LOCUS       NM_001253733            3698 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens relaxin family peptide receptor 1 (RXFP1), transcript
            variant 7, mRNA.
ACCESSION   NM_001253733
VERSION     NM_001253733.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3698)
  AUTHORS   Dominska,K., Urbanek,K.A., Kowalska,K., Habrowska-Gorczynska,D.E.,
            Koziel,M.J., Ochedalski,T. and Piastowska-Ciesielska,A.W.
  TITLE     The consequences of manipulating relaxin family peptide receptor 1
            (RXFP1) level in ovarian cancer cells
  JOURNAL   Reprod Biol 24 (2), 100864 (2024)
   PUBMED   38640630
  REMARK    GeneRIF: The consequences of manipulating relaxin family peptide
            receptor 1 (RXFP1) level in ovarian cancer cells.
REFERENCE   2  (bases 1 to 3698)
  AUTHORS   Illiano,S., Poirier,B., Minoletti,C., Pasquier,O., Riva,L.,
            Chenede,X., Menguy,I., Guillotel,M., Prigent,P., Le Claire,S.,
            Gillot,F., Thill,G., Lo Presti,F., Corbier,A., Le Bail,J.C.,
            Grailhe,P., Monteagudo,E., Ingenito,R., Bianchi,E., Philippo,C.,
            Duclos,O., Mallart,S., Bathgate,R. and Janiak,P.
  TITLE     Characterization of a new potent and long-lasting single chain
            peptide agonist of RXFP1 in cells and in vivo translational models
  JOURNAL   Sci Rep 12 (1), 20435 (2022)
   PUBMED   36443381
  REMARK    GeneRIF: Characterization of a new potent and long-lasting single
            chain peptide agonist of RXFP1 in cells and in vivo translational
            models.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3698)
  AUTHORS   Chen,T.Y., Li,X., Goobie,G.C., Hung,C.H., Hung,T.K., Hamilton,K.,
            Bahudhanapati,H., Tan,J., Kass,D.J. and Zhang,Y.
  TITLE     Identification of a distal RXFP1 gene enhancer with differential
            activity in fibrotic lung fibroblasts involving AP-1
  JOURNAL   PLoS One 16 (12), e0254466 (2021)
   PUBMED   34972106
  REMARK    GeneRIF: Identification of a distal RXFP1 gene enhancer with
            differential activity in fibrotic lung fibroblasts involving AP-1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3698)
  AUTHORS   Morelli,S.S., Petraglia,F., Weiss,G., Luisi,S., Florio,P. and
            Goldsmith,L.T.
  TITLE     Relaxin in endometriosis
  JOURNAL   Ann N Y Acad Sci 1160, 138-139 (2009)
   PUBMED   19416175
  REMARK    GeneRIF: Data tested the hypothesis that relaxin plays a role in
            endometriosis by comparing the expression of relaxin mRNA and its
            LGR7 (RXFP1) receptor mRNA in normal human endometrium to those in
            samples from patients with endometriosis.
REFERENCE   5  (bases 1 to 3698)
  AUTHORS   Kern,A., Hubbard,D., Amano,A. and Bryant-Greenwood,G.D.
  TITLE     Cloning, expression, and functional characterization of relaxin
            receptor (leucine-rich repeat-containing g protein-coupled receptor
            7) splice variants from human fetal membranes
  JOURNAL   Endocrinology 149 (3), 1277-1294 (2008)
   PUBMED   18079195
  REMARK    GeneRIF: The dominant-negative effects of the LGR7 splice variants
            expressed in the chorion and decidua could be functionally
            significant in the peripartal period.
REFERENCE   6  (bases 1 to 3698)
  AUTHORS   Scott,D.J., Layfield,S., Yan,Y., Sudo,S., Hsueh,A.J., Tregear,G.W.
            and Bathgate,R.A.
  TITLE     Characterization of novel splice variants of LGR7 and LGR8 reveals
            that receptor signaling is mediated by their unique low density
            lipoprotein class A modules
  JOURNAL   J Biol Chem 281 (46), 34942-34954 (2006)
   PUBMED   16963451
  REMARK    GeneRIF: The essential role of the LDLa module in LGR7 and LGR8
            function is reported.
REFERENCE   7  (bases 1 to 3698)
  AUTHORS   Muda,M., He,C., Martini,P.G., Ferraro,T., Layfield,S., Taylor,D.,
            Chevrier,C., Schweickhardt,R., Kelton,C., Ryan,P.L. and
            Bathgate,R.A.
  TITLE     Splice variants of the relaxin and INSL3 receptors reveal
            unanticipated molecular complexity
  JOURNAL   Mol Hum Reprod 11 (8), 591-600 (2005)
   PUBMED   16051677
  REMARK    GeneRIF: LGR7.10 splice variant is expressed at the cell surface,
            LGR7.2 is predominantly retained within cells and LGR7.1 is
            partially secreted.  None stimulates cAMP production.
REFERENCE   8  (bases 1 to 3698)
  AUTHORS   Hsu,S.Y., Nakabayashi,K., Nishi,S., Kumagai,J., Kudo,M.,
            Sherwood,O.D. and Hsueh,A.J.
  TITLE     Activation of orphan receptors by the hormone relaxin
  JOURNAL   Science 295 (5555), 671-674 (2002)
   PUBMED   11809971
  REMARK    GeneRIF: capable of mediating the action of relaxin through an
            adenosine 3',5'-monophosphate (cAMP)-dependent pathway
REFERENCE   9  (bases 1 to 3698)
  AUTHORS   Bartsch,O., Bartlick,B. and Ivell,R.
  TITLE     Relaxin signalling links tyrosine phosphorylation to
            phosphodiesterase and adenylyl cyclase activity
  JOURNAL   Mol Hum Reprod 7 (9), 799-809 (2001)
   PUBMED   11517286
REFERENCE   10 (bases 1 to 3698)
  AUTHORS   Hsu,S.Y., Kudo,M., Chen,T., Nakabayashi,K., Bhalla,A., van der
            Spek,P.J., van Duin,M. and Hsueh,A.J.
  TITLE     The three subfamilies of leucine-rich repeat-containing G
            protein-coupled receptors (LGR): identification of LGR6 and LGR7
            and the signaling mechanism for LGR7
  JOURNAL   Mol Endocrinol 14 (8), 1257-1271 (2000)
   PUBMED   10935549
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA241507.1, AK312470.1,
            AK122647.1 and BX647980.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001253733.1.
            
            Summary: This gene encodes a member of the leucine-rich
            repeat-containing subgroup of the G protein-coupled 7-transmembrane
            receptor superfamily. The encoded protein plays a critical role in
            sperm motility, pregnancy and parturition as a receptor for the
            protein hormone relaxin. Decreased expression of this gene may play
            a role in endometriosis. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (7) lacks an internal exon,
            includes an alternate internal exon and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (7) is shorter and has a distinct N-terminus, compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312470.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DA241507.1         141-158
            19-1129             AK312470.1         19-1129
            1130-2538           AK122647.1         1327-2735
            2539-3698           BX647980.1         2634-3793
FEATURES             Location/Qualifiers
     source          1..3698
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.1"
     gene            1..3698
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /note="relaxin family peptide receptor 1"
                     /db_xref="GeneID:59350"
                     /db_xref="HGNC:HGNC:19718"
                     /db_xref="MIM:606654"
     exon            1..144
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            145..282
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            283..381
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..487
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..559
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..643
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             576..2381
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /note="isoform 7 is encoded by transcript variant 7;
                     leucine-rich repeat-containing G protein-coupled receptor
                     7; relaxin/insulin like family peptide receptor 1"
                     /codon_start=1
                     /product="relaxin receptor 1 isoform 7"
                     /protein_id="NP_001240662.1"
                     /db_xref="CCDS:CCDS75206.1"
                     /db_xref="GeneID:59350"
                     /db_xref="HGNC:HGNC:19718"
                     /db_xref="MIM:606654"
                     /translation="MVTCTQNMKAALKSLLYHSRNLGYLQNNKITSISIYAFRGLNSL
                     TKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVL
                     TRLPDKPLCQHMPRLHWLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFK
                     DLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYF
                     KKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPY
                     IRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGS
                     LAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLS
                     NKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSV
                     HQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSW
                     VVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWVEM
                     WPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS"
     exon            644..715
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..787
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..859
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..934
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1006
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1078
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1150
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1222
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1452
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1863
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2082
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..3698
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3668..3673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /note="hexamer: AATAAA"
     polyA_site      3698
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /note="major polyA site"
ORIGIN      
        1 agaaatagca cacaaccact gtgagctgta tgcgattcag aaaccaagac caaattttgc
       61 tcactttcat taatcagttg ctcagataga aggaaatgac atctggttct gtcttcttct
      121 acatcttaat ttttggaaaa tatttttctc atgggggtgg acaggatgtc aagtgctccc
      181 ttggctattt cccctgtggg aacatcacaa agtgcttgcc tcagctcctg cactgtaacg
      241 gtgtggacga ctgcgggaat caggccgatg aggacaactg tggagacaac aatggatggt
      301 ctctgcaatt tgacaaatat tttgccagtt actacaaaat gacttcccaa tatccttttg
      361 aggcagaaac acctgaatgt ttggtcggtt ctgtgccagt gcaatgtctt tgccaaggtc
      421 tggagcttga ctgtgatgaa accaatttac gagctgttcc atcggtttct tcaaatgtga
      481 ctgcaatgtc acttcagtgg aacttaataa gaaagcttcc tcctgattgc ttcaagaatt
      541 atcatgatct tcagaagctg acactctaaa gaacaatggt gacctgcact cagaacatga
      601 aggcagcctt gaaatcctta ctttatcatt cccgcaatct ggggtacctg caaaacaata
      661 agattacatc catctccatc tatgctttca gaggactgaa tagccttact aaactgtatc
      721 tcagtcataa cagaataacc ttcctgaagc cgggtgtttt tgaagatctt cacagactag
      781 aatggctgat aattgaagat aatcacctca gtcgaatttc cccaccaaca ttttatggac
      841 taaattctct tattctctta gtcctgatga ataacgtcct cacccgttta cctgataaac
      901 ctctctgtca acacatgcca agactacatt ggctagtgat gaggaaaaac aaaattaatc
      961 acttaaatga aaatactttt gcacctctcc agaaactgga tgaattggat ttaggaagta
     1021 ataagattga aaatcttcca ccgcttatat tcaaggacct gaaggagctg tcacaattga
     1081 atctttccta taatccaatc cagaaaattc aagcaaacca atttgattat cttgtcaaac
     1141 tcaagtctct cagcctagaa gggattgaaa tttcaaatat ccaacaaagg atgtttagac
     1201 ctcttatgaa tctctctcac atatatttta agaaattcca gtactgtggg tatgcaccac
     1261 atgttcgcag ctgtaaacca aacactgatg gaatttcatc tctagagaat ctcttggcaa
     1321 gcattattca gagagtattt gtctgggttg tatctgcagt tacctgcttt ggaaacattt
     1381 ttgtcatttg catgcgacct tatatcaggt ctgagaacaa gctgtatgcc atgtcaatca
     1441 tttctctctg ctgtgccgac tgcttaatgg gaatatattt attcgtgatc ggaggctttg
     1501 acctaaagtt tcgtggagaa tacaataagc atgcgcagct gtggatggag agtactcatt
     1561 gtcagcttgt aggatctttg gccattctgt ccacagaagt atcagtttta ctgttaacat
     1621 ttctgacatt ggaaaaatac atctgcattg tctatccttt tagatgtgtg agacctggaa
     1681 aatgcagaac aattacagtt ctgattctca tttggattac tggttttata gtggctttca
     1741 ttccattgag caataaggaa tttttcaaaa actactatgg caccaatgga gtatgcttcc
     1801 ctcttcattc agaagataca gaaagtattg gagcccagat ttattcagtg gcaatttttc
     1861 ttggtattaa tttggccgca tttatcatca tagttttttc ctatggaagc atgttttata
     1921 gtgttcatca aagtgccata acagcaactg aaatacggaa tcaagttaaa aaagagatga
     1981 tccttgccaa acgttttttc tttatagtat ttactgatgc attatgctgg atacccattt
     2041 ttgtagtgaa atttctttca ctgcttcagg tagaaatacc aggtaccata acctcttggg
     2101 tagtgatttt tattctgccc attaacagtg ctttgaaccc aattctctat actctgacca
     2161 caagaccatt taaagaaatg attcatcggt tttggtataa ctacagacaa agaaaatcta
     2221 tggacagcaa aggtcagaaa acatatgctc catcattcat ctgggtggaa atgtggccac
     2281 tgcaggagat gccacctgag ttaatgaagc cggacctttt cacatacccc tgtgaaatgt
     2341 cactgatttc tcaatcaacg agactcaatt cctattcatg actgactctg aaattcattt
     2401 cttcgcagag aatactgtgg gggtgcttca tgagggattt actggtatga aatgaatacc
     2461 acaaaattaa tttataataa tagctaagat aaatatttta caaggacatg aggaaaaata
     2521 aaaatgacta atgctcttac aaagggaagt aattatatca ataatgtata tatattagta
     2581 gacattttgc ataagaaatt aagagaaatc tacttcagta acattcattc atttttctaa
     2641 catgcattta ttgagtaccc actactatgt gcatagcatt gcaatatagt cctggaagta
     2701 gacagtgcag aacctttcaa tctgtagatg gtgtttaatg acaaaagact atacaaagtc
     2761 catctgcagt tcctagttta aagtagagct ttacctgtca tgtgcatcag caagaatcat
     2821 aggcactttt aaataaaggt ttaaagtttt ggaatactca gtgtatttgc atcatagaaa
     2881 atgtctgact gtttgcaaaa taatattctg ttttaagaat ccatcttacc tctctttaag
     2941 tttccataca cttgagagcc aacacaacat atttattact aaaaagatgc tttgctagaa
     3001 actcaaaaac agcacttctt ttggcacttc ctgcccagtt ttctctttgc tttaaatgaa
     3061 catcatcata tggaattgga ataggagagt atgagtacgg cagagaagtg gatcagaaaa
     3121 actagaatga ggataaacat ttacattagt ggaaactcct gaaataaatc cttgtattgt
     3181 cagttaactg attttcaaca aggatgccaa gacaaaaagg cttttcaaca aaccgtgctg
     3241 ttttaagaac agacctaagt ggtttaattc acccacttta gatgggtgaa tgttatggtg
     3301 tgtgaaatat ctcagtaaag cagttaaaag gaaaaagagc tggaatgcac tgattcagga
     3361 acttaatttc aggaaggaaa ggtctgtatg tacacatttc actttaagca gaaaatcttt
     3421 cttcaagaaa tgactttact ttctctttgc actgccagca cgtgagatac taacttttta
     3481 actagttgtt cttctctagt ctctacgtta ttagaatttt ttgctttcat aatgtgaaac
     3541 ctttaagcag gagaagaaaa tgttttcaga tagtttcaaa tacaccaaaa atgtttgaaa
     3601 cacaaaaata ctggaatcaa accataatgc acttattgaa tatatagttg tatagatttg
     3661 ttctgaaaat aaattatctg aaatttaact attaaaaa
//
