LOCUS       NM_006271                559 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens S100 calcium binding protein A1 (S100A1), mRNA.
ACCESSION   NM_006271
VERSION     NM_006271.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 559)
  AUTHORS   Sanlav,G., Baran,B., Kum Ozsengezer,S., Kizmazoglu,D., Altun,Z.,
            Aktas,S. and Olgun,N.
  TITLE     S-100 and MATH-1 Protein Expressions Can Be Useful for the
            Prediction of Clinical Outcome in Neuroblastoma Patients
  JOURNAL   J Pediatr Hematol Oncol 46 (1), 21-28 (2024)
   PUBMED   37943051
  REMARK    GeneRIF: S-100 and MATH-1 Protein Expressions Can Be Useful for the
            Prediction of Clinical Outcome in Neuroblastoma Patients.
REFERENCE   2  (bases 1 to 559)
  AUTHORS   Shamir,A., Yitzhaky,A., Segev,A., Haroutunian,V., Katsel,P. and
            Hertzberg,L.
  TITLE     Up-Regulation of S100 Gene Family in Brain Samples of a Subgroup of
            Individuals with Schizophrenia: Meta-analysis
  JOURNAL   Neuromolecular Med 25 (3), 388-401 (2023)
   PUBMED   37005977
  REMARK    GeneRIF: Up-Regulation of S100 Gene Family in Brain Samples of a
            Subgroup of Individuals with Schizophrenia: Meta-analysis.
REFERENCE   3  (bases 1 to 559)
  AUTHORS   Lin,Y., Guo,R., R,G. and Xu,B.
  TITLE     Tailored modulation of S100A1 and RASSF8 expression by
            butanediamide augments healing of rotator cuff tears
  JOURNAL   PeerJ 11, e15791 (2023)
   PUBMED   37601265
  REMARK    GeneRIF: Tailored modulation of S100A1 and RASSF8 expression by
            butanediamide augments healing of rotator cuff tears.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 559)
  AUTHORS   Mandarino,A., Thiyagarajan,S., Martins,A.C.F., Gomes,R.D.S.,
            Vetter,S.W. and Leclerc,E.
  TITLE     S100s and HMGB1 Crosstalk in Pancreatic Cancer Tumors
  JOURNAL   Biomolecules 13 (8), 1175 (2023)
   PUBMED   37627239
  REMARK    GeneRIF: S100s and HMGB1 Crosstalk in Pancreatic Cancer Tumors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 559)
  AUTHORS   Sari,Z.B., Acikalin,M.F., Arik,D., Ozen,A., Can,C. and Colak,E.
  TITLE     The Role of CK7, S100A1, and CD82 (KAI1) Expression in the
            Differential Diagnosis of Chromophobe Renal Cell Carcinoma and
            Renal Oncocytoma
  JOURNAL   Appl Immunohistochem Mol Morphol 29 (7), 534-540 (2021)
   PUBMED   33605572
  REMARK    GeneRIF: The Role of CK7, S100A1, and CD82 (KAI1) Expression in the
            Differential Diagnosis of Chromophobe Renal Cell Carcinoma and
            Renal Oncocytoma.
REFERENCE   6  (bases 1 to 559)
  AUTHORS   Zimmer,D.B., Cornwall,E.H., Landar,A. and Song,W.
  TITLE     The S100 protein family: history, function, and expression
  JOURNAL   Brain Res Bull 37 (4), 417-429 (1995)
   PUBMED   7620916
  REMARK    Review article
REFERENCE   7  (bases 1 to 559)
  AUTHORS   Engelkamp,D., Schafer,B.W., Erne,P. and Heizmann,C.W.
  TITLE     S100 alpha, CAPL, and CACY: molecular cloning and expression
            analysis of three calcium-binding proteins from human heart
  JOURNAL   Biochemistry 31 (42), 10258-10264 (1992)
   PUBMED   1384693
REFERENCE   8  (bases 1 to 559)
  AUTHORS   Morii,K., Tanaka,R., Takahashi,Y., Minoshima,S., Fukuyama,R.,
            Shimizu,N. and Kuwano,R.
  TITLE     Structure and chromosome assignment of human S100 alpha and beta
            subunit genes
  JOURNAL   Biochem Biophys Res Commun 175 (1), 185-191 (1991)
   PUBMED   1998503
  REMARK    Erratum:[Biochem Biophys Res Commun 1991 Jun 14;177(2):894]
REFERENCE   9  (bases 1 to 559)
  AUTHORS   Baudier,J., Glasser,N. and Gerard,D.
  TITLE     Ions binding to S100 proteins. I. Calcium- and zinc-binding
            properties of bovine brain S100 alpha alpha, S100a (alpha beta),
            and S100b (beta beta) protein: Zn2+ regulates Ca2+ binding on S100b
            protein
  JOURNAL   J Biol Chem 261 (18), 8192-8203 (1986)
   PUBMED   3722149
REFERENCE   10 (bases 1 to 559)
  AUTHORS   Kato,K. and Kimura,S.
  TITLE     S100ao (alpha alpha) protein is mainly located in the heart and
            striated muscles
  JOURNAL   Biochim Biophys Acta 842 (2-3), 146-150 (1985)
   PUBMED   4052452
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X58079.1 and AL162258.12.
            
            On Jun 2, 2019 this sequence version replaced NM_006271.1.
            
            Summary: The protein encoded by this gene is a member of the S100
            family of proteins containing 2 EF-hand calcium-binding motifs.
            S100 proteins are localized in the cytoplasm and/or nucleus of a
            wide range of cells, and involved in the regulation of a number of
            cellular processes such as cell cycle progression and
            differentiation. S100 genes include at least 13 members which are
            located as a cluster on chromosome 1q21. This protein may function
            in stimulation of Ca2+-induced Ca2+ release, inhibition of
            microtubule assembly, and inhibition of protein kinase C-mediated
            phosphorylation. Reduced expression of this protein has been
            implicated in cardiomyopathies. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014392.1, BX096164.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292169.6/ ENSP00000292169.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-557               X58079.1           38-594
            558-559             AL162258.12        7546-7547
FEATURES             Location/Qualifiers
     source          1..559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..559
                     /gene="S100A1"
                     /gene_synonym="S100; S100-alpha; S100A"
                     /note="S100 calcium binding protein A1"
                     /db_xref="GeneID:6271"
                     /db_xref="HGNC:HGNC:10486"
                     /db_xref="MIM:176940"
     exon            1..63
                     /gene="S100A1"
                     /gene_synonym="S100; S100-alpha; S100A"
                     /inference="alignment:Splign:2.1.0"
     exon            64..217
                     /gene="S100A1"
                     /gene_synonym="S100; S100-alpha; S100A"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..361
                     /gene="S100A1"
                     /gene_synonym="S100; S100-alpha; S100A"
                     /note="S100 alpha; S100 protein, alpha polypeptide; S-100
                     protein alpha chain; S-100 protein subunit alpha"
                     /codon_start=1
                     /product="protein S100-A1"
                     /protein_id="NP_006262.1"
                     /db_xref="CCDS:CCDS1047.1"
                     /db_xref="GeneID:6271"
                     /db_xref="HGNC:HGNC:10486"
                     /db_xref="MIM:176940"
                     /translation="MGSELETAMETLINVFHAHSGKEGDKYKLSKKELKELLQTELSG
                     FLDAQKDVDAVDKVMKELDENGDGEVDFQEYVVLVAALTVACNNFFWENS"
     exon            218..559
                     /gene="S100A1"
                     /gene_synonym="S100; S100-alpha; S100A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      534..539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100A1"
                     /gene_synonym="S100; S100-alpha; S100A"
                     /note="hexamer: ATTAAA"
     polyA_site      559
                     /gene="S100A1"
                     /gene_synonym="S100; S100-alpha; S100A"
                     /note="major polyA site"
ORIGIN      
        1 agccacattt gcaaccttgg ccatctgtcc agaacctgct cccacctcag gcccaggcca
       61 accgtgcact gctgcaatgg gctctgagct ggagacggcg atggagaccc tcatcaacgt
      121 gttccacgcc cactcgggca aagaggggga caagtacaag ctgagcaaga aggagctgaa
      181 agagctgctg cagacggagc tctctggctt cctggatgcc cagaaggatg tggatgctgt
      241 ggacaaggtg atgaaggagc tagacgagaa tggagacggg gaggtggact tccaggagta
      301 tgtggtgctt gtggctgctc tcacagtggc ctgtaacaat ttcttctggg agaacagttg
      361 agcagacagc cacattgggc agcgcccttc ctctccaccc tcccagacct gcctcttccc
      421 cctgcttcca cctcacccca cttatccctc tccataaccc cacccttgcc caccccaccc
      481 ccacccccac caagggcgca agagtagcgg tccaagcctg caactcatct ttcattaaag
      541 gcttctctct caccagcca
//
