LOCUS       NM_001253730            3608 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens relaxin family peptide receptor 1 (RXFP1), transcript
            variant 5, mRNA.
ACCESSION   NM_001253730
VERSION     NM_001253730.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3608)
  AUTHORS   Dominska,K., Urbanek,K.A., Kowalska,K., Habrowska-Gorczynska,D.E.,
            Koziel,M.J., Ochedalski,T. and Piastowska-Ciesielska,A.W.
  TITLE     The consequences of manipulating relaxin family peptide receptor 1
            (RXFP1) level in ovarian cancer cells
  JOURNAL   Reprod Biol 24 (2), 100864 (2024)
   PUBMED   38640630
  REMARK    GeneRIF: The consequences of manipulating relaxin family peptide
            receptor 1 (RXFP1) level in ovarian cancer cells.
REFERENCE   2  (bases 1 to 3608)
  AUTHORS   Illiano,S., Poirier,B., Minoletti,C., Pasquier,O., Riva,L.,
            Chenede,X., Menguy,I., Guillotel,M., Prigent,P., Le Claire,S.,
            Gillot,F., Thill,G., Lo Presti,F., Corbier,A., Le Bail,J.C.,
            Grailhe,P., Monteagudo,E., Ingenito,R., Bianchi,E., Philippo,C.,
            Duclos,O., Mallart,S., Bathgate,R. and Janiak,P.
  TITLE     Characterization of a new potent and long-lasting single chain
            peptide agonist of RXFP1 in cells and in vivo translational models
  JOURNAL   Sci Rep 12 (1), 20435 (2022)
   PUBMED   36443381
  REMARK    GeneRIF: Characterization of a new potent and long-lasting single
            chain peptide agonist of RXFP1 in cells and in vivo translational
            models.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3608)
  AUTHORS   Chen,T.Y., Li,X., Goobie,G.C., Hung,C.H., Hung,T.K., Hamilton,K.,
            Bahudhanapati,H., Tan,J., Kass,D.J. and Zhang,Y.
  TITLE     Identification of a distal RXFP1 gene enhancer with differential
            activity in fibrotic lung fibroblasts involving AP-1
  JOURNAL   PLoS One 16 (12), e0254466 (2021)
   PUBMED   34972106
  REMARK    GeneRIF: Identification of a distal RXFP1 gene enhancer with
            differential activity in fibrotic lung fibroblasts involving AP-1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3608)
  AUTHORS   Morelli,S.S., Petraglia,F., Weiss,G., Luisi,S., Florio,P. and
            Goldsmith,L.T.
  TITLE     Relaxin in endometriosis
  JOURNAL   Ann N Y Acad Sci 1160, 138-139 (2009)
   PUBMED   19416175
  REMARK    GeneRIF: Data tested the hypothesis that relaxin plays a role in
            endometriosis by comparing the expression of relaxin mRNA and its
            LGR7 (RXFP1) receptor mRNA in normal human endometrium to those in
            samples from patients with endometriosis.
REFERENCE   5  (bases 1 to 3608)
  AUTHORS   Kern,A., Hubbard,D., Amano,A. and Bryant-Greenwood,G.D.
  TITLE     Cloning, expression, and functional characterization of relaxin
            receptor (leucine-rich repeat-containing g protein-coupled receptor
            7) splice variants from human fetal membranes
  JOURNAL   Endocrinology 149 (3), 1277-1294 (2008)
   PUBMED   18079195
  REMARK    GeneRIF: The dominant-negative effects of the LGR7 splice variants
            expressed in the chorion and decidua could be functionally
            significant in the peripartal period.
REFERENCE   6  (bases 1 to 3608)
  AUTHORS   Scott,D.J., Layfield,S., Yan,Y., Sudo,S., Hsueh,A.J., Tregear,G.W.
            and Bathgate,R.A.
  TITLE     Characterization of novel splice variants of LGR7 and LGR8 reveals
            that receptor signaling is mediated by their unique low density
            lipoprotein class A modules
  JOURNAL   J Biol Chem 281 (46), 34942-34954 (2006)
   PUBMED   16963451
  REMARK    GeneRIF: The essential role of the LDLa module in LGR7 and LGR8
            function is reported.
REFERENCE   7  (bases 1 to 3608)
  AUTHORS   Muda,M., He,C., Martini,P.G., Ferraro,T., Layfield,S., Taylor,D.,
            Chevrier,C., Schweickhardt,R., Kelton,C., Ryan,P.L. and
            Bathgate,R.A.
  TITLE     Splice variants of the relaxin and INSL3 receptors reveal
            unanticipated molecular complexity
  JOURNAL   Mol Hum Reprod 11 (8), 591-600 (2005)
   PUBMED   16051677
  REMARK    GeneRIF: LGR7.10 splice variant is expressed at the cell surface,
            LGR7.2 is predominantly retained within cells and LGR7.1 is
            partially secreted.  None stimulates cAMP production.
REFERENCE   8  (bases 1 to 3608)
  AUTHORS   Hsu,S.Y., Nakabayashi,K., Nishi,S., Kumagai,J., Kudo,M.,
            Sherwood,O.D. and Hsueh,A.J.
  TITLE     Activation of orphan receptors by the hormone relaxin
  JOURNAL   Science 295 (5555), 671-674 (2002)
   PUBMED   11809971
  REMARK    GeneRIF: capable of mediating the action of relaxin through an
            adenosine 3',5'-monophosphate (cAMP)-dependent pathway
REFERENCE   9  (bases 1 to 3608)
  AUTHORS   Bartsch,O., Bartlick,B. and Ivell,R.
  TITLE     Relaxin signalling links tyrosine phosphorylation to
            phosphodiesterase and adenylyl cyclase activity
  JOURNAL   Mol Hum Reprod 7 (9), 799-809 (2001)
   PUBMED   11517286
REFERENCE   10 (bases 1 to 3608)
  AUTHORS   Hsu,S.Y., Kudo,M., Chen,T., Nakabayashi,K., Bhalla,A., van der
            Spek,P.J., van Duin,M. and Hsueh,A.J.
  TITLE     The three subfamilies of leucine-rich repeat-containing G
            protein-coupled receptors (LGR): identification of LGR6 and LGR7
            and the signaling mechanism for LGR7
  JOURNAL   Mol Endocrinol 14 (8), 1257-1271 (2000)
   PUBMED   10935549
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX647985.1, BC143559.1 and
            BX647980.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001253730.1.
            
            Summary: This gene encodes a member of the leucine-rich
            repeat-containing subgroup of the G protein-coupled 7-transmembrane
            receptor superfamily. The encoded protein plays a critical role in
            sperm motility, pregnancy and parturition as a receptor for the
            protein hormone relaxin. Decreased expression of this gene may play
            a role in endometriosis. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (5) lacks an internal exon, uses
            two alternate splice sites and initiates translation at a
            downstream, in-frame start codon, compared to variant 1. The
            encoded isoform (5) has a shorter N-terminus, compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC143559.1, SRR1803615.7198.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BX647985.1         136-145
            11-2347             BC143559.1         1-2337
            2348-3608           BX647980.1         2533-3793
FEATURES             Location/Qualifiers
     source          1..3608
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.1"
     gene            1..3608
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /note="relaxin family peptide receptor 1"
                     /db_xref="GeneID:59350"
                     /db_xref="HGNC:HGNC:19718"
                     /db_xref="MIM:606654"
     exon            1..144
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            145..306
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..412
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             411..2291
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /note="isoform 5 is encoded by transcript variant 5;
                     leucine-rich repeat-containing G protein-coupled receptor
                     7; relaxin/insulin like family peptide receptor 1"
                     /codon_start=1
                     /product="relaxin receptor 1 isoform 5"
                     /protein_id="NP_001240659.1"
                     /db_xref="CCDS:CCDS75205.1"
                     /db_xref="GeneID:59350"
                     /db_xref="HGNC:HGNC:19718"
                     /db_xref="MIM:606654"
                     /translation="MSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLN
                     SLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNN
                     VLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENT
                     FAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSL
                     LEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASII
                     QRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFD
                     LKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRP
                     GKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSV
                     AIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDAL
                     CWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWY
                     NYRQRKSMDSKGQKTYAPSFIWVEMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNS
                     YS"
     exon            413..484
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..556
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..628
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..700
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..775
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..847
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..919
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..991
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1063
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1132
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1362
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1773
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1992
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..3608
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3578..3583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /note="hexamer: AATAAA"
     polyA_site      3608
                     /gene="RXFP1"
                     /gene_synonym="LGR7; RXFPR1"
                     /note="major polyA site"
ORIGIN      
        1 agaaatagca cacaaccact gtgagctgta tgcgattcag aaaccaagac caaattttgc
       61 tcactttcat taatcagttg ctcagataga aggaaatgac atctggttct gtcttcttct
      121 acatcttaat ttttggaaaa tatttttctc atgggggtgg acaggatgtc aagtgctccc
      181 ttggctattt cccctgtggg aacatcacaa agtgcttgcc tcagctcctg cactgtaacg
      241 gtgtggacga ctgcgggaat caggccgatg aggacaactg tggtgagtga agcccctgca
      301 gtcacgtggt cggttctgtg ccagtgcaat gtctttgcca aggtctggag cttgactgtg
      361 atgaaaccaa tttacgagct gttccatcgg tttcttcaaa tgtgactgca atgtcacttc
      421 agtggaactt aataagaaag cttcctcctg attgcttcaa gaattatcat gatcttcaga
      481 agctgtacct gcaaaacaat aagattacat ccatctccat ctatgctttc agaggactga
      541 atagccttac taaactgtat ctcagtcata acagaataac cttcctgaag ccgggtgttt
      601 ttgaagatct tcacagacta gaatggctga taattgaaga taatcacctc agtcgaattt
      661 ccccaccaac attttatgga ctaaattctc ttattctctt agtcctgatg aataacgtcc
      721 tcacccgttt acctgataaa cctctctgtc aacacatgcc aagactacat tggctggacc
      781 ttgaaggcaa ccatatccat aatttaagaa atttgacttt tatttcctgc agtaatttaa
      841 ctgttttagt gatgaggaaa aacaaaatta atcacttaaa tgaaaatact tttgcacctc
      901 tccagaaact ggatgaattg gatttaggaa gtaataagat tgaaaatctt ccaccgctta
      961 tattcaagga cctgaaggag ctgtcacaat tgaatctttc ctataatcca atccagaaaa
     1021 ttcaagcaaa ccaatttgat tatcttgtca aactcaagtc tctcctagaa gggattgaaa
     1081 tttcaaatat ccaacaaagg atgtttagac ctcttatgaa tctctctcac atatatttta
     1141 agaaattcca gtactgtggg tatgcaccac atgttcgcag ctgtaaacca aacactgatg
     1201 gaatttcatc tctagagaat ctcttggcaa gcattattca gagagtattt gtctgggttg
     1261 tatctgcagt tacctgcttt ggaaacattt ttgtcatttg catgcgacct tatatcaggt
     1321 ctgagaacaa gctgtatgcc atgtcaatca tttctctctg ctgtgccgac tgcttaatgg
     1381 gaatatattt attcgtgatc ggaggctttg acctaaagtt tcgtggagaa tacaataagc
     1441 atgcgcagct gtggatggag agtactcatt gtcagcttgt aggatctttg gccattctgt
     1501 ccacagaagt atcagtttta ctgttaacat ttctgacatt ggaaaaatac atctgcattg
     1561 tctatccttt tagatgtgtg agacctggaa aatgcagaac aattacagtt ctgattctca
     1621 tttggattac tggttttata gtggctttca ttccattgag caataaggaa tttttcaaaa
     1681 actactatgg caccaatgga gtatgcttcc ctcttcattc agaagataca gaaagtattg
     1741 gagcccagat ttattcagtg gcaatttttc ttggtattaa tttggccgca tttatcatca
     1801 tagttttttc ctatggaagc atgttttata gtgttcatca aagtgccata acagcaactg
     1861 aaatacggaa tcaagttaaa aaagagatga tccttgccaa acgttttttc tttatagtat
     1921 ttactgatgc attatgctgg atacccattt ttgtagtgaa atttctttca ctgcttcagg
     1981 tagaaatacc aggtaccata acctcttggg tagtgatttt tattctgccc attaacagtg
     2041 ctttgaaccc aattctctat actctgacca caagaccatt taaagaaatg attcatcggt
     2101 tttggtataa ctacagacaa agaaaatcta tggacagcaa aggtcagaaa acatatgctc
     2161 catcattcat ctgggtggaa atgtggccac tgcaggagat gccacctgag ttaatgaagc
     2221 cggacctttt cacatacccc tgtgaaatgt cactgatttc tcaatcaacg agactcaatt
     2281 cctattcatg actgactctg aaattcattt cttcgcagag aatactgtgg gggtgcttca
     2341 tgagggattt actggtatga aatgaatacc acaaaattaa tttataataa tagctaagat
     2401 aaatatttta caaggacatg aggaaaaata aaaatgacta atgctcttac aaagggaagt
     2461 aattatatca ataatgtata tatattagta gacattttgc ataagaaatt aagagaaatc
     2521 tacttcagta acattcattc atttttctaa catgcattta ttgagtaccc actactatgt
     2581 gcatagcatt gcaatatagt cctggaagta gacagtgcag aacctttcaa tctgtagatg
     2641 gtgtttaatg acaaaagact atacaaagtc catctgcagt tcctagttta aagtagagct
     2701 ttacctgtca tgtgcatcag caagaatcat aggcactttt aaataaaggt ttaaagtttt
     2761 ggaatactca gtgtatttgc atcatagaaa atgtctgact gtttgcaaaa taatattctg
     2821 ttttaagaat ccatcttacc tctctttaag tttccataca cttgagagcc aacacaacat
     2881 atttattact aaaaagatgc tttgctagaa actcaaaaac agcacttctt ttggcacttc
     2941 ctgcccagtt ttctctttgc tttaaatgaa catcatcata tggaattgga ataggagagt
     3001 atgagtacgg cagagaagtg gatcagaaaa actagaatga ggataaacat ttacattagt
     3061 ggaaactcct gaaataaatc cttgtattgt cagttaactg attttcaaca aggatgccaa
     3121 gacaaaaagg cttttcaaca aaccgtgctg ttttaagaac agacctaagt ggtttaattc
     3181 acccacttta gatgggtgaa tgttatggtg tgtgaaatat ctcagtaaag cagttaaaag
     3241 gaaaaagagc tggaatgcac tgattcagga acttaatttc aggaaggaaa ggtctgtatg
     3301 tacacatttc actttaagca gaaaatcttt cttcaagaaa tgactttact ttctctttgc
     3361 actgccagca cgtgagatac taacttttta actagttgtt cttctctagt ctctacgtta
     3421 ttagaatttt ttgctttcat aatgtgaaac ctttaagcag gagaagaaaa tgttttcaga
     3481 tagtttcaaa tacaccaaaa atgtttgaaa cacaaaaata ctggaatcaa accataatgc
     3541 acttattgaa tatatagttg tatagatttg ttctgaaaat aaattatctg aaatttaact
     3601 attaaaaa
//
