LOCUS       NM_001035              16583 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ryanodine receptor 2 (RYR2), mRNA.
ACCESSION   NM_001035
VERSION     NM_001035.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 16583)
  AUTHORS   Fernandez-Morales,J.C., Toth,N., Bayram,P., Rienzo,T. and Morad,M.
  TITLE     Loss-of-function W4645R mutation in the RyR2-caffeine binding site:
            implications for synchrony and arrhythmogenesis
  JOURNAL   Cell Calcium 123, 102925 (2024)
   PUBMED   38908063
  REMARK    GeneRIF: Loss-of-function W4645R mutation in the RyR2-caffeine
            binding site: implications for synchrony and arrhythmogenesis.
            Erratum:[Cell Calcium. 2024 Dec;124:102960. doi:
            10.1016/j.ceca.2024.102960.. PMID: 39432975]
REFERENCE   2  (bases 1 to 16583)
  AUTHORS   Hsu,C.H., Hong,S.F., Lo,Y.S., Ho,H.Y., Lin,C.C., Chuang,Y.C.,
            Hsieh,M.J. and Chou,M.C.
  TITLE     The Role of Ryanodine Receptor 2 Polymorphisms in Oral Squamous
            Cell Carcinoma Susceptibility and Clinicopathological Features
  JOURNAL   Int J Mol Sci 25 (19), 10328 (2024)
   PUBMED   39408657
  REMARK    GeneRIF: The Role of Ryanodine Receptor 2 Polymorphisms in Oral
            Squamous Cell Carcinoma Susceptibility and Clinicopathological
            Features.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 16583)
  AUTHORS   Ben-Haim,Y., Bird,M., Johnson,D., Mohiddin,S., Favaloro,L., Dyrberg
            Andersen,J., Sheppard,M.N., Pittman,A., Futema,M. and Behr,E.R.
  TITLE     RYR2 Variant and Sudden Death in Patients With Dilated
            Cardiomyopathy
  JOURNAL   J Am Coll Cardiol 83 (11), 1105-1107 (2024)
   PUBMED   38479959
  REMARK    GeneRIF: RYR2 Variant and Sudden Death in Patients With Dilated
            Cardiomyopathy.
REFERENCE   4  (bases 1 to 16583)
  AUTHORS   Hasegawa,H., Tamura,S., Nakajima,T., Kawabata-Iwakawa,R.,
            Kobari,T., Matsumoto,N., Sano,Y., Nishiyama,M., Kurabayashi,M.,
            Kaneko,Y., Nakatani,Y. and Ishii,H.
  TITLE     Diverse Phenotypic Manifestations in a Family with a Novel RYR2
            E4107A Variant
  JOURNAL   Int Heart J 65 (3), 580-585 (2024)
   PUBMED   38825499
  REMARK    GeneRIF: Diverse Phenotypic Manifestations in a Family with a Novel
            RYR2 E4107A Variant.
REFERENCE   5  (bases 1 to 16583)
  AUTHORS   Meyers,M.B., Pickel,V.M., Sheu,S.S., Sharma,V.K., Scotto,K.W. and
            Fishman,G.I.
  TITLE     Association of sorcin with the cardiac ryanodine receptor
  JOURNAL   J Biol Chem 270 (44), 26411-26418 (1995)
   PUBMED   7592856
REFERENCE   6  (bases 1 to 16583)
  AUTHORS   Otsu,K., Fujii,J., Periasamy,M., Difilippantonio,M., Uppender,M.,
            Ward,D.C. and MacLennan,D.H.
  TITLE     Chromosome mapping of five human cardiac and skeletal muscle
            sarcoplasmic reticulum protein genes
  JOURNAL   Genomics 17 (2), 507-509 (1993)
   PUBMED   8406504
REFERENCE   7  (bases 1 to 16583)
  AUTHORS   Cirino,A.L. and Ho,C.
  TITLE     Hypertrophic Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301725
REFERENCE   8  (bases 1 to 16583)
  AUTHORS   Napolitano,C., Mazzanti,A., Bloise,R. and Priori,S.G.
  TITLE     Catecholaminergic Polymorphic Ventricular Tachycardia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301466
REFERENCE   9  (bases 1 to 16583)
  AUTHORS   McNally,E., MacLeod,H. and Dellefave-Castillo,L.
  TITLE     Arrhythmogenic Right Ventricular Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301310
REFERENCE   10 (bases 1 to 16583)
  AUTHORS   Otsu,K., Willard,H.F., Khanna,V.K., Zorzato,F., Green,N.M. and
            MacLennan,D.H.
  TITLE     Molecular cloning of cDNA encoding the Ca2+ release channel
            (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic
            reticulum
  JOURNAL   J Biol Chem 265 (23), 13472-13483 (1990)
   PUBMED   2380170
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391809.21, X98330.1,
            AL442065.11, AL365332.9, AL359924.13 and AI218003.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001035.2.
            
            Summary: This gene encodes a ryanodine receptor found in cardiac
            muscle sarcoplasmic reticulum. The encoded protein is one of the
            components of a calcium channel, composed of a tetramer of the
            ryanodine receptor proteins and a tetramer of FK506 binding protein
            1B proteins, that supplies calcium to cardiac muscle. Mutations in
            this gene are associated with stress-induced polymorphic
            ventricular tachycardia and arrhythmogenic right ventricular
            dysplasia. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X98330.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366574.7/ ENSP00000355533.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               AL391809.21        2081-2298
            219-3310            X98330.1           2-3093
            3311-3311           AL442065.11        54673-54673
            3312-3447           X98330.1           3095-3230
            3448-3448           AL442065.11        56763-56763
            3449-7243           X98330.1           3232-7026
            7244-7244           AL365332.9         42083-42083
            7245-8125           X98330.1           7028-7908
            8126-8126           AL365332.9         55078-55078
            8127-8690           X98330.1           7910-8473
            8691-8704           AL365332.9         64477-64490
            8705-9655           X98330.1           8488-9438
            9656-9656           AL365332.9         104031-104031
            9657-9961           X98330.1           9440-9744
            9962-9962           AL365332.9         110605-110605
            9963-10840          X98330.1           9746-10623
            10841-10841         AL365332.9         122083-122083
            10842-11047         X98330.1           10625-10830
            11048-11048         AL365332.9         129906-129906
            11049-11113         X98330.1           10832-10896
            11114-11114         AL365332.9         130750-130750
            11115-15349         X98330.1           10898-15132
            15350-15350         AL359924.13        54262-54262
            15351-15948         X98330.1           15134-15731
            15949-16134         AL359924.13        54861-55046
            16135-16583         AI218003.1         3-451               c
FEATURES             Location/Qualifiers
     source          1..16583
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q43"
     gene            1..16583
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /note="ryanodine receptor 2"
                     /db_xref="GeneID:6262"
                     /db_xref="HGNC:HGNC:10484"
                     /db_xref="MIM:180902"
     exon            1..386
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..15242
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /note="cardiac muscle ryanodine receptor-calcium release
                     channel; cardiac-type ryanodine receptor; islet-type
                     ryanodine receptor; kidney-type ryanodine receptor; type 2
                     ryanodine receptor; ryanodine receptor 2 (cardiac)"
                     /codon_start=1
                     /product="ryanodine receptor 2"
                     /protein_id="NP_001026.2"
                     /db_xref="CCDS:CCDS55691.1"
                     /db_xref="GeneID:6262"
                     /db_xref="HGNC:HGNC:10484"
                     /db_xref="MIM:180902"
                     /translation="MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGN
                     RLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMM
                     KTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWW
                     TIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPIS
                     SGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWR
                     LETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSS
                     KEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAI
                     MHHEGHMDDGISLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKASTVDLPIE
                     SVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVY
                     SSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLE
                     ASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVA
                     VRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHT
                     EPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIART
                     VSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGI
                     KVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVS
                     LTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQ
                     HPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDKVKKMKLPKNYQL
                     TSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNP
                     RLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGTGERFRIF
                     RAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWH
                     QGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPV
                     CSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVP
                     SNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAG
                     GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQ
                     EKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQ
                     EPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESM
                     SPGQGRNNNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNV
                     FQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSR
                     ISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALG
                     NHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYI
                     VPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPL
                     DILKSKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHI
                     LQLIEPSVFKEAATPEEESDTLEKELSVDDAKLQGAGEEEAKGGKRPKEGLLQMKLPE
                     PVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALT
                     ARKTKEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGS
                     LDGNSDLTIRGRLLSLVEKVTYLKKKQAEKPVESDSKKSSTLQQLISETMVRWAQESV
                     IEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSV
                     RMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFP
                     KMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVM
                     DNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAV
                     FCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSP
                     NSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLGRCAPEMHLIHAGKGEAIRIRSI
                     LRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEV
                     QDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGT
                     EHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDV
                     PLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQ
                     KKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNIT
                     IPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEI
                     YRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAIDM
                     SNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDR
                     EKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFD
                     GGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKE
                     MVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF
                     LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFG
                     EDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLD
                     KHNIYSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHV
                     MEVILPMLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDE
                     GAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSE
                     AELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSK
                     SHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLI
                     VAALKRLLPIGLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAI
                     RWQMALYKDLPNRTDDTSDPEKTVERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRS
                     KKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKL
                     IEDLAKPGAEPPEEDEGTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKS
                     CHDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVA
                     ATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKA
                     EGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIII
                     STVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTG
                     NQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEG
                     NVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKR
                     DFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTN
                     LSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEK
                     PQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEE
                     SEKERPEEQGPRMAFFSILTVRSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTVKD
                     MVTAFFSSYWSIFMTLLHFVASVFRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPD
                     PTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLI
                     PHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEKAEGEDGEKEEK
                     AKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVA
                     FAINFILLFYKVSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIAVHYVLEESSGYM
                     EPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDI
                     KGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDARE
                     KKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAH
                     LLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGD
                     TPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVIL
                     LAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLA
                     NYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN"
     exon            387..506
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            507..611
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            612..632
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            633..647
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            648..722
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            723..801
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            802..914
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1014
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1111
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1186
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1343
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1508
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1630
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1814
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1950
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2046
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2165
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2299
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2541
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2734
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2951
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3056
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3160
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3244
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3404
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3405..3552
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3761
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3762..3936
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3937..4145
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..4498
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4499..4613
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4614..4774
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4775..4934
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4935..5021
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5022..5248
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5249..6053
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6054..6254
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6255..6360
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6361..6504
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6505..6778
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6779..6893
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6894..7026
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7027..7130
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7131..7266
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7267..7453
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7454..7559
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7560..7680
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7681..7850
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7851..8071
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            8072..8162
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            8163..8303
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            8304..8467
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            8468..8546
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            8547..8636
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            8637..8774
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            8775..8852
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            8853..8928
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            8929..9052
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            9053..9168
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            9169..9233
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            9234..9355
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            9356..9405
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            9406..9466
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            9467..9705
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            9706..9787
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            9788..9918
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            9919..10239
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            10240..10480
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            10481..10568
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            10569..10661
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            10662..10832
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            10833..10892
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            10893..11027
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            11028..11063
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            11064..11176
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            11177..11273
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            11274..11377
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            11378..11429
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            11430..11483
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            11484..11583
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            11584..11663
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            11664..11740
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            11741..11814
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            11815..11895
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            11896..11984
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            11985..12113
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            12114..12218
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            12219..12300
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            12301..13598
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            13599..13666
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            13667..13814
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            13815..13901
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            13902..14120
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            14121..14251
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            14252..14294
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            14295..14428
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            14429..14489
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            14490..14636
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            14637..14771
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            14772..14928
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            14929..14993
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            14994..15094
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            15095..15146
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     exon            15147..16583
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      16565..16570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /note="hexamer: ATTAAA"
     polyA_site      16583
                     /gene="RYR2"
                     /gene_synonym="ARVC2; ARVD2; RyR; RYR-2; VACRDS; VTSIP"
                     /note="major polyA site"
ORIGIN      
        1 acttgctcgg aggagccggg gccgagcgga ccgccggctg caggcagcga gcgcggctgg
       61 gctgcggggc tgcttccccg cgtcctccgg gcccgggccg ccctcctccc gcacagtgcg
      121 gagcagggag gccccgcgcc tcgaccaccc gcgcccgagc gtccgcgcct cctcctccgc
      181 tctgcaggcg gggaccgccc ggcgctcggc acccggcagc gcggccccct ccagcccccg
      241 gctcccggca gcagaagcag aaggcagcgc caggggccgc cgccgccgcc gagctccgcg
      301 gggctcggga gccggccccg gcgaggaggc gcggaaccat ggccgatggg ggcgagggcg
      361 aagacgagat ccagttcctg cgaactgatg atgaagtggt tctgcagtgc accgcaacca
      421 tccacaaaga acaacagaag ctatgcttgg cagcagaagg atttggcaac agactttgtt
      481 tcttggagtc cacttccaat tccaagaatg tgcccccaga cctctccatc tgcacctttg
      541 tgctggagca gtccctctct gtccgggcgc tgcaggagat gctggctaac accgtggaga
      601 aatcagaagg gcaagttgat gtggaaaaat ggaaattcat gatgaagact gctcaaggtg
      661 gtggtcatcg aacactcctc tacggacatg ccatattgct gcgccattcc tatagtggca
      721 tgtatctgtg ctgcctgtcc acctcccggt cttcaactga taagctggct tttgatgttg
      781 gcttgcaaga ggacaccaca ggggaggctt gttggtggac catacaccct gcctctaagc
      841 agcgatcaga aggagaaaaa gtacgagttg gagatgacct catcttagtt agcgtgtcct
      901 ctgaaaggta cttgcacttg tcttatggca acggcagctt acacgtggat gccgctttcc
      961 agcagactct ctggagcgtg gccccaatca gctcaggaag tgaggcagcc caagggtatc
     1021 tcattggtgg tgatgtcctc aggttgctgc atggacacat ggacgagtgt ctcactgtcc
     1081 cttcaggaga acatggtgaa gagcagcgga gaactgttca ttatgaaggt ggcgctgtgt
     1141 ctgttcatgc acgttccctt tggagactag agacgctaag agttgcgtgg agtggaagcc
     1201 acataagatg gggacagcca ttccgactac gccatgtcac aacaggaaaa tacttgagtc
     1261 tcatggaaga caaaaacctt ctactcatgg acaaagagaa agctgatgta aaatcaacag
     1321 catttacctt ccggtcttcc aaggaaaaat tggatgtagg ggtgagaaaa gaagtagatg
     1381 gcatgggaac atctgaaata aaatacggtg actcagtatg ctatatacaa catgtagaca
     1441 caggcctatg gcttacttac cagtctgtgg acgtgaaatc cgtgagaatg ggatctatac
     1501 aacgtaaggc tattatgcat catgaaggcc acatggatga tggcataagt ttgtcgagat
     1561 cccagcatga agaatcacgc acagcccgag ttatccggag cacagtcttc cttttcaata
     1621 gatttataag gggccttgat gctctcagca agaaagcgaa ggcttccaca gtcgatttgc
     1681 ctatagagtc cgtaagccta agtctgcagg atctcattgg ctacttccac cccccagatg
     1741 agcatttaga gcatgaagac aaacagaaca gactacgagc cctgaagaat cggcaaaatc
     1801 tcttccagga agagggaatg atcaacctcg tgcttgagtg catagaccgt ttgcacgtct
     1861 acagcagtgc agcacacttt gctgatgttg ctgggcgaga agcaggagag tcttggaaat
     1921 ccattctgaa ttctctgtat gagttgctgg cggctctaat tagaggaaat cgtaaaaact
     1981 gtgctcaatt ttctggctcc ctcgactggt tgatcagcag attggaaaga ctggaagctt
     2041 cttcaggcat tctggaagtt ttacactgtg ttttagtaga aagtccagaa gctctaaata
     2101 ttattaaaga aggacatatt aaatctatta tctcactttt agacaaacat ggaagaaatc
     2161 acaaggttct ggatgtcttg tgctcactct gtgtttgcca cggggttgca gtccgttcta
     2221 accagcatct catctgtgac aatctcctac caggaagaga cttgttattg cagacacgtc
     2281 ttgtgaacca tgtcagcagc atgagaccca atatttttct gggcgtcagt gaaggttctg
     2341 ctcagtataa gaaatggtac tatgaattga tggtggacca cacagagccc tttgtgacag
     2401 ctgaagcaac tcacctgcga gtgggctggg cttccactga aggatattct ccctaccctg
     2461 gagggggcga agagtggggt ggaaatggtg ttggagatga tctcttctcc tatggatttg
     2521 atggccttca tctctggtca ggttgtattg ctcgtactgt aagctcacca aaccaacatc
     2581 tgttaagaac tgatgatgtc atcagttgct gtttagatct gagtgcccca agcatctcgt
     2641 tccgaattaa tggacaacct gttcaaggaa tgtttgagaa tttcaacatc gatggcctct
     2701 tctttccagt cgttagtttc tctgcaggaa taaaagtacg ctttctgctt ggagggcgac
     2761 atggagaatt caaatttctt cctccacctg ggtatgctcc ttgttatgaa gctgttctgc
     2821 caaaagaaaa gttgaaagtg gaacacagcc gagagtacaa gcaagaaaga acttacacac
     2881 gcgacctgct gggccccaca gtttccctga cgcaagctgc cttcacaccc atccctgtgg
     2941 ataccagcca gatcgtgttg cctcctcatc tagaaagaat aagagaaaaa ctggcagaga
     3001 atatccatga actctgggtt atgaataaaa ttgagcttgg ctggcagtat ggtccggtta
     3061 gagatgacaa caagagacaa cacccatgcc tggtggagtt ctccaagctg cctgaacagg
     3121 agcgcaatta caacttacaa atgtcgcttg agaccctgaa gactttgttg gcattaggat
     3181 gtcatgtggg tatatcagat gaacatgctg aagacaaggt gaaaaaaatg aagctaccca
     3241 agaattacca gctgacaagt ggatacaagc ctgcccctat ggacctgagc tttatcaaac
     3301 tcaccccatc acaagaagca atggtggaca agttggcaga aaatgcacat aatgtgtggg
     3361 cgcgggatcg aatccggcag ggctggactt atggcatcca acaggacgta aagaacagaa
     3421 gaaatcctcg ccttgttccc tacactcttc tggatgaccg aaccaagaaa tccaacaagg
     3481 acagcctccg cgaggctgtg cgcacgctgc tggggtacgg ctacaacttg gaagcaccag
     3541 atcaagatca tgcagccaga gccgaagtgt gcagcggcac cggggaaagg ttccgaatct
     3601 tccgtgccga gaagacctat gcagtgaagg ccggacggtg gtattttgaa tttgagacgg
     3661 tcactgctgg agacatgagg gttggttgga gtcgtcctgg ttgtcaaccg gatcaggagc
     3721 ttggctcaga tgaacgtgcc tttgcctttg atggcttcaa ggcccagcgg tggcatcagg
     3781 gcaatgaaca ctatgggcgc tcttggcaag caggcgatgt cgtggggtgt atggttgaca
     3841 tgaacgaaca caccatgatg ttcacactga atggtgaaat ccttcttgat gattcaggct
     3901 cagaactggc tttcaaggac tttgatgttg gcgatggatt catacctgtg tgtagccttg
     3961 gagtggctca agtgggtagg atgaactttg gaaaggatgt cagcaccttg aaatatttca
     4021 ccatctgtgg cttacaagag ggctatgaac catttgccgt taatacaaac agggatatta
     4081 ccatgtggct gagcaagagg cttcctcagt ttcttcaagt tccatcaaac catgaacata
     4141 tagaggtgac cagaatagac ggcaccatag acagttcccc atgtttaaag gtcactcaga
     4201 agtcttttgg ttctcagaac agcaacactg atatcatgtt ttatcgcctg agcatgccga
     4261 tcgagtgcgc ggaggtcttc tccaagacgg tggctggagg gctccctggg gctggccttt
     4321 ttgggcccaa gaatgacttg gaagattatg atgctgattc tgactttgag gttctgatga
     4381 agacagctca tggccatcta gtgcccgatc gtgttgacaa agacaaagaa gctactaaac
     4441 cagagtttaa caaccacaaa gattatgccc aggaaaagcc ctctcgtctg aaacaaagat
     4501 ttttgcttag aagaacaaag ccagattaca gcacaagcca ttctgcaaga ctcaccgaag
     4561 atgtccttgc tgatgatcgg gatgactatg atttcttgat gcaaacgtcc acgtactatt
     4621 actcagtgag aatctttcct ggacaagaac ctgctaatgt ctgggtgggc tggattacat
     4681 cagatttcca tcagtatgac acaggctttg acttggacag agttcgcaca gtaacagtta
     4741 ctctaggaga tgaaaaagga aaagtgcatg aaagcatcaa acgcagcaac tgctatatgg
     4801 tatgtgcggg tgagagcatg agccccgggc aaggacgcaa caataatgga ctggagattg
     4861 gctgtgtggt ggatgctgcc agcgggctgc tcacattcat tgccaatggc aaggaactga
     4921 gcacatacta tcaggtggaa ccgagtacaa aattatttcc tgcggttttt gcacaagcta
     4981 caagtcccaa tgttttccag tttgagttgg gaagaataaa gaatgtgatg cctctctcgg
     5041 cgggattatt caagagtgag cacaagaacc ccgtgccgca gtgccccccg cgcctccacg
     5101 tgcagttcct gtcacacgtc ctgtggagca gaatgcccaa ccagtttttg aaggtagatg
     5161 tgtctcgaat aagtgaacgc caaggctggt tggtgcagtg tttggatcct ctgcagttca
     5221 tgtctcttca tatccctgag gaaaacagat ctgttgacat cttagagttg acagagcagg
     5281 aggaattgct gaaatttcac tatcacactc tccggctcta ctcagccgtc tgtgctcttg
     5341 ggaaccaccg ggtggcccat gccctgtgca gccatgtgga tgaacctcag ctcctctatg
     5401 ccattgagaa caagtacatg cctggtttgc tgcgtgctgg ctactatgac ctgctgattg
     5461 acatccacct gagctcctat gccactgcca ggctcatgat gaacaacgag tacattgtcc
     5521 ccatgacgga ggagacgaag agcatcaccc tgttccctga tgagaacaaa aaacacggcc
     5581 ttccagggat cggcctcagc acctccctca ggccacggat gcagttttcc tcccccagtt
     5641 ttgtaagcat tagtaatgaa tgttaccagt acagtccaga gttcccactg gacatcctca
     5701 agtccaaaac catacagatg ctgacagaag ctgttaaaga gggcagtctt catgcccggg
     5761 acccagttgg agggactact gaattcctct ttgtacctct catcaagctt ttctataccc
     5821 tgctgatcat gggcatcttt cacaacgagg acttgaagca catcttgcag ttgattgagc
     5881 ccagtgtgtt taaagaagct gccactccgg aggaggagag tgacacgctg gagaaagagc
     5941 tcagtgtgga cgatgcaaag ctgcaaggag ctggtgagga agaagccaag gggggcaagc
     6001 ggcccaagga aggcctgctc caaatgaaac tgccagagcc agttaaattg cagatgtgcc
     6061 tactgcttca gtacctctgt gactgccagg tccggcaccg gatagaagcc attgtagcct
     6121 tttcagatga ttttgtggct aagctccaag acaatcaacg tttccgatac aacgaagtca
     6181 tgcaagcctt aaacatgtca gctgcactca cagccaggaa gacaaaggaa tttagatcac
     6241 cacctcaaga acagatcaat atgcttctca attttaagga tgacaaaagt gaatgtccat
     6301 gtccagaaga aattcgtgac caactattgg atttccatga agatttgatg acacattgtg
     6361 gaattgagct ggatgaagat gggtctctgg atggaaacag tgatttaaca attagagggc
     6421 gtctgctatc cctggtagaa aaggtgacat atctgaagaa gaagcaagca gaaaaaccag
     6481 ttgagagtga ctccaaaaag tcctccactc tgcagcagct gatttctgag accatggtcc
     6541 gatgggctca ggagtctgtc attgaagacc ccgagctggt gagggccatg tttgtgttgc
     6601 tccatcggca gtatgacggc attgggggtc ttgttcgggc cctgccaaag acctacacga
     6661 taaatggtgt gtccgtggag gacaccatca acctgctggc atcccttggt cagattcggt
     6721 ccctgctgag tgtgagaatg ggcaaagaag aagagaagct catgattcgt ggattagggg
     6781 atattatgaa taacaaagtg ttttaccagc accctaatct catgagggca ctggggatgc
     6841 acgagactgt gatggaggtc atggtgaacg tccttggagg tggagagtcc aaggaaatca
     6901 cctttcccaa gatggtggcc aactgttgcc gttttctctg ttacttctgt cgtataagta
     6961 ggcagaatca aaaagctatg tttgatcatc tcagttattt actggaaaac agcagtgttg
     7021 gtcttgcctc cccagctatg agaggttcaa caccactgga tgtggctgca gcttcggtga
     7081 tggataataa tgaactagca ttagctctgc gtgagccgga tctagaaaag gtagttcgtt
     7141 atttggctgg ttgtggactg caaagttgcc agatgctggt gtctaagggc tatccagaca
     7201 ttgggtggaa cccagttgaa ggagagagat atcttgactt tcttagattt gctgtcttct
     7261 gtaatgggga gagtgtggag gaaaatgcaa atgtcgtggt gagattgctc attcggaggc
     7321 ctgagtgttt tggtcctgct ttgagaggag aaggtgggaa tgggcttctt gcagcaatgg
     7381 aagaagccat caaaatcgcc gaggatcctt cccgagatgg tccctcacca aatagcggat
     7441 ccagtaaaac acttgacaca gaggaggagg aagatgacac tatccacatg gggaacgcga
     7501 tcatgacctt ctattcagct ttgattgacc tcttgggacg ctgtgctcct gagatgcatt
     7561 tgattcatgc cgggaaggga gaagccatca gaattaggtc cattttgaga tccctcattc
     7621 ccctgggaga tttggtgggc gttatcagca tcgcttttca gatgccaaca atagccaaag
     7681 atgggaatgt ggtggaacct gacatgtctg cggggttttg cccagatcac aaggcagcca
     7741 tggttttatt ccttgacagg gtctatggga ttgaggttca agacttcctc ctccatcttc
     7801 ttgaggttgg ctttctgcca gatctccggg cggctgcttc tttagatacg gcagctttga
     7861 gtgctacaga catggccttg gccctcaatc ggtacctttg cacagccgtc ttgccattgt
     7921 taacaagatg tgctcctctc tttgctggca cagagcacca cgcttctctc attgactcat
     7981 tacttcatac tgtgtataga ctttctaagg gctgttcact taccaaagct cagcgggatt
     8041 ccatagaagt ttgtttactc tctatttgtg gacaactgag accttctatg atgcagcact
     8101 tactcagaag attagtattt gatgttccat tattaaatga acacgcaaag atgcctctta
     8161 aactgctgac aaatcattat gaaagatgct ggaaatatta ctgcctgcct ggagggtggg
     8221 gaaactttgg tgctgcctca gaagaagaac ttcatttatc aagaaagttg ttctggggca
     8281 tttttgatgc cctgtctcaa aagaaatatg aacaagaact tttcaaactg gcactgcctt
     8341 gcctgagtgc agttgcggga gctttgcctc cagactacat ggagtcaaat tatgtcagta
     8401 tgatggaaaa acagtcatca atggattctg aagggaactt taacccacaa cctgttgata
     8461 cctcaaatat tacaattcct gagaaattgg aatacttcat taacaaatat gcagaacact
     8521 cccatgacaa atggtcaatg gacaagttgg caaatggatg gatttatgga gaaatatatt
     8581 cagactcttc taaggttcag ccattaatga agccatataa gctattgtct gaaaaggaaa
     8641 aagaaattta tcgctggcca atcaaagaat ctttaaaaac tatgctggct tggggctgga
     8701 gaattgaaag aactcgggag ggagacagca tggcccttta caaccggact cgtcgtattt
     8761 ctcagacaag ccaggtttct gtggacgctg cccatggtta cagtccccgg gccattgaca
     8821 tgagcaatgt tacactatct agagacctgc atgctatggc agaaatgatg gctgaaaact
     8881 accataatat atgggcaaag aaaaagaaaa tggagttgga gtccaaagga ggaggaaacc
     8941 atcctctgct ggtgccctat gatacactga cagccaaaga gaaagccaag gatagagaaa
     9001 aagcacagga catcctcaag ttcttgcaga tcaatggata tgctgtatcc agaggattta
     9061 aggacctgga actggacacg ccttctattg agaaacgatt tgcctatagt ttcctccaac
     9121 aactcattcg ctatgtggat gaagcccatc agtatatcct ggagtttgat ggtggcagca
     9181 gaggcaaagg agaacatttc ccttatgaac aagaaatcaa gttctttgca aaagtcgttc
     9241 ttcctttaat tgatcagtat ttcaaaaacc atcgtttata cttcttatct gcagcaagca
     9301 gacctctctg ctctggagga catgcttcca acaaagagaa agaaatggtg actagcctat
     9361 tctgcaaact tggagttctt gtcaggcata ggatttcact atttggcaat gatgcaacat
     9421 caattgtcaa ctgtcttcat attttgggtc agactttgga tgcaaggaca gtgatgaaga
     9481 ctggcctgga gagtgttaaa agtgcactca gagcttttct ggacaacgct gcagaggatc
     9541 tggagaagac catggaaaac ctcaagcagg gccagttcac tcacacccga aaccagccca
     9601 aaggggttac tcagattatc aattacacca cagtggccct gctgccaatg ctgtcttcat
     9661 tatttgaaca tattggccag catcagttcg gagaagacct aatattggaa gatgtccagg
     9721 tgtcttgtta tagaattctg actagcttat atgctttggg aaccagcaag agtatttacg
     9781 tggagaggca acgttctgca ttaggagaat gtctagctgc ctttgctggt gcttttcctg
     9841 tagcattttt ggaaactcat ctggacaaac ataatattta ctccatctac aataccaagt
     9901 cttcacgaga aagagcagct ctcagtttgc caactaatgt ggaagatgtt tgtccaaaca
     9961 taccgtcttt ggagaaactc atggaagaaa tcgtggaatt agccgagtcc ggcattcgct
    10021 acactcaaat gccacatgtc atggaagtca tactgcccat gctttgcagc tacatgtctc
    10081 gttggtggga gcatggacct gagaacaatc cagaacgggc cgagatgtgc tgcacagccc
    10141 tgaactcaga gcacatgaac acacttctag ggaacatatt gaaaatcata tataataact
    10201 tggggattga tgagggagcc tggatgaaga ggctagcagt gttttcccag cctataataa
    10261 ataaagtgaa acctcagctc ttgaaaactc atttcttgcc gttaatggag aaactcaaga
    10321 aaaaggcagc tacggtggtg tctgaggaag accacctgaa agctgaggcc aggggggaca
    10381 tgtcggaggc agaactcctc atcctagatg agttcaccac actggccaga gatctctatg
    10441 ccttctaccc tctcttgatt agatttgtgg actataacag ggcaaagtgg ctaaaggagc
    10501 ctaacccaga agcagaggag ctcttccgca tggtggctga agtgtttatc tactggtcga
    10561 agtcccataa tttcaaaaga gaagagcaga acttcgttgt acagaatgaa atcaacaata
    10621 tgtctttcct tattactgat accaagtcaa agatgtcaaa ggcagctgtt tctgatcagg
    10681 aaaggaagaa aatgaagcgc aaaggagatc ggtattccat gcagacctct ctgattgtag
    10741 cagctctgaa gcggttactg cccattgggt tgaacatctg tgcccctggg gaccaggagc
    10801 tcattgctct ggccaaaaat cgatttagcc tgaaagatac cgaggatgaa gtacgagata
    10861 taatccgcag caatattcat ttacaaggca agttggagga tcctgctatt agatggcaaa
    10921 tggctcttta caaagactta ccaaacagga ctgatgatac ctcagatcca gagaagacgg
    10981 tagaaagagt attggatata gcaaatgtgc tttttcatct tgaacagaag tctaaacgtg
    11041 tgggtcggag acattactgt ctggtggaac atcctcagag atctaaaaag gctgtatggc
    11101 ataaactact gtccaagcag aggaaaaggg ctgttgtagc ctgcttccgg atggccccct
    11161 tatataatct gccaaggcat cgggctgtca atctctttct tcagggatat gaaaagtctt
    11221 ggattgaaac agaagaacat tactttgaag ataaactgat agaagattta gcaaaacctg
    11281 gggctgaacc tccagaagaa gatgaaggca ctaagagagt tgatcctcta catcagctga
    11341 tccttctgtt tagtcggaca gctttaacag agaaatgcaa actggaggaa gattttttat
    11401 atatggccta tgcagatatt atggcaaaga gttgtcatga tgaggaagat gacgatggtg
    11461 aagaggaagt gaagagtttt gaagaaaaag aaatggaaaa gcaaaagctt ctataccagc
    11521 aagcccgact ccacgatcgt ggcgcggctg agatggtgct acagacaatc agtgccagca
    11581 aaggtgaaac tggaccaatg gtagcagcta ctctgaaact tggaattgct attttaaatg
    11641 gtgggaactc cacagtacag cagaaaatgc ttgactacct caaggagaaa aaggatgtgg
    11701 gcttctttca gagcctggcc ggcctgatgc agtcatgtag tgtccttgac ctaaatgcat
    11761 ttgagcgaca aaacaaagct gaaggtcttg ggatggtgac agaggaagga tcaggagaaa
    11821 aggttctgca ggacgatgag ttcacctgtg acctcttccg attcctgcaa ctactctgtg
    11881 agggacacaa ctcagatttt cagaattatc tgagaactca gactggcaat aatacaactg
    11941 tcaacataat tatctccact gtagactacc tactgagagt tcaggaatca attagtgact
    12001 tttattggta ttactctggg aaagatgtta ttgatgaaca aggacaacgg aatttctcca
    12061 aagctatcca agtggcaaaa caagtcttta acactcttac agagtatatt cagggtcctt
    12121 gcactgggaa tcaacagagt ttggcacaca gcaggctgtg ggatgctgtg gtcggctttc
    12181 ttcatgtgtt tgcccatatg cagatgaagc tgtcgcagga ttccagtcaa attgagctat
    12241 taaaagaatt aatggatctg cagaaggata tggtggtcat gttgctgtcc atgttagaag
    12301 gtaatgttgt taatggaacg attggcaaac agatggtgga tatgcttgtg gaatcttcca
    12361 acaacgtgga gatgattctc aaattttttg acatgttctt aaaactaaag gatttgacgt
    12421 cgtctgatac ttttaaagaa tatgaccccg atggcaaggg agtcatttcc aagagggact
    12481 tccacaaagc gatggagagc cataagcact acacgcagtc agaaacggaa tttcttttgt
    12541 cttgtgcgga gacggatgag aatgaaaccc tcgactacga agagttcgtc aaacgcttcc
    12601 acgaacctgc gaaggacatc ggcttcaacg tcgccgtcct tctgacaaac ctctctgagc
    12661 acatgcccaa cgatacccga cttcagactt ttctggaatt agcagagagc gtcctgaatt
    12721 atttccagcc ctttctgggc cgcatcgaaa tcatgggaag cgccaaacgc atcgagaggg
    12781 tctattttga aatcagtgag tccagccgaa cccagtggga gaagccccag gtcaaggagt
    12841 ccaaaagaca gttcatattt gacgtggtca acgaaggcgg agagaaagag aagatggaac
    12901 tctttgtgaa cttctgcgag gacaccatct ttgaaatgca gctggcggct cagatctcgg
    12961 agtcggactt gaacgagagg tcagcgaata aggaagaaag cgagaaggag aggccggaag
    13021 agcaggggcc gaggatggct ttcttctcca ttctgacggt caggtcggcc ctgtttgcgc
    13081 tcaggtacaa tatcttgacc cttatgcgaa tgctcagtct gaagagcctg aagaagcaga
    13141 tgaaaaaagt aaaaaagatg accgtgaagg acatggtcac ggccttcttt tcatcctact
    13201 ggagtatttt catgaccctc ttgcacttcg tggccagcgt tttcagaggc tttttccgca
    13261 tcatttgcag cctgctgctt gggggaagcc tcgtcgaagg tgctaaaaag atcaaagttg
    13321 cagaactgtt agccaacatg ccagacccca ctcaggatga ggttagagga gatggggagg
    13381 agggagagag gaaacccctg gaagccgccc tgccctccga ggatctgacc gacttaaagg
    13441 agctgacaga ggaaagtgac cttctttcgg acatctttgg cctggatctg aagagagaag
    13501 gaggacagta caaactgatt cctcataatc caaatgctgg gctcagtgac ctcatgagca
    13561 acccagtccc catgcctgag gtgcaggaaa aatttcagga acagaaggca aaagaagaag
    13621 aaaaggaaga aaaagaagaa accaaatctg aacctgaaaa agccgaggga gaagatggag
    13681 aaaaagaaga gaaagccaag gaagacaagg gcaaacaaaa gttgaggcag cttcacacac
    13741 acagatacgg agaaccagaa gtgccagagt cagcattctg gaagaaaatc atagcatatc
    13801 aacagaaact tctaaactat tttgctcgca acttttacaa catgagaatg ttagccttat
    13861 ttgtcgcatt tgctatcaat ttcatcttgc tcttttataa ggtctccact tcttctgtgg
    13921 ttgaaggaaa ggagctcccc acgagaagtt caagtgaaaa tgccaaagtg acaagcctgg
    13981 acagcagctc ccatagaatc atcgcagttc actatgtact agaggagagc agcggctaca
    14041 tggagcccac gttgcgtatc ttagctattc tgcacacggt catttctttc ttctgcatca
    14101 ttggatacta ctgcttgaaa gtcccattgg ttatttttaa gcgagaaaag gaagtggcac
    14161 ggaaattgga atttgatggg ctttatatta cagaacagcc ttcagaagat gatattaaag
    14221 gccagtggga tagactcgta atcaacacac agtcatttcc caacaactac tgggacaaat
    14281 ttgttaaaag aaaggttatg gataaatatg gagagttcta cggccgagac agaatcagtg
    14341 aattacttgg catggacaag gcagctctgg acttcagtga tgccagagaa aagaagaagc
    14401 caaagaaaga cagctcctta tcagctgtac tgaactccat tgatgtgaag tatcagatgt
    14461 ggaaactagg agtcgttttc actgacaact ccttcctcta cctagcctgg tatatgacta
    14521 tgtctgttct tggacactat aacaactttt tttttgccgc tcaccttctc gacattgcta
    14581 tgggattcaa gacattaaga accatcttgt cctcagtaac tcacaatggc aaacagctcg
    14641 tattaaccgt tggcttatta gctgttgttg tatacctata cactgtggtg gcattcaatt
    14701 ttttccgaaa attctacaat aaaagtgaag atggtgatac accagatatg aaatgtgacg
    14761 atatgctaac atgctatatg ttccacatgt atgttggagt tcgtgctgga ggagggatcg
    14821 gggatgaaat cgaagaccca gcaggagatg aatatgagat ctatcgaatc atctttgaca
    14881 tcactttctt cttctttgtt attgtcattc tcttggccat aatacaaggt ctaattattg
    14941 atgcttttgg agaactaaga gaccaacagg aacaagtcaa agaagacatg gagaccaaat
    15001 gcttcatctg tgggataggc aatgattact tcgacacagt gccacatggc tttgaaaccc
    15061 acactttaca ggagcacaac ttggctaatt acttgttttt tctgatgtat cttataaaca
    15121 aagatgaaac agaacacaca ggacaggaat cttatgtctg gaagatgtat caagaaaggt
    15181 gttgggaatt tttcccagca ggggattgct tccggaaaca gtatgaagac cagctaaatt
    15241 aaactcagac ccaatcacct ctaaaaacca aaaccctacc cctctctctc cctctctcaa
    15301 tttctctgct ctcttggaaa cattttgctg attttgtgaa ttgccagcgt tgtgtgtttt
    15361 ctgggagcat cgaagctctg tttcggaaga gctgtttcct ccccccacct tttgtattta
    15421 ctttgagact aaagactgaa gaataatcta aattcatact cagacaaaaa aaggaattct
    15481 ggaaagaaaa ccattctgga cactgtcata acacacatag atagattttc ttctgagact
    15541 cccggagtct tctcgagcta cgagaccttc acagagacac gtggcagcca cactcaccca
    15601 gcctctttat ttcaccatcc tggaaggaaa ctgtctgtct aatggtcaca gagcactgta
    15661 gcacttaaca gattgccatg gacaccagtt gcgaagggaa atagtgcctt actatatgtg
    15721 ggttgagcta tgcagaagat acgtgcatga aaaaacatct ttattttctt tatgtcgacc
    15781 tttcttttct tagattgatt ttgtgaggtt tttttttttt cctttagtct tttctttagt
    15841 gggggagggt aagaaaagca gtttgcactt aaaaagaaaa aaaaaaaacg ggtggtgtgt
    15901 ctcaggacaa aaggaggctc ttctcattca gctaaattca catttgcccc ccccccccgc
    15961 ccccgccccc atatgctcct gctattattt tggtaatgct ctgatgcaac attgcaactt
    16021 tatgaaatct ttgtatgaaa acaaaaagac tgcaaaaaat acactttcaa aagaaaccat
    16081 tcattgcatg tttattatgc aagtttaaat gaacaaagaa aaccttcaga aacaagttga
    16141 tcaacgtgag agaaatttca tgataattat tcatagtaat aaagtgtcgt gggcttaatt
    16201 gtatatctgg agccagtgtc atccaccaac aatgtgatac aatatgaact tgacagtagt
    16261 tttgggtttt gctcattctt tcagccacct gtgatcagtt ttgttgatta aggacttctt
    16321 gtcaggccat tttttaatat caaagctgaa gcaatatcca ttcagggatt tcatcagttg
    16381 catcacaaaa cacggatgat aatatacatc actccatttt ttccattttg agtcctttta
    16441 aatgtaatgc taacctttac aattaaaaag tcagattcag aatggaaaca aggtcatttt
    16501 gcaaacattg gagctctttt attacaagtc tgcttgttaa ttttagaact gtaaaaccgc
    16561 tctgattaaa ctatttaact aac
//
