A14 inhibits cell growth and epithelial-mesenchymal
            transition (EMT) in prostate cancer through FAT1-mediated Hippo
            signaling pathway.
REFERENCE   6  (bases 1 to 1054)
  AUTHORS   Wolf,R., Lewerenz,V., Buchau,A.S., Walz,M. and Ruzicka,T.
  TITLE     Human S100A15 splice variants are differentially expressed in
            inflammatory skin diseases and regulated through Th1 cytokines and
            calcium
  JOURNAL   Exp Dermatol 16 (8), 685-691 (2007)
   PUBMED   17620096
REFERENCE   7  (bases 1 to 1054)
  AUTHORS   Boeshans,K.M., Wolf,R., Voscopoulos,C., Gillette,W., Esposito,D.,
            Mueser,T.C., Yuspa,S.H. and Ahvazi,B.
  TITLE     Purification, crystallization and preliminary X-ray diffraction of
            human S100A15
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 62 (Pt 5), 467-470
            (2006)
   PUBMED   16682778
REFERENCE   8  (bases 1 to 1054)
  AUTHORS   Adam,P.J., Boyd,R., Tyson,K.L., Fletcher,G.C., Stamps,A.,
            Hudson,L., Poyser,H.R., Redpath,N., Griffiths,M., Steers,G.,
            Harris,A.L., Patel,S., Berry,J., Loader,J.A., Townsend,R.R.,
            Daviet,L., Legrain,P., Parekh,R. and Terrett,J.A.
  TITLE     Comprehensive proteomic analysis of breast cancer cell membranes
            reveals unique proteins with potential roles in clinical cancer
  JOURNAL   J Biol Chem 278 (8), 6482-6489 (2003)
   PUBMED   12477722
REFERENCE   9  (bases 1 to 1054)
  AUTHORS   Pietas,A., Schluns,K., Marenholz,I., Schafer,B.W., Heizmann,C.W.
            and Petersen,I.
  TITLE     Molecular cloning and characterization of the human S100A14 gene
            encoding a novel member of the S100 family
  JOURNAL   Genomics 79 (4), 513-522 (2002)
   PUBMED   11944983
REFERENCE   10 (bases 1 to 1054)
  AUTHORS   Schafer,B.W., Wicki,R., Engelkamp,D., Mattei,M.G. and Heizmann,C.W.
  TITLE     Isolation of a YAC clone covering a cluster of nine S100 genes on
            human chromosome 1q21: rationale for a new nomenclature of the S100
            calcium-binding protein family
  JOURNAL   Genomics 25 (3), 638-643 (1995)
   PUBMED   7759097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG677973.1, AY007220.1 and BX470102.12.
            
            On Nov 22, 2018 this sequence version replaced NM_020672.2.
            
            Summary: This gene encodes a member of the S100 protein family
            which contains an EF-hand motif and binds calcium. The gene is
            located in a cluster of S100 genes on chromosome 1. Levels of the
            encoded protein have been found to be lower in cancerous tissue and
            associated with metastasis suggesting a tumor suppressor function
            (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.138654.1,
                                           ERR279834.11404.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344616.4/ ENSP00000340463.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BG677973.1         8-18
            12-103              AY007220.1         1-92
            104-104             BX470102.12        89962-89962         c
            105-1054            AY007220.1         94-1043
FEATURES             Location/Qualifiers
     source          1..1054
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1054
                     /gene="S100A14"
                     /gene_synonym="BCMP84; S100A15"
                     /note="S100 calcium binding protein A14"
                     /db_xref="GeneID:57402"
                     /db_xref="HGNC:HGNC:18901"
                     /db_xref="MIM:607986"
     exon            1..31
                     /gene="S100A14"
                     /gene_synonym="BCMP84; S100A15"
                     /inference="alignment:Splign:2.1.0"
     exon            32..139
                     /gene="S100A14"
                     /gene_synonym="BCMP84; S100A15"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..424
                     /gene="S100A14"
                     /gene_synonym="BCMP84; S100A15"
                     /note="breast cancer membrane protein 84; S114"
                     /codon_start=1
                     /product="protein S100-A14"
                     /protein_id="NP_065723.1"
                     /db_xref="CCDS:CCDS1046.1"
                     /db_xref="GeneID:57402"
                     /db_xref="HGNC:HGNC:18901"
                     /db_xref="MIM:607986"
                     /translation="MGQCRSANAEDAQEFSDVERAIETLIKNFHQYSVEGGKETLTPS
                     ELRDLVTQQLPHLMPSNCGLEEKIANLGSCNDSKLEFRSFWELIGEAAKSVKLERPVR
                     GH"
     exon            140..286
                     /gene="S100A14"
                     /gene_synonym="BCMP84; S100A15"
                     /inference="alignment:Splign:2.1.0"
     exon            287..1054
                     /gene="S100A14"
                     /gene_synonym="BCMP84; S100A15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1029..1034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100A14"
                     /gene_synonym="BCMP84; S100A15"
                     /note="hexamer: AATAAA"
     polyA_site      1054
                     /gene="S100A14"
                     /gene_synonym="BCMP84; S100A15"
                     /note="major polyA site"
ORIGIN      
        1 cctcctgtct tgtctcagcg gctgccaaca gatcatgagc catcagctcc tctggggcca
       61 gctataggac aacagaactc tcaccaaagg accagacaca gtgggcacca tgggacagtg
      121 tcggtcagcc aacgcagagg atgctcagga attcagtgat gtggagaggg ccattgagac
      181 cctcatcaag aactttcacc agtactccgt ggagggtggg aaggagacgc tgaccccttc
      241 tgagctacgg gacctggtca cccagcagct gccccatctc atgccgagca actgtggcct
      301 ggaagagaaa attgccaacc tgggcagctg caatgactct aaactggagt tcaggagttt
      361 ctgggagctg attggagaag cggccaagag tgtgaagctg gagaggcctg tccgggggca
      421 ctgagaactc cctctggaat tcttgggggg tgttggggag agactgtggg cctggagata
      481 aaacttgtct cctctaccac caccctgtac cctagcctgc acctgtcctc atctctgcaa
      541 agttcagctt ccttccccag gtctctgtgc actctgtctt ggatgctctg gggagctcat
      601 gggtggagga gtctccacca gagggaggct caggggactg gttgggccag ggatgaatat
      661 ttgagggata aaaattgtgt aagagccaaa gaattggtag tagggggaga acagagagga
      721 gctgggctat gggaaatgat ttgaataatg gagctgggaa tatggctgga tatctggtac
      781 taaaaaaggg tctttaagaa cctacttcct aatctcttcc ccaatccaaa ccatagctgt
      841 ctgtccagtg ctctcttcct gcctccagct ctgccccagg ctcctcctag actctgtccc
      901 tgggctaggg caggggagga gggagagcag ggttggggga gaggctgagg agagtgtgac
      961 atgtggggag aggaccagct gggtgcttgg gcattgacag aatgatggtt gttttgtatc
     1021 atttgattaa taaaaaaaaa tgaaaaaagt gaaa
//
