LOCUS       NM_016568               2533 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens relaxin family peptide receptor 3 (RXFP3), mRNA.
ACCESSION   NM_016568
VERSION     NM_016568.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2533)
  AUTHORS   Wong,W.L.E., Arathimos,R., Lewis,C.M., Young,A.H. and Dawe,G.S.
  TITLE     Investigating the role of the relaxin-3/RXFP3 system in
            neuropsychiatric disorders and metabolic phenotypes: A candidate
            gene approach
  JOURNAL   PLoS One 18 (11), e0294045 (2023)
   PUBMED   37967073
  REMARK    GeneRIF: Investigating the role of the relaxin-3/RXFP3 system in
            neuropsychiatric disorders and metabolic phenotypes: A candidate
            gene approach.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2533)
  AUTHORS   Wong,W.L.E., Dawe,G.S. and Young,A.H.
  TITLE     The putative role of the relaxin-3/RXFP3 system in clinical
            depression and anxiety: A systematic literature review
  JOURNAL   Neurosci Biobehav Rev 131, 429-450 (2021)
   PUBMED   34537263
  REMARK    GeneRIF: The putative role of the relaxin-3/RXFP3 system in
            clinical depression and anxiety: A systematic literature review.
            Review article
REFERENCE   3  (bases 1 to 2533)
  AUTHORS   Li,H.Z., Li,N., Shao,X.X., Liu,Y.L., Xu,Z.G. and Guo,Z.Y.
  TITLE     Hydrophobic interactions of relaxin family peptide receptor 3 with
            ligands identified using a NanoBiT-based binding assay
  JOURNAL   Biochimie 177, 117-126 (2020)
   PUBMED   32810565
  REMARK    GeneRIF: Hydrophobic interactions of relaxin family peptide
            receptor 3 with ligands identified using a NanoBiT-based binding
            assay.
REFERENCE   4  (bases 1 to 2533)
  AUTHORS   Wang,J.H., Nie,W.H., Shao,X.X., Li,H.Z., Hu,M.J., Liu,Y.L., Xu,Z.G.
            and Guo,Z.Y.
  TITLE     Exploring electrostatic interactions of relaxin family peptide
            receptor 3 and 4 with ligands using a NanoBiT-based binding assay
  JOURNAL   Biochim Biophys Acta Biomembr 1861 (4), 776-786 (2019)
   PUBMED   30684458
  REMARK    GeneRIF: present work shed new light on the interaction mechanism
            of RXFP3 and RXFP4 with agonists and antagonists, and also provided
            a novel approach for interaction studies of some plasma membrane
            receptors with their ligands.
REFERENCE   5  (bases 1 to 2533)
  AUTHORS   Heidari,S., Taromchi,A.H., Nejatbakhsh,R. and Shokri,S.
  TITLE     Expression and localisation of RXFP3 in human spermatozoa and
            impact of INSL7 on sperm functions
  JOURNAL   Andrologia 50 (3) (2018)
   PUBMED   29159832
  REMARK    GeneRIF: This study indicated that RXFP3 mainly localised in the
            post-acrosomal region of sperm head and neck.
REFERENCE   6  (bases 1 to 2533)
  AUTHORS   Bathgate,R.A., Ivell,R., Sanborn,B.M., Sherwood,O.D. and
            Summers,R.J.
  TITLE     Receptors for relaxin family peptides
  JOURNAL   Ann N Y Acad Sci 1041, 61-76 (2005)
   PUBMED   15956688
  REMARK    Review article
REFERENCE   7  (bases 1 to 2533)
  AUTHORS   Liu,C., Chen,J., Kuei,C., Sutton,S., Nepomuceno,D., Bonaventure,P.
            and Lovenberg,T.W.
  TITLE     Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective
            ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over
            leucine-rich repeat-containing G protein-coupled receptor 7
  JOURNAL   Mol Pharmacol 67 (1), 231-240 (2005)
   PUBMED   15465925
  REMARK    GeneRIF: Substitution of the relaxin-3 A-chain with the A-chain
            from insulin-like peptide 5 results in a chimeric peptide that
            selectively activates GPCR135 and GPCR142.
REFERENCE   8  (bases 1 to 2533)
  AUTHORS   Liu,C., Eriste,E., Sutton,S., Chen,J., Roland,B., Kuei,C.,
            Farmer,N., Jornvall,H., Sillard,R. and Lovenberg,T.W.
  TITLE     Identification of relaxin-3/INSL7 as an endogenous ligand for the
            orphan G-protein-coupled receptor GPCR135
  JOURNAL   J Biol Chem 278 (50), 50754-50764 (2003)
   PUBMED   14522968
  REMARK    GeneRIF: GPCR135 (SALPR) is the receptor for relaxin-3
REFERENCE   9  (bases 1 to 2533)
  AUTHORS   Matsumoto,M., Kamohara,M., Sugimoto,T., Hidaka,K., Takasaki,J.,
            Saito,T., Okada,M., Yamaguchi,T. and Furuichi,K.
  TITLE     The novel G-protein coupled receptor SALPR shares sequence
            similarity with somatostatin and angiotensin receptors
  JOURNAL   Gene 248 (1-2), 183-189 (2000)
   PUBMED   10806363
REFERENCE   10 (bases 1 to 2533)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D88437.1, BC113438.1 and AC139777.3.
            
            On Mar 31, 2010 this sequence version replaced NM_016568.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330120.5/ ENSP00000328708.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1174              D88437.1           6-1179
            1175-1829           BC113438.1         896-1550
            1830-2533           AC139777.3         144233-144936
FEATURES             Location/Qualifiers
     source          1..2533
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.2"
     gene            1..2533
                     /gene="RXFP3"
                     /gene_synonym="GPCR135; RLN3R1; RXFPR3; SALPR"
                     /note="relaxin family peptide receptor 3"
                     /db_xref="GeneID:51289"
                     /db_xref="HGNC:HGNC:24883"
                     /db_xref="MIM:609445"
     exon            1..2533
                     /gene="RXFP3"
                     /gene_synonym="GPCR135; RLN3R1; RXFPR3; SALPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..1765
                     /gene="RXFP3"
                     /gene_synonym="GPCR135; RLN3R1; RXFPR3; SALPR"
                     /note="G-protein coupled receptor SALPR; somatostatin and
                     angiotensin-like peptide receptor; relaxin/insulin like
                     family peptide receptor 3; RLN3 receptor 1; g
                     protein-coupled receptor SALPR; G-protein coupled receptor
                     GPCR135"
                     /codon_start=1
                     /product="relaxin-3 receptor 1"
                     /protein_id="NP_057652.1"
                     /db_xref="CCDS:CCDS3900.1"
                     /db_xref="GeneID:51289"
                     /db_xref="HGNC:HGNC:24883"
                     /db_xref="MIM:609445"
                     /translation="MQMADAATIATMNKAAGGDKLAELFSLVPDLLEAANTSGNASLQ
                     LPDLWWELGLELPDGAPPGHPPGSGGAESADTEARVRILISVVYWVVCALGLAGNLLV
                     LYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSM
                     VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGDCCGRSLGDSCCFSAKALC
                     VWIWALAALASLPSAIFSTTVKVMGEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGF
                     VLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGGRPTGASARRLSKVTKSVTIVVLS
                     FFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLV
                     RREFRKALKSLLWRIASPSITSMRPFTATTKPEHEDQGLQAPAPPHAAAEPDLLYYPP
                     GVVVYSGGRYDLLPSSSAY"
ORIGIN      
        1 ggggagttat gcgccagtgc cccagtgacc gcgggacacg gagaggggaa gtctgcgttg
       61 tacataagga cctagggact ccgagcttgg cctgagaacc cttggacgcc gagtgcttgc
      121 cttacgggct gcactcctca actctgctcc aaagcagccg ctgagctcaa ctcctgcgtc
      181 cagggcgttc gctgcgcgcc aggacgcgct tagtacccag ttcctgggct ctctcttcag
      241 tagctgcttt gaaagctccc acgcacgtcc cgcaggctag cctggcaaca aaactggggt
      301 aaaccgtgtt atcttaggtc ttgtccccca gaacatgacc tagaggtacc tgcgcatgca
      361 gatggccgat gcagccacga tagccaccat gaataaggca gcaggcgggg acaagctagc
      421 agaactcttc agtctggtcc cggaccttct ggaggcggcc aacacgagtg gtaacgcgtc
      481 gctgcagctt ccggacttgt ggtgggagct ggggctggag ttgccggacg gcgcgccgcc
      541 aggacatccc ccgggcagcg gcggggcaga gagcgcggac acagaggccc gggtgcggat
      601 tctcatcagc gtggtgtact gggtggtgtg cgccctgggg ttggcgggca acctgctggt
      661 tctctacctg atgaagagca tgcagggctg gcgcaagtcc tctatcaacc tcttcgtcac
      721 caacctggcg ctgacggact ttcagtttgt gctcaccctg cccttctggg cggtggagaa
      781 cgctcttgac ttcaaatggc ccttcggcaa ggccatgtgt aagatcgtgt ccatggtgac
      841 gtccatgaac atgtacgcca gcgtgttctt cctcactgcc atgagtgtga cgcgctacca
      901 ttcggtggcc tcggctctga agagccaccg gacccgagga cacggccggg gcgactgctg
      961 cggccggagc ctgggggaca gctgctgctt ctcggccaag gcgctgtgtg tgtggatctg
     1021 ggctttggcc gcgctggcct cgctgcccag tgccattttc tccaccacgg tcaaggtgat
     1081 gggcgaggag ctgtgcctgg tgcgtttccc ggacaagttg ctgggccgcg acaggcagtt
     1141 ctggctgggc ctctaccact cgcagaaggt gctgctgggc ttcgtgctgc cgctgggcat
     1201 cattatcttg tgctacctgc tgctggtgcg cttcatcgcc gaccgccgcg cggcggggac
     1261 caaaggaggg gccgcggtag ccggaggacg cccgaccgga gccagcgccc ggagactgtc
     1321 gaaggtcacc aaatcagtga ccatcgttgt cctgtccttc ttcctgtgtt ggctgcccaa
     1381 ccaggcgctc accacctgga gcatcctcat caagttcaac gcggtgccct tcagccagga
     1441 gtatttcctg tgccaggtat acgcgttccc tgtgagcgtg tgcctagcgc actccaacag
     1501 ctgcctcaac cccgtcctct actgcctcgt gcgccgcgag ttccgcaagg cgctcaagag
     1561 cctgctgtgg cgcatcgcgt ctccttcgat caccagcatg cgccccttca ccgccactac
     1621 caagccggag cacgaggatc aggggctgca ggccccggcg ccgccccacg cggccgcgga
     1681 gccggacctg ctctactacc cacctggcgt cgtggtctac agcggggggc gctacgacct
     1741 gctgcccagc agctctgcct actgacgcag gcctcaggcc cagggcgcgc cgtcggggca
     1801 aggtggcctt ccccgggcgg taaagaggtg aaaggatgaa ggagggctgg ggggggcccc
     1861 atttaagaag taggtgggag gaggatgggc agagcatgga ggaggagcct gtggataggc
     1921 cgaggacctt ctctggagag gagatgcttc gaaatcgggt ggagagagga aattggcaaa
     1981 gggatagaga cgagccccac gggccagaca gccaacctcc gctccgcacc ccacagcctc
     2041 tccttactct tcccacgctg agtagtgtgg gggcgcccag aagcgaagac aagcagcaaa
     2101 aatgtagaga aattggcacg gggagcgggg cttagccaaa tgatgcacag acaattgtgc
     2161 ccgtttattc cagcgacttc tgcggagagg gcagccgtcg gcacaaacac tcctttgcgt
     2221 cttggcaaac gagactgcag cagcgccaag gtcctacttg ctgcggggct gccccaggaa
     2281 tctagagctg gtaggcaaga aacgcttttg gagttaagaa aaagaactga ccatcctggt
     2341 ccgcccacag gagaaacggc aaaggaaagc cacctccaat ggagtcatta tgacaattat
     2401 cattccggac tgggccagcg ggaacaccct gagcccgacc tagctgcaca gccccggagc
     2461 tcagacgtta gcagggggat aacacctgtc accagcttgg gagagccatt ctctggggag
     2521 tgtcgtcgct gcg
//
