LOCUS       NM_000540              15400 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens ryanodine receptor 1 (RYR1), transcript variant 1,
            mRNA.
ACCESSION   NM_000540
VERSION     NM_000540.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15400)
  AUTHORS   Janssen,S., Erbe,L.S., Kneifel,M., Vorgerd,M., Doring,K.,
            Lubieniecki,K.P., Lubieniecka,J.M., Gerding,W.M., Casadei,N.,
            Guttsches,A.K., Heyer,C., Lucke,T., Nguyen,H.H.P., Kohler,C. and
            Hoffjan,S.
  TITLE     Compound Heterozygous RYR1 Variants in a Patient with Severe
            Congenital Myopathy: Case Report and Comparison with Additional
            Cases of Recessive RYR1-Related Myopathy
  JOURNAL   Int J Mol Sci 25 (19), 10867 (2024)
   PUBMED   39409197
  REMARK    GeneRIF: Compound Heterozygous RYR1 Variants in a Patient with
            Severe Congenital Myopathy: Case Report and Comparison with
            Additional Cases of Recessive RYR1-Related Myopathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15400)
  AUTHORS   Jackson,M., Thomas,M.A., Suchet,I., Mahallati,H., Kuret,V. and
            Lauzon,J.
  TITLE     Lethal multiple pterygium syndrome, large cystic hygroma, and cleft
            palate: Rare and severe fetal presentations of RYR1- and
            NEB-related congenital myopathies
  JOURNAL   Prenat Diagn 44 (4), 522-526 (2024)
   PUBMED   38520674
  REMARK    GeneRIF: Lethal multiple pterygium syndrome, large cystic hygroma,
            and cleft palate: Rare and severe fetal presentations of RYR1- and
            NEB-related congenital myopathies.
REFERENCE   3  (bases 1 to 15400)
  AUTHORS   van de Camp,S.A.J.H., Stinissen,L., Huseth,A., Simon,B., Ryan,J.,
            Sarkozy,A., Van Petegem,F., Goldberg,M.F., Jungbluth,H., Bohm,J.,
            Oortwijn,W., Dirksen,R.T. and Voermans,N.C.
  TITLE     Individuals and Families Affected by RYR1-Related Diseases: The
            Patient/Caregiver Perspective
  JOURNAL   J Neuromuscul Dis 11 (5), 1067-1083 (2024)
   PUBMED   39150833
  REMARK    GeneRIF: Individuals and Families Affected by RYR1-Related
            Diseases: The Patient/Caregiver Perspective.
REFERENCE   4  (bases 1 to 15400)
  AUTHORS   Malicdan,M.C.V. and Nishino,I.
  TITLE     Central Core Disease - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301565
REFERENCE   5  (bases 1 to 15400)
  AUTHORS   Beggs,A.H. and Agrawal,P.B.
  TITLE     Multiminicore Disease - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301467
REFERENCE   6  (bases 1 to 15400)
  AUTHORS   DeChene,E.T., Kang,P.B. and Beggs,A.H.
  TITLE     Congenital Fiber-Type Disproportion - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301436
REFERENCE   7  (bases 1 to 15400)
  AUTHORS   Rosenberg,H., Sambuughin,N., Riazi,S. and Dirksen,R.
  TITLE     Malignant Hyperthermia Susceptibility
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301325
REFERENCE   8  (bases 1 to 15400)
  AUTHORS   Gillard,E.F., Otsu,K., Fujii,J., Duff,C., de Leon,S., Khanna,V.K.,
            Britt,B.A., Worton,R.G. and MacLennan,D.H.
  TITLE     Polymorphisms and deduced amino acid substitutions in the coding
            sequence of the ryanodine receptor (RYR1) gene in individuals with
            malignant hyperthermia
  JOURNAL   Genomics 13 (4), 1247-1254 (1992)
   PUBMED   1354642
REFERENCE   9  (bases 1 to 15400)
  AUTHORS   Otsu,K., Phillips,M.S., Khanna,V.K., de Leon,S. and MacLennan,D.H.
  TITLE     Refinement of diagnostic assays for a probable causal mutation for
            porcine and human malignant hyperthermia
  JOURNAL   Genomics 13 (3), 835-837 (1992)
   PUBMED   1639409
REFERENCE   10 (bases 1 to 15400)
  AUTHORS   Jayaraman,T., Brillantes,A.M., Timerman,A.P., Fleischer,S.,
            Erdjument-Bromage,H., Tempst,P. and Marks,A.R.
  TITLE     FK506 binding protein associated with the calcium release channel
            (ryanodine receptor)
  JOURNAL   J Biol Chem 267 (14), 9474-9477 (1992)
   PUBMED   1374404
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011469.6, AC067969.1 and
            AC005933.1.
            
            On Aug 31, 2019 this sequence version replaced NM_000540.2.
            
            Summary: This gene encodes a ryanodine receptor found in skeletal
            muscle. The encoded protein functions as a calcium release channel
            in the sarcoplasmic reticulum but also serves to connect the
            sarcoplasmic reticulum and transverse tubule. Mutations in this
            gene are associated with malignant hyperthermia susceptibility,
            central core disease, and minicore myopathy with external
            ophthalmoplegia. Alternatively spliced transcripts encoding
            different isoforms have been described. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2158800,
                              SAMEA2162946 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359596.8/ ENSP00000352608.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC011469.6         19927-19935
            10-184              AC011469.6         19936-20110
            185-304             AC011469.6         26981-27100
            305-409             AC011469.6         28585-28689
            410-484             AC011469.6         29794-29868
            485-563             AC011469.6         29954-30032
            564-676             AC011469.6         30385-30497
            677-770             AC011469.6         30820-30913
            771-864             AC011469.6         32708-32801
            865-939             AC011469.6         32930-33004
            940-1096            AC011469.6         34591-34747
            1097-1261           AC011469.6         34885-35049
            1262-1383           AC011469.6         38000-38121
            1384-1579           AC011469.6         39055-39250
            1580-1715           AC011469.6         41471-41606
            1716-1811           AC011469.6         41687-41782
            1812-1930           AC011469.6         41869-41987
            1931-2064           AC011469.6         43733-43866
            2065-2306           AC011469.6         44287-44528
            2307-2499           AC011469.6         45382-45574
            2500-2716           AC011469.6         46611-46827
            2717-2821           AC011469.6         49659-49763
            2822-2925           AC011469.6         49983-50086
            2926-3009           AC011469.6         50875-50958
            3010-3317           AC011469.6         52327-52634
            3318-3520           AC011469.6         53846-54048
            3521-3695           AC011469.6         55202-55376
            3696-3904           AC011469.6         55541-55749
            3905-4299           AC011469.6         59613-60007
            4300-4432           AC011469.6         61554-61686
            4433-4593           AC011469.6         63946-64106
            4594-4759           AC011469.6         64671-64836
            4760-4846           AC011469.6         69263-69349
            4847-5073           AC011469.6         69526-69752
            5074-5686           AC011469.6         71826-72438
            5687-5953           AC011469.6         75413-75679
            5954-6154           AC011469.6         76312-76512
            6155-6266           AC011469.6         76857-76968
            6267-6413           AC011469.6         78726-78872
            6414-6687           AC011469.6         80588-80861
            6688-6802           AC011469.6         82451-82565
            6803-6935           AC011469.6         82645-82777
            6936-7030           AC011469.6         83096-83190
            7031-7166           AC011469.6         85344-85479
            7167-7353           AC011469.6         85871-86057
            7354-7462           AC011469.6         86144-86252
            7463-7583           AC011469.6         86842-86962
            7584-7753           AC011469.6         87057-87226
            7754-7974           AC011469.6         88743-88963
            7975-8065           AC011469.6         89116-89206
            8066-8206           AC011469.6         90456-90596
            8207-8370           AC011469.6         90984-91147
            8371-8449           AC011469.6         91239-91317
            8450-8539           AC011469.6         91545-91634
            8540-8680           AC011469.6         92042-92182
            8681-8755           AC011469.6         92539-92613
            8756-8831           AC011469.6         92707-92782
            8832-8955           AC011469.6         93065-93188
            8956-9071           AC011469.6         93948-94063
            9072-9139           AC011469.6         96734-96801
            9140-9261           AC011469.6         96896-97017
            9262-9311           AC011469.6         97797-97846
            9312-9372           AC011469.6         98308-98368
            9373-9611           AC011469.6         98481-98719
            9612-9693           AC011469.6         101262-101343
            9694-9824           AC011469.6         102323-102453
            9825-10157          AC011469.6         103595-103927
            10158-10398         AC011469.6         105450-105690
            10399-10486         AC011469.6         109264-109351
            10487-10579         AC011469.6         109453-109545
            10580-10594         AC011469.6         110151-110165
            10595-10765         AC067969.1         6277-6447
            10766-10825         AC067969.1         7938-7997
            10826-10963         AC067969.1         8592-8729
            10964-11076         AC067969.1         9251-9363
            11077-11173         AC067969.1         9544-9640
            11174-11280         AC067969.1         9896-10002
            11281-11332         AC067969.1         13435-13486
            11333-11398         AC067969.1         13616-13681
            11399-11498         AC067969.1         15665-15764
            11499-11578         AC067969.1         16086-16165
            11579-11655         AC067969.1         16261-16337
            11656-11729         AC067969.1         16942-17015
            11730-11747         AC067969.1         17695-17712
            11748-11828         AC067969.1         18825-18905
            11829-11917         AC067969.1         24292-24380
            11918-12046         AC067969.1         24477-24605
            12047-12151         AC067969.1         24716-24820
            12152-12233         AC067969.1         27390-27471
            12234-12421         AC067969.1         29178-29365
            12422-12763         AC005933.1         6886-7227
            12764-13576         AC005933.1         10732-11544
            13577-13653         AC005933.1         12684-12760
            13654-13798         AC005933.1         13546-13690
            13799-13885         AC005933.1         16380-16466
            13886-14137         AC005933.1         17792-18043
            14138-14268         AC005933.1         18950-19080
            14269-14311         AC005933.1         21692-21734
            14312-14442         AC005933.1         23691-23821
            14443-14503         AC005933.1         23917-23977
            14504-14650         AC005933.1         25755-25901
            14651-14785         AC005933.1         26143-26277
            14786-14942         AC005933.1         30716-30872
            14943-15007         AC005933.1         31711-31775
            15008-15108         AC005933.1         31864-31964
            15109-15160         AC005933.1         32298-32349
            15161-15400         AC005933.1         33098-33337
FEATURES             Location/Qualifiers
     source          1..15400
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..15400
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /note="ryanodine receptor 1"
                     /db_xref="GeneID:6261"
                     /db_xref="HGNC:HGNC:10483"
                     /db_xref="MIM:180901"
     exon            1..184
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..15256
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sarcoplasmic reticulum calcium release channel; central
                     core disease of muscle; protein phosphatase 1, regulatory
                     subunit 137; skeletal muscle ryanodine receptor; type
                     1-like ryanodine receptor; skeletal muscle calcium release
                     channel; ryanodine receptor 1 (skeletal)"
                     /codon_start=1
                     /product="ryanodine receptor 1 isoform 1"
                     /protein_id="NP_000531.2"
                     /db_xref="CCDS:CCDS33011.1"
                     /db_xref="GeneID:6261"
                     /db_xref="HGNC:HGNC:10483"
                     /db_xref="MIM:180901"
                     /translation="MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNR
                     LCFLEPTSNAQNVPPDLAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLY
                     GHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGE
                     KVRVGDDIILVSVSSERYLHLSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHV
                     LRLFHGHMDECLTISPADSDDQRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWG
                     QPLRVRHVTTGQYLALTEDQGLVVVDASKAHTKATSFCFRISKEKLDVAPKRDVEGMG
                     PPEIKYGESLCFVQHVASGLWLTYAAPDPKALRLGVLKKKAMLHQEGHMDDALSLTRC
                     QQEESQAARMIHSTNGLYNQFIKSLDSFSGKPRGSGPPAGTALPIEGVILSLQDLIIY
                     FEPPSEDLQHEEKQSKLRSLRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGE
                     EAAESWKEIVNLLYELLASLIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYCV
                     LIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENL
                     LPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSKWYFEVMVDEVTPFLTAQATHLR
                     VGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLHLWTGHVARPVTSPGQHLLAPE
                     DVISCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVVSFSAGVKVRFLLGGRHGE
                     FKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVGPSRCLSHTDFVPCPVD
                     TVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVDFHSLPE
                     PERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMMSNGYKPAPLDLS
                     HVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRLVPYRLLDEAT
                     KRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRCDRVRIFRAEKSYTVQSGRWY
                     FEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGRPWQPGD
                     VVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGHLNLG
                     QDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVDGT
                     VDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED
                     EARAAEPDPDYENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDA
                     TTEKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSV
                     RVFAGQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMV
                     WGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVF
                     VLPTHQNVIQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNH
                     FLQVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRL
                     YRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSR
                     RSMLSEYIVPLTPETRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVA
                     ALPAAGAAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVL
                     KLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETA
                     QEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESL
                     AAFAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGT
                     DEEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVK
                     KKEEKPEEERSAEESKPRSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLG
                     ELLRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKV
                     FYQHPNLMRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQR
                     SMFDHLSYLLENSGIGLGMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCG
                     LQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECF
                     GPALRGEGGSGLLAAIEEAIRISEDPARDGPGIRRDRRREHFGEEPPEENRVHLGHAI
                     MSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLEDLVGIISLPLQIPTLG
                     KDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDT
                     ATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLT
                     KAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKY
                     YCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAMPCLCAIAGALPP
                     DYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDK
                     IQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTIEKARE
                     GEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQLAENYHNTW
                     GRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRGLKDM
                     ELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKIL
                     LPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTD
                     APAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQA
                     RTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLG
                     TTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPN
                     SVEEMCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAP
                     PSALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRAR
                     PELLQSHFIPTIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYAL
                     YPLLIRYVDNNRAQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINN
                     MSFLTADNKSKMAKAGDIQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNM
                     CAPTDQDLITLAKTRYALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGR
                     EEDADDPEKIVRRVQEVSAVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTP
                     LYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPL
                     HQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKQ
                     MEKQRLLYQQARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQK
                     MLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEK
                     VMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESIS
                     DFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAV
                     VGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDM
                     LVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSG
                     PEIQFLLSCSEADENEMINCEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNF
                     LELAESILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDV
                     VNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETDEDEGAGAAEAGAEGAEEG
                     AAGLEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRLRRLTAREAATAVAALL
                     WAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELLAGMPDPTSDEVHGE
                     QPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAG
                     GLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGE
                     KEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYTLRFLAL
                     FLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEAEGDEDE
                     NMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEF
                     DGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELL
                     GMDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMS
                     LLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFN
                     FFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVV
                     FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPH
                     GFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQ
                     YEDQLS"
     exon            185..304
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            305..409
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            410..484
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            485..563
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            564..676
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            677..770
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            771..864
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            865..939
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1096
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1261
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1383
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1579
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1715
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1811
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1930
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2064
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2306
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2499
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2716
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2821
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2925
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3009
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3317
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            3318..3520
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3695
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            3696..3904
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            3905..4299
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            4300..4432
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            4433..4593
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            4594..4759
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            4760..4846
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            4847..5073
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            5074..5686
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            5687..5953
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            5954..6154
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            6155..6266
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            6267..6413
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            6414..6687
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            6688..6802
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            6803..6935
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            6936..7030
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            7031..7166
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            7167..7353
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            7354..7462
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            7463..7583
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            7584..7753
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            7754..7974
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            7975..8065
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            8066..8206
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            8207..8370
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            8371..8449
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            8450..8539
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            8540..8680
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            8681..8755
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            8756..8831
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            8832..8955
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            8956..9071
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            9072..9139
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            9140..9261
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            9262..9311
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            9312..9372
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            9373..9611
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            9612..9693
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            9694..9824
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            9825..10157
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            10158..10398
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            10399..10486
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            10487..10579
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            10580..10594
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            10595..10765
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            10766..10825
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            10826..10963
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            10964..11076
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            11077..11173
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            11174..11280
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            11281..11332
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            11333..11398
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            11399..11498
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            11499..11578
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            11579..11655
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            11656..11729
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            11730..11747
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            11748..11828
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            11829..11917
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            11918..12046
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            12047..12151
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            12152..12233
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            12234..12421
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            12422..12763
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            12764..13576
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            13577..13653
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            13654..13798
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            13799..13885
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            13886..14137
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            14138..14268
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            14269..14311
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            14312..14442
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            14443..14503
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            14504..14650
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            14651..14785
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            14786..14942
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            14943..15007
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            15008..15108
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            15109..15160
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     exon            15161..15400
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15374..15379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /note="hexamer: AATAAA"
     polyA_site      15400
                     /gene="RYR1"
                     /gene_synonym="CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS;
                     MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR"
                     /note="major polyA site"
ORIGIN      
        1 gcagttccat ctacctcgcg ggtgcctctg gtgtctccag aggtctccga ccccagcccg
       61 cccccagccc tcccgcccag cccgcagccc cctccctctg ttccccgacc tcagaccctg
      121 ggcttccgac ctcgacatca tgggtgacgc agaaggcgaa gacgaggtcc agttcctgcg
      181 gacggacgat gaggtggtcc tgcagtgcag cgctaccgtg ctcaaggagc agctcaagct
      241 ctgcctggcc gccgagggct tcggcaaccg cctgtgcttc ctggagccca ctagcaacgc
      301 gcagaatgtg ccccccgatc tggccatctg ttgcttcgtc ctggagcagt ccctgtctgt
      361 gcgagccctg caggagatgc tggctaacac ggtggaggct ggcgtggagt catcccaggg
      421 cgggggacac aggacgctcc tgtatggcca tgccatcctg ctccggcatg cacacagccg
      481 catgtatctg agctgcctca ccacctcccg ctccatgact gacaagctgg ccttcgatgt
      541 gggactgcag gaggacgcaa caggagaggc ttgctggtgg accatgcacc cagcctccaa
      601 gcagaggtct gaaggagaaa aggtccgcgt tggggatgac atcatccttg tcagtgtctc
      661 ctccgagcgc tacctgcacc tgtcgaccgc cagtggggag ctccaggttg acgcttcctt
      721 catgcagaca ctatggaaca tgaaccccat ctgctcccgc tgcgaagagg gcttcgtgac
      781 gggaggtcac gtcctccgcc tctttcatgg acatatggat gagtgtctga ccatttcccc
      841 tgctgacagt gatgaccagc gcagacttgt ctactatgag gggggagctg tgtgcactca
      901 tgcccgctcc ctctggaggc tggagccact gagaatcagc tggagtggga gccacctgcg
      961 ctggggccag ccactccgag tccggcatgt cactaccggg cagtacctag cgctcaccga
     1021 ggaccagggc ctggtggtgg ttgacgccag caaggctcac accaaggcta cctccttctg
     1081 cttccgcatc tccaaggaga agctggatgt ggcccccaag cgggatgtgg agggcatggg
     1141 cccccctgag atcaagtacg gggagtcact gtgcttcgtg cagcatgtgg cctcaggact
     1201 gtggctcacc tatgctgctc cagaccccaa ggccctgcgg ctcggcgtgc tcaagaagaa
     1261 ggccatgctg caccaggagg gccacatgga cgacgcactg tcgctgaccc gctgccagca
     1321 ggaggagtcc caggccgccc gcatgatcca cagcaccaat ggcctataca accagttcat
     1381 caagagcctg gacagcttca gcgggaagcc acggggctcg gggccacccg ctggcacggc
     1441 gctgcccatc gagggcgtta tcctgagcct gcaggacctc atcatctact tcgagcctcc
     1501 ctccgaggac ttgcagcacg aggagaagca gagcaagctg cgaagcctgc gcaaccgcca
     1561 gagcctcttc caggaggagg ggatgctctc catggtcctg aattgcatag accgcctaaa
     1621 tgtctacacc actgctgccc actttgctga gtttgcaggg gaggaggcag ccgagtcctg
     1681 gaaagagatt gtgaatcttc tctatgaact cctagcttct ctaatccgtg gcaatcgtag
     1741 caactgtgcc ctcttctcca caaacttgga ctggctggtc agcaagctgg atcggctgga
     1801 ggcctcgtct ggcatcctgg aggtcctgta ctgtgtcctc attgagagtc cagaggttct
     1861 gaacatcatc caggagaatc acatcaagtc catcatctcc ctcctggaca agcatgggag
     1921 gaaccacaag gtcctggacg tgctatgctc cctgtgtgtg tgtaatggtg tggctgtacg
     1981 ctccaaccaa gatcttatta ctgagaactt gctgcctggc cgtgagcttc tgctgcagac
     2041 aaacctcatc aactatgtca ccagcatccg ccccaacatc tttgtgggcc gagcggaagg
     2101 caccacgcag tacagcaaat ggtactttga ggtgatggtg gacgaggtga ctccatttct
     2161 gacagctcag gccacccact tgcgggtggg ctgggccctc accgagggct acacccccta
     2221 ccctggggcc ggcgagggct ggggcggcaa cggggtcggc gatgacctct attcctacgg
     2281 ctttgatgga ctgcatctct ggacaggaca cgtggcacgc ccagtgactt ccccagggca
     2341 gcacctcctg gcccctgaag acgtgatcag ctgctgcctg gacctcagcg tgccgtccat
     2401 ctccttccgc atcaacggct gccccgtgca gggtgtcttt gagtccttca acctggacgg
     2461 gctcttcttc cctgttgtca gcttctcggc tggtgtcaag gtgcggttcc tccttggtgg
     2521 ccgccatggt gaattcaagt tcctgccccc acctggctat gctccatgcc atgaggctgt
     2581 gctccctcga gagcgactcc atcttgaacc catcaaggag tatcgacggg aggggccccg
     2641 ggggcctcac ctggtgggcc ccagtcgctg cctctcacac accgacttcg tgccctgccc
     2701 tgtggacact gtccagattg tcctgccgcc ccatctggag cgcattcggg agaagctggc
     2761 ggagaacatc cacgagctct gggcgctaac ccgcatcgag cagggctgga cctacggccc
     2821 ggttcgggat gacaacaaga ggctgcaccc gtgtcttgtg gacttccaca gccttccaga
     2881 gcctgagagg aactacaacc tgcagatgtc tggggagacg ctcaagactc tgctggctct
     2941 gggctgccac gtgggcatgg cggatgagaa ggcggaggac aacctgaaga agacaaaact
     3001 ccccaagacg tatatgatga gcaatgggta caagccggct ccgctggacc tgagccacgt
     3061 gcggctgacg ccggcgcaga cgacactggt ggaccgtctg gcagaaaatg ggcacaacgt
     3121 gtgggcccga gaccgcgtgg gccagggctg gagctacagc gcagtgcagg acatcccagc
     3181 gcgccgaaac cctcggctgg tgccctaccg cctgctggat gaagccacca agcgcagcaa
     3241 ccgggacagc ctctgccagg ccgtgcgcac cctcctgggc tacggctaca acatcgagcc
     3301 tcctgaccag gagcccagtc aggtggagaa ccagtctcgt tgtgaccggg tgcgcatctt
     3361 ccgggcagag aaatcctata cagtgcagag cggccgctgg tacttcgagt ttgaagcagt
     3421 caccacaggc gagatgcgcg tgggctgggc gaggcccgag ctgaggcctg atgtagagct
     3481 gggagctgac gagctggcct atgtcttcaa tgggcaccgc ggccagcgct ggcacttggg
     3541 cagtgaacca tttgggcgcc cctggcagcc gggcgatgtc gttggctgta tgatcgacct
     3601 cacagagaac accattatct tcaccctcaa tggcgaggtc ctcatgtctg actcaggctc
     3661 cgaaacagcc ttccgggaga ttgagattgg ggacggcttc ctgcccgtct gcagcttggg
     3721 acctggccag gtgggtcatc tgaacctggg ccaggacgtg agctctctga ggttctttgc
     3781 catctgtggc ctccaggaag gcttcgagcc atttgccatc aacatgcagc gcccagtcac
     3841 cacctggttc agcaaaggcc tgccccagtt tgagccagtg ccccttgaac accctcacta
     3901 tgaggtatcc cgagtggacg gcactgtgga cacgcccccc tgcctgcgcc tgacccaccg
     3961 cacctggggc tcccagaaca gcctggtgga gatgcttttc ctgcggctga gcctcccagt
     4021 ccagttccac cagcacttcc gctgcactgc aggggccacc ccgctggcac ctcctggcct
     4081 gcagcccccc gccgaggacg aggcccgggc ggcggaaccc gaccctgact acgaaaacct
     4141 gcgccgctca gctgggggct ggagcgaggc agagaacggc aaagaaggga ctgcgaagga
     4201 gggcgccccc gggggcaccc cgcaggcggg gggagaggcg cagcccgcca gggcggagaa
     4261 tgagaaggat gccaccaccg agaagaacaa gaagagaggc ttcttattca aggccaagaa
     4321 ggtcgccatg atgacccagc caccggccac ccccacgctg ccccgactcc ctcacgacgt
     4381 ggtgcctgca gacaaccgcg atgaccccga gatcatcctc aacaccacca cgtactatta
     4441 ctccgtgagg gtctttgctg gacaggagcc cagctgcgtg tgggcgggct gggtcacccc
     4501 tgactaccat cagcacgaca tgagcttcga cctcagcaag gtccgggtcg tgacggtgac
     4561 catgggggat gaacaaggca acgtccacag cagcctcaag tgtagcaact gctacatggt
     4621 gtggggcgga gactttgtga gtcccgggca gcagggccgg atcagccaca cggaccttgt
     4681 cattgggtgc ctggtggact tggccactgg cttaatgacc tttacagcca atggcaaaga
     4741 gagcaacacc tttttccagg tggaacccaa cactaagcta tttcctgccg tcttcgtcct
     4801 gcccacccac cagaacgtca tccagtttga gctggggaag cagaagaaca tcatgccgtt
     4861 gtcagccgcc atgttccaaa gcgagcgcaa gaacccggcc ccgcagtgcc caccgcggct
     4921 ggagatgcag atgctgatgc cagtgtcctg gagccgcatg cccaaccact tcctgcaggt
     4981 ggagacgagg cgtgccggcg agcggctggg ctgggccgtg cagtgccagg agccgctgac
     5041 catgatggcg ctgcacatcc ccgaggagaa ccggtgcatg gacatcctgg agctgtcgga
     5101 gcgcctggac ctgcagcgct tccactcgca caccctgcgc ctctaccgcg ctgtgtgcgc
     5161 cctgggcaac aatcgcgtgg cgcacgctct gtgcagccac gtagaccaag ctcagctgct
     5221 gcacgccctg gaggacgcgc acctgccagg cccactgcgc gcaggctact atgacctcct
     5281 catcagcatc cacctcgaaa gtgcctgccg cagccgccgc tccatgctct ctgaatacat
     5341 cgtgcccctc acgcctgaga cccgcgccat cacgctcttc cctcctggaa ggagcacaga
     5401 aaatggtcac ccccggcatg gcctgccggg agttggagtc accacttcgc tgaggccccc
     5461 gcatcatttc tcgcccccct gtttcgtggc cgctctgcca gctgctgggg cagcagaggc
     5521 cccggcccgc ctcagccctg ccatcccgct ggaggccctg cgggacaagg cactgaggat
     5581 gctgggggag gcggtgcgcg acggtgggca gcacgctcgc gaccccgtcg ggggctccgt
     5641 ggagttccag tttgtgcctg tgctcaagct cgtgtccacc ctgctggtga tgggcatctt
     5701 tggcgatgag gatgtgaaac agatcttgaa gatgattgag cctgaggtct tcactgagga
     5761 agaagaggag gaggacgagg aggaagaggg tgaagaggaa gatgaggagg agaaggagga
     5821 ggatgaggag gaaacagcac aggaaaagga agatgaggaa aaagaggaag aggaggcagc
     5881 agaaggggag aaagaagaag gcttggagga agggctgctc cagatgaagt tgccagagtc
     5941 tgtgaagtta cagatgtgcc acctgctgga gtatttctgt gaccaagagc tgcagcaccg
     6001 tgtggagtcc ctggcagcct ttgcggagcg ctatgtggac aagctccagg ccaaccagcg
     6061 gagccgctat ggcctcctca taaaagcctt cagcatgacc gcagcagaga ctgcaagacg
     6121 tacccgcgag ttccgctccc caccccagga acagatcaat atgctattgc aattcaaaga
     6181 tggtacagat gaggaagact gtcctctccc tgaagagatt cgacaggatt tgcttgactt
     6241 tcatcaagac ctgctggcac actgtggaat tcagctagat ggagaggagg aggaaccaga
     6301 ggaagagacc accctgggca gccgcctcat gagcctgttg gagaaagtgc ggctggtgaa
     6361 gaagaaggaa gagaaacctg aggaggagcg gtcagcagag gagagcaaac cccggtccct
     6421 gcaggagctg gtgtcccaca tggtggtgcg ctgggcccaa gaggacttcg tgcagagccc
     6481 cgagctggtg cgggccatgt tcagcctcct gcaccggcag tacgacgggc tgggtgagct
     6541 gctgcgtgcc ctgccgcggg cgtacaccat ctcaccgtcc tccgtggaag acaccatgag
     6601 cctgctcgag tgcctcggcc agatccgctc gctgctcatc gtgcagatgg gcccccagga
     6661 ggagaacctc atgatccaga gcatcgggaa catcatgaac aacaaagtct tctaccaaca
     6721 cccgaacctg atgagggcgc tgggcatgca cgagacggtc atggaggtca tggtcaacgt
     6781 cctcgggggc ggcgagtcca aggagatccg cttccccaag atggtgacaa gctgctgccg
     6841 cttcctctgc tatttctgcc gaatcagccg gcagaaccag cgctccatgt ttgaccacct
     6901 gagctacctg ctggagaaca gtggcatcgg cctgggcatg cagggctcca cgcccctgga
     6961 cgtggctgct gcctccgtca ttgacaacaa tgagctggcc ttggcattgc aggagcagga
     7021 cctggaaaag gttgtgtcct acctggcagg ctgtggcctc cagagctgcc ccatgcttgt
     7081 ggccaaaggg tacccagaca ttggctggaa cccctgtggt ggagagcgct acctggactt
     7141 cctgcgcttt gctgtcttcg tcaacggcga gagcgtggag gagaacgcca atgtggtggt
     7201 gcggctgctc atccggaagc ctgagtgctt cggacccgcc ctgcggggtg agggtggctc
     7261 agggctgctg gctgccatcg aagaggccat ccgcatctcc gaggaccctg cgagggatgg
     7321 cccaggcatc cgcagggacc ggcggcgcga gcactttggt gaggaaccgc ctgaagaaaa
     7381 ccgggtgcac ctgggacacg ccatcatgtc cttctatgcc gccttgatcg acctgctcgg
     7441 acgctgtgca ccagagatgc atctaatcca agccggcaag ggtgaggccc tgcggatccg
     7501 cgccatcctc cgctcccttg tgcccttgga ggaccttgtg ggcatcatca gcctcccact
     7561 gcagattccc accctgggca aagatggggc tctggtgcag ccaaagatgt cagcatcctt
     7621 cgtgccggac cacaaggcgt ccatggtgct cttcctggac cgtgtgtatg gcatcgagaa
     7681 ccaggacttc ttgctgcacg tgctggacgt ggggttcctg cccgacatga gggcagccgc
     7741 ctcgctggac acggccactt tcagcaccac cgagatggcg ctggcgctga accgctacct
     7801 gtgcctggcc gtgctgccgc tcatcaccaa gtgtgcgccg ctctttgcgg gcacagaaca
     7861 ccgcgccatc atggtggact ctatgctgca taccgtgtac cgcctgtctc ggggtcgttc
     7921 gctcaccaag gcgcagcgtg acgtcatcga ggactgcctc atgtcgctct gcaggtacat
     7981 ccgcccgtcg atgctgcagc acctgttgcg ccgcctggtg ttcgacgtgc ccatcctcaa
     8041 cgagttcgcc aagatgccac tcaagctcct caccaaccac tatgagcgct gttggaagta
     8101 ctactgccta cccacgggct gggccaactt cggggtcacc tcagaggagg agctgcacct
     8161 cacacggaaa ctcttctggg gcatctttga ctctctggcc cataagaaat acgacccgga
     8221 gctgtaccgc atggccatgc cttgtctgtg cgccattgcc ggggctctgc cccccgacta
     8281 tgtggatgcc tcatactcat ctaaggcaga gaaaaaggcc acagtggatg ctgaaggcaa
     8341 ctttgatccc cggcctgtgg agaccctcaa tgtgatcatc ccggagaagc tggactcctt
     8401 cattaacaag tttgcggagt acacacacga gaagtgggcc ttcgacaaga tccagaacaa
     8461 ctggtcctat ggagagaaca tagacgagga gctgaagacc caccccatgc tgaggcccta
     8521 caagaccttt tcagagaagg acaaagagat ttaccgctgg cccatcaagg agtccctgaa
     8581 ggccatgatt gcctgggaat ggacgataga gaaggccagg gagggtgagg aggagaagac
     8641 ggaaaagaaa aaaacgcgga agatatcaca aagtgcccag acctatgatc ctcgagaagg
     8701 ctacaaccct cagccccccg accttagtgc tgttaccctg tcccgggagc tgcaggccat
     8761 ggcagaacaa ctggcagaaa attaccacaa cacgtgggga cggaagaaga agcaggagct
     8821 ggaagccaaa ggcggtggga cccaccccct gctggtcccc tacgacacgc tcacggccaa
     8881 ggagaaggca cgagatcgag agaaggccca ggagctactg aaattcctgc agatgaatgg
     8941 ctacgcggtt acaagaggcc ttaaggacat ggaactggac tcgtcttcca ttgaaaagcg
     9001 gtttgccttt ggcttcctgc agcagctgct gcgctggatg gacatttctc aggagttcat
     9061 tgcccacctg gaggctgtgg tcagcagtgg gcgagtggaa aagtccccac atgaacagga
     9121 gattaaattc tttgccaaga tcctgctccc tttgatcaac cagtacttca ccaaccactg
     9181 cctctatttc ttgtccactc cggctaaagt gctgggcagc ggtggccacg cctctaacaa
     9241 ggagaaggaa atgatcacca gcctcttctg caaacttgct gctctcgtcc gccaccgagt
     9301 ctctctcttt gggacagacg ccccagctgt ggtcaactgt cttcacatcc tggcccgctc
     9361 cctggatgcc aggacagtga tgaagtcagg ccctgagatc gtgaaggctg gcctccgctc
     9421 cttcttcgag agtgcctcgg aggacatcga gaagatggtg gagaacctgc ggctgggcaa
     9481 ggtgtcgcag gcgcgcaccc aggtgaaagg cgtgggccag aacctcacct acaccactgt
     9541 ggcactgctg ccggtcctca ccaccctctt ccagcacatc gcccagcacc agttcggaga
     9601 tgacgtcatc ctggacgacg tccaggtctc ttgctaccga acgctgtgca gtatctactc
     9661 cctgggaacc accaagaaca cttatgtgga aaagcttcgg ccagccctcg gggagtgcct
     9721 ggcccgtctg gcagcagcca tgccggtggc gttcctggag ccgcagctga acgagtacaa
     9781 cgcctgctcc gtgtacacca ccaagtctcc gcgggagcgg gccatcctgg ggctccccaa
     9841 cagtgtggag gagatgtgtc ccgacatccc ggtgctggag cggctcatgg cagacattgg
     9901 ggggctggcc gagtcaggtg cccgctacac agagatgccg catgtcatcg agatcacgct
     9961 gcccatgcta tgcagctacc tgccccgatg gtgggagcgc gggcccgagg cacccccttc
    10021 cgccctgccc gccggcgccc ccccaccctg cacagctgtc acctctgacc acctcaactc
    10081 cctgctgggg aatatcctga gaatcatcgt caacaacctg ggcattgacg aggcctcctg
    10141 gatgaagcgg ctggctgtgt tcgcacagcc cattgtgagc cgtgcacggc cggagctcct
    10201 gcagtcccac ttcatcccaa ctatcgggcg gctgcgcaag agggcaggga aggtggtgtc
    10261 cgaggaggag cagctgcgcc tggaggccaa ggcggaggcc caggagggcg agctgctggt
    10321 gcgggacgag ttctctgtgc tctgccggga cctctacgcc ctgtatccgc tgctcatccg
    10381 ctacgtggac aacaacaggg cgcagtggct gacggagccg aatcccagcg cggaggagct
    10441 gttcaggatg gtgggcgaga tcttcatcta ctggtccaag tcccacaact tcaagcgcga
    10501 ggagcagaac tttgtggtcc agaatgagat caacaacatg tccttcctga ctgctgacaa
    10561 caaaagcaaa atggctaagg cgggagatat acagtccggt ggctcggacc aggaacgcac
    10621 caagaagaag cgccgggggg accggtactc tgtgcagacg tcactgatcg tggccacact
    10681 gaagaagatg ctgcccatcg gcctgaatat gtgtgcgccc accgaccaag acctcatcac
    10741 gctggccaag acccgttacg ccctgaaaga cacagatgag gaggtccggg aatttctgca
    10801 caacaacctt caccttcagg gaaaggtcga aggctccccg tctctgcgct ggcagatggc
    10861 tctgtaccgg ggcgtcccgg gtcgcgagga ggacgccgat gaccccgaga aaatcgtgcg
    10921 cagagtccag gaagtgtcag ccgtgctcta ctacctggac cagaccgagc acccttacaa
    10981 gtctaagaag gccgtgtggc acaagctttt gtccaaacag cgccggcggg cagtcgtggc
    11041 ctgtttccgt atgacgcccc tgtacaacct gcccacgcac cgggcatgta acatgttcct
    11101 ggagagctac aaggctgcat ggatcctgac tgaagaccac agttttgagg accgcatgat
    11161 agatgacctt tcaaaagctg gggagcagga ggaggaggag gaagaggtgg aagagaagaa
    11221 gccagacccc ctgcaccagt tggtcctgca cttcagccgc actgccctga cggaaaagag
    11281 caaactggat gaggattacc tgtacatggc ctatgctgat atcatggcaa agagctgcca
    11341 cctggaggag ggaggggaga acggtgaagc tgaagaggag gttgaggtct cctttgagga
    11401 gaaacagatg gagaagcaga ggctcttgta ccagcaagca cggctgcaca cccggggggc
    11461 ggccgagatg gtgctgcaga tgatcagtgc ctgcaaagga gagacaggtg ccatggtgtc
    11521 ctccaccctg aagctgggca tctccatcct caatggaggc aatgctgagg tccagcagaa
    11581 aatgctggat tatcttaagg acaagaagga agttggcttc ttccagagta tccaggcact
    11641 gatgcaaaca tgcagcgtcc tggatctcaa tgcctttgag agacagaaca aggccgaggg
    11701 gctgggcatg gtgaatgagg atggcactgt catcaatcgc cagaacggag agaaggtcat
    11761 ggcggatgat gaattcacac aagacctgtt ccgattccta caattgctct gtgaggggca
    11821 caataatgat ttccagaact acctacggac acagacaggg aacacgacca ctattaacat
    11881 catcatttgc actgtggact acctcctgcg gctgcaggaa tccatcagcg acttctactg
    11941 gtactactcg ggcaaggatg tcattgaaga gcagggcaag aggaacttct ccaaagccat
    12001 gtcggtggct aagcaggtgt tcaacagcct cactgagtac atccagggtc cctgcaccgg
    12061 gaaccagcag agcctggcgc acagtcgcct atgggacgca gtggtgggat tcctgcacgt
    12121 gttcgcccac atgatgatga agctcgctca ggactcaagc cagatcgagc tgctgaagga
    12181 gctgctggat ctgcagaagg acatggtggt gatgttgctg tcgctactag aagggaacgt
    12241 ggtgaacggc atgatcgccc ggcagatggt ggacatgctc gtggaatcct catccaatgt
    12301 ggagatgatc ctcaagttct tcgacatgtt cctgaaactc aaggacattg tgggctctga
    12361 agccttccag gactacgtaa cggatccccg tggcctcatc tccaagaagg acttccagaa
    12421 ggccatggac agccagaagc agttcagcgg tccagaaatc cagttcctgc tttcgtgctc
    12481 cgaagcggat gagaacgaaa tgatcaactg cgaagagttc gccaaccgct tccaggagcc
    12541 agcacgcgac atcggcttca acgtggcggt gctgctgacc aacctgtcgg agcatgtgcc
    12601 gcatgaccct cgcctgcaca acttcctgga gctggccgag agcatccttg agtacttccg
    12661 cccctacctg ggccgcatcg agatcatggg cgcgtcacgc cgcatcgagc gcatctactt
    12721 cgagatctca gagaccaacc gcgcccagtg ggagatgccc caggtgaagg agtccaagcg
    12781 ccagttcatc ttcgacgtgg tgaacgaggg cggcgaggct gagaagatgg agctcttcgt
    12841 gagtttctgc gaggacacca tcttcgagat gcagatcgcc gcgcagatct cggagcccga
    12901 gggcgagccg gagaccgacg aggacgaggg cgcgggcgcg gcggaggcgg gcgcggaagg
    12961 cgcggaggag ggcgcggcgg ggctcgaggg cacggcggcc acggcggcgg cgggggcgac
    13021 ggcgcgggtt gtggcggccg caggccgggc cctgcgaggc ctcagctacc gcagcctgcg
    13081 gcggcgcgtg cggcggctgc ggcggcttac ggcccgcgag gcggccaccg cagtggcggc
    13141 gctgctctgg gcagcagtga cgcgcgctgg ggccgctggc gcgggggcgg cggcgggcgc
    13201 gctgggcctg ctctggggct cgctgttcgg cggcggcctg gtggagggcg ccaagaaggt
    13261 gacggtgacc gagctcctgg caggcatgcc cgaccccacc agcgacgagg tgcacggcga
    13321 gcagccggcc gggccgggcg gagacgcaga cggcgagggt gccagcgagg gcgctggaga
    13381 cgccgcggag ggcgctggag acgaggagga ggcggtgcac gaggccgggc cgggcggtgc
    13441 cgacggggcg gtggccgtga ccgatggggg ccccttccgg cccgaagggg ctggcggtct
    13501 cggggacatg ggggacacga cgcctgcgga accgcccaca cccgagggct ctcccatcct
    13561 caagaggaaa ttgggggtgg atggagtgga ggaggagctc ccgccagagc cagagcccga
    13621 gccggaacca gagctggagc cggagaaagc cgatgccgag aatggggaga aggaagaagt
    13681 tcccgagccc acaccagagc cccccaagaa gcaagcacct ccctcacccc ctccaaagaa
    13741 ggaggaagct ggaggcgaat tctggggaga actggaggtg cagagggtga agttcctgaa
    13801 ctacctgtcc cggaactttt acaccctgcg gttccttgcc ctcttcttgg catttgccat
    13861 caacttcatc ttgctgtttt ataaggtctc agactctcca ccaggggagg acgacatgga
    13921 aggctcagct gctggggatg tgtcaggtgc aggctctggt ggcagctctg gctggggctt
    13981 gggggccgga gaggaggcag agggcgatga ggatgagaac atggtgtact acttcctgga
    14041 ggaaagcaca ggctacatgg aacccgccct gcggtgtctg agcctcctgc atacactggt
    14101 ggcctttctc tgcatcattg gctataattg tctcaaggtg cccctggtaa tctttaagcg
    14161 ggagaaggag ctggcccgga agctggagtt tgatggcctg tacatcacgg agcagcctga
    14221 ggacgatgac gtgaaggggc agtgggaccg actggtgctc aacacgccgt ctttccctag
    14281 caactactgg gacaagtttg tcaagcgcaa ggtcctggac aaacatgggg acatctacgg
    14341 gcgggagcgg attgctgagc tactgggcat ggacctggcc acactagaga tcacagccca
    14401 caatgagcgc aagcccaacc cgccgccagg gctgctgacc tggctcatgt ccatcgatgt
    14461 caagtaccag atctggaagt tcggggtcat cttcacagac aactccttcc tgtacctggg
    14521 ctggtatatg gtgatgtccc tcttgggaca ctacaacaac ttcttctttg ctgcccatct
    14581 cctggacatc gccatggggg tcaagacgct gcgcaccatc ctgtcctctg tcacccacaa
    14641 tgggaaacag ctggtgatga ccgtgggcct tctggcggtg gtcgtctacc tgtacaccgt
    14701 ggtggccttc aacttcttcc gcaagttcta caacaagagc gaggatgagg atgaacctga
    14761 catgaagtgt gatgacatga tgacgtgtta cctgtttcac atgtacgtgg gtgtccgggc
    14821 tggcggaggc attggggacg agatcgagga ccccgcgggt gacgaatacg agctctacag
    14881 ggtggtcttc gacatcacct tcttcttctt cgtcatcgtc atcctgttgg ccatcatcca
    14941 gggtctgatc atcgacgctt ttggtgagct ccgagaccaa caagagcaag tgaaggagga
    15001 tatggagacc aagtgcttca tctgtggaat cggcagtgac tactttgata cgacaccgca
    15061 tggcttcgag actcacacgc tggaggagca caacctggcc aattacatgt ttttcctgat
    15121 gtatttgata aacaaggatg agacagaaca cacgggtcag gagtcttatg tctggaagat
    15181 gtaccaagag agatgttggg atttcttccc agctggtgat tgtttccgta agcagtatga
    15241 ggaccagctt agctgacaca cccccagctg gccctccacc cccacctcaa gtgccttatt
    15301 ctcacagcaa gccccttagt ccccaagccc ctccccctaa ggcagctggg ggagaggtga
    15361 cctagtactg gaaaataaat ctgtgctacg ccccccagca
//
