LOCUS       NM_006917               1966 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens retinoid X receptor gamma (RXRG), transcript variant
            1, mRNA.
ACCESSION   NM_006917
VERSION     NM_006917.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1966)
  AUTHORS   Yu,X.Y., Song,L.P., Zheng,H.T., Wei,S.D., Wen,X.L., Huang,B. and
            Liu,D.B.
  TITLE     Association between functional genetic variants in retinoid X
            receptor-alpha/gamma and the risk of gestational diabetes mellitus
            in a southern Chinese population
  JOURNAL   Biosci Rep 41 (10) (2021)
   PUBMED   34633445
  REMARK    GeneRIF: Association between functional genetic variants in
            retinoid X receptor-alpha/gamma and the risk of gestational
            diabetes mellitus in a southern Chinese population.
REFERENCE   2  (bases 1 to 1966)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1966)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1966)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1966)
  AUTHORS   Barger,P.M. and Kelly,D.P.
  TITLE     Identification of a retinoid/chicken ovalbumin upstream promoter
            transcription factor response element in the human retinoid X
            receptor gamma2 gene promoter
  JOURNAL   J Biol Chem 272 (5), 2722-2728 (1997)
   PUBMED   9006910
REFERENCE   6  (bases 1 to 1966)
  AUTHORS   Nagata,T., Weiss,E.H., Abe,K., Kitagawa,K., Ando,A.,
            Yara-Kikuti,Y., Seldin,M.F., Ozato,K., Inoko,H. and Taketo,M.
  TITLE     Physical mapping of the retinoid X receptor B gene in mouse and
            human
  JOURNAL   Immunogenetics 41 (2-3), 83-90 (1995)
   PUBMED   7806300
REFERENCE   7  (bases 1 to 1966)
  AUTHORS   Almasan,A., Mangelsdorf,D.J., Ong,E.S., Wahl,G.M. and Evans,R.M.
  TITLE     Chromosomal localization of the human retinoid X receptors
  JOURNAL   Genomics 20 (3), 397-403 (1994)
   PUBMED   8034312
REFERENCE   8  (bases 1 to 1966)
  AUTHORS   Muscat,G.E., Mynett-Johnson,L., Dowhan,D., Downes,M. and Griggs,R.
  TITLE     Activation of myoD gene transcription by
            3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone
            and retinoid X receptors
  JOURNAL   Nucleic Acids Res 22 (4), 583-591 (1994)
   PUBMED   8127707
REFERENCE   9  (bases 1 to 1966)
  AUTHORS   Liu,Q. and Linney,E.
  TITLE     The mouse retinoid-X receptor-gamma gene: genomic organization and
            evidence for functional isoforms
  JOURNAL   Mol Endocrinol 7 (5), 651-658 (1993)
   PUBMED   8391126
REFERENCE   10 (bases 1 to 1966)
  AUTHORS   Leid,M., Kastner,P., Lyons,R., Nakshatri,H., Saunders,M.,
            Zacharewski,T., Chen,J.Y., Staub,A., Garnier,J.M., Mader,S. et al.
  TITLE     Purification, cloning, and RXR identity of the HeLa cell factor
            with which RAR or TR heterodimerizes to bind target sequences
            efficiently
  JOURNAL   Cell 68 (2), 377-395 (1992)
   PUBMED   1310259
  REMARK    Erratum:[Cell. 1992 Nov 27;71(5):887.. PMID: 1330328]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA251671.1, BC012063.1 and
            BE349162.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006917.4.
            
            Summary: This gene encodes a member of the retinoid X receptor
            (RXR) family of nuclear receptors which are involved in mediating
            the antiproliferative effects of retinoic acid (RA). This receptor
            forms dimers with the retinoic acid, thyroid hormone, and vitamin D
            receptors, increasing both DNA binding and transcriptional function
            on their respective response elements. This gene is expressed at
            significantly lower levels in non-small cell lung cancer cells.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform (a,
            also known as RXRgamma1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.230428.1,
                                           SRR1803615.193294.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359842.10/ ENSP00000352900.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                DA251671.1         231-275
            46-1770             BC012063.1         1-1725
            1771-1966           BE349162.1         22-217              c
FEATURES             Location/Qualifiers
     source          1..1966
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..1966
                     /gene="RXRG"
                     /gene_synonym="NR2B3; RXR-gamma; RXRC; RXRgamma"
                     /note="retinoid X receptor gamma"
                     /db_xref="GeneID:6258"
                     /db_xref="HGNC:HGNC:10479"
                     /db_xref="MIM:180247"
     exon            1..282
                     /gene="RXRG"
                     /gene_synonym="NR2B3; RXR-gamma; RXRC; RXRgamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1625
                     /gene="RXRG"
                     /gene_synonym="NR2B3; RXR-gamma; RXRC; RXRgamma"
                     /note="isoform a is encoded by transcript variant 1;
                     retinoic acid receptor RXR-gamma; nuclear receptor
                     subfamily 2 group B member 3"
                     /codon_start=1
                     /product="retinoic acid receptor RXR-gamma isoform a"
                     /protein_id="NP_008848.1"
                     /db_xref="CCDS:CCDS1248.1"
                     /db_xref="GeneID:6258"
                     /db_xref="HGNC:HGNC:10479"
                     /db_xref="MIM:180247"
                     /translation="MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPS
                     YTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNV
                     VNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCK
                     GFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRE
                     RAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQ
                     LFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVH
                     RSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVET
                     LREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDT
                     FLMEMLETPLQIT"
     exon            283..530
                     /gene="RXRG"
                     /gene_synonym="NR2B3; RXR-gamma; RXRC; RXRgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            531..675
                     /gene="RXRG"
                     /gene_synonym="NR2B3; RXR-gamma; RXRC; RXRgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            676..855
                     /gene="RXRG"
                     /gene_synonym="NR2B3; RXR-gamma; RXRC; RXRgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1016
                     /gene="RXRG"
                     /gene_synonym="NR2B3; RXR-gamma; RXRC; RXRgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1146
                     /gene="RXRG"
                     /gene_synonym="NR2B3; RXR-gamma; RXRC; RXRgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1279
                     /gene="RXRG"
                     /gene_synonym="NR2B3; RXR-gamma; RXRC; RXRgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1371
                     /gene="RXRG"
                     /gene_synonym="NR2B3; RXR-gamma; RXRC; RXRgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1477
                     /gene="RXRG"
                     /gene_synonym="NR2B3; RXR-gamma; RXRC; RXRgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1966
                     /gene="RXRG"
                     /gene_synonym="NR2B3; RXR-gamma; RXRC; RXRgamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1750..1755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RXRG"
                     /gene_synonym="NR2B3; RXR-gamma; RXRC; RXRgamma"
                     /note="hexamer: AATAAA"
     polyA_site      1775
                     /gene="RXRG"
                     /gene_synonym="NR2B3; RXR-gamma; RXRC; RXRgamma"
     regulatory      1940..1945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RXRG"
                     /gene_synonym="NR2B3; RXR-gamma; RXRC; RXRgamma"
                     /note="hexamer: AATAAA"
     polyA_site      1966
                     /gene="RXRG"
                     /gene_synonym="NR2B3; RXR-gamma; RXRC; RXRgamma"
                     /note="major polyA site"
ORIGIN      
        1 accagctgct gccgccacag ccgtctcaaa cgcactatgt ggactctccg atctagaggc
       61 agattcctga ctaatcccag agggctggcc cagcctgtgc tccccgggct gctaggaagc
      121 gatgaccact cttgttagcc caagttgaag aaagccgggc tgtgcctggg agccgagaga
      181 ggcggtaata tttagaagct gcacaggaga ggaacatgaa ctgacgagta aacatgtatg
      241 gaaattattc tcacttcatg aagtttcccg caggctatgg aggctcccct ggccacactg
      301 gctctacatc catgagccca tcagcagcct tgtccacagg gaagccaatg gacagccacc
      361 ccagctacac agatacccca gtgagtgccc cacggactct gagtgcagtg gggacccccc
      421 tcaatgccct gggctctcca tatcgagtca tcacctctgc catgggccca ccctcaggag
      481 cacttgcagc gcctccagga atcaacttgg ttgccccacc cagctctcag ctaaatgtgg
      541 tcaacagtgt cagcagttca gaggacatca agcccttacc agggcttccc gggattggaa
      601 acatgaacta cccatccacc agccccggat ctctggttaa acacatctgt gccatctgtg
      661 gagacagatc ctcaggaaag cactacgggg tatacagttg tgaaggctgc aaagggttct
      721 tcaagaggac gataaggaag gacctcatct acacgtgtcg ggataataaa gactgcctca
      781 ttgacaagcg tcagcgcaac cgctgccagt actgtcgcta tcagaagtgc cttgtcatgg
      841 gcatgaagag ggaagctgtg caagaagaaa gacagaggag ccgagagcga gctgagagtg
      901 aggcagaatg tgctaccagt ggtcatgaag acatgcctgt ggagaggatt ctagaagctg
      961 aacttgctgt tgaaccaaag acagaatcct atggtgacat gaatatggag aactcgacaa
     1021 atgaccctgt taccaacata tgtcatgctg ctgacaagca gcttttcacc ctcgttgaat
     1081 gggccaagcg tattccccac ttctctgacc tcaccttgga ggaccaggtc attttgcttc
     1141 gggcagggtg gaatgaattg ctgattgcct ctttctccca ccgctcagtt tccgtgcagg
     1201 atggcatcct tctggccacg ggtttacatg tccaccggag cagtgcccac agtgctgggg
     1261 tcggctccat ctttgacaga gtcctaactg agctggtttc caaaatgaaa gacatgcaga
     1321 tggacaagtc ggaactggga tgcctgcgag ccattgtact ctttaaccca gatgccaagg
     1381 gcctgtccaa cccctctgag gtggagactc tgcgagagaa ggtttatgcc acccttgagg
     1441 cctacaccaa gcagaagtat ccggaacagc caggcaggtt tgccaagctg ctgctgcgcc
     1501 tcccagctct gcgttccatt ggcttgaaat gcctggagca cctcttcttc ttcaagctca
     1561 tcggggacac ccccattgac accttcctca tggagatgtt ggagaccccg ctgcagatca
     1621 cctgagcccc accagccaca gcctccccac ccaggatgac ccctgggcag gtgtgtgtgg
     1681 acccccaccc tgcactttcc tccacctccc accctgaccc ccttcctgtc cccaaaatgt
     1741 gatgcttata ataaagaaaa cctttctaca catgagactt ttataggtgg acttttgtat
     1801 agatgttaaa ggtaatacgc tttgctgtct acagggctgg gagactttct ggaagttctt
     1861 gggaaaacta atcaagcctc tgtacataca attggtttaa attatttttt cacttgccct
     1921 ggaaagcaaa caaatgagta ataaaataat atgtgtgaaa ttggca
//
