LOCUS       NM_001036              15568 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens ryanodine receptor 3 (RYR3), transcript variant 1,
            mRNA.
ACCESSION   NM_001036
VERSION     NM_001036.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15568)
  AUTHORS   Pergande,M., Motameny,S., Ozdemir,O., Kreutzer,M., Wang,H.,
            Daimaguler,H.S., Becker,K., Karakaya,M., Ehrhardt,H., Elcioglu,N.,
            Ostojic,S., Chao,C.M., Kawalia,A., Duman,O., Koy,A., Hahn,A.,
            Reimann,J., Schoner,K., Schanzer,A., Westhoff,J.H.,
            Schwaibold,E.M.C., Cossee,M., Imbert-Bouteille,M., von Pein,H.,
            Haliloglu,G., Topaloglu,H., Altmuller,J., Nurnberg,P., Thiele,H.,
            Heller,R. and Cirak,S.
  TITLE     The genomic and clinical landscape of fetal akinesia
  JOURNAL   Genet Med 22 (3), 511-523 (2020)
   PUBMED   31680123
  REMARK    GeneRIF: The genomic and clinical landscape of fetal akinesia.
            Erratum:[Genet Med. 2020 Aug;22(8):1426-1428. doi:
            10.1038/s41436-020-0839-9.. PMID: 32451403]
REFERENCE   2  (bases 1 to 15568)
  AUTHORS   O' Donnell,A.M., Nakamura,H. and Puri,P.
  TITLE     Altered ryanodine receptor gene expression in Hirschsprung's
            disease
  JOURNAL   Pediatr Surg Int 35 (9), 923-927 (2019)
   PUBMED   31263958
  REMARK    GeneRIF: The Ryr Ca2+ release channel is central to cytoplasmic
            Ca2+ signalling in skeletal muscle, the heart, and many other
            tissues, playing a vital role in muscular contraction.
REFERENCE   3  (bases 1 to 15568)
  AUTHORS   Gong,S., Su,B.B., Tovar,H., Mao,C., Gonzalez,V., Liu,Y., Lu,Y.,
            Wang,K.S. and Xu,C.
  TITLE     Polymorphisms Within RYR3 Gene Are Associated With Risk and Age at
            Onset of Hypertension, Diabetes, and Alzheimer's Disease
  JOURNAL   Am J Hypertens 31 (7), 818-826 (2018)
   PUBMED   29590321
  REMARK    GeneRIF: RYR3 variants are associated with risk of and age of onset
            for hypertension, diabetes, and Alzheimer disease.
REFERENCE   4  (bases 1 to 15568)
  AUTHORS   Yang,F., Zhu,X.H., Zhang,Q., Sun,N.X., Ji,Y.X., Ma,J.Z., Xiao,B.,
            Ding,H.X., Sun,S.H. and Li,W.
  TITLE     Genomic Characteristics of Gender Dysphoria Patients and
            Identification of Rare Mutations in RYR3 Gene
  JOURNAL   Sci Rep 7 (1), 8339 (2017)
   PUBMED   28827537
  REMARK    GeneRIF: Mutations in RYR3 Gene is associated with Gender
            Dysphoria.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 15568)
  AUTHORS   Chang,Y.C., Chiu,Y.F., He,C.T., Sheu,W.H., Lin,M.W., Seto,T.B.,
            Assimes,T., Jou,Y.S., Su,L., Lee,W.J., Lee,P.C., Tsai,S.H. and
            Chuang,L.M.
  TITLE     Genome-wide linkage analysis and regional fine mapping identified
            variants in the RYR3 gene as a novel quantitative trait locus for
            circulating adiponectin in Chinese population
  JOURNAL   Medicine (Baltimore) 95 (44), e5174 (2016)
   PUBMED   27858853
  REMARK    GeneRIF: a genome-wide linkage scan and regional association
            fine-mapping identified variants in the RYR3 gene as a quantitative
            trail locus for plasma adiponectin levels in Chinese population
REFERENCE   6  (bases 1 to 15568)
  AUTHORS   Bertocchini,F., Ovitt,C.E., Conti,A., Barone,V., Scholer,H.R.,
            Bottinelli,R., Reggiani,C. and Sorrentino,V.
  TITLE     Requirement for the ryanodine receptor type 3 for efficient
            contraction in neonatal skeletal muscles
  JOURNAL   EMBO J 16 (23), 6956-6963 (1997)
   PUBMED   9384575
  REMARK    GeneRIF: RyR3 is expressed in all murine skeletal muscles during
            the post-natal phase of muscle development and in fewer muscles in
            adult mice. In agreement, RyR3 KO mice present impaired
            contractility during the first weeks after birth but not in adult
            life.
REFERENCE   7  (bases 1 to 15568)
  AUTHORS   Lynn,S., Morgan,J.M., Lamb,H.K., Meissner,G. and Gillespie,J.I.
  TITLE     Isolation and partial cloning of ryanodine-sensitive Ca2+ release
            channel protein isoforms from human myometrial smooth muscle
  JOURNAL   FEBS Lett 372 (1), 6-12 (1995)
   PUBMED   7556644
REFERENCE   8  (bases 1 to 15568)
  AUTHORS   Hakamata,Y., Nishimura,S., Nakai,J., Nakashima,Y., Kita,T. and
            Imoto,K.
  TITLE     Involvement of the brain type of ryanodine receptor in T-cell
            proliferation
  JOURNAL   FEBS Lett 352 (2), 206-210 (1994)
   PUBMED   7523185
REFERENCE   9  (bases 1 to 15568)
  AUTHORS   Sorrentino,V., Giannini,G., Malzac,P. and Mattei,M.G.
  TITLE     Localization of a novel ryanodine receptor gene (RYR3) to human
            chromosome 15q14-q15 by in situ hybridization
  JOURNAL   Genomics 18 (1), 163-165 (1993)
   PUBMED   8276408
REFERENCE   10 (bases 1 to 15568)
  AUTHORS   Giannini,G., Clementi,E., Ceci,R., Marziali,G. and Sorrentino,V.
  TITLE     Expression of a ryanodine receptor-Ca2+ channel that is regulated
            by TGF-beta
  JOURNAL   Science 257 (5066), 91-94 (1992)
   PUBMED   1320290
  REMARK    GeneRIF: This is the first published report on RyR3 and also
            establishes the first evidence of wide expression of the RyR3 gene.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC055874.8, AC067793.9,
            AC011938.4, AC087638.7 and AC010809.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 23, 2020 this sequence version replaced NM_001036.5.
            
            Summary: The protein encoded by this gene is a ryanodine receptor,
            which functions to release calcium from intracellular storage for
            use in many cellular processes. For example, the encoded protein is
            involved in skeletal muscle contraction by releasing calcium from
            the sarcoplasmic reticulum followed by depolarization of T-tubules.
            Two transcript variants encoding different isoforms have been found
            for this gene. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ001515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465404 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000634891.2/ ENSP00000489262.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AC055874.8         22026-22155         c
            131-250             AC067793.9         12993-13112         c
            251-358             AC011938.4         98006-98113         c
            359-433             AC011938.4         71078-71152         c
            434-512             AC011938.4         68355-68433         c
            513-625             AC011938.4         62282-62394         c
            626-725             AC011938.4         60854-60953         c
            726-819             AC011938.4         58029-58122         c
            820-894             AC011938.4         53540-53614         c
            895-1051            AC011938.4         51428-51584         c
            1052-1225           AC011938.4         38734-38907         c
            1226-1347           AC011938.4         34945-35066         c
            1348-1516           AC011938.4         21600-21768         c
            1517-1652           AC011938.4         20101-20236         c
            1653-1748           AC011938.4         17254-17349         c
            1749-1867           AC011938.4         15628-15746         c
            1868-2001           AC011938.4         192-325             c
            2002-2243           AC087638.7         29465-29706
            2244-2436           AC087638.7         39525-39717
            2437-2653           AC087638.7         50149-50365
            2654-2758           AC087638.7         54813-54917
            2759-2862           AC087638.7         56282-56385
            2863-2946           AC087638.7         57552-57635
            2947-3106           AC087638.7         59291-59450
            3107-3254           AC087638.7         60928-61075
            3255-3460           AC087638.7         61956-62161
            3461-3635           AC087638.7         62718-62892
            3636-3844           AC087638.7         70653-70861
            3845-4020           AC087638.7         72693-72868
            4021-4057           AC087638.7         73766-73802
            4058-4221           AC087638.7         75414-75577
            4222-4387           AC087638.7         79060-79225
            4388-4474           AC087638.7         86062-86148
            4475-4701           AC087638.7         86539-86765
            4702-5497           AC087638.7         88495-89290
            5498-5698           AC087638.7         89879-90079
            5699-5801           AC087638.7         95696-95798
            5802-5939           AC087638.7         96761-96898
            5940-6213           AC087638.7         122560-122833
            6214-6328           AC087638.7         124224-124338
            6329-6458           AC087638.7         126046-126175
            6459-6562           AC087638.7         127319-127422
            6563-6698           AC087638.7         133261-133396
            6699-6879           AC087638.7         149057-149237
            6880-6991           AC087638.7         150407-150518
            6992-7112           AC087638.7         152728-152848
            7113-7282           AC087638.7         155199-155368
            7283-7503           AC087638.7         157816-158036
            7504-7594           AC087638.7         162577-162667
            7595-7735           AC087638.7         164792-164932
            7736-7899           AC087638.7         166174-166337
            7900-7978           AC087638.7         168708-168786
            7979-8068           AC087638.7         172410-172499
            8069-8215           AC010809.10        147735-147881       c
            8216-8278           AC010809.10        147465-147527       c
            8279-8354           AC010809.10        145941-146016       c
            8355-8478           AC010809.10        145709-145832       c
            8479-8594           AC010809.10        140815-140930       c
            8595-8662           AC010809.10        139622-139689       c
            8663-8784           AC010809.10        138399-138520       c
            8785-8834           AC010809.10        127288-127337       c
            8835-8895           AC010809.10        126823-126883       c
            8896-9134           AC010809.10        123837-124075       c
            9135-9216           AC010809.10        122380-122461       c
            9217-9347           AC010809.10        115654-115784       c
            9348-9668           AC010809.10        110013-110333       c
            9669-9909           AC010809.10        107537-107777       c
            9910-9997           AC010809.10        95138-95225         c
            9998-10090          AC010809.10        94034-94126         c
            10091-10105         AC010809.10        88426-88440         c
            10106-10276         AC010809.10        85346-85516         c
            10277-10336         AC010809.10        84958-85017         c
            10337-10468         AC010809.10        83001-83132         c
            10469-10581         AC010809.10        82416-82528         c
            10582-10678         AC010809.10        79037-79133         c
            10679-10785         AC010809.10        77311-77417         c
            10786-10837         AC010809.10        76188-76239         c
            10838-10894         AC010809.10        75183-75239         c
            10895-10994         AC010809.10        74626-74725         c
            10995-11074         AC010809.10        74393-74472         c
            11075-11151         AC010809.10        72923-72999         c
            11152-11225         AC010809.10        70319-70392         c
            11226-11243         AC010809.10        69726-69743         c
            11244-11324         AC010809.10        69243-69323         c
            11325-11413         AC010809.10        68708-68796         c
            11414-11542         AC010809.10        64904-65032         c
            11543-11647         AC010809.10        60923-61027         c
            11648-11729         AC010809.10        59008-59089         c
            11730-13057         AC010809.10        57037-58364         c
            13058-13116         AC010809.10        55112-55170         c
            13117-13288         AC010809.10        53960-54131         c
            13289-13375         AC010809.10        52421-52507         c
            13376-13576         AC010809.10        50933-51133         c
            13577-13707         AC010809.10        47574-47704         c
            13708-13750         AC010809.10        42908-42950         c
            13751-13878         AC010809.10        42313-42440         c
            13879-13939         AC010809.10        41546-41606         c
            13940-14086         AC010809.10        41083-41229         c
            14087-14221         AC010809.10        38081-38215         c
            14222-14378         AC010809.10        36264-36420         c
            14379-14443         AC010809.10        35336-35400         c
            14444-14544         AC010809.10        34817-34917         c
            14545-14596         AC010809.10        31806-31857         c
            14597-15568         AC010809.10        29893-30864         c
FEATURES             Location/Qualifiers
     source          1..15568
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q13.3-q14"
     gene            1..15568
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /note="ryanodine receptor 3"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
     exon            1..130
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..14692
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     brain-type ryanodine receptor; brain ryanodine
                     receptor-calcium release channel; type 3 ryanodine
                     receptor"
                     /codon_start=1
                     /product="ryanodine receptor 3 isoform 1"
                     /protein_id="NP_001027.3"
                     /db_xref="CCDS:CCDS45210.1"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
                     /translation="MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLG
                     NRLCFLEPTSEAKYIPPDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRT
                     LLYGHAVLLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRS
                     EGEKVRIGDDLILVSVSSERYLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYL
                     LGGHVVRLFHGHDECLTIPSTDQNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGS
                     NIRWGQAFRLRHLTTGHYLALTEDQGLILQDRAKSDTKSTAFSFRASKELKEKLDSSH
                     KRDIEGMGVPEIKYGDSVCFVQHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMD
                     DGLTLQRCQREESQAARIIRNTTALFSQFVSGNNRTAAPITLPIEEVLQTLQDLIAYF
                     QPPEEEMRHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNVYNSVAHFAGIAREE
                     SGMAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILEVLHCIL
                     TESPEALNLIAEGHIKSIISLLDKHGRNHKVLDILCSLCLCNGVAVRANQNLICDNLL
                     PRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEPTHLRV
                     GWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRIPRAVASINQHLLRSDD
                     VVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMSFSAGVKVRFLMGGRHGEF
                     KFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGIRDLLGTTQFLSQASFIPCPVDT
                     SQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKRQHPCLVEFSKLPET
                     EKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMSNGYKPAPLDLSD
                     VKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVPYALLDERTK
                     KSNRDSLREAVRTFVGYGYNIEPSDQELADSAVEKVSIDKIRFFRVERSYAVRSGKWY
                     FEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGNRGQRWHQGSGYFGRTWQPGD
                     VVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICCLGLSQIGRMNLG
                     TDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVMRIDGT
                     MDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEI
                     LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRV
                     HESVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQ
                     VEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFRSEEKNPVPQCPPRLDVQT
                     IQPVLWSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQE
                     DLMRFHYHTLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLL
                     ISIHLASAKERKLMMKNEYIIPITSTTRNIRLFPDESKRHGLPGVGLRTCLKPGFRFS
                     TPCFVVTGEDHQKQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVL
                     KLIGTLLVMGVFDDDDVRQILLLIDPSVFGEHSAGTEEGAEKEEVTQVEEKAVEAGEK
                     AGKEAPVKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQK
                     FRYNELMQALNMSAALTARKTKEFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFH
                     EDLLLHCGVPLEEEEEEEEDTSWTGKLCALVYKIKGPPKPEKEQPTEEEERCPTTLKE
                     LISQTMICWAQEDQIQDSELVRMMFNLLRRQYDSIGELLQALRKTYTISHTSVSDTIN
                     LLAALGQIRSLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMV
                     NVLGTEKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMR
                     GSTPLDVAASSVMDNNELALSLEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPI
                     EGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAI
                     KISENPALDLPSQGYKREVSTGDDEEEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLI
                     QTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKAP
                     MVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYICSAVL
                     PLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPS
                     MLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLT
                     EKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTRITATLEKQISVDADG
                     NFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLI
                     RPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRENEKLRSVSQANQ
                     GNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYD
                     TLTAKEKFKDREKAQDLFKFLQVNGIIVSRGMKDMELDASSMEKRFAYKFLKKILKYV
                     DSAQEFIAHLEAIVSSGKTEKSPRDQEIKFFAKVLLPLVDQYFTSHCLYFLSSPLKPL
                     SSSGYASHKEKEMVAGLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVMKS
                     GSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILT
                     SIFEHVTQHQFGMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAA
                     AIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLA
                     ESGARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGNI
                     LKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEE
                     QLKADGKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLF
                     RMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQER
                     KKTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSHRDTDEEVRE
                     HLRNNLHLQEKSDDPAVKWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQ
                     PLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSF
                     EEKLVQDLAKSPKVEEEEEEETEKQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSS
                     MMAKSCQSGEDEEEDEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGE
                     MSPMVVETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAF
                     ERQNKAEGLGMVTEEGTLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRT
                     QMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFN
                     SLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQ
                     DMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKE
                     YDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNYVDFVDRFHEPAK
                     DIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYF
                     EISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISE
                     SDSADRPEEEEEDEDSSYVLEIAGEEEEDGSLEPASAFAMACASVKRNVTDFLKRATL
                     KNLRKQYRNVKKMTAKELVKVLFSFFWMLFVGLFQLLFTILGGIFQILWSTVFGGGLV
                     EGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGITTELVHFIKGEKGDTDIM
                     SDLFGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLESTVQKKRKAQAAEMKAANEA
                     EGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVTKKKKRRCGQKVEKPEAFTANFFKG
                     LEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETEDVANLWNSF
                     NDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKVPLVVFKREKE
                     IARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGA
                     ERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLA
                     WYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLY
                     TVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPY
                     EMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDY
                     FDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAG
                     DCFRKQYEDQLG"
     exon            131..250
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            251..358
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            359..433
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            434..512
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            513..625
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            626..725
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            726..819
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            820..894
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1051
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1225
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1347
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1516
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1652
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1748
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1867
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2001
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2243
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2436
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2653
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2758
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2862
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..2946
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3106
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3254
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3460
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3635
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3844
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3845..4020
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4021..4057
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4058..4221
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4222..4387
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4388..4474
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4475..4701
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4702..5497
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            5498..5698
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            5699..5801
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            5802..5939
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            5940..6213
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6214..6328
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6329..6458
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6459..6562
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6563..6698
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6699..6879
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6880..6991
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6992..7112
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7113..7282
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7283..7503
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7504..7594
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7595..7735
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7736..7899
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7900..7978
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7979..8068
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8069..8215
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8216..8278
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8279..8354
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8355..8478
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8479..8594
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8595..8662
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8663..8784
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8785..8834
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8835..8895
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8896..9134
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            9135..9216
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            9217..9347
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            9348..9668
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            9669..9909
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            9910..9997
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            9998..10090
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10091..10105
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10106..10276
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10277..10336
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10337..10468
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10469..10581
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10582..10678
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10679..10785
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10786..10837
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10838..10894
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10895..10994
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10995..11074
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11075..11151
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11152..11225
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11226..11243
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11244..11324
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11325..11413
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11414..11542
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11543..11647
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11648..11729
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11730..13057
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13058..13116
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13117..13288
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13289..13375
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13376..13576
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13577..13707
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13708..13750
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13751..13878
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13879..13939
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13940..14086
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            14087..14221
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            14222..14378
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            14379..14443
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            14444..14544
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            14545..14596
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            14597..15568
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14688..14693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /note="hexamer: GATAAA"
     polyA_site      14704
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
     regulatory      15547..15552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /note="hexamer: AATAAA"
     polyA_site      15568
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /note="major polyA site"
ORIGIN      
        1 agcagtcagc gcacgccgag cggctgccgg gggaagcaga ggcgccggag gctggggcac
       61 cgccgacgcc tcgggagcca tggccgaagg gggagaagga ggcgaggacg agatccagtt
      121 tctgaggact gaggatgaag tggtactcca gtgcatcgcc accattcata aggagcagag
      181 gaagttctgc ctggcagccg agggacttgg gaatcgcctg tgcttcttgg aacccacttc
      241 agaagccaag tacattcctc cagatctctg cgtctgcaat tttgtgctgg aacagtccct
      301 atctgtcaga gccctgcagg aaatgcttgc caacacaggt gaaaatggcg gcgaaggggc
      361 agcacaagga ggtggccaca ggaccctgtt atacggccat gcagttctcc tgaggcactc
      421 tttcagcgga atgtatctaa catgcttgac tacatcaaga tcccagacag acaaacttgc
      481 ctttgatgta ggtctacggg aacatgccac aggagaagcc tgttggtgga ctatacatcc
      541 tgcttccaaa cagaggtccg aaggagagaa agttcgaatt ggcgatgacc tcatcctcgt
      601 cagcgtgtcc tctgaaagat accttcatct ctcagtatca aatggtaaca tacaagtgga
      661 tgcctccttt atgcaaacac tctggaatgt acatcctacg tgctcaggaa gtagcatcga
      721 agaaggatac ctacttggtg ggcatgtagt acgtcttttc catggtcatg atgaatgttt
      781 gacgatacca tctacagacc agaatgattc ccagcacagg aggatattct acgaagctgg
      841 gggagctggg actcgagcca ggtctctttg gagagtggaa ccccttcgga taagctggag
      901 tggcagtaac atcagatggg gccaggcttt ccgactccgg catctcacca caggccacta
      961 cctggccttg acagaagacc aaggccttat actgcaagac cgggcaaagt cagacaccaa
     1021 gtccacagct ttctctttcc gggcatcaaa ggaactcaag gagaaattag actccagtca
     1081 caagcgagac atagaaggca tgggagttcc agaaatcaag tatggagatt ctgtctgctt
     1141 tgtgcagcat atagccagtg gtctgtgggt gacctacaaa gcacaagacg ccaaaacttc
     1201 ccgcctggga cctctaaaaa gaaaggtcat actccatcag gaaggccaca tggatgatgg
     1261 attaacactg cagagatgcc agcgtgagga gtcccaggct gctcggatca tccggaacac
     1321 tacagcctta ttcagccagt ttgtcagcgg aaacaatcgc acagctgccc ccatcaccct
     1381 gcctatagaa gaagtcctgc agaccctaca ggacttgatc gcctacttcc agcccccaga
     1441 ggaggagatg cgacatgaag acaagcagaa caagctccgc tcactcaaaa acagacaaaa
     1501 tcttttcaag gaagagggaa tgttggccct tgtcttaaat tgcattgacc gcttaaatgt
     1561 ctacaatagc gtagcacact ttgcagggat tgcaagggaa gagagtggca tggcctggaa
     1621 agaaattctg aacctcctct acaaattgct ggctgctctc attcgcggaa acagaaacaa
     1681 ttgcgctcaa ttctccaata accttgattg gctcatcagt aaattggaca gactagaatc
     1741 ttcctcaggt atcttggaag ttttgcactg catcttaact gaaagcccag aagccttaaa
     1801 tctgatagcg gagggccaca tcaagtcgat catctccctg ttggataagc acgggcggaa
     1861 tcacaaggtt ctggatatcc tgtgctccct ctgtctctgc aatggggttg cagtgagagc
     1921 caaccagaat ctgatctgtg acaacttgct gccccggaga aacctactcc tgcagacacg
     1981 actgattaac gatgtaacca gtatccggcc aaacatcttc ctgggagtcg cggagggctc
     2041 agcccagtac aagaagtggt acttcgagct gattatcgac caggtggacc ccttcctaac
     2101 agcagagccc acacatctgc gggtgggctg ggcctcttct tcaggctatg ccccataccc
     2161 aggaggtgga gaaggatggg gaggcaatgg tgttggtgac gacctgtact cctatggctt
     2221 tgatggactt cacctttggt caggccggat acccagagct gtggcttcca tcaaccagca
     2281 cctcctgaga tcggatgacg tggtaagctg ctgcctggac ctcggggtgc ccagcatctc
     2341 attccgcatc aatgggcagc ccgtgcaggg gatgtttgag aacttcaaca cagacgggct
     2401 cttcttccct gtgatgagct tttcagcagg tgtcaaagta cgtttcctga tgggtggacg
     2461 tcatggagag tttaagttcc tgcctccctc tggctatgcc ccttgctatg aagccttact
     2521 tccaaaagag aagatgagat tggagcctgt caaagaatat aaacgtgatg ctgatggcat
     2581 tagagatctc ttgggtacca cccagttcct ctcccaagcc tctttcatcc catgccccgt
     2641 agacaccagt caggttattt tgccacctca cctagaaaag atccgagaca gactagctga
     2701 aaacatccat gagctttggg gaatgaataa aatagaactt ggctggactt tcggcaagat
     2761 acgagatgac aataaaagac aacacccttg ccttgtggag ttttcaaagc tcccagaaac
     2821 tgagaagaac tataacctgc aaatgtcaac tgaaacctta aaaaccctct tggccctggg
     2881 gtgccacatt gctcatgtta acccagctgc tgaggaggat ctcaagaagg tcaaactgcc
     2941 caaaaactat atgatgtcca acggctataa gccagcccct ttggatttgt ctgatgtgaa
     3001 gctgttacct cctcaagaaa ttttagtgga taagcttgca gaaaatgcac acaatgtttg
     3061 ggcaaaagac agaataaaac aaggatggac ctatggcatc caacaggatt tgaagaacaa
     3121 aagaaatccc cgtctggtgc catatgcatt actggatgag cgtaccaaga agtcaaacag
     3181 ggacagcctg cgggaagctg tgcgcacttt tgttggttac gggtataaca ttgagccatc
     3241 agaccaagaa ctagctgact cggctgtgga gaaggtcagc atagacaaga tccgattttt
     3301 ccgggtagag cgatcttatg cagtgagatc tggaaagtgg tattttgagt ttgaagtggt
     3361 gactggagga gacatgcgag tcggctgggc gaggccaggc tgtcgacctg atgtcgagct
     3421 gggggccgat gaccaagcct ttgtgtttga aggcaacagg ggccagcgtt ggcatcaagg
     3481 aagtgggtat tttgggcgta cctggcagcc aggggatgtg gtcggatgta tgattaacct
     3541 ggatgatgct tcaatgatct tcacactgaa tggggagctg ctgatcacca acaaaggctc
     3601 tgaacttgcc ttcgctgact acgagattga gaatggcttc gtgcccatct gctgtctggg
     3661 tctatctcag atcggccgca tgaatctcgg gacagatgcc agtaccttca agttttatac
     3721 catgtgcggt ctccaagagg gctttgagcc ttttgctgtc aacatgaaca gagatgttgc
     3781 tatgtggttc agcaagcgcc tcccgacgtt tgtcaacgtg ccaaaggatc atccacacat
     3841 agaggtcatg aggattgatg gcaccatgga cagccctccg tgtctcaagg tgacgcataa
     3901 gacatttggc acacagaata gcaatgccga catgatctat tgccgcttga gcatgcctgt
     3961 cgagtgccac tcctccttca gccacagccc ctgtctggac agtgaagctt tccagaaaag
     4021 gaaacagatg caagaaatac tctctcatac aacaacacag tgctactacg ccatccgcat
     4081 ctttgctgga caggatccat cctgtgtctg ggtcggatgg gtgactccag actatcactt
     4141 gtacagtgaa aagtttgacc tgaataaaaa ctgcacagtg actgtcaccc taggggatga
     4201 aagaggccgg gtccatgaaa gtgtgaaacg cagcaactgc tacatggtct ggggtggaga
     4261 cattgtagcc agttcccaga gatcaaatcg gagcaacgtg gacctggaga tcggctgtct
     4321 cgtggatctg gccatgggca tgttgtcctt ctcagccaat ggaaaggaac tgggcacctg
     4381 ctaccaggtg gagcctaata ccaaagtgtt tccagcagtc ttcctgcagc ctacaagtac
     4441 ttctttgttt cagtttgaac ttggaaagct gaagaacgca atgcccctgt cagcggccat
     4501 attcaggagt gaagagaaga acccagtccc acagtgtcca cctcggctgg acgtccaaac
     4561 catccagccc gtgctctgga gccgcatgcc caacagcttc ctgaaggtgg agaccgagcg
     4621 tgtgagcgag cgccacggct gggtggtgca gtgcctggag cccctgcaga tgatggcgct
     4681 ccacatcccc gaggagaaca ggtgtgtgga tatcctggag ctctgtgagc aggaggacct
     4741 gatgcggttc cattaccaca cgctgaggct ctacagcgcg gtgtgcgccc tgggaaacag
     4801 ccgcgtggcc tacgccctgt gcagccacgt ggacctctcc cagctcttct atgccattga
     4861 caacaagtac ctccccggcc tccttcgatc tggtttctat gacctgctca tcagcatcca
     4921 cctggccagc gccaaggaga ggaagctgat gatgaagaac gagtacatca tccccattac
     4981 cagcaccacc aggaatatcc gcctcttccc ggacgagtcc aagaggcatg gactgcctgg
     5041 ggtgggcctg agaacatgtc tcaagcccgg gttcaggttc tccacccctt gctttgttgt
     5101 gactggtgag gatcaccaaa agcagagccc cgagattccc ttggagagtc tcaggacgaa
     5161 ggctctgagt atgctgacag aggcagtgca gtgcagcggg gcccacatcc gagaccctgt
     5221 aggggggtct gtggagttcc agtttgtgcc tgtgctgaaa ctcattggaa ccctgctggt
     5281 catgggcgtg tttgatgatg atgatgttcg gcagatcctc ctcctgattg atccctctgt
     5341 gtttggggag catagtgcgg ggacagagga gggagcagaa aaggaggaag tgacccaggt
     5401 ggaggagaag gctgtggagg ctggggagaa ggccggcaag gaggctcctg tcaaaggctt
     5461 gttgcagact cgattacccg aatccgtcaa gctgcagatg tgtgagctcc tcagctatct
     5521 ctgcgactgt gagctgcagc accgagtgga ggccattgtg gcatttggtg acatttatgt
     5581 ctccaagctg caggcaaatc agaagttccg ctacaatgag ctcatgcagg ccctgaacat
     5641 gtctgcggcc ctgactgccc ggaagaccaa ggagttccgc tcacccccac aggagcagat
     5701 caacatgctg cttaactttc aactgggaga gaactgcccc tgcccagagg agattcggga
     5761 ggagctgtat gatttccatg aggaccttct ccttcactgt ggggttcctt tggaagaaga
     5821 ggaagaggag gaggaggaca cctcctggac aggaaaactc tgtgccttgg tttacaaaat
     5881 caaaggccca cccaagccag agaaggagca gccgacggag gaggaggaga gatgccccac
     5941 aacattgaag gaactcatct cacagacgat gatctgctgg gcccaggagg accagatcca
     6001 ggattcagag ctggtccgaa tgatgttcaa cctcctccgg aggcagtatg acagcattgg
     6061 ggagctgctg caggcgctgc ggaagaccta caccatcagc cacacctctg taagcgacac
     6121 catcaacctg ctggctgccc tgggccaaat ccgctccctc ctcagtgtca ggatgggcaa
     6181 ggaagaggag ttgctcatga tcaatgggct gggagacata atgaacaaca aggtgtttta
     6241 ccagcatccc aacctcatga gagtcctggg catgcacgag acggtgatgg aggtgatggt
     6301 gaacgtgttg ggtacagaga aatctcagat tgcatttcca aagatggttg ctagctgctg
     6361 ccgtttcctt tgctatttct gtcgaattag ccggcaaaat cagaaggcca tgtttgagca
     6421 tctgagttat cttctggaga atagcagtgt tggcctagcc tccccgtcga tgaggggatc
     6481 caccccgctg gatgtggcag cttcctctgt gatggacaac aatgagttag cgctgagctt
     6541 agaggaacca gacctcgaga aggtggtgac ctacttggca ggctgtggcc tacagagctg
     6601 ccccatgctt ctggccaaag gataccctga tgtcggctgg aaccccattg aaggggaacg
     6661 ctacctgtcc ttcctgaggt ttgctgtctt cgtgaacagt gagagtgtgg aagaaaacgc
     6721 cagcgttgtg gtcaagctgc tcatcagacg cccagagtgc ttcggcccgg ccctgcgggg
     6781 tgagggggga aacgggctct tggcagccat gcagggtgcc attaagatct ctgagaaccc
     6841 agcgctcgac ctcccctctc aaggatacaa aagagaagtc agcacggggg acgatgaaga
     6901 ggaagaagaa atcgtgcata tgggcaatgc aattatgtca ttttattcgg cccttataga
     6961 tctactgggc cgctgtgctc ctgaaatgca cctcatccag acaggaaagg gggaagccat
     7021 ccgcatcagg tccatcctgc gctccctggt ccccacagaa gacctggttg ggatcatcag
     7081 catccccttg aaactgccct ccctcaacaa agatgggtcg gtcagtgagc cagatatggc
     7141 ggccaatttc tgccctgacc acaaggcacc tatggtgctg ttcttggacc gcgtttatgg
     7201 cattaaggat caaacttttc tgctccactt gctggaggtt ggatttttac ctgacctaag
     7261 agcttctgcc tctctagata cagtttccct aagcaccaca gaggctgcgc ttgcactaaa
     7321 taggtatata tgttctgctg tgctcccgct cctcacaaga tgtgcccctc tctttgccgg
     7381 aacagaacac tgcacctctc tgattgattc cacactgcag acaatataca ggctatccaa
     7441 gggacgttcc ctcaccaaag cacaaaggga cactatagaa gaatgtttgc ttgccatttg
     7501 caatcacttg aggccttcca tgttacagca actcctgcga cgcctcgttt ttgatgtgcc
     7561 gcaactcaat gaatactgca aaatgcctct caagcttctg acgaatcact atgaacagtg
     7621 ttggaagtat tactgcctgc cttcaggatg ggggagctac gggctagctg tggaagaaga
     7681 gctgcaccta acggagaagc ttttctgggg gatttttgac tcgctctccc ataagaaata
     7741 tgacccagat cttttccgaa tggccctgcc ttgtctcagt gctatagctg gggccttgcc
     7801 accagattat ttagatacca gaatcacagc cacgttggag aaacagatct cagtggatgc
     7861 ggatggcaac tttgacccaa aacctattaa caccatgaat ttttccttgc ctgaaaaatt
     7921 ggaatacatc gtcaccaagt atgctgagca ttcacatgat aaatgggcct gtgacaagag
     7981 tcagagtgga tggaaatatg ggatttccct ggatgaaaat gtgaagaccc acccactgat
     8041 aaggcctttc aagacattaa cggagaagga gaaggaaatt tatcgctggc ctgcgcgaga
     8101 gtccctgaaa accatgctgg ctgtgggctg gactgtggag aggaccaaag agggagaagc
     8161 tttggttcaa cagcgggaaa atgagaagct tcgaagtgtg tcccaggcca accagggcaa
     8221 cagctacagt cctgctcccc tcgacctctc aaacgttgtg ctctccagag agctccaggg
     8281 aatggtggag gtcgtggctg agaactatca caatatctgg gccaagaaga agaagctgga
     8341 gctggagagc aaaggtggtg gcagccaccc tcttctggta ccatatgaca ccttgactgc
     8401 caaggaaaag ttcaaggacc gggagaaggc acaggacctg tttaagttcc tccaagtgaa
     8461 tggcatcata gtttccaggg gtatgaagga tatggagctg gatgcctcct ccatggagaa
     8521 gaggtttgcc tataagttct tgaagaagat cctgaaatac gttgattctg ctcaagaatt
     8581 tattgcccat ttagaagcca ttgtcagcag tgggaaaact gaaaagtctc cccgtgacca
     8641 ggagatcaaa ttctttgcca aagttctcct cccgctggtt gaccagtact tcaccagtca
     8701 ttgcctctac ttcttgtcat cccctctgaa gccccttagc agcagcggat atgcctccca
     8761 taaggagaaa gaaatggtgg ccggcctgtt ctgcaaactt gccgctctcg ttagacacag
     8821 aatttccctc tttggtagtg attctactac aatggtgagc tgtcttcaca tcttagctca
     8881 gacacttgac acaaggactg tcatgaagtc aggctcagag ctggtgaagg ctgggttacg
     8941 agcattcttt gaaaatgctg cagaagattt ggagaagact tcagaaaacc tgaaacttgg
     9001 gaagttcacc cattcccgaa cgcagattaa aggcgtttct cagaatatta actacactac
     9061 agtggctctg ctccccatcc tgacgtccat ctttgagcac gtcactcagc atcagtttgg
     9121 aatggatcta ctcttgggtg atgtgcagat ttcatgctac cacatactgt gcagcctcta
     9181 ctcccttggg acgggaaaga acatttatgt tgaaaggcaa cgccctgccc ttggagaatg
     9241 tctggcctcg ctggcagctg ccataccagt ggcattcctg gagcccaccc ttaatcgcta
     9301 caatccactc tcggtcttca acaccaaaac ccccagggag aggtctattc tggggatgcc
     9361 agacacggta gaagacatgt gtcctgacat cccccagctg gaaggcctga tgaaggaaat
     9421 caacgacctg gccgagtcag gggcccggta cacagagatg ccccatgtca tcgaggtgat
     9481 cttacccatg ctctgcaact acttgtccta ctggtgggag cggggtcctg agaacctgcc
     9541 ccccagcaca gggccatgct gcaccaaggt cacctctgaa cacctcagtc tcatcctggg
     9601 caacattctg aaaatcatca acaacaacct gggcatcgat gaggcctcct ggatgaagcg
     9661 cattgcagtg tatgcacagc ccatcatcag caaagccagg cccgacctgc tgagaagcca
     9721 cttcatccca actctggaga agctgaagaa aaaggctgtc aagacggtgc aggaggagga
     9781 gcagttgaaa gccgatggca aaggggacac ccaggaggca gaactcctca tcctggacga
     9841 gttcgcggtc ctctgcagag atctctatgc cttctacccc atgctgatcc gctacgtgga
     9901 caacaacaga tctaactggc tgaaaagtcc tgatgctgat tctgaccagc tcttccgcat
     9961 ggtggcagaa gtcttcattc tgtggtgtaa atctcataac ttcaagagag aagagcaaaa
    10021 ttttgtgatt cagaatgaaa ttaataattt ggcattttta actggagaca gcaaaagcaa
    10081 gatgtcaaaa gccatgcaag taaagtctgg aggacaagac caggagcgga agaagacaaa
    10141 gcggcgggga gacttgtatt ccatccagac ctccctcatc gtggctgcac tcaagaaaat
    10201 gctgcccatt ggtttgaata tgtgtactcc aggcgaccag gagctgatct ccctcgcaaa
    10261 atcgcgatac agccataggg acacagatga agaggtcaga gaacatctgc ggaacaactt
    10321 gcacttgcag gaaaagtctg atgacccagc tgtaaaatgg caactgaacc tctacaagga
    10381 tgttctgaag agtgaagaac ctttcaatcc ggaaaagaca gtggagcgtg tgcagagaat
    10441 ttcagcagct gtcttccacc tggaacaggt ggaacagcct ttgaggtcca agaaggccgt
    10501 ctggcacaaa ctgttatcaa agcaacggaa acgggcagtg gtggcctgtt tcaggatggc
    10561 ccctctctac aacctgccca ggcaccgctc tattaacctc ttcctccatg gctatcagag
    10621 attttggata gaaacagagg agtattcctt tgaagagaaa ctagtacagg atttggctaa
    10681 atctccaaag gtggaagagg aggaggagga agagacagaa aaacaacctg acccactaca
    10741 tcagatcatt ctctatttta gccgcaacgc tctcacggag aggagcaaat tggaagacga
    10801 ccctttgtac acctcctatt ccagcatgat ggccaagagt tgtcaaagtg gtgaggatga
    10861 agaagaagat gaagacaagg aaaaaacatt cgaagagaaa gagatggaga agcaaaaaac
    10921 cctctatcag caagctcggc tgcatgagcg tggtgctgca gagatggtcc ttcagatgat
    10981 aagcgctagc aaaggtgaga tgagccccat ggtggttgag acgctgaagc tggggatcgc
    11041 cattctgaac ggaggcaatg ctggtgtgca acagaaaatg ctagattacc taaaggagaa
    11101 aaaggatgct ggattctttc aaagcctttc tggtcttatg cagtcttgca gtgtccttga
    11161 tttgaatgca tttgagaggc agaataaagc tgaaggcctg gggatggtga ctgaagaagg
    11221 aacactcatt gttcgggaac gtggtgaaaa agtactccag aatgacgagt tcacgcgtga
    11281 tctctttaga ttcctacagt tactttgtga gggacataac agtgactttc agaacttcct
    11341 gcggactcag atgggcaaca ccaccaccgt gaatgtcatc atcagcactg tggactacct
    11401 tctgcgtctg caggaatcaa tcagtgattt ctactggtat tattcaggga aggacatcat
    11461 tgatgaatct ggacagcaca atttttccaa agctctggca gtcaccaagc agattttcaa
    11521 ttctcttaca gaatacatcc agggcccttg cattggtaat caacagagcc tggctcacag
    11581 caggctgtgg gacgcagtgg ttggcttcct ccatgtcttt gctaatatgc agatgaaact
    11641 ctctcaggat tccagtcaga tcgagctgct gaaggaactc ttggatctcc ttcaggacat
    11701 ggtggtgatg cttctgtccc tcctggaagg gaatgtggta aatggcacca ttggcaagca
    11761 gatggttgac acactggtag aatcatctac caatgtagaa atgatcttga aattctttga
    11821 catgttcttg aaacttaaag acttaaccag ctcagacacc ttcaaagaat atgacccaga
    11881 tggtaaagga attatctcca aaaaagaatt ccagaaggcc atggaagggc aaaaacagta
    11941 cacgcagtca gagattgact ttctcctgtc gtgtgcagaa gctgatgaga atgacatgtt
    12001 taattacgtt gattttgtag accggttcca tgagccagcc aaggacatag ggtttaatgt
    12061 ggctgtgtta ttgacaaatc tttctgaaca catgccaaac gattcccgcc tgaagtgtct
    12121 gttggaccca gcagaaagtg tgctaaatta cttcgaaccc tacctaggac gcatcgagat
    12181 catgggtggg gccaagaaga ttgagcgtgt ttattttgag atcagtgaat ccagtcgcac
    12241 tcagtgggag aagccccagg tgaaggaatc taagcgacag ttcatttttg atgttgtcaa
    12301 tgaaggtggg gagcaggaaa agatggagct gtttgtgaac ttctgtgagg acaccatctt
    12361 tgaaatgcag ttagcatctc agatctctga atccgattca gctgacaggc cagaagagga
    12421 ggaagaagat gaagattctt cttacgtgtt agaaattgcg ggtgaagagg aagaagacgg
    12481 gtctcttgag ccggcctctg catttgctat ggcctgtgcc tctgtgaaga ggaatgtcac
    12541 cgacttcctg aagagagcaa ccctgaagaa cctcaggaag cagtacagga acgtgaaaaa
    12601 gatgactgcg aaggagctgg tgaaggtgct cttctccttt ttctggatgc tgttcgtggg
    12661 gctattccag ttgctcttca ccatcctggg aggaatcttt cagatcctct ggagcacagt
    12721 gtttggaggg ggcctggtag aaggggcaaa gaacatcaga gtgaccaaga tcctgggtga
    12781 catgcctgac ccaacccaat ttggtatcca tgatgacact atggaggctg agagggcaga
    12841 ggtgatggag ccaggtatca ccactgaact agtacacttc ataaaggggg agaagggaga
    12901 tacagatatc atgtcagacc tctttggact ccacccaaag aaagagggca gcttaaagca
    12961 tgggcctgaa gtgggtttgg gtgacctctc agaaattatt ggcaaggatg aaccccctac
    13021 attagagagt actgtacaga agaagaggaa agctcaggca gcagaaatga aagcagcaaa
    13081 tgaagcagaa ggaaaagtag aatccgagaa ggcagacatg gaagatggag agaaggaaga
    13141 caaagacaaa gaagaggagc aagctgagta cctgtggaca gaagtgacaa aaaagaagaa
    13201 gcggcggtgt ggtcagaagg ttgagaagcc ggaagctttc acagccaatt tctttaaagg
    13261 gctggaaatc tatcagacca agttactgca ttacctggcc aggaatttct acaacctgag
    13321 gttccttgct ctgtttgtag ccttcgctat caacttcatc ctgctttttt ataaggtcac
    13381 tgaagaacct ttagaagaag agacagagga tgttgcaaac ctatggaatt cctttaatga
    13441 cgaggaagag gaagaagcga tggtattctt tgtccttcag gagagcaccg ggtatatggc
    13501 accaaccctg cgtgccctgg ccatcatcca taccatcatc tctctagtct gtgtggtggg
    13561 ctactactgc ctgaaggtgc ctttggtggt tttcaaaagg gaaaaagaaa tcgccaggaa
    13621 gctggagttt gatggcctat atatcaccga acagccatct gaagatgaca tcaaggggca
    13681 gtgggaccgc ttggtgatca acacaccatc ttttcctaat aactactggg acaagtttgt
    13741 aaagagaaag gtgatcaaca agtatggaga tctctacgga gcagaacgca ttgctgaact
    13801 tctgggtttg gacaaaaatg ctcttgactt tagcccagta gaagagacca aagcagaagc
    13861 ggcttctctg gtgtcatggc taagttccat agacatgaag taccatatct ggaagcttgg
    13921 agttgttttt actgacaact cctttctcta ccttgcctgg tatacaacca tgtcagtcct
    13981 gggccactac aataacttct tctttgctgc tcacctattg gacatcgcaa tgggcttcaa
    14041 gacactgagg accattctgt catctgtaac tcacaatggc aaacagttgg ttctgactgt
    14101 cggtctcctg gccgtggtgg tttatctcta tactgtggtg gctttcaact tcttccgcaa
    14161 gttctacaac aaaagcgaag acgatgacga gcccgatatg aagtgcgacg acatgatgac
    14221 gtgttacctt ttccacatgt acgtgggagt gagagcagga ggtggcattg gtgatgaaat
    14281 tgaagaccct gctggtgatc cttatgaaat gtatcgcatt gtctttgaca ttaccttttt
    14341 cttcttcgtc attgtcatct tgctggccat cattcaaggt cttattattg atgctttcgg
    14401 agagctaaga gaccagcagg aacaagtacg agaagatatg gagactaaat gtttcatctg
    14461 tgggattggc aatgactact ttgacacaac ccctcatggt tttgaaacac atacattaca
    14521 agagcacaac ttagccaact acttgttctt tctgatgtat ttgattaata aagatgaaac
    14581 agagcacacg ggtcaggaat cttatgtctg gaagatgtac caagaaaggt gttgggattt
    14641 cttcccagcc ggtgactgct ttcgtaaaca atatgaagat cagcttggat aaatctgaat
    14701 caaagaagcg cgacaattct ggacagtcaa cttcccatga aataaagtcc cctttttaca
    14761 gttctgcaac atatctgaaa tgtgacattt tctaaatgcc tcccttaaaa aaaaaactgc
    14821 tgaaaatctg tgctattttg aaattgattt ggctttttgt gcctaatgga catacactgt
    14881 gggagagaac ctgtcaaaat gtcgaagaag gaaggcgaag aatcaagtaa tctctaggca
    14941 aatgccttca agttttccag ttctgaggta actagttcag tttgttggga tggaagcatg
    15001 aaggaaaggg ctagagaagt atgaaatctc gaatgtgtaa tacctgaaaa tttaaacact
    15061 tgaatgtcat catggtatcc aacttgtgac tcatagggtc tgaactcact ccaaaagata
    15121 ataactgcag tctaattttt cccatggtac ttgctagtga ctgtatccag aaaagcttta
    15181 agcagttaaa gaaacagaaa aaaaccgaca ctttgtcgac actgaaatat cgattaagtg
    15241 ccttaaaacc tctttagaca tagctatgca agttttttat gtttgtgttc cagaaggaca
    15301 gttccattca ttagttgtga tcttccgtct tactttatga aactgcactt gaaggttatt
    15361 catacaagtt tttttagtaa cagctgtcag tcaactgctg ttattagaag aaaagtactg
    15421 tactgaaaat tcagaaaaaa aatctcaacc ttatgccaaa atggagtaat gctttatggt
    15481 cccttgtaag tagtggagct gctctgttta ggtgaatctc ctcaaataca atgaagtgcc
    15541 cactgcaata aagtaatacg taccaata
//
