LOCUS       NM_021634               3686 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens relaxin family peptide receptor 1 (RXFP1), transcript
            variant 1, mRNA.
ACCESSION   NM_021634
VERSION     NM_021634.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3686)
  AUTHORS   Dominska,K., Urbanek,K.A., Kowalska,K., Habrowska-Gorczynska,D.E.,
            Koziel,M.J., Ochedalski,T. and Piastowska-Ciesielska,A.W.
  TITLE     The consequences of manipulating relaxin family peptide receptor 1
            (RXFP1) level in ovarian cancer cells
  JOURNAL   Reprod Biol 24 (2), 100864 (2024)
   PUBMED   38640630
  REMARK    GeneRIF: The consequences of manipulating relaxin family peptide
            receptor 1 (RXFP1) level in ovarian cancer cells.
REFERENCE   2  (bases 1 to 3686)
  AUTHORS   Illiano,S., Poirier,B., Minoletti,C., Pasquier,O., Riva,L.,
            Chenede,X., Menguy,I., Guillotel,M., Prigent,P., Le Claire,S.,
            Gillot,F., Thill,G., Lo Presti,F., Corbier,A., Le Bail,J.C.,
            Grailhe,P., Monteagudo,E., Ingenito,R., Bianchi,E., Philippo,C.,
            Duclos,O., Mallart,S., Bathgate,R. and Janiak,P.
  TITLE     Characterization of a new potent and long-lasting single chain
            peptide agonist of RXFP1 in cells and in vivo translational models
  JOURNAL   Sci Rep 12 (1), 20435 (2022)
   PUBMED   36443381
  REMARK    GeneRIF: Characterization of a new potent and long-lasting single
            chain peptide agonist of RXFP1 in cells and in vivo translational
            models.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3686)
  AUTHORS   Chen,T.Y., Li,X., Goobie,G.C., Hung,C.H., Hung,T.K., Hamilton,K.,
            Bahudhanapati,H., Tan,J., Kass,D.J. and Zhang,Y.
  TITLE     Identification of a distal RXFP1 gene enhancer with differential
            activity in fibrotic lung fibroblasts involving AP-1
  JOURNAL   PLoS One 16 (12), e0254466 (2021)
   PUBMED   34972106
  REMARK    GeneRIF: Identification of a distal RXFP1 gene enhancer with
            differential activity in fibrotic lung fibroblasts involving AP-1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3686)
  AUTHORS   Morelli,S.S., Petraglia,F., Weiss,G., Luisi,S., Florio,P. and
            Goldsmith,L.T.
  TITLE     Relaxin in endometriosis
  JOURNAL   Ann N Y Acad Sci 1160, 138-139 (2009)
   PUBMED   19416175
  REMARK    GeneRIF: Data tested the hypothesis that relaxin plays a role in
            endometriosis by comparing the expression of relaxin mRNA and its
            LGR7 (RXFP1) receptor mRNA in normal human endometrium to those in
            samples from patients with endometriosis.
REFERENCE   5  (bases 1 to 3686)
  AUTHORS   Kern,A., Hubbard,D., Amano,A. and Bryant-Greenwood,G.D.
  TITLE     Cloning, expression, and functional characterization of relaxin
            receptor (leucine-rich repeat-containing g protein-coupled receptor
            7) splice variants from human fetal membranes
  JOURNAL   Endocrinology 149 (3), 1277-1294 (2008)
   PUBMED   18079195
  REMARK    GeneRIF: The dominant-negative effects of the LGR7 splice variants
            expressed in the chorion and decidua could be functionally
            significant in the peripartal period.
REFERENCE   6  (bases 1 to 3686)
  AUTHORS   Scott,D.J., Layfield,S., Yan,Y., Sudo,S., Hsueh,A.J., Tregear,G.W.
            and Bathgate,R.A.
  TITLE     Characterization of novel splice variants of LGR7 and LGR8 reveals
            that receptor signaling is mediated by their unique low density
            lipoprotein class A modules
  JOURNAL   J Biol Chem 281 (46), 34942-34954 (2006)
   PUBMED   16963451
  REMARK    GeneRIF: The essential role of the LDLa module in LGR7 and LGR8
            function is reported.
REFERENCE   7  (bases 1 to 3686)
  AUTHORS   Muda,M., He,C., Martini,P.G., Ferraro,T., Layfield,S., Taylor,D.,
            Chevrier,C., Schweickhardt,R., Kelton,C., Ryan,P.L. and
            Bathgate,R.A.
  TITLE     Splice variants of the relaxin and INSL3 receptors reveal
            unanticipated molecular complexity
  JOURNAL   Mol Hum Reprod 11 (8), 591-600 (2005)
   PUBMED   16051677
  REMARK    GeneRIF: LGR7.10 splice variant is expressed at the cell surface,
            LGR7.2 is predominantly retained within cells and LGR7.1 is
            partially secreted.  None stimulates cAMP production.
REFERENCE   8  (bases 1 to 3686)
  AUTHORS   Hsu,S.Y., Nakabayashi,K., Nishi,S., Kumagai,J., Kudo,M.,
            Sherwood,O.D. and Hsueh,A.J.
  TITLE     Activation of orphan receptors by the hormone relaxin
  JOURNAL   Science 295 (5555), 671-674 (2002)
   PUBMED   11809971
  REMARK    GeneRIF: capable of mediating the action of relaxin through an
            adenosine 3',5'-monophosphate (cAMP)-dependent pathway
REFERENCE   9  (bases 1 to 3686)
  AUTHORS   Bartsch,O., Bartlick,B. and Ivell,R.
  TITLE     Relaxin signalling links tyrosine phosphorylation to
            phosphodiesterase and adenylyl cyclase activity
  JOURNAL   Mol Hum Reprod 7 (9), 799-809 (2001)
   PUBMED   11517286
REFERENCE   10 (bases 1 to 3686)
  AUTHORS   Hsu,S.Y., Kudo,M., Chen,T., Nakabayashi,K., Bhalla,A., van der
            Spek,P.J., van Duin,M. and Hsueh,A.J.
  TITLE     The three subfamilies of leucine-rich repeat-containing G
            protein-coupled receptors (LGR): identification of LGR6 and LGR7
            and the signaling mechanism for LGR7
  JOURNAL   Mol Endocrinol 14 (8), 1257-1271 (2000)
   PUBMED   10935549
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX647980.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021634.3.
            
            Summary: This gene encodes a member of the leucine-rich
            repeat-containing subgroup of the G protein-coupled 7-transmembrane
            receptor superfamily. The encoded protein plays a critical role in
            sperm motility, pregnancy and parturition as a receptor for the
            protein hormone relaxin. Decreased expression of this gene may play
            a role in endometriosis. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647975.1, BX647980.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307765.10/ ENSP00000303248.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1987              BX647980.1         107-2093
            1988-3686           BX647980.1         2095-3793
FEATURES             Location/Qualifiers
     source          1..3686
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.1"
     gene            1..3686
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /note="relaxin family peptide receptor 1"
                     /db_xref="GeneID:59350"
                     /db_xref="HGNC:HGNC:19718"
                     /db_xref="MIM:606654"
     exon            1..144
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..2369
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leucine-rich repeat-containing G
                     protein-coupled receptor 7; relaxin/insulin like family
                     peptide receptor 1"
                     /codon_start=1
                     /product="relaxin receptor 1 isoform 1 precursor"
                     /protein_id="NP_067647.2"
                     /db_xref="CCDS:CCDS43276.1"
                     /db_xref="GeneID:59350"
                     /db_xref="HGNC:HGNC:19718"
                     /db_xref="MIM:606654"
                     /translation="MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQL
                     LHCNGVDDCGNQADEDNCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPV
                     QCLCQGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNN
                     KITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTF
                     YGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVL
                     VMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKI
                     QANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPN
                     TDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCA
                     DCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTL
                     EKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPL
                     HSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEM
                     ILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYT
                     LTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWVEMWPLQEMPPELMKPDLFTY
                     PCEMSLISQSTRLNSYS"
     exon            145..282
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            283..381
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..487
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..559
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..631
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            632..703
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            704..775
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..850
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..922
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..994
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1066
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1138
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1210
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1440
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1851
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2070
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..3686
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3656..3661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /note="hexamer: AATAAA"
     polyA_site      3686
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /note="major polyA site"
ORIGIN      
        1 agaaatagca cacaaccact gtgagctgta tgcgattcag aaaccaagac caaattttgc
       61 tcactttcat taatcagttg ctcagataga aggaaatgac atctggttct gtcttcttct
      121 acatcttaat ttttggaaaa tatttttctc atgggggtgg acaggatgtc aagtgctccc
      181 ttggctattt cccctgtggg aacatcacaa agtgcttgcc tcagctcctg cactgtaacg
      241 gtgtggacga ctgcgggaat caggccgatg aggacaactg tggagacaac aatggatggt
      301 ctctgcaatt tgacaaatat tttgccagtt actacaaaat gacttcccaa tatccttttg
      361 aggcagaaac acctgaatgt ttggtcggtt ctgtgccagt gcaatgtctt tgccaaggtc
      421 tggagcttga ctgtgatgaa accaatttac gagctgttcc atcggtttct tcaaatgtga
      481 ctgcaatgtc acttcagtgg aacttaataa gaaagcttcc tcctgattgc ttcaagaatt
      541 atcatgatct tcagaagctg tacctgcaaa acaataagat tacatccatc tccatctatg
      601 ctttcagagg actgaatagc cttactaaac tgtatctcag tcataacaga ataaccttcc
      661 tgaagccggg tgtttttgaa gatcttcaca gactagaatg gctgataatt gaagataatc
      721 acctcagtcg aatttcccca ccaacatttt atggactaaa ttctcttatt ctcttagtcc
      781 tgatgaataa cgtcctcacc cgtttacctg ataaacctct ctgtcaacac atgccaagac
      841 tacattggct ggaccttgaa ggcaaccata tccataattt aagaaatttg acttttattt
      901 cctgcagtaa tttaactgtt ttagtgatga ggaaaaacaa aattaatcac ttaaatgaaa
      961 atacttttgc acctctccag aaactggatg aattggattt aggaagtaat aagattgaaa
     1021 atcttccacc gcttatattc aaggacctga aggagctgtc acaattgaat ctttcctata
     1081 atccaatcca gaaaattcaa gcaaaccaat ttgattatct tgtcaaactc aagtctctca
     1141 gcctagaagg gattgaaatt tcaaatatcc aacaaaggat gtttagacct cttatgaatc
     1201 tctctcacat atattttaag aaattccagt actgtgggta tgcaccacat gttcgcagct
     1261 gtaaaccaaa cactgatgga atttcatctc tagagaatct cttggcaagc attattcaga
     1321 gagtatttgt ctgggttgta tctgcagtta cctgctttgg aaacattttt gtcatttgca
     1381 tgcgacctta tatcaggtct gagaacaagc tgtatgccat gtcaatcatt tctctctgct
     1441 gtgccgactg cttaatggga atatatttat tcgtgatcgg aggctttgac ctaaagtttc
     1501 gtggagaata caataagcat gcgcagctgt ggatggagag tactcattgt cagcttgtag
     1561 gatctttggc cattctgtcc acagaagtat cagttttact gttaacattt ctgacattgg
     1621 aaaaatacat ctgcattgtc tatcctttta gatgtgtgag acctggaaaa tgcagaacaa
     1681 ttacagttct gattctcatt tggattactg gttttatagt ggctttcatt ccattgagca
     1741 ataaggaatt tttcaaaaac tactatggca ccaatggagt atgcttccct cttcattcag
     1801 aagatacaga aagtattgga gcccagattt attcagtggc aatttttctt ggtattaatt
     1861 tggccgcatt tatcatcata gttttttcct atggaagcat gttttatagt gttcatcaaa
     1921 gtgccataac agcaactgaa atacggaatc aagttaaaaa agagatgatc cttgccaaac
     1981 gttttttctt tatagtattt actgatgcat tatgctggat acccattttt gtagtgaaat
     2041 ttctttcact gcttcaggta gaaataccag gtaccataac ctcttgggta gtgattttta
     2101 ttctgcccat taacagtgct ttgaacccaa ttctctatac tctgaccaca agaccattta
     2161 aagaaatgat tcatcggttt tggtataact acagacaaag aaaatctatg gacagcaaag
     2221 gtcagaaaac atatgctcca tcattcatct gggtggaaat gtggccactg caggagatgc
     2281 cacctgagtt aatgaagccg gaccttttca catacccctg tgaaatgtca ctgatttctc
     2341 aatcaacgag actcaattcc tattcatgac tgactctgaa attcatttct tcgcagagaa
     2401 tactgtgggg gtgcttcatg agggatttac tggtatgaaa tgaataccac aaaattaatt
     2461 tataataata gctaagataa atattttaca aggacatgag gaaaaataaa aatgactaat
     2521 gctcttacaa agggaagtaa ttatatcaat aatgtatata tattagtaga cattttgcat
     2581 aagaaattaa gagaaatcta cttcagtaac attcattcat ttttctaaca tgcatttatt
     2641 gagtacccac tactatgtgc atagcattgc aatatagtcc tggaagtaga cagtgcagaa
     2701 cctttcaatc tgtagatggt gtttaatgac aaaagactat acaaagtcca tctgcagttc
     2761 ctagtttaaa gtagagcttt acctgtcatg tgcatcagca agaatcatag gcacttttaa
     2821 ataaaggttt aaagttttgg aatactcagt gtatttgcat catagaaaat gtctgactgt
     2881 ttgcaaaata atattctgtt ttaagaatcc atcttacctc tctttaagtt tccatacact
     2941 tgagagccaa cacaacatat ttattactaa aaagatgctt tgctagaaac tcaaaaacag
     3001 cacttctttt ggcacttcct gcccagtttt ctctttgctt taaatgaaca tcatcatatg
     3061 gaattggaat aggagagtat gagtacggca gagaagtgga tcagaaaaac tagaatgagg
     3121 ataaacattt acattagtgg aaactcctga aataaatcct tgtattgtca gttaactgat
     3181 tttcaacaag gatgccaaga caaaaaggct tttcaacaaa ccgtgctgtt ttaagaacag
     3241 acctaagtgg tttaattcac ccactttaga tgggtgaatg ttatggtgtg tgaaatatct
     3301 cagtaaagca gttaaaagga aaaagagctg gaatgcactg attcaggaac ttaatttcag
     3361 gaaggaaagg tctgtatgta cacatttcac tttaagcaga aaatctttct tcaagaaatg
     3421 actttacttt ctctttgcac tgccagcacg tgagatacta actttttaac tagttgttct
     3481 tctctagtct ctacgttatt agaatttttt gctttcataa tgtgaaacct ttaagcagga
     3541 gaagaaaatg ttttcagata gtttcaaata caccaaaaat gtttgaaaca caaaaatact
     3601 ggaatcaaac cataatgcac ttattgaata tatagttgta tagatttgtt ctgaaaataa
     3661 attatctgaa atttaactat taaaaa
//
