LOCUS       NM_015952               5385 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RWD domain containing 1 (RWDD1), transcript variant 1,
            mRNA.
ACCESSION   NM_015952
VERSION     NM_015952.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5385)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5385)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5385)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 5385)
  AUTHORS   Vieira,A.R., McHenry,T.G., Daack-Hirsch,S., Murray,J.C. and
            Marazita,M.L.
  TITLE     Candidate gene/loci studies in cleft lip/palate and dental
            anomalies finds novel susceptibility genes for clefts
  JOURNAL   Genet Med 10 (9), 668-674 (2008)
   PUBMED   18978678
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 5385)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290727.1, AK301089.1, CK817864.1 and AL121953.21.
            
            On Nov 22, 2018 this sequence version replaced NM_015952.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.48637.1,
                                           SRR1803615.227285.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000466444.7/ ENSP00000420357.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-901               AK290727.1         138-1038
            902-1298            AK301089.1         1016-1412
            1299-1311           CK817864.1         1-13                c
            1312-5385           AL121953.21        89678-93751
FEATURES             Location/Qualifiers
     source          1..5385
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.1"
     gene            1..5385
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
                     /note="RWD domain containing 1"
                     /db_xref="GeneID:51389"
                     /db_xref="HGNC:HGNC:20993"
                     /db_xref="MIM:620844"
     exon            1..152
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..811
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
                     /note="isoform a is encoded by transcript variant 1; RWD
                     domain-containing protein 1; DRG family-regulatory protein
                     2"
                     /codon_start=1
                     /product="RWD domain-containing protein 1 isoform a"
                     /protein_id="NP_057036.2"
                     /db_xref="CCDS:CCDS34520.1"
                     /db_xref="GeneID:51389"
                     /db_xref="HGNC:HGNC:20993"
                     /db_xref="MIM:620844"
                     /translation="MTDYGEEQRNELEALESIYPDSFTVLSENPPSFTITVTSEAGEN
                     DETVQTTLKFTYSEKYPDEAPLYEIFSQENLEDNDVSDILKLLALQAEENLGMVMIFT
                     LVTAVQEKLNEIVDQIKTRREEEKKQKEKEAEEAEKQLFHGTPVTIENFLNWKAKFDA
                     ELLEIKKKRMKEEEQAGKNKLSGKQLFETDHNLDTSDIQFLEDAGNNVEVDESLFQEM
                     DDLELEDDEDDPDYNPADPESDSAD"
     exon            153..218
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
                     /inference="alignment:Splign:2.1.0"
     exon            219..349
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
                     /inference="alignment:Splign:2.1.0"
     exon            350..493
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
                     /inference="alignment:Splign:2.1.0"
     exon            494..626
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
                     /inference="alignment:Splign:2.1.0"
     exon            627..689
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
                     /inference="alignment:Splign:2.1.0"
     exon            690..5385
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
                     /inference="alignment:Splign:2.1.0"
     regulatory      954..959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
                     /note="hexamer: AATAAA"
     polyA_site      978
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
                     /note="major polyA site"
     regulatory      3447..3452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
                     /note="hexamer: AGTAAA"
     polyA_site      3471
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
     regulatory      5303..5308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
                     /note="hexamer: AATAAA"
     polyA_site      5322
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
     regulatory      5362..5367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
                     /note="hexamer: AATAAA"
     polyA_site      5382
                     /gene="RWDD1"
                     /gene_synonym="CGI-24; PTD013"
ORIGIN      
        1 ctcccggcgc ggcagctgtc tgggctgctg cgcgccgcct aggtgtctgg gcgatctatg
       61 ggcaagagca agggccacga tgacagatta cggcgaggag cagcgcaacg agctggaggc
      121 cctggagtcc atctaccctg actccttcac agtattatca gaaaatccac ccagcttcac
      181 cattactgtg acgtctgagg ctggagaaaa tgatgaaact gtccagacta ccctcaagtt
      241 tacatacagt gaaaaatacc cagatgaagc tcccctttat gaaatattct cccaggaaaa
      301 tctagaagat aatgatgtct cagacatttt aaaattacta gcattacagg ctgaagaaaa
      361 tcttggtatg gtgatgattt ttactctagt gacagctgtg caagaaaaat taaatgaaat
      421 agtagatcag ataaaaacta gaagagaaga agaaaagaaa caaaaagaaa aagaagcaga
      481 agaagctgaa aagcaattat tccatggtac tccagttaca attgagaatt tcttaaattg
      541 gaaagccaag tttgatgcag aactcttgga aattaaaaag aaaaggatga aagaagaaga
      601 acaagcagga aaaaataaat taagtgggaa acaactattt gaaacagatc ataatcttga
      661 cacatctgat atccagttct tggaggatgc tggaaacaac gtggaggtag atgagtcttt
      721 gttccaagaa atggatgact tggagctgga ggatgatgaa gatgatccag actataatcc
      781 tgctgaccca gagagtgact cagctgacta atggactgtc cccatctgca gagaggcttg
      841 actgccacag catctgtggc tatgctcaga gggttatgat tttcctttct ttttttctaa
      901 gaaaaaatta ttttcaggag aatattcttc tgatagcttt catcattgaa cttaataaac
      961 tgaccttaaa atttcaaata taaaatgttc aaggcttctt actgttgagc acaaggttac
     1021 gtatttaaaa tcacctagta tttgagagag atcctgccta tagcaccaag actcgaaggt
     1081 aggctgctgc tgtgcacatg agtttataca caggaaattg gaataacttg gaatttctat
     1141 gctggagact ttggctactt ctggatttca agcattgtat gaagtgtgag aaaactgagg
     1201 tgactagcac attaaaccat ccagattcta gcctccaggc acactaaatt taagtcttga
     1261 taaaaccagg aggccatatt atgatcataa gtaagatgaa gtttagcctt ccttttagtc
     1321 cattttgtat tgccgtaaag gaatatctga ggctgggtaa tttataaaag gtttgccggg
     1381 tgcggtggct cacgcctgta atcccagcac tttgggaggc tgaggcaggt ggatcacgag
     1441 gtcaggagat tgagaccatc ctggctaaca cggtgaaacc ccgtctctat taaaaataca
     1501 aaaaattagc caggtgtggt ggcgagcacc tgtagtccca actactcggg aggctgaggc
     1561 aggacaatgg cgtgaacccg ggaggtggag cttgcagtga gccgagatca cgccactgca
     1621 ctccagcctg ggcaacagag caagactccg tctcaaaaaa aaaaaaaagg tttatttggc
     1681 tcataattct ggatgaccag aaagttgaag attgggtatc tgcatctggt gagagcctca
     1741 cgctgcttcc actcatggta gaaggggaag aggcactatg tgtgtagaga tcacatggcc
     1801 agagagtgag ggtggaagtg ccaggctttt tttttttttt taaactagct ttggtgggaa
     1861 ctccctcacc cctgctcccc acaggaaggc attaatctat ttatgaggga tctacctgct
     1921 ataacccaaa caccccacca gcccccatct cccaacacca ccacactggg gattaaattt
     1981 caatgtggga tttggagagg acaaatatcc aaaccatagc agtcttaaag tatttaaatt
     2041 agaatttaaa ttaaaattta aattacagta tttaaattag aatcatttgt ggagtttcta
     2101 aaaggtatgc attcctaggc ccctctcaag ttagatttat gaacactgat ccccagtctg
     2161 aattttaaaa cagcaaaatc tcatactggt tctacagatt attctgatgc acaatctggg
     2221 ttaagaacca ctgtcctgta gtcgtgaagt ctatatattt tggtattttc tttacctctt
     2281 ctctaattaa ccagtctgaa ggagtttgaa ttttggggat cgtacattgt ctgcaagaga
     2341 aacacattaa catccgtgca catagagtcc tttgtaataa tttgggatga ttgacttggt
     2401 ggctccaggt aggagagcca gtcttcatgc aagttattca gtcactacag ttttggagga
     2461 ctgactctta accccaatag gaaatcagtt gtgctatttt aaattcataa agctattata
     2521 aagagctgcc tccagtaaaa aatacatatg ccacataccc acaaacagca atattaagcc
     2581 ttcatttatt gttggagtta gaccttataa tcaaaaagca aattatttaa gataaaatta
     2641 ccattgagga gtttaatact tttcaaggaa tcttcacgtc agccttgatc ccagaccaat
     2701 agaatggaat aacaacagga atgttcagca tttctttgca gagagaaatc caaaagtttg
     2761 tcctatgtga gattttgctt ttcccatctt tttgaagctg atcagcagat acataagaac
     2821 ctggaagaag ctgctcaatt aaggttaaaa aaaataaaaa gcaattgtta gcaatgtggt
     2881 gctgaaatca agacttaact ttgaagtgtc aagaatgata acctcccatc cacttcatgt
     2941 gatttttaag aataaatttt atatatttct ccaggtatta aagtggatgt ccacctttgc
     3001 catttcagaa cctaaaggca gaatctaatg gtaaaatgaa gacaacctag ttgtcttcta
     3061 ataacctagt tagttctaat aacattctca aatattttca tctagagtaa atatttactg
     3121 ttggctttgt attctgggaa ttagcccaag actatgctgc tcaaatgggt gcaaatatac
     3181 tctcaggttg caatagcatg acgagtggta tttgaagcaa taattgttcc atcttggatt
     3241 atcggttttg ctctttgatt tggtaaagtt tttgtttttc tactcgtgcc agttgtatta
     3301 aaatgtcact aggttaaaaa caaacacaga tatgtttatt cattactgta tccctgtaat
     3361 aatgcctggc atgcagtagg tccctaatat ttgttgaatg aatgaattat agaatagagt
     3421 gcaaaattaa ttctaatgta ttttaaagta aagcatgaga gttcaaagaa atgttgtatt
     3481 tgccatctac aacttggaat aatgttcctt gatcctgctt tacttcatgc acttttgcca
     3541 gcagaggtgg atgccttagg gaaaaagttg gataaatgct gatctaaggc aacacgtcta
     3601 aatggttatg tgaacatttc ccagttgggg taaaactaag aggagtgata ataacatctc
     3661 atcaatttaa aggacaagtt cactgatcgt actgtcatac tccagagata catgtgccaa
     3721 gaagcaaaga gatgcactct tgtattccag aaagaagatg atttgtaagt gttcagtatt
     3781 tgtgtggcag cccttttagg tgtaatgaag tgtaacagaa aagtaagtga actacttcac
     3841 atagctctta atgtttgtct ttcagaggac atacgagtca ggcagcaaaa gttggagcca
     3901 ttgtatgatt gtgtgtcaaa atgagagtca cacacttcaa gaactgtagg aactaatttt
     3961 agaaaaagac tcttcagaac agatgacaca tgaaatgtga gtttatgtaa acatgtaaat
     4021 ttgagtagca ttagtttgtt ttctgtttag gaactgtatc agggtgacaa agatgaaaga
     4081 atgctgccag aaaagtatat tgttaaattt tcaggcctcc attggtgaag tttcaagtaa
     4141 cctttcactt aagttacttg tgtcagagga tggatgatgg ggtcatttaa attgttggac
     4201 aaagccatga aaggactttt aaaattttgt cataaaaata gccaatgatg tttttaattt
     4261 tacatctaaa actaatttgc attatcctgt gttagtgact gaatctcaac tcagtcctca
     4321 ttttttagtt caacttttga caaccttata ttcattgaca ccatggacag cacagtaaaa
     4381 aaatacacaa atttcttttg cagttattga tttggaatga tcactttaaa agagccatca
     4441 aatacgccta catattgagc cactctttat cattaaggtg aaaagttcat tcaattaagg
     4501 tatttgagtg ctactatgcg ccagcctttc tttgtgataa tgttaatttt ttttttcctc
     4561 ccctccatga agggaagaaa aaaaaattaa ttcggccatg aattttaata ttctggccag
     4621 caccttatcc atttgtagcc acgccaacaa atttattctg tgatatacca aacttacaaa
     4681 gtcactctgc gatttcagta aggcccattc ccaacatgag tgctgctgtc cacggtactg
     4741 aaccatcaat gctaaatggt atttagttgt ggatcttcat cctgtcatgc agctaaatat
     4801 tccaggaata ctgaaccaag tgaggagaaa gatagcagtg ggttgctgca aaggaggtga
     4861 ggggagggga gagatagcaa gtgagaaaaa gagagactag tggtgatgtt tttaagtaat
     4921 tgaagtaaaa aagagagaga aagagagaga gaagaggttc tactcagtcc accaaagctt
     4981 tttaatttcc ttacataatt aacatgatga atttttaaat aattgttata tttagttttg
     5041 ttcttccacc ttttggctat ttctactaca tatttactta tcataaaaaa tacttcctag
     5101 accttcctct tatagctatt gcctatctct gcctttgcag ctgttctcct ttaaagagta
     5161 gtctccatta gttttcttga cttcttcatc tccctgcata aagatgaagg gtatttagct
     5221 ctgaaaatcc tttactgttg aatatttaga ttgttttcaa tttttacata atgaacaatg
     5281 catcatggga ttattggctg caaataaatt ggaaacataa aaggtgtttt aagtttaaat
     5341 ttttttaaaa aaacaggtaa aaataaaata tttgccaaag actaa
//
