LOCUS       NM_002966                671 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens S100 calcium binding protein A10 (S100A10), mRNA.
ACCESSION   NM_002966
VERSION     NM_002966.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 671)
  AUTHORS   Li,J., Zhou,C., Gao,X., Tan,T., Zhang,M., Li,Y., Chen,H., Wang,R.,
            Wang,B., Liu,J. and Liu,P.
  TITLE     S100A10 promotes cancer metastasis via recruitment of MDSCs within
            the lungs
  JOURNAL   Oncoimmunology 13 (1), 2381803 (2024)
   PUBMED   39071160
  REMARK    GeneRIF: S100A10 promotes cancer metastasis via recruitment of
            MDSCs within the lungs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 671)
  AUTHORS   Ito,S., Kuromiya,K., Sekai,M., Sako,H., Sai,K., Morikawa,R.,
            Mukai,Y., Ida,Y., Anzai,M., Ishikawa,S., Kozawa,K., Shirai,T.,
            Tanimura,N., Sugie,K., Ikenouchi,J., Ogawa,M., Naguro,I., Ichijo,H.
            and Fujita,Y.
  TITLE     Accumulation of annexin A2 and S100A10 prevents apoptosis of
            apically delaminated, transformed epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 120 (43), e2307118120 (2023)
   PUBMED   37844241
  REMARK    GeneRIF: Accumulation of annexin A2 and S100A10 prevents apoptosis
            of apically delaminated, transformed epithelial cells.
REFERENCE   3  (bases 1 to 671)
  AUTHORS   Wang,X., Huang,H., Sze,K.M., Wang,J., Tian,L., Lu,J., Tsui,Y.M.,
            Ma,H.T., Lee,E., Chen,A., Lee,J., Wang,Y., Yam,J.W.P., Cheung,T.T.,
            Guan,X. and Ng,I.O.
  TITLE     S100A10 promotes HCC development and progression via transfer in
            extracellular vesicles and regulating their protein cargos
  JOURNAL   Gut 72 (7), 1370-1384 (2023)
   PUBMED   36631249
  REMARK    GeneRIF: S100A10 promotes HCC development and progression via
            transfer in extracellular vesicles and regulating their protein
            cargos.
REFERENCE   4  (bases 1 to 671)
  AUTHORS   Wang,H., Sun,Z., Zhao,W. and Geng,B.
  TITLE     [S100A10 promotes proliferation and invasion of lung adenocarcinoma
            cells by activating the Akt-mTOR signaling pathway]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (5), 733-740 (2023)
   PUBMED   37313814
  REMARK    GeneRIF: [S100A10 promotes proliferation and invasion of lung
            adenocarcinoma cells by activating the Akt-mTOR signaling pathway].
REFERENCE   5  (bases 1 to 671)
  AUTHORS   Ling,F. and Lu,Q.
  TITLE     S100 calcium-binding protein A10 contributes to malignant traits in
            osteosarcoma cells by regulating glycolytic metabolism via the
            AKT/mTOR pathway
  JOURNAL   Bioengineered 13 (5), 12298-12308 (2022)
   PUBMED   35579448
  REMARK    GeneRIF: S100 calcium-binding protein A10 contributes to malignant
            traits in osteosarcoma cells by regulating glycolytic metabolism
            via the AKT/mTOR pathway.
REFERENCE   6  (bases 1 to 671)
  AUTHORS   Dooley,T.P., Weiland,K.L. and Simon,M.
  TITLE     cDNA sequence of human p11 calpactin I light chain
  JOURNAL   Genomics 13 (3), 866-868 (1992)
   PUBMED   1386341
REFERENCE   7  (bases 1 to 671)
  AUTHORS   Harder,T., Kube,E. and Gerke,V.
  TITLE     Cloning and characterization of the human gene encoding p11:
            structural similarity to other members of the S-100 gene family
  JOURNAL   Gene 113 (2), 269-274 (1992)
   PUBMED   1533380
REFERENCE   8  (bases 1 to 671)
  AUTHORS   Creutz,C.E., Moss,S., Edwardson,J.M., Hide,I. and Gomperts,B.
  TITLE     Differential recognition of secretory vesicles by annexins.
            European Molecular Biology Organization Course 'Advanced Techniques
            for Studying Secretion'
  JOURNAL   Biochem Biophys Res Commun 184 (1), 347-352 (1992)
   PUBMED   1533123
REFERENCE   9  (bases 1 to 671)
  AUTHORS   Kube,E., Weber,K. and Gerke,V.
  TITLE     Primary structure of human, chicken, and Xenopus laevis p11, a
            cellular ligand of the Src-kinase substrate, annexin II
  JOURNAL   Gene 102 (2), 255-259 (1991)
   PUBMED   1831433
REFERENCE   10 (bases 1 to 671)
  AUTHORS   Becker,T., Weber,K. and Johnsson,N.
  TITLE     Protein-protein recognition via short amphiphilic helices; a
            mutational analysis of the binding site of annexin II for p11
  JOURNAL   EMBO J 9 (13), 4207-4213 (1990)
   PUBMED   2148288
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE378444.1 and BQ050753.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002966.2.
            
            Summary: The protein encoded by this gene is a member of the S100
            family of proteins containing 2 EF-hand calcium-binding motifs.
            S100 proteins are localized in the cytoplasm and/or nucleus of a
            wide range of cells, and involved in the regulation of a number of
            cellular processes such as cell cycle progression and
            differentiation. S100 genes include at least 13 members which are
            located as a cluster on chromosome 1q21. This protein may function
            in exocytosis and endocytosis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM785208.1, BU521490.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368811.8/ ENSP00000357801.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               BE378444.1         233-493
            262-671             BQ050753.1         226-635
FEATURES             Location/Qualifiers
     source          1..671
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..671
                     /gene="S100A10"
                     /gene_synonym="42C; ANX2L; ANX2LG; CAL1L; Ca[1]; CLP11;
                     GP11; p10; P11"
                     /note="S100 calcium binding protein A10"
                     /db_xref="GeneID:6281"
                     /db_xref="HGNC:HGNC:10487"
                     /db_xref="MIM:114085"
     exon            1..108
                     /gene="S100A10"
                     /gene_synonym="42C; ANX2L; ANX2LG; CAL1L; Ca[1]; CLP11;
                     GP11; p10; P11"
                     /inference="alignment:Splign:2.1.0"
     exon            109..261
                     /gene="S100A10"
                     /gene_synonym="42C; ANX2L; ANX2LG; CAL1L; Ca[1]; CLP11;
                     GP11; p10; P11"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..423
                     /gene="S100A10"
                     /gene_synonym="42C; ANX2L; ANX2LG; CAL1L; Ca[1]; CLP11;
                     GP11; p10; P11"
                     /note="annexin II ligand, calpactin I, light polypeptide;
                     S100 calcium binding protein A10 (annexin II ligand,
                     calpactin I, light polypeptide (p11)); calpactin I light
                     chain; calpactin-1 light chain; cellular ligand of annexin
                     II; annexin II tetramer (AIIt) p11 subunit"
                     /codon_start=1
                     /product="protein S100-A10"
                     /protein_id="NP_002957.1"
                     /db_xref="CCDS:CCDS1008.1"
                     /db_xref="GeneID:6281"
                     /db_xref="HGNC:HGNC:10487"
                     /db_xref="MIM:114085"
                     /translation="MPSQMEHAMETMMFTFHKFAGDKGYLTKEDLRVLMEKEFPGFLE
                     NQKDPLAVDKIMKDLDQCRDGKVGFQSFFSLIAGLTIACNDYFVVHMKQKGKK"
     exon            262..671
                     /gene="S100A10"
                     /gene_synonym="42C; ANX2L; ANX2LG; CAL1L; Ca[1]; CLP11;
                     GP11; p10; P11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      647..652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100A10"
                     /gene_synonym="42C; ANX2L; ANX2LG; CAL1L; Ca[1]; CLP11;
                     GP11; p10; P11"
                     /note="hexamer: AATAAA"
     polyA_site      671
                     /gene="S100A10"
                     /gene_synonym="42C; ANX2L; ANX2LG; CAL1L; Ca[1]; CLP11;
                     GP11; p10; P11"
                     /note="major polyA site"
ORIGIN      
        1 acccacccgc cgcacgtact aaggaaggcg cacagcccgc cgcgctcgcc tctccgcccc
       61 gcgtccagct cgcccagctc gcccagcgtc cgccgcgcct cggccaaggc ttcaacggac
      121 cacaccaaaa tgccatctca aatggaacac gccatggaaa ccatgatgtt tacatttcac
      181 aaattcgctg gggataaagg ctacttaaca aaggaggacc tgagagtact catggaaaag
      241 gagttccctg gatttttgga aaatcaaaaa gaccctctgg ctgtggacaa aataatgaag
      301 gacctggacc agtgtagaga tggcaaagtg ggcttccaga gcttcttttc cctaattgcg
      361 ggcctcacca ttgcatgcaa tgactatttt gtagtacaca tgaagcagaa gggaaagaag
      421 taggcagaaa tgagcagttc gctcctccct gataagagtt gtcccaaagg gtcgcttaag
      481 gaatctgccc cacagcttcc cccatagaag gatttcatga gcagatcagg acacttagca
      541 aatgtaaaaa taaaatctaa ctctcatttg acaagcagag aaagaaaagt taaataccag
      601 ataagctttt gatttttgta ttgtttgcat ccccttgccc tcaataaata aagttctttt
      661 ttagttccaa a
//
