LOCUS       NM_033411               3769 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RWD domain containing 2A (RWDD2A), transcript variant
            1, mRNA.
ACCESSION   NM_033411
VERSION     NM_033411.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3769)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3769)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3769)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 3769)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   5  (bases 1 to 3769)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC377982.1, AK313083.1, BC104816.1, DA032938.1, CN414510.1,
            AJ420581.1 and AW197622.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033411.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.398838.1,
                                           SRR1803612.268688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369724.5/ ENSP00000358739.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                DC377982.1         45-74
            31-278              AK313083.1         1-248
            279-1204            BC104816.1         108-1033
            1205-1741           DA032938.1         45-581
            1742-2290           CN414510.1         103-651
            2291-3488           AJ420581.1         474-1671
            3489-3769           AW197622.1         11-291              c
FEATURES             Location/Qualifiers
     source          1..3769
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.1"
     gene            1..3769
                     /gene="RWDD2A"
                     /gene_synonym="dJ747H23.2; RWDD2"
                     /note="RWD domain containing 2A"
                     /db_xref="GeneID:112611"
                     /db_xref="HGNC:HGNC:21385"
     exon            1..87
                     /gene="RWDD2A"
                     /gene_synonym="dJ747H23.2; RWDD2"
                     /inference="alignment:Splign:2.1.0"
     exon            88..428
                     /gene="RWDD2A"
                     /gene_synonym="dJ747H23.2; RWDD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1106
                     /gene="RWDD2A"
                     /gene_synonym="dJ747H23.2; RWDD2"
                     /note="isoform a is encoded by transcript variant 1; RWD
                     domain containing 2; RWD domain-containing protein 2A"
                     /codon_start=1
                     /product="RWD domain-containing protein 2A isoform a"
                     /protein_id="NP_219479.2"
                     /db_xref="CCDS:CCDS4998.1"
                     /db_xref="GeneID:112611"
                     /db_xref="HGNC:HGNC:21385"
                     /translation="MSASVKESLQLQLLEMEMLFSMFPNQGEVKLEDVNALTNIKRYL
                     EGTREALPPKIEFVITLQIEEPKVKIDLQVTMPHSYPYVALQLFGRSSELDRHQQLLL
                     NKGLTSYIGTFDPGELCVCAAIQWLQDNSASYFLNRKLVYEPSTQAKPVKNTFLRMWI
                     YSHHIYQQDLRKKILDVGKRLDVTGFCMTGKPGIICVEGFKEHCEEFWHTIRYPNWKH
                     ISCKHAESVETEGNGEDLRLFHSFEELLLEAHGDYGLRNDYHMNLGQFLEFLKKHKSE
                     HVFQILFGIESKSSDS"
     exon            429..3769
                     /gene="RWDD2A"
                     /gene_synonym="dJ747H23.2; RWDD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1352..1357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RWDD2A"
                     /gene_synonym="dJ747H23.2; RWDD2"
                     /note="hexamer: AATAAA"
     polyA_site      1371
                     /gene="RWDD2A"
                     /gene_synonym="dJ747H23.2; RWDD2"
                     /note="major polyA site"
     regulatory      2271..2276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RWDD2A"
                     /gene_synonym="dJ747H23.2; RWDD2"
                     /note="hexamer: ATTAAA"
     polyA_site      2292
                     /gene="RWDD2A"
                     /gene_synonym="dJ747H23.2; RWDD2"
                     /note="major polyA site"
     regulatory      3749..3754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RWDD2A"
                     /gene_synonym="dJ747H23.2; RWDD2"
                     /note="hexamer: AATGAA"
     polyA_site      3769
                     /gene="RWDD2A"
                     /gene_synonym="dJ747H23.2; RWDD2"
                     /note="major polyA site"
ORIGIN      
        1 gcaggtcgcg cgcagctggc gcctgaggaa ctgcggctgc ggttccgagc ggggtctggg
       61 gctgttacca ttgagtgacc agaaaggctc tcggtgcaaa gcgttcctgc agaattgctt
      121 ccacgtaaag ggaccttcgg gaaatttcgc tggataccgg ctggcattga caaacccagc
      181 gtccctgagc cttgtgaggt ttccaggcag gctgattgcg aggcaacatg tctgcttcgg
      241 tgaaagaaag ccttcagctt cagctactgg agatggaaat gctgttttct atgtttccta
      301 accaaggaga agtaaaactt gaagatgtaa atgccctgac gaatataaag aggtatttgg
      361 aaggcacaag ggaggcgctg ccaccaaaaa tcgaatttgt aattacactc cagattgaag
      421 agcccaaggt gaaaattgat ttgcaagtga ccatgcctca cagctacccc tatgtagcat
      481 tgcagctgtt tggacggtca tctgaacttg acagacatca gcagctactt ctcaacaaag
      541 gtctcacttc ttacataggg acttttgatc caggtgagct ctgtgtatgt gcagcaatcc
      601 agtggctaca ggacaacagt gcatcttatt tcctgaacag aaagcttgta tatgaaccat
      661 ctacacaagc aaagccagtc aagaacacat tcctccgaat gtggatctac agtcaccata
      721 tatatcagca ggacctaagg aaaaagattt tggatgttgg gaaaaggtta gatgtgactg
      781 gattttgcat gacaggaaag cctggtataa tctgtgtgga gggtttcaaa gagcactgtg
      841 aggagttctg gcacacaatt aggtacccca attggaagca catttcctgt aagcatgctg
      901 aaagcgtgga gacagaagga aatggtgagg acctgcgcct tttccattct tttgaagagt
      961 tactccttga ggctcatggt gactatggat taaggaatga ctatcacatg aatctgggcc
     1021 aattcttaga atttctcaag aagcacaaaa gtgagcatgt ttttcagata ctatttggta
     1081 ttgaaagcaa aagttcagac tcataaaaag cgattaagag gcctatgcct gtaatttcac
     1141 taagtcagta tttctgttaa taagaccaaa ttaaaaaggc tagtggctgt gtagcatcct
     1201 cagtgcaaaa cccagctcca gaattttcac ctggtaacga atttcaactg acagtgaaat
     1261 gaataggcct ttaaacttta taacattgca attgtgatgt tatctctagg tttttgtgtg
     1321 aagtcattca aaaactattt cattgtaaat taataaaaac aatccattta acttgtgaag
     1381 ctgatttgat tgaagaggaa tccaaagccc ataactaaca tcaaaaatca aactgcaatt
     1441 atgaattgag aaatatgaat agcatttgtt tcacattgct agcacacatg tgacacaccc
     1501 acttgtcttt cattattgga aatctaaatc aagtttaaaa tgagaacagg aaggacatgt
     1561 ttacttcctt ttttgagacg gtgcgatctc ggctcactgc atcctcagct tcccaggttc
     1621 aagcgattct cctgcctcag cctcccaagt agctgggact acaggcgtgc gccaccacgc
     1681 ccagctaatt gttatatttt tagtagagac agggtttcat catgttggct aggatggtct
     1741 caatctctta acctcgtgat ctgcctgcct cggccttcca aagtgctggg attacaggtg
     1801 tgagccaccg cgcccagccc gtttacttca tttcttactt taaactccta tttcgagtgt
     1861 tttagtaaaa ctagatccta atagcagtgg caaaggactc atagacatga agtcccacga
     1921 gttaaaagat gacacacaat gctatgtgtt ctggctgttt atatcagttc atgatactag
     1981 caatcctgat accagtatta gtttaattct tatccagaaa agataaacac atggttcctt
     2041 gtctacaaag tattcgcctg tttcaatcca acctttgcct gtgtgccagt atgcattact
     2101 ataaagggca agagactgtt gaggggacca gtgtggatat ctgcatcatt accttattgg
     2161 gaaaaaaaaa atctaattct acagtccgat gatgttactg ccatctcctc tgaaaattcc
     2221 aagctccaca ggcttcacca ggcttttcaa aatgagagtt tattttaatg attaaaaacc
     2281 gctatttaag tagctcttgc caagcctttt cattaccagg tctccatccc tccccaagta
     2341 tttctgcgag tctcatgtgc taagagatgt cttgagcagc ctctgcagct ttccgtgttt
     2401 ctgtggtcag ctactgctgc cctttcccgg gaggcattcc attctcctac tgggtcctct
     2461 caagatgcca aagcttggtg ctgggattta ggaacacatc ctgttagatg tcagacagtg
     2521 ctgcttgtgc tggggagcct acagaacttc tgatgaaact accatctggt tttaccctct
     2581 gtgccgtgga tgcagacgtg tccttgggct acagagagga catgatggag caggaggccc
     2641 tatcccaagg aggtgttaga actgggtcca ctttgtactg cctctttctt cttaggtcac
     2701 aatgagtgtc ctctcagggc acaactcaga tcttcaaccc atggctcgct gtaggcctgc
     2761 cccgccaggt cctccagctt gccattcatg tttccatcct agccttggtt gtgctggaac
     2821 tcaggctgga gcctgacact ttgcctatat gcaaagggaa gaaataggac ttacattgcc
     2881 aaggaatcac ttcttaatgt ttgccagcac taaaaacaac aaagtatagg aatctttttc
     2941 ccccacagtc tccacaaagc tatcaataag tataattcgc atttacaagt tttaggcctt
     3001 caacagatgt aactccatcc aaatgaatca atatgtgcca tcaacctacc ttatagaggt
     3061 gtttttcctg attacatgag caaaagtagc tacagaaaga tgggtgtaaa gaaaaggcaa
     3121 taaattctag gttatgaact ctactgcttc tggagctatt tctgagattt ttcagaacct
     3181 acttttttat aaataagtct aatttgagca ttctgcaata ctttttttcc tatcaggaaa
     3241 actaatgcag atagtattat ggggacgtgt aggttttata gaaaaaaaaa gtacatgtat
     3301 aattcaaaac tcaactttgt atgtatagga gtctgctggt tgtttgcaca gcctgatatg
     3361 agcacataat aaaagtccgt cattccccaa ccccctcccc ctacacacac agcttatttt
     3421 gggaaactgc cccttccctg tgtgatttgg gaagagaaag tgataggaat caagttgtcc
     3481 tctggcagcc tcctggagag atggctgtga gctcttgctg cttaaacctc tagtgccacc
     3541 ctcatttctg acctactgaa tgctcagctg tttggcattt cctttgaatg acccagcatc
     3601 ttcccttttg ttgtcggaaa tcagaatcag tctctattgc ttgtaactta agaatctgga
     3661 tattctgttt attatattct taaatggtta tttggaaaat gtgctcattt ataaaagtta
     3721 cagtgtcttt ttaaagtttg ctgaagtaaa tgaagcatat cgtcaagta
//
