LOCUS       NM_005621                485 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens S100 calcium binding protein A12 (S100A12), mRNA.
ACCESSION   NM_005621
VERSION     NM_005621.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Zhang,Y., Li,Z., Chen,C., Wei,W., Li,Z., Huang,H., Zhou,H., He,W.,
            Xia,J., Li,B. and Yang,Y.
  TITLE     S100A12 is involved in the pathology of osteoarthritis by promoting
            M1 macrophage polarization via the NF-kappaB pathway
  JOURNAL   Connect Tissue Res 65 (2), 133-145 (2024)
   PUBMED   38492210
  REMARK    GeneRIF: S100A12 is involved in the pathology of osteoarthritis by
            promoting M1 macrophage polarization via the NF-kappaB pathway.
REFERENCE   2  (bases 1 to 485)
  AUTHORS   D'Accolti,M., Bellotti,D., Dzien,E., Leonetti,C., Leveraro,S.,
            Albanese,V., Marzola,E., Guerrini,R., Caselli,E., Rowinska-Zyrek,M.
            and Remelli,M.
  TITLE     Impact of C- and N-terminal protection on the stability, metal
            chelation and antimicrobial properties of calcitermin
  JOURNAL   Sci Rep 13 (1), 18228 (2023)
   PUBMED   37880318
  REMARK    GeneRIF: Impact of C- and N-terminal protection on the stability,
            metal chelation and antimicrobial properties of calcitermin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 485)
  AUTHORS   Korhonen,L., Paul,E.R., Wahlen,K., Haring,L., Vasar,E., Vaheri,A.
            and Lindholm,D.
  TITLE     Multivariate analyses of immune markers reveal increases in plasma
            EN-RAGE in first-episode psychosis patients
  JOURNAL   Transl Psychiatry 13 (1), 326 (2023)
   PUBMED   37863883
  REMARK    GeneRIF: Multivariate analyses of immune markers reveal increases
            in plasma EN-RAGE in first-episode psychosis patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 485)
  AUTHORS   Kazakov,A.S., Zemskova,M.Y., Rystsov,G.K., Vologzhannikova,A.A.,
            Deryusheva,E.I., Rastrygina,V.A., Sokolov,A.S., Permyakova,M.E.,
            Litus,E.A., Uversky,V.N., Permyakov,E.A. and Permyakov,S.E.
  TITLE     Specific S100 Proteins Bind Tumor Necrosis Factor and Inhibit Its
            Activity
  JOURNAL   Int J Mol Sci 23 (24), 15956 (2022)
   PUBMED   36555597
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 485)
  AUTHORS   Gellen,B., Thorin-Trescases,N., Thorin,E., Gand,E., Ragot,S.,
            Montaigne,D., Pucheu,Y., Mohammedi,K., Gatault,P., Potier,L.,
            Liuu,E., Hadjadj,S. and Saulnier,P.J.
  CONSRTM   SURDIAGENE Study group
  TITLE     Increased serum S100A12 levels are associated with higher risk of
            acute heart failure in patients with type 2 diabetes
  JOURNAL   ESC Heart Fail 9 (6), 3909-3919 (2022)
   PUBMED   36637406
  REMARK    GeneRIF: Increased serum S100A12 levels are associated with higher
            risk of acute heart failure in patients with type 2 diabetes.
REFERENCE   6  (bases 1 to 485)
  AUTHORS   Cole,A.M., Kim,Y.H., Tahk,S., Hong,T., Weis,P., Waring,A.J. and
            Ganz,T.
  TITLE     Calcitermin, a novel antimicrobial peptide isolated from human
            airway secretions
  JOURNAL   FEBS Lett 504 (1-2), 5-10 (2001)
   PUBMED   11522286
  REMARK    GeneRIF: The antimicrobial peptide calcitermin was isolated from
            human airway secretions and targets Gram-negative bacteria.
REFERENCE   7  (bases 1 to 485)
  AUTHORS   Marti,T., Erttmann,K.D. and Gallin,M.Y.
  TITLE     Host-parasite interaction in human onchocerciasis: identification
            and sequence analysis of a novel human calgranulin
  JOURNAL   Biochem Biophys Res Commun 221 (2), 454-458 (1996)
   PUBMED   8619876
REFERENCE   8  (bases 1 to 485)
  AUTHORS   Yamamura,T., Hitomi,J., Nagasaki,K., Suzuki,M., Takahashi,E.,
            Saito,S., Tsukada,T. and Yamaguchi,K.
  TITLE     Human CAAF1 gene--molecular cloning, gene structure, and chromosome
            mapping
  JOURNAL   Biochem Biophys Res Commun 221 (2), 356-360 (1996)
   PUBMED   8619860
REFERENCE   9  (bases 1 to 485)
  AUTHORS   Guignard,F., Mauel,J. and Markert,M.
  TITLE     Identification and characterization of a novel human neutrophil
            protein related to the S100 family
  JOURNAL   Biochem J 309 (Pt 2) (Pt 2), 395-401 (1995)
   PUBMED   7626002
REFERENCE   10 (bases 1 to 485)
  AUTHORS   Schafer,B.W., Wicki,R., Engelkamp,D., Mattei,M.G. and Heizmann,C.W.
  TITLE     Isolation of a YAC clone covering a cluster of nine S100 genes on
            human chromosome 1q21: rationale for a new nomenclature of the S100
            calcium-binding protein family
  JOURNAL   Genomics 25 (3), 638-643 (1995)
   PUBMED   7759097
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591704.7 and D83664.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005621.1.
            
            Summary: The protein encoded by this gene is a member of the S100
            family of proteins containing 2 EF-hand calcium-binding motifs.
            S100 proteins are localized in the cytoplasm and/or nucleus of a
            wide range of cells, and involved in the regulation of a number of
            cellular processes such as cell cycle progression and
            differentiation. S100 genes include at least 13 members which are
            located as a cluster on chromosome 1q21. This protein is proposed
            to be involved in specific calcium-dependent signal transduction
            pathways and its regulatory effect on cytoskeletal components may
            modulate various neutrophil activities. The protein includes an
            antimicrobial peptide which has antibacterial activity. [provided
            by RefSeq, Nov 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV715975.1, BC070294.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000368737.5/
                                                  ENSP00000357726.3
            Protein has antimicrobial activity :: PMID: 11522286
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL591704.7         71240-71261         c
            23-485              D83664.1           1-463
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..485
                     /gene="S100A12"
                     /gene_synonym="CAAF1; CAGC; CGRP; ENRAGE; MRP-6; MRP6; p6"
                     /note="S100 calcium binding protein A12"
                     /db_xref="GeneID:6283"
                     /db_xref="HGNC:HGNC:10489"
                     /db_xref="MIM:603112"
     exon            1..70
                     /gene="S100A12"
                     /gene_synonym="CAAF1; CAGC; CGRP; ENRAGE; MRP-6; MRP6; p6"
                     /inference="alignment:Splign:2.1.0"
     exon            71..228
                     /gene="S100A12"
                     /gene_synonym="CAAF1; CAGC; CGRP; ENRAGE; MRP-6; MRP6; p6"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..369
                     /gene="S100A12"
                     /gene_synonym="CAAF1; CAGC; CGRP; ENRAGE; MRP-6; MRP6; p6"
                     /note="calgranulin C; EN-RAGE; neutrophil S100 protein;
                     calcium-binding protein in amniotic fluid 1; extracellular
                     newly identified RAGE-binding protein; migration
                     inhibitory factor-related protein 6; calcitermin"
                     /codon_start=1
                     /product="protein S100-A12"
                     /protein_id="NP_005612.1"
                     /db_xref="CCDS:CCDS1037.1"
                     /db_xref="GeneID:6283"
                     /db_xref="HGNC:HGNC:10489"
                     /db_xref="MIM:603112"
                     /translation="MTKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELANT
                     IKNIKDKAVIDEIFQGLDANQDEQVDFQEFISLVAIALKAAHYHTHKE"
     exon            229..485
                     /gene="S100A12"
                     /gene_synonym="CAAF1; CAGC; CGRP; ENRAGE; MRP-6; MRP6; p6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      466..471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100A12"
                     /gene_synonym="CAAF1; CAGC; CGRP; ENRAGE; MRP-6; MRP6; p6"
                     /note="hexamer: AATAAA"
     polyA_site      485
                     /gene="S100A12"
                     /gene_synonym="CAAF1; CAGC; CGRP; ENRAGE; MRP-6; MRP6; p6"
                     /note="major polyA site"
ORIGIN      
        1 cttccttggc tcagtgccct tcaccactgc tggctttttg ctgtagctcc acattcctgt
       61 gcattgaggg gttaacatta ggctgggaag atgacaaaac ttgaagagca tctggaggga
      121 attgtcaata tcttccacca atactcagtt cggaaggggc attttgacac cctctctaag
      181 ggtgagctga agcagctgct tacaaaggag cttgcaaaca ccatcaagaa tatcaaagat
      241 aaagctgtca ttgatgaaat attccaaggc ctggatgcta atcaagatga acaggtcgac
      301 tttcaagaat tcatatccct ggtagccatt gcgctgaagg ctgcccatta ccacacccac
      361 aaagagtagg tagctctctg aaggcttttt acccagcaat gtcctcaatg agggtctttt
      421 ctttccctca ccaaaaccca gccttgcccg tggggagtaa gagttaataa acacactcac
      481 gaaaa
//
