LOCUS       NM_005620                563 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens S100 calcium binding protein A11 (S100A11), mRNA.
ACCESSION   NM_005620
VERSION     NM_005620.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 563)
  AUTHORS   Deng,C., Xu,Y., Chen,H., Zhu,X., Huang,L., Chen,Z., Xu,H., Song,G.,
            Lu,J., Huang,W., Liu,R., Tang,Q. and Wang,J.
  TITLE     Extracellular-vesicle-packaged S100A11 from osteosarcoma cells
            mediates lung premetastatic niche formation by recruiting gMDSCs
  JOURNAL   Cell Rep 43 (2), 113751 (2024)
   PUBMED   38341855
  REMARK    GeneRIF: Extracellular-vesicle-packaged S100A11 from osteosarcoma
            cells mediates lung premetastatic niche formation by recruiting
            gMDSCs.
REFERENCE   2  (bases 1 to 563)
  AUTHORS   Han,D., Guo,C., Cheng,H., Lu,J., Hou,Z., Zhang,X., Luo,Y.,
            Zhang,B., Zhao,W. and Shang,P.
  TITLE     Downregulation of S100A11 promotes T cell infiltration by
            regulating cancer-associated fibroblasts in prostate cancer
  JOURNAL   Int Immunopharmacol 128, 111323 (2024)
   PUBMED   38286714
  REMARK    GeneRIF: Downregulation of S100A11 promotes T cell infiltration by
            regulating cancer-associated fibroblasts in prostate cancer.
REFERENCE   3  (bases 1 to 563)
  AUTHORS   Zhou,R., Pei,B., Li,X. and Zhang,X.
  TITLE     Involvement of S100A6/S100A11 in T-Cell Immune Regulatory in HCC
            Revealed by Single Cell RNA-seq
  JOURNAL   Technol Cancer Res Treat 23, 15330338241252610 (2024)
   PUBMED   38766816
  REMARK    GeneRIF: Involvement of S100A6/S100A11 in T-Cell Immune Regulatory
            in HCC Revealed by Single Cell RNA-seq.
REFERENCE   4  (bases 1 to 563)
  AUTHORS   He,J., Lei,Y., Li,X., Wu,B. and Tang,Y.
  TITLE     Exploring the prognostic value of S100A11 and its association with
            immune infiltration in breast cancer
  JOURNAL   Sci Rep 13 (1), 22922 (2023)
   PUBMED   38129538
  REMARK    GeneRIF: Exploring the prognostic value of S100A11 and its
            association with immune infiltration in breast cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 563)
  AUTHORS   Zheng,M., Meng,H., Li,Y., Shi,J., Han,Y., Zhao,C., Chen,J., Han,J.,
            Liang,J., Chen,Y., Liu,Q. and Wang,Y.
  TITLE     S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and
            Has a Diagnostic Role in Hepatocellular Carcinoma
  JOURNAL   Int J Med Sci 20 (3), 318-328 (2023)
   PUBMED   36860671
  REMARK    GeneRIF: S100A11 Promotes Metastasis via AKT and ERK Signaling
            Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 563)
  AUTHORS   Mailliard,W.S., Haigler,H.T. and Schlaepfer,D.D.
  TITLE     Calcium-dependent binding of S100C to the N-terminal domain of
            annexin I
  JOURNAL   J Biol Chem 271 (2), 719-725 (1996)
   PUBMED   8557678
REFERENCE   7  (bases 1 to 563)
  AUTHORS   Tomasetto,C., Regnier,C., Moog-Lutz,C., Mattei,M.G., Chenard,M.P.,
            Lidereau,R., Basset,P. and Rio,M.C.
  TITLE     Identification of four novel human genes amplified and
            overexpressed in breast carcinoma and localized to the q11-q21.3
            region of chromosome 17
  JOURNAL   Genomics 28 (3), 367-376 (1995)
   PUBMED   7490069
REFERENCE   8  (bases 1 to 563)
  AUTHORS   Tanaka,M., Adzuma,K., Iwami,M., Yoshimoto,K., Monden,Y. and
            Itakura,M.
  TITLE     Human calgizzarin; one colorectal cancer-related gene selected by a
            large scale random cDNA sequencing and northern blot analysis
  JOURNAL   Cancer Lett 89 (2), 195-200 (1995)
   PUBMED   7889529
REFERENCE   9  (bases 1 to 563)
  AUTHORS   Schafer,B.W., Wicki,R., Engelkamp,D., Mattei,M.G. and Heizmann,C.W.
  TITLE     Isolation of a YAC clone covering a cluster of nine S100 genes on
            human chromosome 1q21: rationale for a new nomenclature of the S100
            calcium-binding protein family
  JOURNAL   Genomics 25 (3), 638-643 (1995)
   PUBMED   7759097
REFERENCE   10 (bases 1 to 563)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D38583.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005620.1.
            
            Summary: The protein encoded by this gene is a member of the S100
            family of proteins containing 2 EF-hand calcium-binding motifs.
            S100 proteins are localized in the cytoplasm and/or nucleus of a
            wide range of cells, and involved in the regulation of a number of
            cellular processes such as cell cycle progression and
            differentiation. S100 genes include at least 13 members which are
            located as a cluster on chromosome 1q21. This protein may function
            in motility, invasion, and tubulin polymerization. Chromosomal
            rearrangements and altered expression of this gene have been
            implicated in tumor metastasis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP305686.1, D38583.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271638.3/ ENSP00000271638.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-563               D38583.1           32-594
FEATURES             Location/Qualifiers
     source          1..563
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..563
                     /gene="S100A11"
                     /gene_synonym="HEL-S-43; MLN70; S100C"
                     /note="S100 calcium binding protein A11"
                     /db_xref="GeneID:6282"
                     /db_xref="HGNC:HGNC:10488"
                     /db_xref="MIM:603114"
     exon            1..92
                     /gene="S100A11"
                     /gene_synonym="HEL-S-43; MLN70; S100C"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..407
                     /gene="S100A11"
                     /gene_synonym="HEL-S-43; MLN70; S100C"
                     /note="calgizzarin; MLN 70; protein S100-C; metastatic
                     lymph node gene 70 protein; epididymis secretory protein
                     Li 43"
                     /codon_start=1
                     /product="protein S100-A11"
                     /protein_id="NP_005611.1"
                     /db_xref="CCDS:CCDS1009.1"
                     /db_xref="GeneID:6282"
                     /db_xref="HGNC:HGNC:10488"
                     /db_xref="MIM:603114"
                     /translation="MAKISSPTETERCIESLIAVFQKYAGKDGYNYTLSKTEFLSFMN
                     TELAAFTKNQKDPGVLDRMMKKLDTNSDGQLDFSEFLNLIGGLAMACHDSFLKAVPSQ
                     KRT"
     exon            93..245
                     /gene="S100A11"
                     /gene_synonym="HEL-S-43; MLN70; S100C"
                     /inference="alignment:Splign:2.1.0"
     exon            246..563
                     /gene="S100A11"
                     /gene_synonym="HEL-S-43; MLN70; S100C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      532..537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100A11"
                     /gene_synonym="HEL-S-43; MLN70; S100C"
                     /note="hexamer: AATAAA"
     polyA_site      563
                     /gene="S100A11"
                     /gene_synonym="HEL-S-43; MLN70; S100C"
                     /note="major polyA site"
ORIGIN      
        1 gaggagaggc tccagacccg cacgccgcgc gcacagagct ctcagcgccg ctcccagcca
       61 cagcctcccg cgcctcgctc agctccaaca tggcaaaaat ctccagccct acagagactg
      121 agcggtgcat cgagtccctg attgctgtct tccagaagta tgctggaaag gatggttata
      181 actacactct ctccaagaca gagttcctaa gcttcatgaa tacagaacta gctgccttca
      241 caaagaacca gaaggaccct ggtgtccttg accgcatgat gaagaaactg gacaccaaca
      301 gtgatggtca gctagatttc tcagaatttc ttaatctgat tggtggccta gctatggctt
      361 gccatgactc cttcctcaag gctgtccctt cccagaagcg gacctgagga ccccttggcc
      421 ctggccttca aacccacccc ctttccttcc agcctttctg tcatcatctc cacagcccac
      481 ccatcccctg agcacactaa ccacctcatg caggccccac ctgccaatag taataaagca
      541 atgtcacttt tttaaaacat gaa
//
