LOCUS       NM_002957               5537 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens retinoid X receptor alpha (RXRA), transcript variant
            1, mRNA.
ACCESSION   NM_002957
VERSION     NM_002957.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5537)
  AUTHORS   Niu,Q., Li,Z., Jiang,H. and Hu,B.
  TITLE     Linc-ROR inhibits NK cell-killing activity by promoting RXRA
            ubiquitination and reducing MICB expression in gastric cancer
            patients
  JOURNAL   J Cell Biochem 125 (2), e30516 (2024)
   PUBMED   38205878
  REMARK    GeneRIF: Linc-ROR inhibits NK cell-killing activity by promoting
            RXRA ubiquitination and reducing MICB expression in gastric cancer
            patients.
REFERENCE   2  (bases 1 to 5537)
  AUTHORS   Yao,X., Xu,K., Tao,N., Cheng,S., Chen,H., Zhang,D., Yang,M.,
            Tan,M., Yu,H., Chen,P., Zhan,Z., He,S., Li,R., Wang,C., Wu,D. and
            Ren,J.
  TITLE     ZNF148 inhibits HBV replication by downregulating RXRalpha
            transcription
  JOURNAL   Virol J 21 (1), 35 (2024)
   PUBMED   38297280
  REMARK    GeneRIF: ZNF148 inhibits HBV replication by downregulating RXRalpha
            transcription.
            Erratum:[Virol J. 2024 Jun 25;21(1):145. doi:
            10.1186/s12985-024-02420-z.. PMID: 38918845]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5537)
  AUTHORS   Liu,R.Z., Choi,W.S., Jain,S., Xu,X., Elsherbiny,M.E.,
            Glubrecht,D.D., Tessier,A.G., Easaw,J.C., Fallone,B.G. and
            Godbout,R.
  TITLE     Stationary-to-migratory transition in glioblastoma stem-like cells
            driven by a fatty acid-binding protein 7-RXRalpha neurogenic
            pathway
  JOURNAL   Neuro Oncol 25 (12), 2177-2190 (2023)
   PUBMED   37499046
  REMARK    GeneRIF: Stationary-to-migratory transition in glioblastoma
            stem-like cells driven by a fatty acid-binding protein 7-RXRalpha
            neurogenic pathway.
REFERENCE   4  (bases 1 to 5537)
  AUTHORS   AlEjielat,R., Khaleel,A., Batarseh,Y.S., Abu-Qatouseh,L.,
            Al-Wawi,S. and AlSunna,T.
  TITLE     SNP rs11185644 in RXRA gene and SNP rs2235544 in DIO1 gene predict
            dosage requirements in a cross-sectional sample of hypothyroid
            patients
  JOURNAL   BMC Endocr Disord 23 (1), 167 (2023)
   PUBMED   37563580
  REMARK    GeneRIF: SNP rs11185644 in RXRA gene and SNP rs2235544 in DIO1 gene
            predict dosage requirements in a cross-sectional sample of
            hypothyroid patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5537)
  AUTHORS   Chen,S., Ji,L., Wang,Y., Zhang,L., Xu,M., Su,Y. and Zhang,X.
  TITLE     lncRNA RMST suppresses the progression of colorectal cancer by
            competitively binding to miR-27a-3p/RXRalpha axis and inactivating
            Wnt signaling pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (5), 726-735 (2023)
   PUBMED   37246895
  REMARK    GeneRIF: lncRNA RMST suppresses the progression of colorectal
            cancer by competitively binding to miR-27a-3p/RXRalpha axis and
            inactivating Wnt signaling pathway.
REFERENCE   6  (bases 1 to 5537)
  AUTHORS   Kliewer,S.A., Umesono,K., Mangelsdorf,D.J. and Evans,R.M.
  TITLE     Retinoid X receptor interacts with nuclear receptors in retinoic
            acid, thyroid hormone and vitamin D3 signalling
  JOURNAL   Nature 355 (6359), 446-449 (1992)
   PUBMED   1310351
REFERENCE   7  (bases 1 to 5537)
  AUTHORS   Zhang,X.K., Hoffmann,B., Tran,P.B., Graupner,G. and Pfahl,M.
  TITLE     Retinoid X receptor is an auxiliary protein for thyroid hormone and
            retinoic acid receptors
  JOURNAL   Nature 355 (6359), 441-446 (1992)
   PUBMED   1310350
REFERENCE   8  (bases 1 to 5537)
  AUTHORS   Heyman,R.A., Mangelsdorf,D.J., Dyck,J.A., Stein,R.B., Eichele,G.,
            Evans,R.M. and Thaller,C.
  TITLE     9-cis retinoic acid is a high affinity ligand for the retinoid X
            receptor
  JOURNAL   Cell 68 (2), 397-406 (1992)
   PUBMED   1310260
REFERENCE   9  (bases 1 to 5537)
  AUTHORS   Levin,A.A., Sturzenbecker,L.J., Kazmer,S., Bosakowski,T.,
            Huselton,C., Allenby,G., Speck,J., Kratzeisen,C., Rosenberger,M.,
            Lovey,A. et al.
  TITLE     9-cis retinoic acid stereoisomer binds and activates the nuclear
            receptor RXR alpha
  JOURNAL   Nature 355 (6358), 359-361 (1992)
   PUBMED   1309942
REFERENCE   10 (bases 1 to 5537)
  AUTHORS   Mangelsdorf,D.J., Ong,E.S., Dyck,J.A. and Evans,R.M.
  TITLE     Nuclear receptor that identifies a novel retinoic acid response
            pathway
  JOURNAL   Nature 345 (6272), 224-229 (1990)
   PUBMED   2159111
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354796.21, BQ220698.1,
            BC110998.1, BM563384.1, BC063827.1, CN391132.1, BQ637722.1,
            AF052092.1 and BP422254.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002957.5.
            
            Summary: Retinoid X receptors (RXRs) and retinoic acid receptors
            (RARs) are nuclear receptors that mediate the biological effects of
            retinoids by their involvement in retinoic acid-mediated gene
            activation. These receptors function as transcription factors by
            binding as homodimers or heterodimers to specific sequences in the
            promoters of target genes. The protein encoded by this gene is a
            member of the steroid and thyroid hormone receptor superfamily of
            transcriptional regulators. Alternative splicing of this gene
            results in multiple transcript variants. [provided by RefSeq, May
            2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063827.1, X52773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000481739.2/ ENSP00000419692.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL354796.21        29352-29359         c
            9-46                BQ220698.1         1-38
            47-2217             BC110998.1         1-2171
            2218-2531           BM563384.1         362-675
            2532-3665           BC063827.1         2517-3650
            3666-3814           CN391132.1         523-671
            3815-4294           BQ637722.1         6-485
            4295-5054           BC063827.1         4276-5035
            5055-5417           AF052092.1         1055-1417
            5418-5537           BP422254.1         376-495
FEATURES             Location/Qualifiers
     source          1..5537
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..5537
                     /gene="RXRA"
                     /gene_synonym="NR2B1; RXR-alpha; RXRalpha"
                     /note="retinoid X receptor alpha"
                     /db_xref="GeneID:6256"
                     /db_xref="HGNC:HGNC:10477"
                     /db_xref="MIM:180245"
     exon            1..205
                     /gene="RXRA"
                     /gene_synonym="NR2B1; RXR-alpha; RXRalpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1566
                     /gene="RXRA"
                     /gene_synonym="NR2B1; RXR-alpha; RXRalpha"
                     /note="isoform a is encoded by transcript variant 1;
                     retinoic acid receptor RXR-alpha; retinoid X nuclear
                     receptor alpha; nuclear receptor subfamily 2 group B
                     member 1"
                     /codon_start=1
                     /product="retinoic acid receptor RXR-alpha isoform a"
                     /protein_id="NP_002948.1"
                     /db_xref="CCDS:CCDS35172.1"
                     /db_xref="GeneID:6256"
                     /db_xref="HGNC:HGNC:10477"
                     /db_xref="MIM:180245"
                     /translation="MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSP
                     GQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVS
                     SSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFK
                     RTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNEN
                     EVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQL
                     FTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHR
                     NSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEAL
                     REKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTF
                     LMEMLEAPHQMT"
     exon            206..456
                     /gene="RXRA"
                     /gene_synonym="NR2B1; RXR-alpha; RXRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            457..607
                     /gene="RXRA"
                     /gene_synonym="NR2B1; RXR-alpha; RXRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            608..787
                     /gene="RXRA"
                     /gene_synonym="NR2B1; RXR-alpha; RXRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            788..957
                     /gene="RXRA"
                     /gene_synonym="NR2B1; RXR-alpha; RXRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1087
                     /gene="RXRA"
                     /gene_synonym="NR2B1; RXR-alpha; RXRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1220
                     /gene="RXRA"
                     /gene_synonym="NR2B1; RXR-alpha; RXRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1312
                     /gene="RXRA"
                     /gene_synonym="NR2B1; RXR-alpha; RXRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1418
                     /gene="RXRA"
                     /gene_synonym="NR2B1; RXR-alpha; RXRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..5537
                     /gene="RXRA"
                     /gene_synonym="NR2B1; RXR-alpha; RXRalpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5515..5520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RXRA"
                     /gene_synonym="NR2B1; RXR-alpha; RXRalpha"
                     /note="hexamer: AATACA"
     polyA_site      5537
                     /gene="RXRA"
                     /gene_synonym="NR2B1; RXR-alpha; RXRalpha"
                     /note="major polyA site"
ORIGIN      
        1 agtttacatt gttgggcgac ttttgcaaca actcgccgcg ccgcggcctc cgcgcgccgc
       61 cgccgccacc gcagccgccg gctccccgcc gcccgggccc gggccggccg cgccgggggc
      121 cgccgcgccc gccgcccgct gcctgcgccg ccggccgggc atgagttagt cgcagacatg
      181 gacaccaaac atttcctgcc gctcgatttc tccacccagg tgaactcctc cctcacctcc
      241 ccgacggggc gaggctccat ggctgccccc tcgctgcacc cgtccctggg gcctggcatc
      301 ggctccccgg gacagctgca ttctcccatc agcaccctga gctcccccat caacggcatg
      361 ggcccgcctt tctcggtcat cagctccccc atgggccccc actccatgtc ggtgcccacc
      421 acacccaccc tgggcttcag cactggcagc ccccagctca gctcacctat gaaccccgtc
      481 agcagcagcg aggacatcaa gccccccctg ggcctcaatg gcgtcctcaa ggtccccgcc
      541 cacccctcag gaaacatggc ttccttcacc aagcacatct gcgccatctg cggggaccgc
      601 tcctcaggca agcactatgg agtgtacagc tgcgaggggt gcaagggctt cttcaagcgg
      661 acggtgcgca aggacctgac ctacacctgc cgcgacaaca aggactgcct gattgacaag
      721 cggcagcgga accggtgcca gtactgccgc taccagaagt gcctggccat gggcatgaag
      781 cgggaagccg tgcaggagga gcggcagcgt ggcaaggacc ggaacgagaa tgaggtggag
      841 tcgaccagca gcgccaacga ggacatgccg gtggagagga tcctggaggc tgagctggcc
      901 gtggagccca agaccgagac ctacgtggag gcaaacatgg ggctgaaccc cagctcgccg
      961 aacgaccctg tcaccaacat ttgccaagca gccgacaaac agcttttcac cctggtggag
     1021 tgggccaagc ggatcccaca cttctcagag ctgcccctgg acgaccaggt catcctgctg
     1081 cgggcaggct ggaatgagct gctcatcgcc tccttctccc accgctccat cgccgtgaag
     1141 gacgggatcc tcctggccac cgggctgcac gtccaccgga acagcgccca cagcgcaggg
     1201 gtgggcgcca tctttgacag ggtgctgacg gagcttgtgt ccaagatgcg ggacatgcag
     1261 atggacaaga cggagctggg ctgcctgcgc gccatcgtcc tctttaaccc tgactccaag
     1321 gggctctcga acccggccga ggtggaggcg ctgagggaga aggtctatgc gtccttggag
     1381 gcctactgca agcacaagta cccagagcag ccgggaaggt tcgctaagct cttgctccgc
     1441 ctgccggctc tgcgctccat cgggctcaaa tgcctggaac atctcttctt cttcaagctc
     1501 atcggggaca cacccattga caccttcctt atggagatgc tggaggcgcc gcaccaaatg
     1561 acttaggcct gcgggcccat cctttgtgcc cacccgttct ggccaccctg cctggacgcc
     1621 agctgttctt ctcagcctga gccctgtccc tgcccttctc tgcctggcct gtttggactt
     1681 tggggcacag cctgtcactg ctctgcctaa gagatgtgtt gtcaccctcc ttatttctgt
     1741 tactacttgt ctgtggccca gggcagtggc tttcctgagg cagcagcctt cgtggcaaga
     1801 actagcgtga gcccagccag gcgcctcccc accgggctct caggacaccc tgccacaccc
     1861 cacggggctt gggcgactac agggtcttcg ggccccagcc ctggagctgc aggagttggg
     1921 aacggggctt ttgtttccgt tgctgtttat cgatgctggt tttcagaatt cctgtgtggc
     1981 cctcctgtct ggagtgacat cttcatctgc tctgaatact ggtgcccagc cagcccgtga
     2041 cagcttcccc ctaatcagga ggggacagct gggggcgcaa gctggtgtgt catcagcaaa
     2101 gacctcagcc gcctcgggga tgagagggga ctcgtggggc aagcaagctg ccctgtgctc
     2161 tgagtgaggg ggaaggtagc ccctttttcc aaagataact cacagttttg ccctcgagcc
     2221 aatgagaaca tgagctgccc tctgtgcaag gtttcggggc cacctccagg ctgcaggggc
     2281 gggtcactca cccccctgtt ttctctctgc cttggtgttc tggtttcaga ctcccgactc
     2341 cccgttcaga ccagagtgcc ccggcccctc cccagcctga gtcttctcct tgctctgcgg
     2401 ggtgggctga ggcttgtcct tgtttcctgc agggctggcc ctggctcggg cagggtgggg
     2461 catcaccacc tcactggcct tgctggaggc acagggctct gcggacctgc agccatctgt
     2521 gaggcccgcg gggatgggag gggaggaggg tggcctgttg gtttccctca gagggggcag
     2581 gtggcctgga gagagagggg ctcaggaact gggagcctcg tgggtggggc agatgctccg
     2641 cggcctggag tggctctgcc ggggcattgg tgggacccct gctcaggcct tctctctggc
     2701 tgccagttgt gtctaaaaga ctcttggaat ctgagaaccc ggagtcgcag cgccctcggg
     2761 cctgggccac acgcaggccc tggtgggacc acccagcctg gtattgtcca cggacagcgt
     2821 tgttcaccca gagccttact tgggagcctc actgaacgcc tgctctggtt gaaggtgggg
     2881 tgggggcggg gcttggggcc tccctggctc agcccagtgc ggcctggcgc tcctcccgca
     2941 ggctctgccc ccgggctccg gtggtgcggg gccctctcag gttgaactcg cctcttttgc
     3001 actggaaggc cctccctttg gcctgagtac ttttcccgtt cacgcctcag tcccgtggac
     3061 ccagcctttg tcagtggcag gtgcctgaac agagggtgga tgggggggat accggagggg
     3121 gtcttgtctt cccagccgca gtctaggaat gatgcggggg ggtggacgcc ttctccatag
     3181 tctttcccca cctggagcag gggcttcctc agtggtgagg ggagctgcct acaggttgga
     3241 ccgggaggca gtggcttgga gaggcagctt tccagccttg gtggggaaga aagtgtccat
     3301 tctttgcctt cctggagctc ccagccagag ctgagcttag gcacccgagt ggagcctgca
     3361 gctgagtctg tgcccgagac aggctgtcag agattccaga agcctctcct ccccgccgcc
     3421 ctccacccct gcctttcagc gttgtggatc cctagaggtg gccccctgcc cgatccaccg
     3481 tcctgaggca gagtgttgag cctcatacct gtaccaggtc cccggccagc tgggcccctc
     3541 ccaggcactg ccaggaagcc ccagctgccc ctggcgggtg tggtggaaat ggcaggaggg
     3601 tgcaggtact cttggggccc cagcggtggg agtgcaaaag acccaacgcc aacacctggt
     3661 gccttctgca gccagcgccc acccatccgt gcccggaccc ttgggaatgc ccgcggctcc
     3721 agaggaaaaa gcccagggac ggggcctccg ttgcgggggg tcggctgctt cttgggaact
     3781 ttgtcgtttc cggcgctggc tggctggctg gctggctgta aagcactgaa gccccccggc
     3841 cgccaacccc tgaaagcaga acctggcctc cctggccaca gcagccttac ccaccgctct
     3901 acgtgtcccg ggcacttccc gcagccttcc cgtccctttc tcatcggcct tgtagttgta
     3961 cagtgctgtt ggtttgaaaa ggtgatgtgt ggggagtgcg gctcatcact gagtagagag
     4021 gtagaatttc tatttaacca gacctgtagt agtattacca atccagttca attaaggtga
     4081 ttttttgtaa ttattattat tttggtggga caatctttaa ttttctaaag atagcactaa
     4141 catcagctca ttagccacct gtgcctgtcc ccgccttggc ccggctggat gaagcggctt
     4201 ccccgcaggg cccccacttc ccagtggctg cttcctgggg acccagggca ccccggcacc
     4261 ttcaggcacg ctcctcagct ggtcacctcc cggctttgcc gttcagatgg ggctcctgag
     4321 gctcaggagt gaagatgcca cagagccggg ctcccctagg ctgcgtcggg catgcttgga
     4381 agctggcctg ccaggacctt ccaccctggg gcctgtgtca gccgccggcc ctccgcaccc
     4441 tggaagcaca cggcctctgg gaaggacagc cctgaccttc ggttttccga gcacggtgtt
     4501 tcccaagaat tctgggctgg cggcctggtg gcagtgctgg agatgacccc gagcccctcc
     4561 ccgtggggca cccaggaggg ccctgccgga atgtgcagcc tgtgggtagt cggctggtgt
     4621 ccctgtcgtg gagctggggt gcgtgatctg gtgctcgtcc acgcaggtgt gtggtgtaaa
     4681 catgtatgtg ctgtacagag agacgcgtgt ggagagagcc gcacaccagc gccacccagg
     4741 aaaggcggag cggttaccag tgttttgtgt ttatttttaa tcaagacgtt tcccctgttt
     4801 tcctataaat ttgcttcgtg taagcaagta cataaggacc ctcctttggt gaaatccggg
     4861 ttcgaatgaa tatctcaagg caggagatgc atctatttta agatgctttg gagcagacag
     4921 ctttagccgt tcccaatcct tagcaatgcc ttagctggga cgcatagcta atactttaga
     4981 gaggatgaca gatccataaa gagagtaaag ataagagaaa atgtctaaag catctggaaa
     5041 ggtaaaaaaa aaaaatctat ttttgtacaa atgtaatttt atccctcatg tatacttgga
     5101 tatggcgggg ggagggctgg gactgtttcg tttctgcttc tagagattga ggtgaaagct
     5161 tcgtccgaga aacgccagga cagacgatgg cagaggagag ggctcctgtg acggcggcga
     5221 ggcttgggag gaaaccgccg caatgggggt gtcttccctc ggggcaggag ggtgggcctg
     5281 aggctttcaa gggttttctt ccctttcgag taatttttaa agccttgctc tgttgtgtcc
     5341 tgttgccggc tctggccttc ctgtgactga ctgtgaagtg gcttctccgt acgattgtct
     5401 ctgaaacatc gtggcctcag gtgccagggt ttgatggaca gtagcattag aattgtggaa
     5461 aaggaacacg caaagggaga agtgtgagag gagaaacaaa atatgagcgt ttaaaataca
     5521 tcgccattca gttcgtt
//
