LOCUS       NM_022744               2785 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RUS family member 1 (RUSF1), mRNA.
ACCESSION   NM_022744
VERSION     NM_022744.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2785)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2785)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2785)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2785)
  AUTHORS   Leasure,C.D., Tong,H.Y., Hou,X.W., Shelton,A., Minton,M.,
            Esquerra,R., Roje,S., Hellmann,H. and He,Z.H.
  TITLE     root uv-b sensitive mutants are suppressed by specific mutations in
            ASPARTATE AMINOTRANSFERASE2 and by exogenous vitamin B6
  JOURNAL   Mol Plant 4 (4), 759-770 (2011)
   PUBMED   21511809
REFERENCE   5  (bases 1 to 2785)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2785)
  AUTHORS   Leasure,C.D., Tong,H., Yuen,G., Hou,X., Sun,X. and He,Z.H.
  TITLE     ROOT UV-B SENSITIVE2 acts with ROOT UV-B SENSITIVE1 in a root
            ultraviolet B-sensing pathway
  JOURNAL   Plant Physiol 150 (4), 1902-1915 (2009)
   PUBMED   19515790
  REMARK    GeneRIF: Functional characterization of related Arabidopsis
            proteins that contain a DUF647 domain and are involved in UV-B
            sensing in roots. C16orf58 is the closest human homolog.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA742232.1, AK023930.1, AC026471.6 and BC000822.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022744.3.
            
            Summary: This gene encodes a putative transmembrane protein
            containing a conserved DUF647 domain that may be involved in
            protein-protein interaction. The encoded protein is related to a
            plant protein that participates in ultraviolet B light-sensing
            during root morphogenesis. [provided by RefSeq, Feb 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023930.1, AK222913.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327237.7/ ENSP00000317579.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 DA742232.1         29-34
            7-1375              AK023930.1         1-1369
            1376-1376           AC026471.6         160514-160514       c
            1377-2766           AK023930.1         1371-2760
            2767-2785           BC000822.1         1165-1183
FEATURES             Location/Qualifiers
     source          1..2785
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2785
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /note="RUS family member 1"
                     /db_xref="GeneID:64755"
                     /db_xref="HGNC:HGNC:25848"
     exon            1..318
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1425
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /note="UPF0420 protein C16orf58; RUS1 family protein
                     C16orf58; RUS1 homolog; root UVB sensitivity"
                     /codon_start=1
                     /product="RUS family member 1"
                     /protein_id="NP_073581.2"
                     /db_xref="CCDS:CCDS10715.1"
                     /db_xref="GeneID:64755"
                     /db_xref="HGNC:HGNC:25848"
                     /translation="MADDAGLETPLCSEQFGSGEARGCRAAADGSLQWEVGGWRWWGL
                     SRAFTVKPEGRDAGEVGASGAPSPPLSGLQAVFLPQGFPDSVSPDYLPYQLWDSVQAF
                     ASSLSGSLATQAVLLGIGVGNAKATVSAATATWLVKDSTGMLGRIVFAWWKGSKLDCN
                     AKQWRLFADILNDVAMFLEIMAPVYPICFTMTVSTSNLAKCIVSVAGGATRAALTVHQ
                     ARRNNMADVSAKDSSQETLVNLAGLLVSLLMLPLVSGCPGFSLGCFFFLTALHIYANY
                     RAVRALVMETLNEGRLRLVLKHYLQRGEVLDPTAANRMEPLWTGFWPAPSLSLGVPLH
                     RLVSSVFELQQLVEGHQESYLLCWDQSQNQVQVVLNQKAGPKTILRAATHGLMLGALQ
                     GDGPLPAELEELRNRVRAGPKKESWVVVKETHEVLDMLFPKFLKGLQDAGWKTEKHQL
                     EVDEWRATWLLSPEKKVL"
     exon            319..433
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /inference="alignment:Splign:2.1.0"
     exon            434..479
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /inference="alignment:Splign:2.1.0"
     exon            480..512
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /inference="alignment:Splign:2.1.0"
     exon            513..618
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /inference="alignment:Splign:2.1.0"
     exon            619..720
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /inference="alignment:Splign:2.1.0"
     exon            721..791
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /inference="alignment:Splign:2.1.0"
     exon            792..976
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1034
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1105
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1249
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1327
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..2785
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2750..2755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /note="hexamer: AATAAA"
     regulatory      2764..2769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /note="hexamer: AATAAA"
     polyA_site      2771
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
                     /note="major polyA site"
     polyA_site      2785
                     /gene="RUSF1"
                     /gene_synonym="C16orf58; RUS"
ORIGIN      
        1 gggatccaaa agctcggcat ggctgacgac gcgggtttgg agaccccgct gtgttccgag
       61 cagttcggct ccggggaggc acggggctgc cgcgccgccg cggacgggag cctgcagtgg
      121 gaggtcgggg gctggcgctg gtgggggctc tccagggcct tcacggtcaa acctgaagga
      181 cgagatgcgg gcgaagtggg ggcttccggg gccccctcac cgcccctctc cgggctccag
      241 gccgtgttcc tgcctcaggg cttccctgat agcgtcagcc cggactactt gccctaccag
      301 ctgtgggatt ccgtgcaggc gtttgcttcc agcctctccg gctccctagc cacccaggca
      361 gtcttgctgg gcataggggt ggggaacgca aaagccactg tttcagctgc cacggccacc
      421 tggctcgtga aagattcaac tggcatgctg ggccgcatcg tctttgcctg gtggaaaggg
      481 agcaaactgg actgcaatgc caagcagtgg aggctttttg cggacatcct caatgacgta
      541 gccatgttcc ttgagattat ggctcctgta tacccaatct gtttcaccat gaccgtctcc
      601 accagcaacc tagccaagtg catcgtgagt gttgctggtg gggccactcg ggctgccctg
      661 accgtgcacc aggctcggag gaacaacatg gctgacgtgt cagccaagga cagcagccag
      721 gagacgctgg tgaacctggc ggggctcttg gtcagcctcc tgatgctccc tctggtgtca
      781 ggttgccctg gcttcagcct tggatgtttc ttcttcctca ctgccctcca catctacgcc
      841 aactaccgcg cggtccgagc cctggtcatg gagaccttga acgaaggccg gctccggctg
      901 gtcctgaagc actaccttca gaggggagag gtactcgacc caactgcagc caatcgcatg
      961 gagccgctgt ggacaggttt ctggccagct ccgtctctat ccctgggggt ccccttacac
     1021 cgcttggtct ccagtgtctt tgagctgcag cagctggttg aggggcacca agaatcctac
     1081 ctcctctgct gggaccagtc acaaaaccag gtacaggtag ttctgaacca gaaggcaggc
     1141 cccaagacca tcctaagggc cgccacacat gggctgatgc ttggggccct gcagggagat
     1201 ggaccccttc cagcagagct ggaggagctg aggaaccggg tgcgggcagg tcctaagaaa
     1261 gagagctggg tcgtcgtcaa ggagacacac gaagtgttgg acatgctgtt cccaaagttc
     1321 ttgaaaggac tgcaggatgc cggctggaag accgagaagc accagctaga ggtggatgag
     1381 tggagggcca catggcttct gtctcccgaa aagaaggtct tgtgagcagc ccagacggag
     1441 gcccaagccc agggcaggaa cctggagcaa ggacactttg gccacagcag gacaggggaa
     1501 aggcagcttt atttttcctt agggcaactg cagcgggtgg gccaggccct catgggaagt
     1561 gactgccaat cagatgcagt gggccccagg cagaggaagg ccgggagaag gggagccagg
     1621 accttctcac cccactgccc cttccccttt tctggggagc accgcaggct cctcaccccc
     1681 acttcctgtg aggctgtggc ttatggtgtc caacgcagtt ggtcttaggc atagaagccc
     1741 cagaggaaca cggccactgc catcatgagc agggcattga ggttgaccac acgggcccag
     1801 ctcgggtcct cgctgatgtc ctccagccgc ctggctgctg ccgctgcctc ctcctgggta
     1861 aggggcggag gactgcccac cccacctctg ctcattccac aaaaccagag caggcactgg
     1921 cggaagaggc ttggtgccgg ggcctggggc tctgagggaa attgaggccc tgcagttagt
     1981 ttgcgggaac tcagctcctc cagccccacc tcccagcatg gtgccctacc attcatctcc
     2041 atggcactct ctgggcaccc attctgtaca gggagtgagg agccttgctg ctcatcagca
     2101 tccaggtcct cccgttcctc cttgctatgc cggagactga agaccaggcg gtggagctgg
     2161 ggagggtggg agcacgaacg aggtgggagt tctgtccccc catgcctggc cctaaagtct
     2221 cttgcacacc agctcgtcac tgcctgccct acccacctct gtccagtcta cacacccagc
     2281 ccaggcttaa ctcatgccaa ctccacccta catggctgcc ctgtgccctc gggataaacc
     2341 ccaagcccct gagcttgtgt ttaaagccgt tggccttgct cccccagctt tgtcagctca
     2401 ggtctgtcta cacccagatg gtagcgcttg tgacactggc ctggcagtcc tgctcacagt
     2461 gttctgtgcc tgtgtgctcc caccctttcc tcctgctgct gcagaaaccc ggccatcctt
     2521 ccacacccag atctcttgtc ctgtcctcac cccaccctgc caccatcagc cctgcctgga
     2581 gccacctgcc ctttggcaac aaaaccaaac ctttttgtgg gcgttcaaga tggtattgtg
     2641 cccaccagtc agatcctgtg ttttgagtcc caaaggccat gccaaggatt ggctttggga
     2701 ggctttaatc accaacccat caacatcaag cctcccccag gccggttcaa ataaatgtat
     2761 ttaaataaaa attcttgctc ggcaa
//
