LOCUS       NM_001024211             477 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens S100 calcium binding protein A13 (S100A13), transcript
            variant 3, mRNA.
ACCESSION   NM_001024211
VERSION     NM_001024211.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Kazakov,A.S., Zemskova,M.Y., Rystsov,G.K., Vologzhannikova,A.A.,
            Deryusheva,E.I., Rastrygina,V.A., Sokolov,A.S., Permyakova,M.E.,
            Litus,E.A., Uversky,V.N., Permyakov,E.A. and Permyakov,S.E.
  TITLE     Specific S100 Proteins Bind Tumor Necrosis Factor and Inhibit Its
            Activity
  JOURNAL   Int J Mol Sci 23 (24), 15956 (2022)
   PUBMED   36555597
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Li,T., Xu,Y., Shi,Y., Chen,J., Lin,S., Zhu,J., Xu,X., Lu,L. and
            Zou,H.
  TITLE     Genome-wide analysis of DNA methylation identifies S100A13 as an
            epigenetic biomarker in individuals with chronic (>/= 30 years)
            type 2 diabetes without diabetic retinopathy
  JOURNAL   Clin Epigenetics 12 (1), 77 (2020)
   PUBMED   32493412
  REMARK    GeneRIF: Genome-wide analysis of DNA methylation identifies S100A13
            as an epigenetic biomarker in individuals with chronic (>/= 30
            years) type 2 diabetes without diabetic retinopathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 477)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 477)
  AUTHORS   Al-Mutairy,E.A., Imtiaz,F.A., Khalid,M., Al Qattan,S., Saleh,S.,
            Mahmoud,L.M., Al-Saif,M.M., Al-Haj,L., Al-Enazi,A., AlJebreen,A.M.,
            Mohammed,S.F., Mobeireek,A.F., Alkattan,K., Chisti,M.A.,
            Luzina,I.G., Al-Owain,M., Weheba,I., Abdelsayed,A.M., Ramzan,K.,
            Janssen,L.J., Conca,W., Alaiya,A., Collison,K.S., Meyer,B.F.,
            Atamas,S.P., Khabar,K.S., Hasday,J.D. and Al-Mohanna,F.
  TITLE     An atypical pulmonary fibrosis is associated with co-inheritance of
            mutations in the calcium binding protein genes S100A3 and S100A13
  JOURNAL   Eur Respir J 54 (1), 1802041 (2019)
   PUBMED   31073086
  REMARK    GeneRIF: An atypical pulmonary fibrosis is associated with
            co-inheritance of mutations in the calcium binding protein genes
            S100A3 and S100A13.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 477)
  AUTHORS   Su,Y., Xu,C., Sun,Z., Liang,Y., Li,G., Tong,T. and Chen,J.
  TITLE     S100A13 promotes senescence-associated secretory phenotype and
            cellular senescence via modulation of non-classical secretion of
            IL-1alpha
  JOURNAL   Aging (Albany NY) 11 (2), 549-572 (2019)
   PUBMED   30670674
  REMARK    GeneRIF: These findings unveil a critical role of the non-classical
            secretory pathway of IL-1alpha in cellular senescence and SASP
            regulation.
REFERENCE   6  (bases 1 to 477)
  AUTHORS   Mouta Carreira,C., LaVallee,T.M., Tarantini,F., Jackson,A.,
            Lathrop,J.T., Hampton,B., Burgess,W.H. and Maciag,T.
  TITLE     S100A13 is involved in the regulation of fibroblast growth factor-1
            and p40 synaptotagmin-1 release in vitro
  JOURNAL   J Biol Chem 273 (35), 22224-22231 (1998)
   PUBMED   9712836
REFERENCE   7  (bases 1 to 477)
  AUTHORS   Wicki,R., Marenholz,I., Mischke,D., Schafer,B.W. and Heizmann,C.W.
  TITLE     Characterization of the human S100A12 (calgranulin C, p6, CAAF1,
            CGRP) gene, a new member of the S100 gene cluster on chromosome
            1q21
  JOURNAL   Cell Calcium 20 (6), 459-464 (1996)
   PUBMED   8985590
REFERENCE   8  (bases 1 to 477)
  AUTHORS   Wicki,R., Schafer,B.W., Erne,P. and Heizmann,C.W.
  TITLE     Characterization of the human and mouse cDNAs coding for S100A13, a
            new member of the S100 protein family
  JOURNAL   Biochem Biophys Res Commun 227 (2), 594-599 (1996)
   PUBMED   8878558
REFERENCE   9  (bases 1 to 477)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   10 (bases 1 to 477)
  AUTHORS   Schafer,B.W., Wicki,R., Engelkamp,D., Mattei,M.G. and Heizmann,C.W.
  TITLE     Isolation of a YAC clone covering a cluster of nine S100 genes on
            human chromosome 1q21: rationale for a new nomenclature of the S100
            calcium-binding protein family
  JOURNAL   Genomics 25 (3), 638-643 (1995)
   PUBMED   7759097
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162258.12 and BX470102.12.
            
            On Sep 29, 2020 this sequence version replaced NM_001024211.1.
            
            Summary: The protein encoded by this gene is a member of the S100
            family of proteins containing 2 EF-hand calcium-binding motifs.
            S100 proteins are localized in the cytoplasm and/or nucleus of a
            wide range of cells, and involved in the regulation of a number of
            cellular processes such as cell cycle progression and
            differentiation. S100 genes include at least 13 members which are
            located as a cluster on chromosome 1q21. This protein is widely
            expressed in various types of tissues with a high expression level
            in thyroid gland. In smooth muscle cells, this protein co-expresses
            with other family members in the nucleus and in stress fibers,
            suggesting diverse functions in signal transduction. Multiple
            alternatively spliced transcript variants encoding the same protein
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL702514.1, BU752831.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000476133.6/ ENSP00000507299.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AL162258.12        2991-3013           c
            24-64               AL162258.12        2001-2041           c
            65-237              BX470102.12        100418-100590       c
            238-477             BX470102.12        92897-93136         c
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..477
                     /gene="S100A13"
                     /note="S100 calcium binding protein A13"
                     /db_xref="GeneID:6284"
                     /db_xref="HGNC:HGNC:10490"
                     /db_xref="MIM:601989"
     exon            1..23
                     /gene="S100A13"
                     /inference="alignment:Splign:2.1.0"
     exon            24..237
                     /gene="S100A13"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..381
                     /gene="S100A13"
                     /codon_start=1
                     /product="protein S100-A13"
                     /protein_id="NP_001019382.1"
                     /db_xref="CCDS:CCDS30874.1"
                     /db_xref="GeneID:6284"
                     /db_xref="HGNC:HGNC:10490"
                     /db_xref="MIM:601989"
                     /translation="MAAEPLTELEESIETVVTTFFTFARQEGRKDSLSVNEFKELVTQ
                     QLPHLLKDVGSLDEKMKSLDVNQDSELKFNEYWRLIGELAKEIRKKKDLKIRKK"
     exon            238..477
                     /gene="S100A13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      451..456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100A13"
                     /note="hexamer: AATAAA"
     polyA_site      477
                     /gene="S100A13"
                     /note="major polyA site"
ORIGIN      
        1 actctacccc atctccttgc cgggtcagcc ctgacaaagg tcagctagcc ccttgaggac
       61 atcagctttg gcctcagggt cctaatggca gcagaaccac tgacagagct agaggagtcc
      121 attgagaccg tggtcaccac cttcttcacc tttgcaaggc aggagggccg gaaggatagc
      181 ctcagcgtca acgagttcaa agagctggtt acccagcagt tgccccatct gctcaaggat
      241 gtgggctctc ttgatgagaa gatgaagagc ttggatgtga atcaggactc ggagctcaag
      301 ttcaatgagt actggagatt gattggggag ctggccaagg aaatcaggaa gaagaaagac
      361 ctgaagatca ggaagaagta aagccgcctg gctgagatgg ggtgggcagg gcagagctga
      421 tcagggccga gcagaaccgc actcttccca aataaagctt cctccttgaa acacaaa
//
